Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 246-254

  Pathania, Anup Singh ^a,b   Guru, Santosh Kumar ^b   Verma, M K ^b   Sharma, Chetna ^b   Abdullah, Sheikh Tasduq ^a,b   Malik, Fayaz ^a,b   Chandra, Suresh ^b   Katoch, Meenu ^b   Bhushan, Shashi ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Apoptosis; Essential oil; Monarda citriodora; PI3K AKT mTOR

Indexed keywords

ANTINEOPLASTIC AGENT; CARVACROL; CASPASE 3; CASPASE 8; CASPASE 9; ESSENTIAL OIL; MAMMALIAN TARGET OF RAPAMYCIN; MONARDA EXTRACT; MYRCENE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PARA CYMENE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; TERPINEN 4 OL; THYMOL; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; RBCL PROTEIN, PLASTID; RIBULOSEBISPHOSPHATE CARBOXYLASE; TARGET OF RAPAMYCIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DISRUPTION; CELL PROLIFERATION; CELL STRAIN HL 60; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MONARDA; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMYELOCYTIC LEUKEMIA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GENETICS; HL 60 CELL LINE; METABOLISM; PROTEIN TRANSPORT; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MONARDA; OILS, VOLATILE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RIBULOSE-BISPHOSPHATE CARBOXYLASE; SIGNAL TRANSDUCTION; THYMOL; TOR SERINE-THREONINE KINASES;

EID: 84884401591     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.037     Document Type: Article

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