Glucose metabolism in pigs expressing human genes under an insulin promoter

Xenotransplantation

Volumn 22, Issue 1, 2015, Pages 70-79

  Wijkstrom, Martin ^a   Bottino, Rita ^a,d   Iwase, Hayoto ^a   Hara, Hidetaka ^a   Ekser, Burcin ^a,e   Van Der Windt, Dirk ^a   Long, Cassandra ^a   Toledo, Frederico G S ^b   Phelps, Carol J ^b   Trucco, Massimo ^a,d   Cooper, David K C ^a   Ayares, David ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c REVIVICOR INC   (United States)

^d ALLEGHENY HEALTH NETWORK   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

arginine stimulation test; C peptide; genetic engineering; glucagon; insulin; IVGTT; pig; xenotransplantation

Indexed keywords

ARGININE; C PEPTIDE; CD39 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCAGON; GLUCOSE; IMMUNOGLOBULIN; INSULIN; MEMBRANE COFACTOR PROTEIN; TISSUE FACTOR PATHWAY INHIBITOR; ABATACEPT; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; APYRASE; CD46 PROTEIN, HUMAN; GALACTOSYLTRANSFERASE; GLUCOSE BLOOD LEVEL; HYBRID PROTEIN; LEUKOCYTE ANTIGEN; LIPOPROTEIN; LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR; SYNTHETIC DNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC MANIPULATION; GLUCOSE METABOLISM; HORMONE RESPONSE; IMMUNOFLUORESCENCE; LANDRACE PIG; NONHUMAN; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; ANALYSIS; ANIMAL; BIOSYNTHESIS; BLOOD; CELL LINE; DEFICIENCY; DIET RESTRICTION; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; METABOLISM; PANCREAS ISLET; PIG; SECRETION (PROCESS); TRANSGENIC ANIMAL;

ABATACEPT; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; ANTIGENS, CD46; APYRASE; ARGININE; BLOOD GLUCOSE; C-PEPTIDE; CELL LINE; FASTING; FIBROBLASTS; GALACTOSYLTRANSFERASES; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GENES, SYNTHETIC; GLUCAGON; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIPOPROTEINS; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; SUS SCROFA; SWINE; TRANSGENES;

EID: 84922677709     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12145     Document Type: Article

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