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Volumn 11, Issue 8, 2014, Pages 755-764

Prion-like mechanisms in alzheimer's disease

Author keywords

Alzheimer's disease; Prion like mechanism; Tanscellular propagation; Tau proteins; Templated conformational change; amyloid peptide

Indexed keywords

AMYLOID BETA PROTEIN; PRION PROTEIN; TAU PROTEIN; PRION;

EID: 84922716198     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720501108140910121425     Document Type: Article
Times cited : (24)

References (87)
  • 1
    • 19444374721 scopus 로고    scopus 로고
    • Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells
    • Magalhaes AC, Baron GS, Lee KS, Steele-Mortimer O, Dorward D, Prado MA, et al. Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci 25(21): 5207-16 (2005).
    • (2005) J Neurosci , vol.25 , Issue.21 , pp. 5207-5216
    • Magalhaes, A.C.1    Baron, G.S.2    Lee, K.S.3    Steele-Mortimer, O.4    Dorward, D.5    Prado, M.A.6
  • 3
    • 84872346089 scopus 로고    scopus 로고
    • Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy
    • Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci 33(3): 1024-37 (2013).
    • (2013) J Neurosci , vol.33 , Issue.3 , pp. 1024-1037
    • Iba, M.1    Guo, J.L.2    McBride, J.D.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 4
    • 67649273927 scopus 로고    scopus 로고
    • Propagation of tau misfolding from the outside to the inside of a cell
    • Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284(19): 12845-52 (2009).
    • (2009) J Biol Chem , vol.284 , Issue.19 , pp. 12845-12852
    • Frost, B.1    Jacks, R.L.2    Diamond, M.I.3
  • 5
    • 79955441814 scopus 로고    scopus 로고
    • Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
    • Guo JL, Lee VM. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286(17): 15317-31 (2011).
    • (2011) J Biol Chem , vol.286 , Issue.17 , pp. 15317-15331
    • Guo, J.L.1    Lee, V.M.2
  • 8
    • 78149392229 scopus 로고    scopus 로고
    • Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
    • Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, et al. Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330 (6006): 980-2 (2010).
    • (2010) Science , vol.330 , Issue.6006 , pp. 980-982
    • Eisele, Y.S.1    Obermuller, U.2    Heilbronner, G.3    Baumann, F.4    Kaeser, S.A.5    Wolburg, H.6
  • 9
    • 84862868531 scopus 로고    scopus 로고
    • Spreading of neurodegenerative pathology via neuronto- neuron transmission of beta-amyloid
    • Nath S, Agholme L, Kurudenkandy FR, Granseth B, Marcusson J, Hallbeck M. Spreading of neurodegenerative pathology via neuronto- neuron transmission of beta-amyloid. J Neurosci 32(26): 8767-77 (2012).
    • (2012) J Neurosci , vol.32 , Issue.26 , pp. 8767-8777
    • Nath, S.1    Agholme, L.2    Kurudenkandy, F.R.3    Granseth, B.4    Marcusson, J.5    Hallbeck, M.6
  • 10
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14(5): 504-6 (2008).
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 11
    • 79551519276 scopus 로고    scopus 로고
    • Alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    • Hansen C, Angot E, Bergstrom AL, Steiner JA, Pieri L, Paul G, et al. Alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 121(2): 715-25 (2011).
    • (2011) J Clin Invest , vol.121 , Issue.2 , pp. 715-725
    • Hansen, C.1    Angot, E.2    Bergstrom, A.L.3    Steiner, J.A.4    Pieri, L.5    Paul, G.6
  • 12
    • 84868148328 scopus 로고    scopus 로고
    • Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport
    • Freundt EC, Maynard N, Clancy EK, Roy S, Bousset L, Sourigues Y, et al. Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport. Ann Neurol 72(4): 517-24 (2012).
    • (2012) Ann Neurol , vol.72 , Issue.4 , pp. 517-524
    • Freundt, E.C.1    Maynard, N.2    Clancy, E.K.3    Roy, S.4    Bousset, L.5    Sourigues, Y.6
  • 13
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates Parkinsonlike neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, et al. Pathological alpha-synuclein transmission initiates Parkinsonlike neurodegeneration in nontransgenic mice. Science 338(6109): 949-53 (2012).
    • (2012) Science , vol.338 , Issue.6109 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'brien, P.5    Trojanowski, J.Q.6
  • 14
    • 84865522898 scopus 로고    scopus 로고
    • Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface
    • Trevino RS, Lauckner JE, Sourigues Y, Pearce MM, Bousset L, Melki R, et al. Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface. The J Biol Chemi 287(35): 29722-8 (2012).
    • (2012) The J Biol Chemi , vol.287 , Issue.35 , pp. 29722-29728
    • Trevino, R.S.1    Lauckner, J.E.2    Sourigues, Y.3    Pearce, M.M.4    Bousset, L.5    Melki, R.6
  • 15
    • 59649095699 scopus 로고    scopus 로고
    • Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
    • Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, Kopito RR. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Bio 11(2): 219-25 (2009).
    • (2009) Nat Cell Bio , vol.11 , Issue.2 , pp. 219-225
    • Ren, P.H.1    Lauckner, J.E.2    Kachirskaia, I.3    Heuser, J.E.4    Melki, R.5    Kopito, R.R.6
  • 16
    • 79952743365 scopus 로고    scopus 로고
    • Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
    • Munch C, O'Brien J, Bertolotti A. Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci USA 108(9): 3548-53 (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.9 , pp. 3548-3553
    • Munch, C.1    O'brien, J.2    Bertolotti, A.3
  • 17
    • 79956311051 scopus 로고    scopus 로고
    • A seeding reaction recapitulates intracellular formation of Sarkosylinsoluble transactivation response element (TAR) DNA-binding protein-43 inclusions
    • Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N. A seeding reaction recapitulates intracellular formation of Sarkosylinsoluble transactivation response element (TAR) DNA-binding protein-43 inclusions. J Biol Chem 286(21): 18664-72 (2011).
    • (2011) J Biol Chem , vol.286 , Issue.21 , pp. 18664-18672
    • Furukawa, Y.1    Kaneko, K.2    Watanabe, S.3    Yamanaka, K.4    Nukina, N.5
  • 18
    • 84888062913 scopus 로고    scopus 로고
    • Epidemiology and Etiology of Alzheimer's disease: From Genetic to Non- Genetic Factors
    • Jiang T, Yu JT, Tian Y, Tan L. Epidemiology and Etiology of Alzheimer's disease: From Genetic to Non- Genetic Factors. Curr Alzheimer Res 10(8): 852-67 (2013).
    • (2013) Curr Alzheimer Res , vol.10 , Issue.8 , pp. 852-867
    • Jiang, T.1    Yu, J.T.2    Tian, Y.3    Tan, L.4
  • 19
    • 84865576332 scopus 로고    scopus 로고
    • Novel disease-modifying therapies for Alzheimer's disease
    • Jiang T, Yu JT, Tan L. Novel disease-modifying therapies for Alzheimer's disease. Journal of Alzheimer's disease: JAD 31(3): 475-92 (2012).
    • (2012) Journal of Alzheimer's Disease: JAD , vol.31 , Issue.3 , pp. 475-492
    • Jiang, T.1    Yu, J.T.2    Tan, L.3
  • 20
    • 84888594143 scopus 로고    scopus 로고
    • Biology and genetics of prions causing neurodegeneration
    • Prusiner SB. Biology and genetics of prions causing neurodegeneration. Annu Rev Genet 47: 601-23 (2013).
    • (2013) Annu Rev Genet , vol.47 , pp. 601-623
    • Prusiner, S.B.1
  • 21
    • 0020321767 scopus 로고
    • Novel proteinaceous infectious particles cause scrapie
    • Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 216(4542): 136-44 (1982).
    • (1982) Science , vol.216 , Issue.4542 , pp. 136-144
    • Prusiner, S.B.1
  • 22
    • 84870531806 scopus 로고    scopus 로고
    • Mapping the prion protein distribution in marsupials: Insights from comparing opossum with mouse CNS
    • Poggiolini I, Legname G. Mapping the prion protein distribution in marsupials: insights from comparing opossum with mouse CNS. PloS one 7(11): e50370 (2012).
    • (2012) Plos One , vol.7 , Issue.11
    • Poggiolini, I.1    Legname, G.2
  • 23
    • 84859465192 scopus 로고    scopus 로고
    • Direct observation of multiple misfolding pathways in a single prion protein molecule
    • Yu H, Liu X, Neupane K, Gupta AN, Brigley AM, Solanki A, et al. Direct observation of multiple misfolding pathways in a single prion protein molecule. Proc Natl Acad Sci USA 109(14): 5283-8 (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.14 , pp. 5283-5288
    • Yu, H.1    Liu, X.2    Neupane, K.3    Gupta, A.N.4    Brigley, A.M.5    Solanki, A.6
  • 24
    • 84879980118 scopus 로고    scopus 로고
    • Prion-like propagation of protein aggregation and related therapeutic strategies
    • Kaufman SK, Diamond MI. Prion-like propagation of protein aggregation and related therapeutic strategies. Neurotherapeutics 10(3): 371-82 (2013).
    • (2013) Neurotherapeutics , vol.10 , Issue.3 , pp. 371-382
    • Kaufman, S.K.1    Diamond, M.I.2
  • 25
    • 80155157847 scopus 로고    scopus 로고
    • The seeds of neurodegeneration: Prion-like spreading in ALS
    • Polymenidou M, Cleveland DW. The seeds of neurodegeneration: prion-like spreading in ALS. Cell 147(3): 498-508 (2011).
    • (2011) Cell , vol.147 , Issue.3 , pp. 498-508
    • Polymenidou, M.1    Cleveland, D.W.2
  • 26
    • 67649286622 scopus 로고    scopus 로고
    • Cell biology: Beyond the prion principle
    • Aguzzi A. Cell biology: Beyond the prion principle. Nature 459(7249): 924-5 (2009).
    • (2009) Nature , vol.459 , Issue.7249 , pp. 924-925
    • Aguzzi, A.1
  • 27
    • 72149125838 scopus 로고    scopus 로고
    • The transcellular spread of cytosolic amyloids, prions, and prionoids
    • Aguzzi A, Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 64(6): 783-90 (2009).
    • (2009) Neuron , vol.64 , Issue.6 , pp. 783-790
    • Aguzzi, A.1    Rajendran, L.2
  • 28
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 11(4): 301-7 (2010).
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.4 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 29
    • 84862620376 scopus 로고    scopus 로고
    • Cell biology. A unifying role for prions in neurodegenerative diseases
    • Prusiner SB. Cell biology. A unifying role for prions in neurodegenerative diseases. Science 336(6088): 1511-3 (2012).
    • (2012) Science , vol.336 , Issue.6088 , pp. 1511-1513
    • Prusiner, S.B.1
  • 30
    • 80054024011 scopus 로고    scopus 로고
    • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
    • Jucker M, Walker LC. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 70(4): 532-40 (2011).
    • (2011) Ann Neurol , vol.70 , Issue.4 , pp. 532-540
    • Jucker, M.1    Walker, L.C.2
  • 31
    • 84858648349 scopus 로고    scopus 로고
    • A network diffusion model of disease progression in dementia
    • Raj A, Kuceyeski A, Weiner M. A network diffusion model of disease progression in dementia. Neuron 73(6): 1204-15 (2012).
    • (2012) Neuron , vol.73 , Issue.6 , pp. 1204-1215
    • Raj, A.1    Kuceyeski, A.2    Weiner, M.3
  • 32
    • 84863337784 scopus 로고    scopus 로고
    • Predicting regional neurodegeneration from the healthy brain functional connectome
    • Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW. Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron 73(6): 1216-27 (2012).
    • (2012) Neuron , vol.73 , Issue.6 , pp. 1216-1227
    • Zhou, J.1    Gennatas, E.D.2    Kramer, J.H.3    Miller, B.L.4    Seeley, W.W.5
  • 33
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nature reviews Drug discovery 10(9): 698-712 (2011).
    • (2011) Nature Reviews Drug Discovery , vol.10 , Issue.9 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 34
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • Jarrett JT, Lansbury PT, Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73(6): 1055-8.(1993).
    • (1993) Cell , vol.73 , Issue.6 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury, P.T.2
  • 35
    • 0027363383 scopus 로고
    • Evidence for the experimental transmission of cerebral beta-amyloidosis to primates
    • Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ. Evidence for the experimental transmission of cerebral beta-amyloidosis to primates. Int J Exp Pathol 74(5): 441-54 (1993).
    • (1993) Int J Exp Pathol , vol.74 , Issue.5 , pp. 441-454
    • Baker, H.F.1    Ridley, R.M.2    Duchen, L.W.3    Crow, T.J.4    Bruton, C.J.5
  • 36
    • 0034657130 scopus 로고    scopus 로고
    • Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice
    • Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, et al. Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. Neurosci 20(10): 3606-11 (2000).
    • (2000) Neurosci , vol.20 , Issue.10 , pp. 3606-3611
    • Kane, M.D.1    Lipinski, W.J.2    Callahan, M.J.3    Bian, F.4    Durham, R.A.5    Schwarz, R.D.6
  • 38
    • 33749020837 scopus 로고    scopus 로고
    • Exogenous induction of cerebral betaamyloidogenesis is governed by agent and host
    • Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, et al. Exogenous induction of cerebral betaamyloidogenesis is governed by agent and host. Science 313(5794): 1781-4 (2006).
    • (2006) Science , vol.313 , Issue.5794 , pp. 1781-1784
    • Meyer-Luehmann, M.1    Coomaraswamy, J.2    Bolmont, T.3    Kaeser, S.4    Schaefer, C.5    Kilger, E.6
  • 39
    • 84874853965 scopus 로고    scopus 로고
    • Mechanisms of protein seeding in neurodegenerative diseases
    • Walker LC, Diamond MI, Duff KE, Hyman BT. Mechanisms of protein seeding in neurodegenerative diseases. JAMA 70(3): 304-10 (2013).
    • (2013) JAMA , vol.70 , Issue.3 , pp. 304-310
    • Walker, L.C.1    Diamond, M.I.2    Duff, K.E.3    Hyman, B.T.4
  • 40
    • 12244249201 scopus 로고    scopus 로고
    • Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
    • Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 307(5707): 262-5 (2005).
    • (2005) Science , vol.307 , Issue.5707 , pp. 262-265
    • Petkova, A.T.1    Leapman, R.D.2    Guo, Z.3    Yau, W.M.4    Mattson, M.P.5    Tycko, R.6
  • 42
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 18(4): 351-7 (1997).
    • (1997) Neurobiol Aging , vol.18 , Issue.4 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 44
    • 78149378411 scopus 로고    scopus 로고
    • Medicine. Prion-like behavior of amyloidbeta
    • Kim J, Holtzman DM. Medicine. Prion-like behavior of amyloidbeta. Science 330(6006): 918-9 (2010).
    • (2010) Science , vol.330 , Issue.6006 , pp. 918-919
    • Kim, J.1    Holtzman, D.M.2
  • 45
    • 84857034922 scopus 로고    scopus 로고
    • The presence of Abeta seeds, and not age per se, is critical to the initiation of Abeta deposition in the brain
    • Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M. The presence of Abeta seeds, and not age per se, is critical to the initiation of Abeta deposition in the brain. Acta Neuropathologica 123(1): 31-7 (2012).
    • (2012) Acta Neuropathologica , vol.123 , Issue.1 , pp. 31-37
    • Hamaguchi, T.1    Eisele, Y.S.2    Varvel, N.H.3    Lamb, B.T.4    Walker, L.C.5    Jucker, M.6
  • 46
    • 84856961915 scopus 로고    scopus 로고
    • Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions
    • Ronnback A, Sagelius H, Bergstedt KD, Naslund J, Westermark GT, Winblad B, et al. Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions. Neurobiol Aging 33(4): 831 e11-9 (2012).
    • (2012) Neurobiol Aging , vol.33 , Issue.4
    • Ronnback, A.1    Sagelius, H.2    Bergstedt, K.D.3    Naslund, J.4    Westermark, G.T.5    Winblad, B.6
  • 47
    • 84871118236 scopus 로고    scopus 로고
    • The exosome secretory pathway transports amyloid precursor protein carboxylterminal fragments from the cell into the brain extracellular space
    • Perez-Gonzalez R, Gauthier SA, Kumar A, Levy E. The exosome secretory pathway transports amyloid precursor protein carboxylterminal fragments from the cell into the brain extracellular space. J Biol Chem 287(51): 43108-15 (2012).
    • (2012) J Biol Chem , vol.287 , Issue.51 , pp. 43108-43115
    • Perez-Gonzalez, R.1    Gauthier, S.A.2    Kumar, A.3    Levy, E.4
  • 48
    • 79952619322 scopus 로고    scopus 로고
    • Tunneling-nanotube development in astrocytes depends on p53 activation
    • Wang Y, Cui J, Sun X, Zhang Y. Tunneling-nanotube development in astrocytes depends on p53 activation. Cell death and differentiation 18(4): 732-42 (2011).
    • (2011) Cell Death and Differentiation , vol.18 , Issue.4 , pp. 732-742
    • Wang, Y.1    Cui, J.2    Sun, X.3    Zhang, Y.4
  • 49
    • 1142286348 scopus 로고    scopus 로고
    • Nanotubular highways for intercellular organelle transport
    • Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science 303(5660): 1007-10 (2004).
    • (2004) Science , vol.303 , Issue.5660 , pp. 1007-1010
    • Rustom, A.1    Saffrich, R.2    Markovic, I.3    Walther, P.4    Gerdes, H.H.5
  • 50
    • 84866327994 scopus 로고    scopus 로고
    • Multifaceted roles of tunneling nanotubes in intercellular communication
    • Marzo L, Gousset K, Zurzolo C. Multifaceted roles of tunneling nanotubes in intercellular communication. Frontiers in physiology 3: 72 (2012).
    • (2012) Frontiers in Physiology , vol.3
    • Marzo, L.1    Gousset, K.2    Zurzolo, C.3
  • 52
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14(8): 837-42 (2008).
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 54
    • 63649160214 scopus 로고    scopus 로고
    • Conformational diversity of wild-type Tau fibrils specified by templated conformation change
    • Frost B, Ollesch J, Wille H, Diamond MI. Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem 284(6): 3546-51 (2009).
    • (2009) J Biol Chem , vol.284 , Issue.6 , pp. 3546-3551
    • Frost, B.1    Ollesch, J.2    Wille, H.3    Diamond, M.I.4
  • 55
    • 77956242962 scopus 로고    scopus 로고
    • Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability
    • Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, Mandelkow E, Muller DJ. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem 285(35): 27302-13 (2010).
    • (2010) J Biol Chem , vol.285 , Issue.35 , pp. 27302-27313
    • Wegmann, S.1    Jung, Y.J.2    Chinnathambi, S.3    Mandelkow, E.M.4    Mandelkow, E.5    Muller, D.J.6
  • 56
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225(4667): 1168-70 (1984).
    • (1984) Science , vol.225 , Issue.4667 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 59
    • 79958110883 scopus 로고    scopus 로고
    • Alzheimer's pathogenesis: Is there neuronto- neuron propagation?
    • Braak H, Del Tredici K. Alzheimer's pathogenesis: is there neuronto- neuron propagation? Acta Neuropathologica 121(5): 589-95 (2011).
    • (2011) Acta Neuropathologica , vol.121 , Issue.5 , pp. 589-595
    • Braak, H.1    Del Tredici, K.2
  • 60
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimerrelated changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimerrelated changes. Acta Neuropathologica 82(4): 239-59 (1991).
    • (1991) Acta Neuropathologica , vol.82 , Issue.4 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 61
    • 84877906835 scopus 로고    scopus 로고
    • Tau pathology and neurodegeneration
    • Spillantini MG, Goedert M. Tau pathology and neurodegeneration. Lancet Neurology 12(6): 609-22 (2013).
    • (2013) Lancet Neurology , vol.12 , Issue.6 , pp. 609-622
    • Spillantini, M.G.1    Goedert, M.2
  • 62
    • 34548289005 scopus 로고    scopus 로고
    • The perforant path: Projections from the entorhinal cortex to the dentate gyrus
    • Witter MP. The perforant path: Projections from the entorhinal cortex to the dentate gyrus. Prog Brain Res 163: 43-61 (2007).
    • (2007) Prog Brain Res , vol.163 , pp. 43-61
    • Witter, M.P.1
  • 63
    • 80052940324 scopus 로고    scopus 로고
    • In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
    • Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. Neuroscience 31(37): 13110-7 (2011).
    • (2011) Neuroscience , vol.31 , Issue.37
    • Yamada, K.1    Cirrito, J.R.2    Stewart, F.R.3    Jiang, H.4    Finn, M.B.5    Holmes, B.B.6
  • 64
    • 84856707794 scopus 로고    scopus 로고
    • Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
    • Saman S, Kim W, Raya M, Visnick Y, Miro S, Jackson B, et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem 287(6): 3842-9 (2012).
    • (2012) J Biol Chem , vol.287 , Issue.6 , pp. 3842-3849
    • Saman, S.1    Kim, W.2    Raya, M.3    Visnick, Y.4    Miro, S.5    Jackson, B.6
  • 66
    • 84861758226 scopus 로고    scopus 로고
    • Trans-cellular propagation of Tau aggregation by fibrillar species
    • Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem 287(23): 19440-51 (2012).
    • (2012) J Biol Chem , vol.287 , Issue.23 , pp. 19440-19451
    • Kfoury, N.1    Holmes, B.B.2    Jiang, H.3    Holtzman, D.M.4    Diamond, M.I.5
  • 69
    • 84864935106 scopus 로고    scopus 로고
    • Constitutive secretion of tau protein by an unconventional mechanism
    • Chai X, Dage JL, Citron M. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol Dis 48(3): 356-66 (2012).
    • (2012) Neurobiol Dis , vol.48 , Issue.3 , pp. 356-366
    • Chai, X.1    Dage, J.L.2    Citron, M.3
  • 70
    • 84863011855 scopus 로고    scopus 로고
    • Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model
    • Lee S, Kim W, Li Z, Hall GF. Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. Int J Alzheimers Dis 2012: 172837 (2012).
    • (2012) Int J Alzheimers Dis , vol.2012
    • Lee, S.1    Kim, W.2    Li, Z.3    Hall, G.F.4
  • 71
    • 41149111293 scopus 로고    scopus 로고
    • Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells
    • Gomez-Ramos A, Diaz-Hernandez M, Rubio A, Miras-Portugal MT, Avila J. Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol Cell Neurosci 37(4): 673-81 (2008).
    • (2008) Mol Cell Neurosci , vol.37 , Issue.4 , pp. 673-681
    • Gomez-Ramos, A.1    Diaz-Hernandez, M.2    Rubio, A.3    Miras-Portugal, M.T.4    Avila, J.5
  • 72
    • 84872714502 scopus 로고    scopus 로고
    • Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
    • Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, et al. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. The J Biol Chem 288(3): 1856-70 (2013).
    • (2013) The J Biol Chem , vol.288 , Issue.3 , pp. 1856-1870
    • Wu, J.W.1    Herman, M.2    Liu, L.3    Simoes, S.4    Acker, C.M.5    Figueroa, H.6
  • 74
    • 79955865565 scopus 로고    scopus 로고
    • Monoclonal antibodies against beta-amyloid (Abeta) for the treatment of Alzheimer's disease: The Abeta target at a crossroads
    • Panza F, Frisardi V, Imbimbo BP, Seripa D, Solfrizzi V, Pilotto A. Monoclonal antibodies against beta-amyloid (Abeta) for the treatment of Alzheimer's disease: the Abeta target at a crossroads. Expert Opin Biol Ther 11(6): 679-86 (2011).
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.6 , pp. 679-686
    • Panza, F.1    Frisardi, V.2    Imbimbo, B.P.3    Seripa, D.4    Solfrizzi, V.5    Pilotto, A.6
  • 75
    • 79951563382 scopus 로고    scopus 로고
    • Passive (Amyloid-beta) immunotherapy attenuates monoaminergic axonal degeneration in the AbetaPPswe/PS1dE9 mice
    • Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, et al. Passive (amyloid-beta) immunotherapy attenuates monoaminergic axonal degeneration in the AbetaPPswe/PS1dE9 mice. J Alzheimer's disease 23(2): 271-9 (2011).
    • (2011) J Alzheimer's Disease , vol.23 , Issue.2 , pp. 271-279
    • Liu, Y.1    Lee, M.K.2    James, M.M.3    Price, D.L.4    Borchelt, D.R.5    Troncoso, J.C.6
  • 76
    • 84855780598 scopus 로고    scopus 로고
    • Gantenerumab: A novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta
    • Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, et al. Gantenerumab: A novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta. J Alzheimer's disease 28(1): 49-69 (2012).
    • (2012) J Alzheimer's Disease , vol.28 , Issue.1 , pp. 49-69
    • Bohrmann, B.1    Baumann, K.2    Benz, J.3    Gerber, F.4    Huber, W.5    Knoflach, F.6
  • 77
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody DL, Holtzman DM. Active and passive immunotherapy for neurodegenerative disorders. Ann Rev Neurosci 31: 175-93 (2008).
    • (2008) Ann Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 78
    • 77954656871 scopus 로고    scopus 로고
    • Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
    • Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H. Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp Neurol 224(2): 472-85 (2010).
    • (2010) Exp Neurol , vol.224 , Issue.2 , pp. 472-485
    • Boimel, M.1    Grigoriadis, N.2    Lourbopoulos, A.3    Haber, E.4    Abramsky, O.5    Rosenmann, H.6
  • 79
    • 79960563632 scopus 로고    scopus 로고
    • Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
    • Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 118(4): 658-67 (2011).
    • (2011) J Neurochem , vol.118 , Issue.4 , pp. 658-667
    • Boutajangout, A.1    Ingadottir, J.2    Davies, P.3    Sigurdsson, E.M.4
  • 80
    • 84891795977 scopus 로고    scopus 로고
    • Panamyloid oligomer specific scFv antibody attenuates memory deficits and brain amyloid burden in mice with Alzheimer's disease
    • Zhao M, Wang SW, Wang YJ, Zhang R, Li YN, Su YJ, et al. Panamyloid oligomer specific scFv antibody attenuates memory deficits and brain amyloid burden in mice with Alzheimer's disease. Curr Alzheimer Res 11(1): 69-78 (2014).
    • (2014) Curr Alzheimer Res , vol.11 , Issue.1 , pp. 69-78
    • Zhao, M.1    Wang, S.W.2    Wang, Y.J.3    Zhang, R.4    Li, Y.N.5    Su, Y.J.6
  • 81
    • 84865826167 scopus 로고    scopus 로고
    • Prions: A piece of the puzzle?
    • Lahiri DK. Prions: a piece of the puzzle? Science 337(6099): 1172 (2012).
    • (2012) Science , vol.337 , Issue.6099
    • Lahiri, D.K.1
  • 82
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases
    • Lahiri DK, Maloney B, Zawia NH. The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases. Mol Psychiatry 14(11): 992-1003 (2009).
    • (2009) Mol Psychiatry , vol.14 , Issue.11 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 84
  • 85
  • 87
    • 84904678185 scopus 로고    scopus 로고
    • Apolipoprotein e in Alzheimer's disease: An update
    • Yu JT, Tan L, Hardy J. Apolipoprotein e in Alzheimer's disease: An update. Ann Rev Neurosci 37: 79-100 (2014).
    • (2014) Ann Rev Neurosci , vol.37 , pp. 79-100
    • Yu, J.T.1    Tan, L.2    Hardy, J.3


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