NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

Toxicology and Applied Pharmacology

Volumn 272, Issue 3, 2013, Pages 736-745

  Sobhakumari, Arya ^a,b   Schickling, Brandon M ^b   Love Homan, Laurie ^b   Raeburn, Ayanna ^b   Fletcher, Elise V M ^a,b   Case, Adam J ^b   Domann, Frederick E ^a,b,c   Miller, Francis J ^b,c   Simons, Andrean L ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Autophagy; EGFR; Erlotinib; HNSCC; LC3B; NOX4

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; COMPLEMENTARY DNA; ERLOTINIB; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PROTEIN EXPRESSION; RNA STABILITY; SITE DIRECTED MUTAGENESIS; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AUTOPHAGY; CHLOROQUINE; CQ; DIPHENYLENE IODONIUM; DN; DOMINANT NEGATIVE; DPI; DUAL OXIDASE; DUOX; EGFR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERL; ERLOTINIB; GFP; GREEN FLUORESCENT PROTEIN; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HNSCC; LC3; LC3B; LIGHT CHAIN 3; NADPH OXIDASE 4; NOX4; REACTIVE OXYGEN SPECIES; ROS; TEM; TKI; TRANSMISSION ELECTRON MICROSCOPY; TYROSINE KINASE INHIBITOR; UNTRANSLATED REGION; UTR; WILDTYPE; WT;

AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CYTOPROTECTION; HEAD AND NECK NEOPLASMS; HEK293 CELLS; HUMANS; NADPH OXIDASE; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 84884726088     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.07.013     Document Type: Article

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