A novel quinazolinone derivative induces cytochrome c interdependent apoptosis and autophagy in human leukemia MOLT-4 cells

Toxicology Reports

Volumn 1, Issue , 2014, Pages 1013-1025

  Kumar, Suresh ^a,b   Guru, Santosh Kumar ^a,b   Pathania, Anup Singh ^a,b   Mupparapu, Nagaraju ^a,b   Kumar, Ajay ^b   Malik, Fayaz ^a,b   Bharate, Sandip B ^a,b   Naveed Ahmed, Qazi ^a,b   Vishwakarma, Ram A ^a,b   Bhushan, Shashi ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

2,3 Dihydro 2 (quinoline 5 yl) quinazolin 4(1H) one structure DQQ ; Apoptosis; Autophagy; Caspase; Cytochrome c

Indexed keywords

2,3 DIHYDRO 2 QUINOLINE 5 YL) QUINAZOLIN 4(1H) ONE; BECLIN 1; CASPASE; CASPASE 3; CYTOCHROME C; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; QUINAZOLINONE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; PHASE CONTRAST MICROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIGNAL TRANSDUCTION; ULTRAVIOLET SPECTROPHOTOMETRY; UPREGULATION; WESTERN BLOTTING;

EID: 84922726915     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2014.07.018     Document Type: Article

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