-
1
-
-
18244365849
-
Protein drug stability: a formulation challenge
-
Frokjaer S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov 2005;4:298-306.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 298-306
-
-
Frokjaer, S.1
Otzen, D.E.2
-
2
-
-
0037393955
-
Challenges for the oral delivery of macromolecules
-
Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov 2003;2:289-95.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 289-295
-
-
Goldberg, M.1
Gomez-Orellana, I.2
-
3
-
-
84881594004
-
Mucosal drug delivery: barriers, in vitro models and formulation strategies
-
Boegh M, Foged C, Mullertz A, Nielsen HM. Mucosal drug delivery: barriers, in vitro models and formulation strategies. J Drug Del Sci Tech 2013;23:383-91.
-
(2013)
J Drug Del Sci Tech
, vol.23
, pp. 383-391
-
-
Boegh, M.1
Foged, C.2
Mullertz, A.3
Nielsen, H.M.4
-
4
-
-
84880557259
-
Novel engineered systems for oral, mucosal and transdermal drug delivery
-
Li H, Yu Y, Faraji DS, Li B, Lee CY, Kang L. Novel engineered systems for oral, mucosal and transdermal drug delivery. J Drug Target 2013;21:611-29.
-
(2013)
J Drug Target
, vol.21
, pp. 611-629
-
-
Li, H.1
Yu, Y.2
Faraji, D.S.3
Li, B.4
Lee, C.Y.5
Kang, L.6
-
5
-
-
75649132886
-
Functional morphology of the gastrointestinal tract
-
Sasakawa C. (ed). Springer, Berlin Heidelberg
-
Shen L. Functional morphology of the gastrointestinal tract. In: Sasakawa C. (ed). Molecular Mechanisms of Bacterial Infection Via the Gut. Springer, Berlin Heidelberg, 2009;1-35.
-
(2009)
Molecular Mechanisms of Bacterial Infection Via the Gut
, pp. 1-35
-
-
Shen, L.1
-
6
-
-
60149089459
-
Barrier properties of mucus
-
Cone RA. Barrier properties of mucus. Adv Drug Deliv Rev 2009;61:75-85.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 75-85
-
-
Cone, R.A.1
-
8
-
-
0030745147
-
Perspectives on the significance of altered glycosylation of glycoproteins in cancer
-
Kim YJ, Varki A. Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj J 1997;14:569-76.
-
(1997)
Glycoconj J
, vol.14
, pp. 569-576
-
-
Kim, Y.J.1
Varki, A.2
-
10
-
-
34447338031
-
The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity
-
Round AN, McMaster TJ, Miles MJ, Corfield AP, Berry M. The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity. Glycobiology 2007;17:578-85.
-
(2007)
Glycobiology
, vol.17
, pp. 578-585
-
-
Round, A.N.1
McMaster, T.J.2
Miles, M.J.3
Corfield, A.P.4
Berry, M.5
-
11
-
-
77957944452
-
Mucin layers and multilayers - physicochemical properties and applications
-
Svensson O, Arnebrant T. Mucin layers and multilayers - physicochemical properties and applications. Curr Opin Colloid Interface Sci 2010;15:395-405.
-
(2010)
Curr Opin Colloid Interface Sci
, vol.15
, pp. 395-405
-
-
Svensson, O.1
Arnebrant, T.2
-
13
-
-
84859719708
-
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers
-
Ensign LM, Cone R, Hanes J. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev 2012;64:557-70.
-
(2012)
Adv Drug Deliv Rev
, vol.64
, pp. 557-570
-
-
Ensign, L.M.1
Cone, R.2
Hanes, J.3
-
14
-
-
84902373800
-
Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption
-
Boegh M, Baldursdottir SG, Mullertz A, Nielsen HM. Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. Eur J Pharm Biopharm 2014;87:227-35.
-
(2014)
Eur J Pharm Biopharm
, vol.87
, pp. 227-235
-
-
Boegh, M.1
Baldursdottir, S.G.2
Mullertz, A.3
Nielsen, H.M.4
-
15
-
-
84868599371
-
Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
-
Kirch J, Schneider A, Abou B, Hopf A, Schaefer UF, Schneider M et al. Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc Natl Acad Sci USA 2012;109:18355-60.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 18355-18360
-
-
Kirch, J.1
Schneider, A.2
Abou, B.3
Hopf, A.4
Schaefer, U.F.5
Schneider, M.6
-
16
-
-
76249115874
-
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
-
Lai SK, Wang YY, Hida K, Cone R, Hanes J. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci USA 2010;107:598-603.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 598-603
-
-
Lai, S.K.1
Wang, Y.Y.2
Hida, K.3
Cone, R.4
Hanes, J.5
-
17
-
-
84878663137
-
Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues
-
Ensign LM, Henning A, Schneider CS, Maisel K, Wang YY, Porosoff MD et al. Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues. Mol Pharm 2013;10:2176-82.
-
(2013)
Mol Pharm
, vol.10
, pp. 2176-2182
-
-
Ensign, L.M.1
Henning, A.2
Schneider, C.S.3
Maisel, K.4
Wang, Y.Y.5
Porosoff, M.D.6
-
19
-
-
34249870086
-
Rheology of gastric mucin exhibits a pH-dependent sol-gel transition
-
Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R et al. Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. Biomacromolecules 2007;8:1580-6.
-
(2007)
Biomacromolecules
, vol.8
, pp. 1580-1586
-
-
Celli, J.P.1
Turner, B.S.2
Afdhal, N.H.3
Ewoldt, R.H.4
McKinley, G.H.5
Bansil, R.6
-
20
-
-
0033022229
-
pH-dependent conformational change of gastric mucin leads to sol-gel transition
-
Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N et al. pH-dependent conformational change of gastric mucin leads to sol-gel transition. Biophys J 1999;76:1250-8.
-
(1999)
Biophys J
, vol.76
, pp. 1250-1258
-
-
Cao, X.1
Bansil, R.2
Bhaskar, K.R.3
Turner, B.S.4
LaMont, J.T.5
Niu, N.6
-
21
-
-
28844476527
-
Atomic force microscopy reveals aggregation of gastric mucin at low pH
-
Hong Z, Chasan B, Bansil R, Turner BS, Bhaskar KR, Afdhal NH. Atomic force microscopy reveals aggregation of gastric mucin at low pH. Biomacromolecules 2005;6:3458-66.
-
(2005)
Biomacromolecules
, vol.6
, pp. 3458-3466
-
-
Hong, Z.1
Chasan, B.2
Bansil, R.3
Turner, B.S.4
Bhaskar, K.R.5
Afdhal, N.H.6
-
22
-
-
84890365790
-
The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH
-
Wang YY, Lai SK, Ensign LM, Zhong W, Cone R, Hanes J. The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH. Biomacromolecules 2013;14:4429-35.
-
(2013)
Biomacromolecules
, vol.14
, pp. 4429-4435
-
-
Wang, Y.Y.1
Lai, S.K.2
Ensign, L.M.3
Zhong, W.4
Cone, R.5
Hanes, J.6
-
23
-
-
80052159184
-
Biological hydrogels as selective diffusion barriers
-
Lieleg O, Ribbeck K. Biological hydrogels as selective diffusion barriers. Trends Cell Biol 2011;21:543-51.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 543-551
-
-
Lieleg, O.1
Ribbeck, K.2
-
25
-
-
84855434887
-
Mucus thickness in the gastrointestinal tract of laboratory animals
-
Varum FJ, Veiga F, Sousa JS, Basit AW. Mucus thickness in the gastrointestinal tract of laboratory animals. J Pharm Pharmacol 2012;64:218-27.
-
(2012)
J Pharm Pharmacol
, vol.64
, pp. 218-227
-
-
Varum, F.J.1
Veiga, F.2
Sousa, J.S.3
Basit, A.W.4
-
26
-
-
60149111908
-
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
-
Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev 2009;61:158-71.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 158-171
-
-
Lai, S.K.1
Wang, Y.Y.2
Hanes, J.3
-
27
-
-
78649835810
-
Barrier properties of gastrointestinal mucus to nanoparticle transport
-
Crater JS, Carrier RL. Barrier properties of gastrointestinal mucus to nanoparticle transport. Macromol Biosci 2010;10:1473-83.
-
(2010)
Macromol Biosci
, vol.10
, pp. 1473-1483
-
-
Crater, J.S.1
Carrier, R.L.2
-
28
-
-
84888203026
-
Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems
-
Friedl H, Dunnhaupt S, Hintzen F, Waldner C, Parikh S, Pearson JP et al. Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems. J Pharm Sci 2013;102:4406-13.
-
(2013)
J Pharm Sci
, vol.102
, pp. 4406-4413
-
-
Friedl, H.1
Dunnhaupt, S.2
Hintzen, F.3
Waldner, C.4
Parikh, S.5
Pearson, J.P.6
-
29
-
-
84884324232
-
Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier
-
Li LD, Crouzier T, Sarkar A, Dunphy L, Han J, Ribbeck K. Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier. Biophys J 2013;105:1357-65.
-
(2013)
Biophys J
, vol.105
, pp. 1357-1365
-
-
Li, L.D.1
Crouzier, T.2
Sarkar, A.3
Dunphy, L.4
Han, J.5
Ribbeck, K.6
-
30
-
-
0029055473
-
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
-
Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 1995;16:351-80.
-
(1995)
Biopharm Drug Dispos
, vol.16
, pp. 351-380
-
-
Kararli, T.T.1
-
31
-
-
84887371418
-
Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery
-
Groo AC, Saulnier P, Gimel JC, Gravier J, Ailhas C, Benoit JP et al. Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery. Int J Nanomedicine 2013;8:4291-302.
-
(2013)
Int J Nanomedicine
, vol.8
, pp. 4291-4302
-
-
Groo, A.C.1
Saulnier, P.2
Gimel, J.C.3
Gravier, J.4
Ailhas, C.5
Benoit, J.P.6
-
32
-
-
0030610168
-
Comparative rheological investigation of crude gastric mucin and natural gastric mucus
-
Kocevar-Nared J, Kristl J, Smid-Korbar J. Comparative rheological investigation of crude gastric mucin and natural gastric mucus. Biomaterials 1997;18:677-81.
-
(1997)
Biomaterials
, vol.18
, pp. 677-681
-
-
Kocevar-Nared, J.1
Kristl, J.2
Smid-Korbar, J.3
-
34
-
-
0013562371
-
The influence of intestinal mucus components on the diffusion of drugs
-
Larhed AW, Artursson P, Bjork E. The influence of intestinal mucus components on the diffusion of drugs. Pharm Res 1998;15:66-71.
-
(1998)
Pharm Res
, vol.15
, pp. 66-71
-
-
Larhed, A.W.1
Artursson, P.2
Bjork, E.3
-
35
-
-
84875219051
-
Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs
-
Antunes F, Andrade F, Araujo F, Ferreira D, Sarmento B. Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs. Eur J Pharm Biopharm 2013;83:427-35.
-
(2013)
Eur J Pharm Biopharm
, vol.83
, pp. 427-435
-
-
Antunes, F.1
Andrade, F.2
Araujo, F.3
Ferreira, D.4
Sarmento, B.5
-
36
-
-
84880262631
-
Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation
-
Navabi N, McGuckin MA, Linden SK. Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One 2013;8:e68761.
-
(2013)
PLoS One
, vol.8
, pp. e68761
-
-
Navabi, N.1
McGuckin, M.A.2
Linden, S.K.3
-
37
-
-
0017064628
-
Human colonic adenocarcinoma cells. I. Establishment and description of a new line
-
Tom BH, Rutzky LP, Jakstys MM, Oyasu R, Kaye CI, Kahan BD. Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 1976;12:180-91.
-
(1976)
In Vitro
, vol.12
, pp. 180-191
-
-
Tom, B.H.1
Rutzky, L.P.2
Jakstys, M.M.3
Oyasu, R.4
Kaye, C.I.5
Kahan, B.D.6
-
38
-
-
33745630072
-
Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier
-
Grainger CI, Greenwell LL, Lockley DJ, Martin GP, Forbes B. Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm Res 2006;23:1482-90.
-
(2006)
Pharm Res
, vol.23
, pp. 1482-1490
-
-
Grainger, C.I.1
Greenwell, L.L.2
Lockley, D.J.3
Martin, G.P.4
Forbes, B.5
-
39
-
-
84878301863
-
The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model
-
Teubl BJ, Absenger M, Frohlich E, Leitinger G, Zimmer A, Roblegg E. The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model. Eur J Pharm Biopharm 2013;84:386-93.
-
(2013)
Eur J Pharm Biopharm
, vol.84
, pp. 386-393
-
-
Teubl, B.J.1
Absenger, M.2
Frohlich, E.3
Leitinger, G.4
Zimmer, A.5
Roblegg, E.6
-
40
-
-
84904267805
-
Development of 2D and 3D mucus models and their interactions with mucus-penetrating paclitaxel-loaded lipid nanocapsules
-
Groo AC, Mircheva K, Bejaud J, Ailhas C, Panaiotov I, Saulnier P et al. Development of 2D and 3D mucus models and their interactions with mucus-penetrating paclitaxel-loaded lipid nanocapsules. Pharm Res 2014;31:1753-65.
-
(2014)
Pharm Res
, vol.31
, pp. 1753-1765
-
-
Groo, A.C.1
Mircheva, K.2
Bejaud, J.3
Ailhas, C.4
Panaiotov, I.5
Saulnier, P.6
-
41
-
-
84878737680
-
Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy
-
Forier K, Messiaen AS, Raemdonck K, Deschout H, Rejman J, De BF et al. Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy. Nanomedicine 2013;8:935-49.
-
(2013)
Nanomedicine
, vol.8
, pp. 935-949
-
-
Forier, K.1
Messiaen, A.S.2
Raemdonck, K.3
Deschout, H.4
Rejman, J.5
De, B.F.6
-
42
-
-
84874239794
-
Nanoparticle diffusion in respiratory mucus from humans without lung disease
-
Schuster BS, Suk JS, Woodworth GF, Hanes J. Nanoparticle diffusion in respiratory mucus from humans without lung disease. Biomaterials 2013;34:3439-46.
-
(2013)
Biomaterials
, vol.34
, pp. 3439-3446
-
-
Schuster, B.S.1
Suk, J.S.2
Woodworth, G.F.3
Hanes, J.4
-
43
-
-
57049085726
-
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
-
Wang YY, Lai SK, Suk JS, Pace A, Cone R, Hanes J. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew Chem Int Ed Engl 2008;47:9726-9.
-
(2008)
Angew Chem Int Ed Engl
, vol.47
, pp. 9726-9729
-
-
Wang, Y.Y.1
Lai, S.K.2
Suk, J.S.3
Pace, A.4
Cone, R.5
Hanes, J.6
-
44
-
-
84864130324
-
Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery
-
Ensign LM, Schneider C, Suk JS, Cone R, Hanes J. Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater 2012;24:3887-94.
-
(2012)
Adv Mater
, vol.24
, pp. 3887-3894
-
-
Ensign, L.M.1
Schneider, C.2
Suk, J.S.3
Cone, R.4
Hanes, J.5
-
45
-
-
0027437938
-
Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations
-
Lesuffleur T, Porchet N, Aubert JP, Swallow D, Gum JR, Kim YS et al. Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J Cell Sci 1993;106:771-83.
-
(1993)
J Cell Sci
, vol.106
, pp. 771-783
-
-
Lesuffleur, T.1
Porchet, N.2
Aubert, J.P.3
Swallow, D.4
Gum, J.R.5
Kim, Y.S.6
-
46
-
-
0034816264
-
Diffusion of macromolecules and virus-like particles in human cervical mucus
-
Olmsted SS, Padgett JL, Yudin AI, Whaley KJ, Moench TR, Cone RA. Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys J 2001;81:1930-7.
-
(2001)
Biophys J
, vol.81
, pp. 1930-1937
-
-
Olmsted, S.S.1
Padgett, J.L.2
Yudin, A.I.3
Whaley, K.J.4
Moench, T.R.5
Cone, R.A.6
-
47
-
-
84863783683
-
Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study
-
Zabaleta V, Ponchel G, Salman H, Agueros M, Vauthier C, Irache JM. Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study. Eur J Pharm Biopharm 2012;81:514-23.
-
(2012)
Eur J Pharm Biopharm
, vol.81
, pp. 514-523
-
-
Zabaleta, V.1
Ponchel, G.2
Salman, H.3
Agueros, M.4
Vauthier, C.5
Irache, J.M.6
-
48
-
-
0030318764
-
Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration
-
Bernkop-Schnürch A, Fragner R. Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration. Pharm Pharmacol Commun 1996;2:361-3.
-
(1996)
Pharm Pharmacol Commun
, vol.2
, pp. 361-363
-
-
Bernkop-Schnürch, A.1
Fragner, R.2
-
49
-
-
0026601671
-
A study of macromolecular diffusion through native porcine mucus
-
Desai MA, Mutlu M, Vadgama P. A study of macromolecular diffusion through native porcine mucus. Experientia 1992;48:22-6.
-
(1992)
Experientia
, vol.48
, pp. 22-26
-
-
Desai, M.A.1
Mutlu, M.2
Vadgama, P.3
-
50
-
-
0032832853
-
Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo
-
Flemstrom G, Hallgren A, Nylander O, Engstrand L, Wilander E, Allen A. Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo. Am J Physiol 1999;277:375-82.
-
(1999)
Am J Physiol
, vol.277
, pp. 375-382
-
-
Flemstrom, G.1
Hallgren, A.2
Nylander, O.3
Engstrand, L.4
Wilander, E.5
Allen, A.6
|