Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 2, 2014, Pages 227-235

  Boegh, Marie ^a   Baldursdóttir, Stefania G ^a   Müllertz, Anette ^a   Nielsen, Hanne M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Biocompatibility; Biomacromolecular drug delivery; Biosimilar mucus; Caco 2 cell culture; Microstructure; Mucosal drug delivery; Permeability; Rheology; Viscoelasticity

Indexed keywords

BOVINE SERUM ALBUMIN; LIPID; MANNITOL; POLYMER; PROTEIN; STOMACH MUCIN; TESTOSTERONE; BUFFER; DRUG;

ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CACO 2 CELL LINE; CELL CULTURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; FLOW KINETICS; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; MOUTH MUCOSA; MUCUS; NONHUMAN; STOMACH MUCUS; SWINE; VISCOELASTICITY; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; HUMAN; METABOLISM; PERMEABILITY; PHARMACEUTICS; PROCEDURES; TIME;

ANIMALS; BUFFERS; CACO-2 CELLS; GASTRIC MUCINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIPIDS; MUCUS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PROTEINS; RHEOLOGY; SWINE; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84902373800     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.01.001     Document Type: Article

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