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Volumn 20, Issue 1, 2013, Pages 5-17

The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival

Author keywords

diabetes; glucose control; immunosuppression; islet xenotransplantation; nonhuman primates; pigs; transplant model limitations

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; INSULIN;

EID: 84873468988     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12012     Document Type: Article
Times cited : (35)

References (52)
  • 2
    • 56049088764 scopus 로고    scopus 로고
    • Pig islet xenotransplantation into non-human primate model
    • Dufrane D, Gianello P,. Pig islet xenotransplantation into non-human primate model. Transplantation 2008; 86: 753-760.
    • (2008) Transplantation , vol.86 , pp. 753-760
    • Dufrane, D.1    Gianello, P.2
  • 3
    • 67349237925 scopus 로고    scopus 로고
    • Pig-to-nonhuman primate islet xenotransplantation
    • Hering BJ, Walawalkar N,. Pig-to-nonhuman primate islet xenotransplantation. Transpl Immunol 2009; 21: 81-86.
    • (2009) Transpl Immunol , vol.21 , pp. 81-86
    • Hering, B.J.1    Walawalkar, N.2
  • 4
    • 0033638309 scopus 로고    scopus 로고
    • Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: The present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases
    • Cooper DKC, Keogh AM, Brink J, et al., Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases. J Heart Lung Transplant 2000; 19: 1125-1165.
    • (2000) J Heart Lung Transplant , vol.19 , pp. 1125-1165
    • Cooper, D.K.C.1    Keogh, A.M.2    Brink, J.3
  • 5
    • 70349655434 scopus 로고    scopus 로고
    • Current status of xenotransplantation and prospects for clinical application
    • Pierson RN 3rd, Dorling A, Ayares D, et al., Current status of xenotransplantation and prospects for clinical application. Xenotransplantation 2009; 16: 263-280.
    • (2009) Xenotransplantation , vol.16 , pp. 263-280
    • Pierson III, R.N.1    Dorling, A.2    Ayares, D.3
  • 6
    • 70349606907 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Executive summary
    • Hering BJ, Cooper DK, Cozzi E, et al., The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-executive summary. Xenotransplantation 2009; 16: 196-202.
    • (2009) Xenotransplantation , vol.16 , pp. 196-202
    • Hering, B.J.1    Cooper, D.K.2    Cozzi, E.3
  • 7
    • 70349597644 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial
    • Cooper DK, Casu A,. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial. Xenotransplantation 2009; 16: 229-238.
    • (2009) Xenotransplantation , vol.16 , pp. 229-238
    • Cooper, D.K.1    Casu, A.2
  • 8
    • 33644831338 scopus 로고    scopus 로고
    • Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    • Hering BJ, Wijkstrom M, Graham ML, et al., Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303.
    • (2006) Nat Med , vol.12 , pp. 301-303
    • Hering, B.J.1    Wijkstrom, M.2    Graham, M.L.3
  • 9
    • 33644829825 scopus 로고    scopus 로고
    • Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
    • Cardona K, Korbutt GS, Milas Z, et al., Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304-306.
    • (2006) Nat Med , vol.12 , pp. 304-306
    • Cardona, K.1    Korbutt, G.S.2    Milas, Z.3
  • 10
    • 79955527672 scopus 로고    scopus 로고
    • CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates
    • Thompson P, Cardona K, Russell M, et al., CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957.
    • (2011) Am J Transplant , vol.11 , pp. 947-957
    • Thompson, P.1    Cardona, K.2    Russell, M.3
  • 11
    • 34548321344 scopus 로고    scopus 로고
    • Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways
    • Cardona K, Milas Z, Strobert E, et al., Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. Am J Transplant 2007; 7: 2260-2268.
    • (2007) Am J Transplant , vol.7 , pp. 2260-2268
    • Cardona, K.1    Milas, Z.2    Strobert, E.3
  • 12
    • 82455210786 scopus 로고    scopus 로고
    • Islet xenotransplantation using Gal-deficient neonatal donors improves engraftment and function
    • Thompson P, Badell IR, Lowe M, et al., Islet xenotransplantation using Gal-deficient neonatal donors improves engraftment and function. Am J Transplant 2011; 11: 2593-2602.
    • (2011) Am J Transplant , vol.11 , pp. 2593-2602
    • Thompson, P.1    Badell, I.R.2    Lowe, M.3
  • 13
    • 70349706907 scopus 로고    scopus 로고
    • Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets
    • Van Der Windt DJ, Bottino R, Casu A, et al., Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009; 9: 2716-2726.
    • (2009) Am J Transplant , vol.9 , pp. 2716-2726
    • Van Der Windt, D.J.1    Bottino, R.2    Casu, A.3
  • 14
    • 66649102397 scopus 로고    scopus 로고
    • Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model
    • Hecht G, Eventov-Friedman S, Rosen C, et al., Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model. Proc Natl Acad Sci USA 2009; 106: 8659-8664.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8659-8664
    • Hecht, G.1    Eventov-Friedman, S.2    Rosen, C.3
  • 15
    • 78650298652 scopus 로고    scopus 로고
    • Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression
    • Dufrane D, Goebbels RM, Gianello P,. Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression. Transplantation 2010; 90: 1054-1062.
    • (2010) Transplantation , vol.90 , pp. 1054-1062
    • Dufrane, D.1    Goebbels, R.M.2    Gianello, P.3
  • 16
    • 84863209784 scopus 로고    scopus 로고
    • Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival
    • Thompson P, Badell IR, Lowe M, et al., Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival. Am J Transplant 2012; 12: 1765-1775.
    • (2012) Am J Transplant , vol.12 , pp. 1765-1775
    • Thompson, P.1    Badell, I.R.2    Lowe, M.3
  • 17
    • 33749149890 scopus 로고    scopus 로고
    • Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: Adverse effects and early responses
    • Rood PPM, Bottino R, Balamurugan AN, et al., Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses. Pancreas 2006; 33: 287-292.
    • (2006) Pancreas , vol.33 , pp. 287-292
    • Rood, P.P.M.1    Bottino, R.2    Balamurugan, A.N.3
  • 18
    • 80053440451 scopus 로고    scopus 로고
    • Refining the high-dose streptozotocin-induced diabetic nonhuman primate model: An evaluation of risk factors and outcomes
    • Graham ML, Mutch LA, Rieke EF, et al., Refining the high-dose streptozotocin-induced diabetic nonhuman primate model: an evaluation of risk factors and outcomes. Exp Biol Med 2011; 236: 1218-1230.
    • (2011) Exp Biol Med , vol.236 , pp. 1218-1230
    • Graham, M.L.1    Mutch, L.A.2    Rieke, E.F.3
  • 19
    • 84865285298 scopus 로고    scopus 로고
    • Management of adverse side-effects after chemotherapy in macaques as exemplified by streptozotocin: Case studies and recommendation
    • Graham ML, Mutch LA, Kittredge JA, et al., Management of adverse side-effects after chemotherapy in macaques as exemplified by streptozotocin: case studies and recommendation. Lab Anim 2012; 46: 178-192.
    • (2012) Lab Anim , vol.46 , pp. 178-192
    • Graham, M.L.1    Mutch, L.A.2    Kittredge, J.A.3
  • 20
    • 84858795741 scopus 로고    scopus 로고
    • Successful implementation of cooperative handling eliminates the need for restraint in a complex nonhuman primate disease model
    • Graham ML, Rieke EF, Mutch LA, et al., Successful implementation of cooperative handling eliminates the need for restraint in a complex nonhuman primate disease model. J Med Primatol 2012; 41: 89-106.
    • (2012) J Med Primatol , vol.41 , pp. 89-106
    • Graham, M.L.1    Rieke, E.F.2    Mutch, L.A.3
  • 21
    • 83755164079 scopus 로고    scopus 로고
    • Ex vivo expanded Treg therapy promotes long-term islet allograft survival in a non-human primate model
    • Bansal-Pakala P, Pahuja A, Hennessey E, et al., Ex vivo expanded Treg therapy promotes long-term islet allograft survival in a non-human primate model. Am J Transplant 2011; 11 (Suppl. 2): 209.
    • (2011) Am J Transplant , vol.11 , Issue.SUPPL. 2 , pp. 209
    • Bansal-Pakala, P.1    Pahuja, A.2    Hennessey, E.3
  • 22
    • 66149191273 scopus 로고    scopus 로고
    • A novel alternative placement site and technique for totally implantable vascular access ports in non-human primates
    • Graham ML, Rieke EF, Dunning M, et al., A novel alternative placement site and technique for totally implantable vascular access ports in non-human primates. J Med Primatol 2009; 38: 204-212.
    • (2009) J Med Primatol , vol.38 , pp. 204-212
    • Graham, M.L.1    Rieke, E.F.2    Dunning, M.3
  • 23
    • 79751506198 scopus 로고    scopus 로고
    • Refinement of vascular access port placement in nonhuman primates: Complication rates and outcomes
    • Graham ML, Mutch LA, Rieke EF, et al., Refinement of vascular access port placement in nonhuman primates: complication rates and outcomes. Comp Med 2010; 60: 479-485.
    • (2010) Comp Med , vol.60 , pp. 479-485
    • Graham, M.L.1    Mutch, L.A.2    Rieke, E.F.3
  • 24
    • 79952067011 scopus 로고    scopus 로고
    • Long-term hepatic vascular access in the nonhuman primate for recurrent portal vein infusion
    • Graham ML, Mutch LA, Rieke EF, et al., Long-term hepatic vascular access in the nonhuman primate for recurrent portal vein infusion. J Invest Surg 2011; 24: 59-66.
    • (2011) J Invest Surg , vol.24 , pp. 59-66
    • Graham, M.L.1    Mutch, L.A.2    Rieke, E.F.3
  • 25
    • 83755206323 scopus 로고    scopus 로고
    • Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: A comparison with allotransplantation
    • Graham ML, Bellin MD, Papas KK, Hering BJ, Schuurman H-J,. Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: a comparison with allotransplantation. Xenotransplantation 2011; 18: 328-342.
    • (2011) Xenotransplantation , vol.18 , pp. 328-342
    • Graham, M.L.1    Bellin, M.D.2    Papas, K.K.3    Hering, B.J.4    Schuurman, H.-J.5
  • 26
    • 10044270631 scopus 로고    scopus 로고
    • Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates
    • Wijkstrom M, Kirchhof N, Graham M, et al., Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates. Toxicology 2005; 207: 117-127.
    • (2005) Toxicology , vol.207 , pp. 117-127
    • Wijkstrom, M.1    Kirchhof, N.2    Graham, M.3
  • 27
    • 36649032233 scopus 로고    scopus 로고
    • Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: Implications for translation into clinical practice
    • Casu A, Bottino R, Balamurugan AN, et al., Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice. Diabetologia 2008; 51: 120-129.
    • (2008) Diabetologia , vol.51 , pp. 120-129
    • Casu, A.1    Bottino, R.2    Balamurugan, A.N.3
  • 28
    • 1842420450 scopus 로고    scopus 로고
    • Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720
    • Wijkstrom M, Kenyon NS, Kirchhof N, et al., Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. Transplantation 2004; 77: 827-835.
    • (2004) Transplantation , vol.77 , pp. 827-835
    • Wijkstrom, M.1    Kenyon, N.S.2    Kirchhof, N.3
  • 29
    • 12144288119 scopus 로고    scopus 로고
    • Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model
    • Kanmaz T, Fechner JJ Jr, Torrealba J, et al., Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. Transplantation 2004; 77: 914-920.
    • (2004) Transplantation , vol.77 , pp. 914-920
    • Kanmaz, T.1    Fechner Jr., J.J.2    Torrealba, J.3
  • 30
    • 42549152142 scopus 로고    scopus 로고
    • Characterization of gastrointestinal drug absorption in cynomolgus monkeys
    • Takahashi M, Washio T, Suzuki N, et al., Characterization of gastrointestinal drug absorption in cynomolgus monkeys. Mol Pharm 2008; 5: 340-348.
    • (2008) Mol Pharm , vol.5 , pp. 340-348
    • Takahashi, M.1    Washio, T.2    Suzuki, N.3
  • 31
    • 33748319204 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Food and Drug Administration, Center For Drug Evaluation and Research. Rockville MD [accessed on 3 July 2012]
    • US Department of Health and Human Services, Food and Drug Administration, Center For Drug Evaluation and Research. Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. Rockville MD, 2005. Available at: http:// www.fda.gov/downloads/Drugs/GuidanceCompliance- RegulatoryInformation/Guidances/ UCM078932.pdf [accessed on 3 July 2012].
    • (2005) Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers
  • 32
    • 0034758786 scopus 로고    scopus 로고
    • Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: Relation to efficacy in kidney allografting
    • Schuurman HJ, Slingerland W, Mennninger K, et al., Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting. Transpl Int 2001; 14: 320-328.
    • (2001) Transpl Int , vol.14 , pp. 320-328
    • Schuurman, H.J.1    Slingerland, W.2    Mennninger, K.3
  • 33
    • 84873432950 scopus 로고    scopus 로고
    • NEORAL® Soft Gelatin Capsules (cyclosporine capsules, USP) MODIFIED
    • [accessed on 3 July 2012]
    • NEORAL® Soft Gelatin Capsules (cyclosporine capsules, USP) MODIFIED; NEORAL® Oral Solution (cyclosporine oral solution, USP) MODIFIED. Available at: http://www.pharma.us.novartis.com/product/pi/pdf/neoral.pdf [accessed on 3 July 2012].
    • NEORAL® Oral Solution (Cyclosporine Oral Solution, USP) MODIFIED
  • 34
    • 84873474759 scopus 로고    scopus 로고
    • [accessed on 3 July 2012]
    • PROGRAF tacrolimus capsules and injection. Available at: http://www.prograf.com/Professionals/Professionals.aspx?section= KidneyTransplantation [accessed on 3 July 2012].
    • PROGRAF Tacrolimus Capsules and Injection
  • 36
    • 84873461444 scopus 로고    scopus 로고
    • CELLCEPT [accessed on 3 July 2012]
    • CELLCEPT, mycophenolate mofetil. Available at: http://www.cellcept.com/ cellcept/ [accessed on 3 July 2012].
    • Mycophenolate Mofetil
  • 37
    • 0036556160 scopus 로고    scopus 로고
    • Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model
    • Montgomery SP, Mog SR, Xu H, et al., Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. Am J Transplant 2002; 2: 381-385.
    • (2002) Am J Transplant , vol.2 , pp. 381-385
    • Montgomery, S.P.1    Mog, S.R.2    Xu, H.3
  • 38
    • 84873466913 scopus 로고    scopus 로고
    • Chronic immunosuppression with tacrolimus is associated with an increased risk of drug-induced diarrhea post islet xenotransplant in cynomolgus macaques
    • Graham M, Mutch L, Munson J, et al., Chronic immunosuppression with tacrolimus is associated with an increased risk of drug-induced diarrhea post islet xenotransplant in cynomolgus macaques. Xenotransplantation 2009; 16: 432.
    • (2009) Xenotransplantation , vol.16 , pp. 432
    • Graham, M.1    Mutch, L.2    Munson, J.3
  • 39
    • 25144496058 scopus 로고    scopus 로고
    • Muscle wasting and protein metabolism
    • Castaneda C,. Muscle wasting and protein metabolism. J Anim Sci 2002; 80 (Suppl. 2): E98-E105.
    • (2002) J Anim Sci , vol.80 , Issue.SUPPL. 2
    • Castaneda, C.1
  • 40
  • 41
    • 0033618462 scopus 로고    scopus 로고
    • Calcineurin is required for skeletal muscle hypertrophy
    • Dunn SE, Burns JL, Michel RN,. Calcineurin is required for skeletal muscle hypertrophy. J Biol Chem 1999; 274: 21908-21912.
    • (1999) J Biol Chem , vol.274 , pp. 21908-21912
    • Dunn, S.E.1    Burns, J.L.2    Michel, R.N.3
  • 42
    • 73849139950 scopus 로고    scopus 로고
    • Effect of insulin on whole body protein metabolism in children with type 1 diabetes
    • Caso G, Mcnurlan MA,. Effect of insulin on whole body protein metabolism in children with type 1 diabetes. Curr Opin Clin Nutr Metab Care 2010; 13: 93-96.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 93-96
    • Caso, G.1    McNurlan, M.A.2
  • 43
    • 84873444457 scopus 로고    scopus 로고
    • Drug-induced diarrhea
    • Guandalini S. Vazari H. eds. Chapter 23. New York: Springer Science plus Business Media
    • Abraham BP, Sellin JH,. Drug-induced diarrhea. In:, Guandalini S, Vazari H, eds. Diarrhea, Clinical Gastroenterology, Chapter 23. New York: Springer Science plus Business Media, 2011; 23: 393- 423.
    • (2011) Diarrhea, Clinical Gastroenterology , vol.23 , pp. 393-423
    • Abraham, B.P.1    Sellin, J.H.2
  • 44
    • 0031735467 scopus 로고    scopus 로고
    • Oral administration of rapamycin and cyclosporine differentially alter intestinal function in rabbits
    • Dias VC, Madsen KL, Mulder KE, et al., Oral administration of rapamycin and cyclosporine differentially alter intestinal function in rabbits. Dig Dis Sci 1998; 43: 2227-2236.
    • (1998) Dig Dis Sci , vol.43 , pp. 2227-2236
    • Dias, V.C.1    Madsen, K.L.2    Mulder, K.E.3
  • 45
    • 0029051550 scopus 로고
    • FK506 increases permeability in rat intestine by inhibiting mitochondrial function
    • Madsen KL, Yanchar NL, Sigalet DL, et al., FK506 increases permeability in rat intestine by inhibiting mitochondrial function. Gastroenterology 1995; 109: 107-114.
    • (1995) Gastroenterology , vol.109 , pp. 107-114
    • Madsen, K.L.1    Yanchar, N.L.2    Sigalet, D.L.3
  • 46
    • 0029914869 scopus 로고    scopus 로고
    • Tacrolimus (FK506) - Its effects on intestinal glucose transport
    • Yanchar NL, Riegel TM, Martin G, et al., Tacrolimus (FK506)-its effects on intestinal glucose transport. Transplantation 1996; 61: 630-634.
    • (1996) Transplantation , vol.61 , pp. 630-634
    • Yanchar, N.L.1    Riegel, T.M.2    Martin, G.3
  • 47
    • 0031749892 scopus 로고    scopus 로고
    • The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans
    • Gabe SM, Bjarnason I, Tolou-Ghamari Z, et al., The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans. Gastroenterology 1998; 115: 67-74.
    • (1998) Gastroenterology , vol.115 , pp. 67-74
    • Gabe, S.M.1    Bjarnason, I.2    Tolou-Ghamari, Z.3
  • 48
    • 84860484558 scopus 로고    scopus 로고
    • Hypoalbuminemia and early mortality after lung transplantation: A cohort study
    • Baldwin MR, Arcasoy SM, Shah A, et al., Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant 2012; 12: 1256-1267.
    • (2012) Am J Transplant , vol.12 , pp. 1256-1267
    • Baldwin, M.R.1    Arcasoy, S.M.2    Shah, A.3
  • 49
    • 79955540729 scopus 로고    scopus 로고
    • Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipients
    • Molnar MZ, Kovesdy CP, Bunnapradist S, et al., Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipients. Am J Transplant 2011; 11: 1006-1015.
    • (2011) Am J Transplant , vol.11 , pp. 1006-1015
    • Molnar, M.Z.1    Kovesdy, C.P.2    Bunnapradist, S.3
  • 50
    • 0030843890 scopus 로고    scopus 로고
    • Association of serum albumin and mortality risk
    • Goldwasser P, Feldman J,. Association of serum albumin and mortality risk. J Clin Epidemiol 1997; 50: 693-703.
    • (1997) J Clin Epidemiol , vol.50 , pp. 693-703
    • Goldwasser, P.1    Feldman, J.2
  • 51
    • 84873453927 scopus 로고    scopus 로고
    • Committee on Animal Nutrition, ad hoc Committee on Nonhuman Primate Nutrition, National Research Council. 2nd revised edn. Washington, DC: National Academies Press
    • Committee on Animal Nutrition, ad hoc Committee on Nonhuman Primate Nutrition, National Research Council. Nutrient Requirements of Nonhuman Primates, 2nd revised edn. Washington, DC: National Academies Press, 2003: 260.
    • (2003) Nutrient Requirements of Nonhuman Primates , pp. 260
  • 52
    • 0035085643 scopus 로고    scopus 로고
    • Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    • Ryan EA, Lakey JR, Rajotte RV, et al., Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710-719.
    • (2001) Diabetes , vol.50 , pp. 710-719
    • Ryan, E.A.1    Lakey, J.R.2    Rajotte, R.V.3


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