The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells

Chemico-Biological Interactions

Volumn 205, Issue 2, 2013, Pages 128-137

  Kumar, Sunil ^a   Pathania, Anup Singh ^a   Saxena, A K ^a   Vishwakarma, R A ^a   Ali, Asif ^a   Bhushan, Shashi ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Apoptosis; Erythrina suberosa; Flavonoids; NF B; STAT

Indexed keywords

4' METHOXY LICOFLAVANONE; ALPHA HYDROXYERYSOTRINE; ALPINUMISOFLAVONE; CASPASE 3; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FLAVONOID; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BID; STAT PROTEIN; UNCLASSIFIED DRUG; WIGHTEONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BARK; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHRINA; ERYTHRINA SUBEROSA; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ΔΨ(M); 3-(4,5-DIMETHYLTHIAZOLE-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; 4′-METHOXY LICOFLAVANONE; AIF; ALPINUMISOFLAVONE; APOPTOSIS; ERYTHRINA SUBEROSA; FLAVONOIDS; IΚB KINASE; IKK; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MLF; MTT; NF-ΚB; NUCLEAR TRANSCRIPTION FACTOR-ΚB; PHOSPHATIDYL SERINE; PI; PROPIDIUM IODIDE; PS; PTP; RH-123; RHODAMINE-123; SER; SERINE; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; STAT; TYR; TYROSINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; ERYTHRINA; FLAVONOIDS; HL-60 CELLS; HUMANS; I-KAPPA B KINASE; ISOFLAVONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NECROSIS; NF-KAPPA B; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84884694791     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.06.020     Document Type: Article

References (33)

1. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the 30 years from 1981 to 2010 J. Nat. Prod. 75 2012 311 335
2. R.L. Thangapazham, A. Sharma, and R.K. Maheshwari Multiple molecular targets in cancer chemoprevention by curcumin AAPS J. 8 2006 E443 449
3. D. Gledhill The Names of Plants fourth Ed 2008 Cambridge University Press
4. O. Flausino, L.A. Santos, H. Verli, A.M. Pereira, V.S. Bolzani, and R.L. Nunes-de-Souza Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu J. Nat. Prod. 70 2007 48 53
5. R. Garcia-Mateos, M. Soto-Hernandez, and D. Kelly Alkaloids form six Erythrina species endemic to Mexico Biochem. Syst. Ecol. 26 1998 545 551 (Pubitemid 28337540)
6. M.H. Sarragiotto, H.L. Filho, and A.J. Marsaioli Erysotrine-N-oxide and erythrartine-N-oxide, two novel alkaloids from Erythrina mulungu Can. J. Chem. 59 1981 2771 2775 (Pubitemid 12250700)
7. R.T. Hargreaves, D. Jonson, D. Millington, M. Mondal, W. Beavers, L. Becker, C. Young, and K.L. Rinehari Alkaloids of American species of Erythrina Lloydia 37 1974 569 580
8. R.N. Chopra, S.L. Nayar, and I.C. Chopra Glossary of Indian Medicinal Plants 1956 CSIR Publication New Delhi
9. M.E. Garín-Aguilar, J.E.R. Luna, M. Soto-Hernández, G.V. del Toro, and M.M. Vázquez Effect of crude extracts of Erythrina americana Mill. on aggressive behavior in rats J. Ethnopharmacol. 69 2000 189 196
10. S.M.A. Rodrigues, A.N.L. Batist, V.S. Bolzani, L.Á. Santos, P.J.C. Nogueira, R.L. Nunes-de-Souza, A. Latif, and M. Arfan Anxiolytic-like effects of erythrinian alkaloids from Erythrina suberosa Quím. Nova 34 2011 808 811
11. G.A. Miana, M. Ikram, F. Sultana, and M. Israr Khan The isolation and characterization of erysotrine from the leaves of Erythrina suberosa Llyodia 35 1972 92 93
12. M.L. Dhar, M.M. Dhar, B.N. Dhawan, B.N. Mehrotra, and C. Ray Screening of Indian plants for biological activity: Part I Indian J. Exp. Biol. 6 1968 232 247
13. S.K. Agrawal, M. Agrawal, P.R. Sharma, B.D. Gupta, S. Arora, and A.K. Saxena Induction of apoptosis in human promyelocytic leukemia HL60 cells by an extract from Erythrina suberosa stem bark Nutr. Cancer 63 2011 802 813
14. J. Jang, M. Na, P.T. Thuong, D. Njamen, J.T. Mbafor, Z.T. Fomum, E.R. Woo, and W.K. Oh Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii Chem. Pharm. Bull. 56 2008 85 88
15. M.Z. Rahman, S.J. Sultana, C.F. Faruquee, F. Ferdous, M.S. Rahman, M.S. Islam, and M.A. Rashid Phytochemical and biological investigation of Erythrina variegate, Saudi Pharm. J. 15 2007 140 145 (Pubitemid 46847862)
16. S.E. Masry, M.E. Amer, M.S. Abdel-Kader, and H.H. Zaatout Prenylated flavonoids of Erythrina lysistemon grown in Egypt Phytochemistry 60 2002 783 787
17. S. Bhushan, J. Singh, M.J. Rao, A.K. Saxena, and G.N. Qazi A novel lignan composition from Cedrus deodara induces apoptosis and early nitric oxide generation in human leukemia Molt -4 and HL-60 cells Nitric Oxide 14 2006 72 88
18. A. Saxena, A.K. Saxena, J. Singh, and S. Bhushan Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells Chem. Biol. Interact. 188 2010 580 590
19. S. Bhushan, A. Kumar, F. Malik, S.S. Andotra, V.K. Sethi, I.P. Kaur, S.C. Taneja, G.N. Qazi, and J. Singh A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells Apoptosis 12 2007 1911 1926 (Pubitemid 47498241)
20. I. Vermes, C. Haanen, H. Steffen-Nakken, and C. Reutellingsperger A novel assay for apoptosis, Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin-V J. Immunol. Methods 184 1995 39 51
21. S. Bhushan, F. Malik, A. Kumar, I.P. Kaur, H.K. Isher, S.C. Taneja, and J. Singh Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata Mol. Carcinog. 48 2009 1093 1108
22. D- arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-Xl J. Pharmacol. Exp. Ther. 301 2002 568 577 (Pubitemid 34429969)
23. T.Y. Shina, S.H. Kimb, K. Sukb, J.H. Ha, I. Kim, M.G. Lee, C.D. Jun, S.Y. Kim, J.P. Lim, J.S. Eun, H.Y. Shin, and H.M. Kim Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model Toxicol. Appl. Pharmacol. 209 2005 255 262 (Pubitemid 41713949)
24. R. Buettner, L.B. Mora, and R. Jove Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention Clin. Cancer Res. 8 2002 945 954 (Pubitemid 35177340)
25. H. Yu, D. Pardoll, and R. Jove STATs in cancer inflammation and immunity: a leading role for STAT3 Nat. Rev. Can. 9 2009 798 809
26. M. Nishikori Classical and alternative NF-kB activation pathways and their roles in lymphoid malignancies J. Clin. Exp. Hematop. 45 2005 15 24
27. H. Douglas, and R.A. Weinberg The Hallmarks of cancer Cell 100 2000 57 70 (Pubitemid 30046295)
28. Y. Aylon, and M. Oren Living with p53, dying of p53 Cell 130 2007 597 600 (Pubitemid 47268063)
29. D.P. Liu, H. Song, and Y. Xu A common gain of function of p53 cancer mutants in inducing genetic instability Oncogene 29 2010 949 956
30. K.M. Debatin Activation of apoptosis pathways by anti-cancer treatment Toxicol. Lett. 112 113 2000 41 48
31. S. Nagata, and P. Golstein The Fas death factor Science 267 1995 1449 1456
32. M. Yingchang, S.D. Thomas, X. Xiaohua, L.K. Casson, D.M. Miller, and P.J. Bates Apoptosis in leukemia cell is accompanied by alterations in the level and localization of nucleolin J. Biol. Chem. 278 2003 8572 8579 (Pubitemid 36800611)
33. K.S. Ahn, and B.B. Aggarwal Transcription factor NF-kappaB: a sensor for smoke and stress signals Ann. N. Y. Acad. Sci. 1056 2005 218 233 (Pubitemid 43030980)