Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata

Molecular Carcinogenesis

Volumn 48, Issue 12, 2009, Pages 1093-1108

  Bhushan, Shashi ^a   Malik, Fayaz ^a   Kumar, Ajay ^a   Isher, Harpreet Kaur ^b   Kaur, Indu Pal ^c   Taneja, Subhash Chandra ^a   Singh, Jaswant ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b Gyan Sagar Medical College and Hospital   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Akt; P53; PUMA; ROS; Triterpenediol

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CASPASE 3; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; DNA TOPOISOMERASE (ATP HYDROLYSING); IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PENTACYCLIC TRITERPENEDIOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN DRP1; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ONCOPROTEIN; PENTACYCLIC TRITERPENE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BOSWELLIA; BOSWELLIA SERRATA; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL DEATH; CELL NUCLEUS; CELL STRAIN HL 60; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UPREGULATION; UTERINE CERVIX CANCER; APOPTOSIS; CELL CYCLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; METABOLISM; PATHOLOGY; TUMOR CELL CULTURE; WESTERN BLOTTING;

BOSWELLIA SERRATA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; BOSWELLIA; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; OXIDATIVE STRESS; PENTACYCLIC TRITERPENES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70849124971     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20559     Document Type: Article

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