A new therapeutic approach in Parkinson's disease: Some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6796-6802

  Laddha, Sachin S ^a   Bhatnagar, Satyendra P ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Anti inflammatory activities; Fused quinazolinones; Parkinson disease; PDE1 inhibitors

Indexed keywords

1,2 DIMETHYL 7H THIENO[2',3':4,5]PYRIMIDO[6,1 B]QUINAZOLIN 7 ONE; 9 BROMO 1 (4 CHLOROPHENYL) 3 (4 TOLYL) 8H PYRIDO[2',3',:4,5]PYRIMIDO[6,1 B]QUINAZOLIN 8 ONE; 9,11 DIBROMO 1 (2 FURYL) 3 (4 TOLYL) 8H PYRIDO[2',3',:4,5]PYRIMIDO[6,1 B]QUINAZOLIN 8 ONE; 9,11 DIBROMO 1 (4 CHLOROPHENYL) 3 (4 TOLYL) 8H PYRIDO[2',3',:4,5]PYRIMIDO[6,1 B]QUINAZOLIN 8 ONE; 9,11 DIBROMO 1 (4 METHOXYPHENYL) 3 PHENYL 8H PYRIDO[2',3',:4,5]PYRIMIDO[6,1 B]QUINAZOLIN 8 ONE; ANTIINFLAMMATORY AGENT; INDOMETACIN; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; QUINAZOLINE DERIVATIVE; ROLIPRAM; TREQUINSIN; UNCLASSIFIED DRUG; VINPOCETINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PARKINSON DISEASE; PAW EDEMA; RAT; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHILD, PRESCHOOL; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; DRUG EVALUATION, PRECLINICAL; EDEMA; HUMANS; PARKINSON DISEASE; PHOSPHODIESTERASE INHIBITORS; QUINAZOLINES; RATS; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 69949169680     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.041     Document Type: Article

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