Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses

Journal of Neuroscience

Volumn 35, Issue 6, 2015, Pages 2612-2623

  Justice, Nicholas J ^a,b,c   Huang, Longwen ^c,d   Tian, Jin Bin ^a   Cole, Allysa ^c   Pruski, Melissa ^a   Hunt, Albert J ^a,b   Flores, Rene ^a   Zhu, Michael X ^a   Arenkiel, Benjamin R ^c,d   Zheng, Hui ^c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Alzheimer s disease; crf; crfr1; crh; PTSD; Stress

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CORTICOSTEROID; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GAMMA SECRETASE INHIBITOR; PRESENILIN 1; CORTICOTROPIN RELEASING FACTOR; SECRETASE;

ACOUSTIC STARTLE TEST; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN INJURY; CEREBROSPINAL FLUID ANALYSIS; DISEASE EXACERBATION; ELECTROPHYSIOLOGY; EXPERIMENTAL BEHAVIORAL TEST; IMMUNOHISTOCHEMISTRY; LABORATORY TEST; LIGHT DARK TRANSFER TEST; MOUSE; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NONHUMAN; OPEN FIELD ASSAY; PHENOTYPE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; CEREBROSPINAL FLUID; CHO CELL LINE; CRICETULUS; GENE TARGETING; MENTAL STRESS; METABOLISM; NERVE CELL; PRIMARY CELL CULTURE; PSYCHOLOGY;

ADRENAL CORTEX HORMONES; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BEHAVIOR, ANIMAL; CHO CELLS; CORTICOTROPIN-RELEASING HORMONE; CRICETULUS; GENE KNOCK-IN TECHNIQUES; MICE; NEURONS; PRIMARY CELL CULTURE; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL;

EID: 84922572390     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3333-14.2015     Document Type: Article

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