Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets

American Journal of Transplantation

Volumn 9, Issue 12, 2009, Pages 2716-2726

  Van Der Windt, D J ^a,b   Bottino, R ^a   Casu, A ^a   Campanile, N ^a,c   Smetanka, C ^d   He, J ^a   Murase, N ^d   Hara, H ^d   Ball, S ^e   Loveland, B E ^f   Ayares, D ^e   Lakkis, F G ^d,g   Cooper, D K C ^d   Trucco, M ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e REVIVICOR INC   (United States)

^f AUSTIN RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Complement regulation; Diabetes mellitus; Islet xenotransplantation; Non human primate; Transgenic pigs

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CD40 LIGAND MONOCLONAL ANTIBODY; INSULIN; MEMBRANE COFACTOR PROTEIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HUMORAL IMMUNITY; HYPERGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN TREATMENT; MONKEY; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; SWINE; TRANSGENIC ANIMAL; WILD TYPE; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD46; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; ISLETS OF LANGERHANS TRANSPLANTATION; MACACA FASCICULARIS; MALE; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 70349706907     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02850.x     Document Type: Article

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