Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 22, 2012, Pages 8740-8745

  Busche, Marc Aurel ^a,b,c   Chen, Xiaowei ^a,c   Henning, Horst A ^a,c   Reichwald, Julia ^d   Staufenbiel, Matthias ^d   Sakmann, Bert ^a   Konnerth, Arthur ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Munich Center for Integrated Protein Science   (Germany)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Brain disease; In vivo imaging

Indexed keywords

AMYLOID BETA PROTEIN; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS POTENTIAL; HYPERACTIVITY; IN VIVO STUDY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TRANSGENIC MOUSE; WILD TYPE;

AGE FACTORS; ALANINE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AZEPINES; CA1 REGION, HIPPOCAMPAL; CALCIUM; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; NEURONS; PLAQUE, AMYLOID;

MUS; MUS MUSCULUS;

EID: 84861844315     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206171109     Document Type: Article

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