The isoprostanes - 25 years later

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1851, Issue 4, 2015, Pages 433-445

  Milne, Ginger L ^a   Dai, Qi ^a   Roberts, L Jackson ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; Isoprostane; Lipid peroxidation; Mass spectrometry; Oxidative stress

Indexed keywords

ICOSAPENTAENOIC ACID; ISOPROSTANE DERIVATIVE; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; THROMBOXANE RECEPTOR; BIOLOGICAL MARKER;

BRAIN ISCHEMIA; CANCER RISK; CENTRAL NERVOUS SYSTEM; DIET; FATTY ACID METABOLISM; GENETIC DISORDER; HUMAN; LIFESTYLE; LIPID OXIDATION; LIPID PEROXIDATION; NEOPLASM; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASES; METABOLISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL MARKERS; DISEASE; HUMANS; ISOPROSTANES; LIPID PEROXIDATION; MOLECULAR STRUCTURE; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922522998     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2014.10.007     Document Type: Review

References (238)

1. J.D. Morrow, T.M. Harris, and L.J. Roberts II Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids Anal. Biochem. 184 1990 1 10
2. W.A. Pryor, and J.P. Stanley Letter: a suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymatic production of prostaglandin endoperoxides during autoxidation J. Org. Chem. 40 1975 3615 3617
3. 2, a novel biologically active prostaglandin Adv. Prostaglandin Thromboxane Leukot. Res. 15 1985 365 367
4. 2: a family of icosanoids produced in vivo in humans Proc. Natl. Acad. Sci. U. S. A. 85 1988 304 308
5. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc. Natl. Acad. Sci. U. S. A. 87 1990 9383 9387
6. 2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation J. Clin. Invest. 90 1992 2502 2507
7. 2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism Methods Enzymol. 233 1994 163 174
8. D.F. Taber, J.D. Morrow, and L.J. Roberts II A nomenclature system for the isoprostanes Prostaglandins 53 1997 63 67
9. J. Rokach, S.P. Khanapure, S.W. Hwang, M. Adiyaman, J.A. Lawson, and G.A. FitzGerald Nomenclature of isoprostanes: a proposal Prostaglandins 54 1997 853 873
10. H. Yin, J.D. Morrow, and N.A. Porter Identification of a novel class of endoperoxides from arachidonate autoxidation J. Biol. Chem. 279 2004 3766 3776
11. J.D. Morrow, T.A. Minton, C.R. Mukundan, M.D. Campbell, W.E. Zackert, V.C. Daniel, K.F. Badr, I.A. Blair, and L.J. Roberts II Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes J. Biol. Chem. 269 1994 4317 4326
12. J.D. Morrow, L.J. Roberts, V.C. Daniel, J.A. Awad, O. Mirochnitchenko, L.L. Swift, and R.F. Burk Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo-effects of oxygen tension and glutathione Arch. Biochem. Biophys. 353 1998 160 171
13. 2) in vivo Biochim. Biophys. Acta 1436 1999 550 556
14. Y. Chen, J.D. Morrow, and L.J. Roberts II Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway J. Biol. Chem. 274 1999 10863 10868
15. 2-isoprostanes) in vivo J. Lipid Res. 52 2011 113 124
16. J.D. Morrow, J.A. Awad, A. Wu, W.E. Zackert, V.C. Daniel, and L.J. Roberts II Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo J. Biol. Chem. 271 1996 23185 23190
17. D.F. Taber, J.P. Fessel, and L.J. Roberts II A nomenclature system for isofurans Prostaglandins Lipid Mediat. 73 1-2 2004 47 50
18. J.P. Fessel, N.A. Porter, K.P. Moore, J.R. Sheller, and L.J. Roberts II Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension Proc. Natl. Acad. Sci. U. S. A. 99 2002 16713 16718
19. 2-isoprostane-containing phospholipids J. Lipid Res. 34 1993 1229 1235
20. 2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases J. Biol. Chem. 281 2006 4616 4623
21. D. Praticò, O.P. Barry, J.A. Lawson, M. Adiyaman, S.W. Hwang, S.P. Khanapure, L. Iuliano, J. Rokach, and G.A. FitzGerald iPF2alpha-I: an index of lipid peroxidation in humans Proc. Natl. Acad. Sci. U. S. A. 95 1998 3449 3454
22. 2-isoprostanes in human urine Proc. Natl. Acad. Sci. U. S. A. 96 1999 13381 13386
23. 2-isoprostane) metabolites in human urine and plasma J. Biol. Chem. 268 1993 4161 4169
24. 2-isoprostane 8-iso-prostaglandin F2alpha in humans J. Biol. Chem. 271 1996 20617 20620
25. S. Basu Metabolism of 8-iso-prostaglandin F2alpha FEBS Lett. 428 1998 32 36
26. E. Schwedhelm, D. Tsikas, T. Durand, F.M. Gutzki, A. Guy, J.C. Rossi, and J.C. Frölich Tandem mass spectrometric quantification of 8-iso-prostaglandin F2alpha and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2alpha in human urine J. Chromatogr. B Biomed. Sci. Appl. 744 2000 99 112
27. J. Nourooz-Zadeh, M.B. Cooper, D. Ziegler, and D.J. Betteridge Urinary 8-epi-PGF2alpha and its endogenous beta-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress Biochem. Biophys. Res. Commun. 330 2005 731 736
28. 2-isoprostane diastereoisomers by mass spectrometry J. Lipid Res. 43 2002 495 509
29. 2-isoprostanes in human urine are excreted as glucuronide conjugates Anal. Biochem. 403 2010 126 128
30. G.L. Milne, G. Zanoni, A. Porta, S. Sasi, G. Vidari, E.S. Musiek, M.L. Freeman, and J.D. Morrow The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione Chem. Res. Toxicol. 17 2004 17 25
31. G.L. Milne, L. Gao, A. Porta, G. Zanoni, G. Vidari, and J.D. Morrow Identification of the major urinary metabolite of the highly reactive cyclopentenone isoprostane 15-A(2 t)-isoprostane in vivo J. Biol. Chem. 280 2005 25178 25184
32. 4 poisoning? Free Radic. Biol. Med. 38 2005 698 710
33. D. Il'yasova, I. Spasojevic, F. Wang, A.A. Tolun, K. Base, S.P. Young, P.K. Marcom, J. Marks, G. Mixon, R. DiGiulio, and D.S. Millington Urinary biomarkers of oxidative status in a clinical model of oxidative assault Cancer Epidemiol. Biomarkers Prev. 19 6 2010 1506 1510
34. M. Masoodi, and A. Nicolaou Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry Rapid Commun. Mass Spectrom. 20 2006 3023 3029
35. D. Sircar, and P.V. Subbaiah Isoprostane measurement in plasma and urine by liquid chromatography-mass spectrometry with one-step sample preparation Clin. Chem. 53 2007 251 258
36. 4t-neuroprostane as an internal standard using gas chromatography-mass spectrometry Application to polytraumatized patients J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 872 2008 133 140
37. 2-isoprostane metabolites: a novel extraction and LC-MS methodology Lipids 43 2008 925 936
38. 2-isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain J. Lipid Res. 49 2008 1990 2000
39. C. Mesaros, S.H. Lee, and I.A. Blair Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 877 2009 2736 2745
40. 2-isoprostanes: sensitive biomarkers of oxidative stress in vitro and in vivo: a gas chromatography-mass spectrometric approach Methods Mol. Biol. 580 2009 3 16
41. 2-isoprostanes by sequential solid phase and liquid-liquid extraction Anal. Biochem. 396 2010 319 321
42. V. Cavalca, F. Minardi, S. Scurati, F. Guidugli, I. Squellerio, F. Veglia, L. Dainese, A. Guarino, E. Tremoli, and D. Caruso Simultaneous quantification of 8-iso-prostaglandin-F(2alpha) and 11-dehydro thromboxane B(2) in human urine by liquid chromatography-tandem mass spectrometry Anal. Biochem. 397 2010 168 174
43. 2-isoprostanes by gas chromatography-mass spectrometry is confounded by interfering substances Free Radic. Res. 44 2010 191 198
44. D.M. Callewaert, and C. Sloan Enzyme immunoassay of isoprostanes Methods Mol. Biol. 610 2010 435 449
45. 2-isoprostanes in urine by online solid phase extraction coupled to liquid chromatography with tandem mass spectrometry J. Agric. Food Chem. 58 2010 6614 6620
46. M. Korecka, C.M. Clark, V.M. Lee, J.Q. Trojanowski, and L.M. Shaw Simultaneous HPLC-MS-MS quantification of 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha) in CSF and brain tissue samples with on-line cleanup J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 878 2010 2209 2216
47. N.E. Bastani, T.E. Gundersen, and R. Blomhoff Dried blood spot (DBS) sample collection for determination of the oxidative stress biomarker 8-epi-PGF(2α) in humans using liquid chromatography/tandem mass spectrometry Rapid Commun. Mass Spectrom. 26 2012 645 652
48. 2-isoprostanes in newborns J. Matern. Fetal Neonatal Med. 25 Suppl. 1 2012 114 118
49. M. Janicka, P. Kubica, A. Kot-Wasik, J. Kot, and J. Namies̈nik Sensitive determination of isoprostanes in exhaled breath condensate samples with use of liquid chromatography-tandem mass spectrometry J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 893-894 2012 144 149
50. 2- isoprostanes and isofurans using gas chromatography-mass spectrometry Free Radic. Biol. Med. 59 2013 36 44
51. 2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometry J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 913-914 2013 161 168
52. 2 series prostaglandins and isoprostanes Lipids 48 2013 411 419
53. 2-isoprostanes in plasma of pregnant women by HPLC-MS/MS using a column packed with core-shell particles J. Lipid Res. 54 2013 1505 1511
54. D. Balgoma, J. Larsson, J. Rokach, J.A. Lawson, K. Daham, B. Dahlén, S.E. Dahlén, and C.E. Wheelock Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects Anal. Chem. 85 2013 7866 7874
55. 2-isoprostanes using gas chromatography-tandem mass spectrometry J. Pharm. Biomed. Anal. 90 2014 161 166
56. Y. Huang, M. Zhu, Z. Li, R. Sa, Q. Chu, Q. Zhang, H. Zhang, W. Tang, M. Zhang, and H. Yin Mass spectrometry-based metabolomic profiling identifies alterations in salivary redox status and fatty acid metabolism in response to inflammation and oxidative stress in periodontal disease Free Radic. Biol. Med. 70 2014 223 232
57. J. Kuligowski, J. Escobar, G. Quintás, I. Lliso, I. Torres-Cuevas, A. Nuñez, E. Cubells, D. Rook, J.B. van Goudoever, and M. Vento Analysis of lipid peroxidation biomarkers in extremely low gestational age neonate urines by UPLC-MS/MS Anal. Bioanal. Chem. 18 May 11 2014 4345 4356
58. H. Zhang, D. Il'yasova, J. Sztaray, S.P. Young, F. Wang, and D.S. Millington Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry Anal. Biochem. 399 2010 302 304
59. 2t-isoprostane Ann. Epidemiol. 14 2004 793 797
60. 2-isoprostanes in experimental and clinical studies: mass spectrometry versus ELISA Hypertension 60 2012 e14 (author reply e15)
61. 2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared Rapid Commun. Mass Spectrom. 25 2011 463 468
62. 2-isoprostanes as markers of in vivo lipid peroxidation: a comparison of enzyme immunoassays with gas chromatography-mass spectrometry in domestic animal species J. Vet. Diagn. Invest. 22 2010 200 209
63. 2-isoprostanes) in plasma during collection and storage Anal. Biochem. 449 2014 129 131
64. B. Halliwell, and C.Y. Lee Using isoprostanes as biomarkers of oxidative stress: some rarely considered issues Antioxid. Redox Signal. 13 2010 145 156
65. J.-L. Cracowski, T. Durand, and G. Bessard Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications Trends Pharmacol. Sci. 23 2002 360 366
66. J.L. Cracowski, and T. Durand Cardiovascular pharmacology and physiology of the isoprostanes Fundam. Clin. Pharmacol. 20 2006 417 427
67. P. Montuschi, P. Barnes, and L.J. Roberts II Insights into oxidative stress: the isoprostanes Curr. Med. Chem. 14 2007 703 717
68. 2-isoprostanes as biomarkers of late-onset Alzheimer's disease J. Mol. Neurosci. 33 2007 114 119
69. G.L. Milne, H. Yin, J.D. Brooks, S. Sanchez, L. Jackson Roberts II, and J.D. Morrow Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress Methods Enzymol. 433 2007 113 126
70. 2-isoprostanes are not just markers of oxidative stress Free Radic. Biol. Med. 44 2008 247 256
71. H. Yin New techniques to detect oxidative stress markers: mass spectrometry-based methods to detect isoprostanes as the gold standard for oxidative stress in vivo Biofactors 34 2008 109 124
72. G.L. Milne, H. Yin, and J.D. Morrow Human biochemistry of the isoprostane pathway J. Biol. Chem. 283 2008 15533 15537
73. L.J. Janssen Isoprostanes and lung vascular pathology Am. J. Respir. Cell Mol. Biol. 39 2008 383 389
74. 2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications Antioxid. Redox Signal. 10 2008 1405 1434
75. J.W. Stephens, M.P. Khanolkar, and S.C. Bain The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease Atherosclerosis 202 2009 321 329
76. 2-isoprostane analysis Biochem. Soc. Trans. 36 2009 1060 1065
77. E. Niki Lipid peroxidation: physiological levels and dual biological effects Free Radic. Biol. Med. 47 2009 469 484
78. J. Belik, G.E. González-Luis, F. Perez-Vizcaino, and E. Villamor Isoprostanes in fetal and neonatal health and disease Free Radic. Biol. Med. 48 2010 177 188
79. H. Yin, F. Gao, and Y. An The application of LC-MS/MS in measurement of oxidative stress parameters Wei Sheng Yan Jiu 38 2009 757 761
80. S. Basu Fatty acid oxidation and isoprostanes: oxidative strain and oxidative stress Prostaglandins Leukot. Essent. Fat. Acids 82 2010 219 225
81. D. Galasko, and T.J. Montine Biomarkers of oxidative damage and inflammation in Alzheimer's disease Biomark. Med 4 2010 27 36
82. T. Durand, V. Bultel-Poncé, A. Guy, S. El Fangour, J.C. Rossi, and J.M. Galano Isoprostanes and phytoprostanes: bioactive lipids Biochimie 93 2011 52 60
83. 2-isoprostanes in inflammation and oxidative stress related pathology Mol. Cells 30 2010 383 391
84. 2-isoprostanes as an indicator and risk factor for coronary heart disease Free Radic. Biol. Med. 50 2011 559 566
85. J.A. Voynow, and A. Kummarapurugu Isoprostanes and asthma Biochim. Biophys. Acta 1810 2011 1091 1095
86. T.T. Reed Lipid peroxidation and neurodegenerative disease Free Radic. Biol. Med. 51 2011 1302 1319
87. G.L. Milne, H. Yin, K.D. Hardy, S.S. Davies, and L.J. Roberts II Isoprostane generation and function Chem. Rev. 111 2011 5973 5996
88. D. Il'yasova, P. Scarbrough, and I. Spasojevic Urinary biomarkers of oxidative status Clin. Chim. Acta 413 2012 1446 1453
89. 2-isoprostanes and cardiovascular disease Ann. Clin. Biochem. 50 Pt 2 2013 108 114
90. K.D. Jacob, N. Noren Hooten, A.R. Trzeciak, and M.K. Evans Markers of oxidant stress that are clinically relevant in aging and age-related disease Mech. Ageing Dev. 134 2013 139 157
91. F.J. Lowe, K. Luettich, and E.O. Gregg Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective Biomarkers 18 2013 183 195
92. E. Niki Biomarkers of lipid peroxidation in clinical material Biochim. Biophys. Acta 1840 2014 809 817
93. C. Signorini, C. De Felice, T. Durand, C. Oger, J.M. Galano, S. Leoncini, A. Pecorelli, G. Valacchi, L. Ciccoli, and J. Hayek Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder Oxidative Med. Cell. Longev. 2013 2013 343824
94. E. Ho, K. Karimi Galougahi, C.C. Liu, R. Bhindi, and G.A. Figtree Biological markers of oxidative stress: applications to cardiovascular research and practice Redox Biol. 1 2013 483 491
95. http://www.cdc.gov/nchs/fastats/obesity-overweight.htm
96. J.D. Morrow Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans Arterioscler. Thromb. Vasc. Biol. 25 2005 279 286
97. H.K. Vincent, and A.G. Taylor Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans Int. J. Obes. 30 2006 400 418
98. H.K. Vincent, K.E. Innes, and K.R. Vincent Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity Diabetes Obes Metab. 9 2007 813 839
99. C.A. Dow, B.C. Wertheim, B.S. Patil, and C.A. Thomson Daily consumption of grapefruit for 6 weeks reduces urine F2-isoprostanes in overweight adults with high baseline values but has no effect on plasma high-sensitivity C-reactive protein or soluble vascular cellular adhesion molecule 1 J Nutr. 143 2013 1586 1592
100. J.F. Keaney Jr., M.G. Larson, R.S. Vasan, P.W. Wilson, I. Lipinska, D. Corey, J.M. Massaro, P. Sutherland, J.A. Vita, and E.J. Benjamin Framingham study. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study Arterioscler. Thromb. Vasc. Biol. 23 2003 434 439
101. J.E. Kaikkonen, T. Vilppo, J. Asikainen, S. Voutilainen, S. Kurl, and J.T. Salonen Fatty acids as determinants of in-vivo lipid peroxidation: the EFFGE study in Eastern Finnish hypertensive and non-hypertensive subjects Ann. Med. 45 2013 455 464
102. H. Urakawa, A. Katsuki, Y. Sumida, E.C. Gabazza, S. Murashima, K. Morioka, N. Maruyama, N. Kitagawa, T. Tanaka, Y. Hori, K. Nakatani, Y. Yano, and Y. Adachi Oxidative stress is associated with adiposity and insulin resistance in men J. Clin. Endocrinol. Metab. 88 2003 4673 4676
103. S. Komakula, S. Khatri, J. Mermis, S. Savill, S. Haque, M. Rojas, L. Brown, G.W. Teague, and F. Holguin Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics Respir. Res. 8 2007 32
104. K.M. Pou, J.M. Massaro, U. Hoffmann, R.S. Vasan, P. Maurovich-Horvat, M.G. Larson, J.F. Keaney Jr., J.B. Meigs, I. Lipinska, S. Kathiresan, J.M. Murabito, C.J. O'Donnell, E.J. Benjamin, and C.S. Fox Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study Circulation 116 2007 1234 1241
105. 2-isoprostane levels in HIV-infected adults HIV Clin. Trials. 10 2009 181 192
106. Q. Dai, Y.T. Gao, X.O. Shu, G. Yang, G. Milne, Q. Cai, W. Wen, N. Rothman, H. Cai, H. Li, Y. Xiang, W.H. Chow, and W. Zheng Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health Study J. Clin. Oncol. 27 2009 2482 2488
107. B.L. Crist, D.L. Alekel, L.M. Ritland, L.N. Hanson, U. Genschel, and M.B. Reddy Association of oxidative stress, iron, and centralized fat mass in healthy postmenopausal women J. Women's Health (Larchmt) 18 2009 795 801
108. T.M. Tadros, J.M. Massaro, G.A. Rosito, U. Hoffmann, R.S. Vasan, M.G. Larson, J.F. Keaney Jr., I. Lipinska, J.B. Meigs, S. Kathiresan, C.J. O'Donnell, C.S. Fox, and E.J. Benjamin Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study Obesity (Silver Spring) 18 2010 1039 1045
109. S. Araki, K. Dobashi, Y. Yamamoto, K. Asayama, and K. Kusuhara Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children Eur. J. Pediatr. 169 2010 965 970
110. M. Pfeuffer, K. Fielitz, C. Laue, P. Winkler, D. Rubin, U. Helwig, K. Giller, J. Kammann, E. Schwedhelm, R.H. Böger, A. Bub, D. Bell, and J. Schrezenmeir CLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjects J. Am. Coll. Nutr. 30 2011 19 28
111. 2-isoprostanes and adiposity in older adults Obesity (Silver Spring) 19 2011 861 867
112. T. Dorjgochoo, Y.T. Gao, W.H. Chow, X.O. Shu, G. Yang, Q. Cai, N. Rothman, H. Cai, H. Li, X. Deng, M.J. Shrubsole, H. Murff, G. Milne, W. Zheng, and Q. Dai Obesity, age, and oxidative stress in middle-aged and older women Antioxid. Redox Signal. 14 2011 2453 2460
113. M.S. Buchowski, N. Hongu, S. Acra, L. Wang, J. Warolin, and L.J. Roberts II Effect of modest caloric restriction on oxidative stress in women, a randomized trial PLoS One 7 2012 e47079
114. F.T. Billings IV, M. Pretorius, J.S. Schildcrout, N.D. Mercaldo, J.G. Byrne, T.A. Ikizler, and N.J. Brown Obesity and oxidative stress predict AKI after cardiac surgery J. Am. Soc. Nephrol. 23 2012 1221 1228
115. D. Il'yasova, F. Wang, I. Spasojevic, K. Base, R.B. D'Agostino Jr., and L.E. Wagenknecht Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI Obesity (Silver Spring) 20 2012 2147 2150
116. D. Alkazemi, G.M. Egeland, L.J. Roberts II, and S. Kubow Isoprostanes and isofurans as non-traditional risk factors for cardiovascular disease among Canadian Inuit Free Radic. Res. 46 2012 1258 1266
117. B.A. Dennis, A. Ergul, B.A. Gower, J.D. Allison, and C.L. Davis Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program Child Obes. 9 2013 15 21
118. M.B. Crist, V.V. Melekhin, A. Bian, A. Shintani, G.L. Milne, A.R. Kallianpur, L.A. Dageforde, D.W. Haas, and T. Hulgan Higher serum iron is associated with increased oxidant stress in HIV-infected men J. Acquir. Immune Defic. Syndr. 64 2013 367 373
119. J. Warolin, K.R. Coenen, J.L. Kantor, L.E. Whitaker, L. Wang, S.A. Acra, L.J. Roberts II, and M.S. Buchowski The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth Pediatr. Obes. 9 2014 43 52
120. 2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself Am. J. Clin. Nutr. 96 2012 405 414
121. H. Sakamoto, T.B. Corcoran, J.G. Laffey, and G.D. Shorten Isoprostanes-markers of ischaemia reperfusion injury Eur. J. Anaesthesiol. 19 2002 550 559
122. P. Rossi, A. Riutta, P. Kuukasjärvi, T. Vehmas, I. Mucha, and J.P. Salenius Revascularization decreases 8-isoprostaglandin F2alpha excretion in chronic lower limb ischemia Prostaglandins Leukot. Essent. Fat. Acids 71 2 2004 97 101
123. P.J. Kelly, J.D. Morrow, M. Ning, W. Koroshetz, E.H. Lo, E. Terry, G.L. Milne, J. Hubbard, H. Lee, E. Stevenson, M. Lederer, and K.L. Furie Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study Stroke 39 1 2008 100 104
124. R.C. Seet, C.Y. Lee, B.P. Chan, V.K. Sharma, H.L. Teoh, N. Venketasubramanian, E.C. Lim, W.L. Chong, W.F. Looi, S.H. Huang, B.K. Ong, and B. Halliwell Oxidative damage in ischemic stroke revealed using multiple biomarkers Stroke 42 8 2011 2326 2329
125. T.F. Lindsay, X.P. Luo, D.C. Lehotay, B.B. Rubin, M. Anderson, P.M. Walker, and A.D. Romaschin Ruptured abdominal aortic aneurysm, a two-hit ischemia/reperfusion injury: evidence from an analysis of oxidative products J. Vasc. Surg. 30 2 1999 219 228
126. S.S. Davies, T. Traustadóttir, A.A. Stock, F. Ye, Y. Shyr, S.M. Harman, and L.J. Roberts II Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult Free Radic. Biol. Med. 47 7 2009 1014 1018
127. T. Traustadóttir, S.S. Davies, Y. Su, L. Choi, H.M. Brown-Borg, L.J. Roberts II, and S.M. Harman Oxidative stress in older adults: effects of physical fitness Age (Dordr) 34 2012 969 982
128. A.T. Ulus, A. Aksoyek, M. Ozkan, S.F. Katircioglu, and S. Basu Cardiopulmonary bypass as a cause of free radical-induced oxidative stress and enhanced blood-borne isoprostanes in humans Free Radic. Biol. Med. 34 2003 911 917
129. S.H. Zhang, S.Y. Wang, and S.L. Yao Antioxidative effect of propofol during cardiopulmonary bypass in adults Acta Pharmacol. Sin. 25 2004 334 340
130. M. Caputo, A. Mokhtari, C.A. Rogers, N. Panayiotou, Q. Chen, M.T. Ghorbel, G.D. Angelini, and A.J. Parry The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: a randomized controlled trial J. Thorac. Cardiovasc. Surg. 138 2009 206 214
131. F. Veglia, J.P. Werba, E. Tremoli, I. Squellerio, E. Sisillo, A. Parolari, F. Minardi, and V. Cavalca Assessment of oxidative stress in coronary artery bypass surgery: comparison between the global index OXY-SCORE and individual biomarkers Biomarkers 14 2009 465 472
132. F.T. Billings IV, S.K. Ball, L.J. Roberts II, and M. Pretorius Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response Free Radic. Biol. Med. 50 2011 1480 1487
133. 2-Isoprostane levels correlate with markers of impaired ventilation in infants with single-ventricle physiology undergoing stage 2 surgical palliation on the cardiopulmonary bypass Pediatr. Cardiol. 33 2012 562 568
134. K. Berg, M. Langaas, M. Ericsson, H. Pleym, S. Basu, I.S. Nordrum, N. Vitale, and R. Haaverstad Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting Eur. J. Cardiothorac. Surg. 43 2013 1154 1163
135. S.A. Simpson, H. Zaccagni, D.P. Bichell, K.G. Christian, B.A. Mettler, B.S. Donahue, L.J. Roberts II, and M. Pretorius Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass Pediatr. Crit. Care Med. 15 Apr 11 2014 503 510
136. M. Ballester, J. Llorens, J. Garcia-de-la-Asuncion, J. Perez-Griera, E. Tebar, J. Martinez-Leon, J. Belda, and M. Juez Myocardial oxidative stress protection by sevoflurane vs. propofol: a randomised controlled study in patients undergoing off-pump coronary artery bypass graft surgery Eur. J. Anaesthesiol. 28 2011 874 881
137. 2-isoprostanes and isofurans during ischemia/reperfusion of the leg in patients undergoing knee replacement surgery Free Radic. Biol. Med. 50 2011 1171 1176
138. 2-isoprostane levels are increased in Alzheimer's disease Ann. Neurol. 44 1998 410 413
139. 2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo FASEB J. 12 1998 1777 1783
140. T.J. Montine, M.F. Beal, M.E. Cudkowicz, H. O'Donnell, R.A. Margolin, L. McFarland, A.F. Bachrach, W.E. Zackert, L.J. Roberts, and J.D. Morrow Increased CSF F2-isoprostane concentration in probable AD Neurology 52 3 Feb 1999 562 565
141. D. Praticò, C.M. Clark, V.M. Lee, J.Q. Trojanowski, J. Rokach, and G.A. FitzGerald Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity Ann. Neurol. 48 5 2000 809 812
142. 2-isoprostanes are elevated in Huntington's disease Neurology 52 5 1999 1104 1105
143. R.C. Seet, C.Y. Lee, E.C. Lim, J.J. Tan, A.M. Quek, W.L. Chong, W.F. Looi, S.H. Huang, H. Wang, Y.H. Chan, and B. Halliwell Oxidative damage in Parkinson disease: measurement using accurate biomarkers Free Radic. Biol. Med. 48 4 2010 560 566
144. 2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease J. Neurochem. 85 3 2003 645 650
145. E. D'Amico, P. Factor-Litvak, R.M. Santella, and H. Mitsumoto Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis Free Radic. Biol. Med. 65 2013 509 527
146. T.J. Montine, L. Shinobu, K.S. Montine, L.J. Roberts II, N.W. Kowall, M.F. Beal, and J.D. Morrow No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls Ann. Neurol. 48 6 2000 950
147. 4-neuroprostanes are not increased in Alzheimer's disease Ann. Neurol. 52 2 2002 175 179
148. G. Li, S.P. Millard, E.R. Peskind, J. Zhang, C.E. Yu, J.B. Leverenz, C. Mayer, J.S. Shofer, M.A. Raskind, J.F. Quinn, D.R. Galasko, and T.J. Montine Cross-sectional and longitudinal relationships between cerebrospinal fluid biomarkers and cognitive function in people without cognitive impairment from across the adult life span JAMA Neurol. 6 71 2014 742 751
149. J. Guest, R. Grant, T.A. Mori, and K.D. Croft Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid PLoS One 9 1 2014 e85335
150. T.B. Corcoran, E. Mas, A.E. Barden, T. Durand, J.M. Galano, L.J. Roberts, M. Phillips, K.M. Ho, and T.A. Mori Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? Antioxid. Redox Signal. 15 10 2011 2663 2667
151. S.E. Farias, K.A. Heidenreich, M.V. Wohlauer, R.C. Murphy, and E.E. Moore Lipid mediators in cerebral spinal fluid of traumatic brain injured patients J. Trauma 71 5 2011 1211 1218
152. E.E. Reich, W.R. Markesbery, L.J. Roberts II, L.L. Swift, J.D. Morrow, and T.J. Montine Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease Am. J. Pathol. 158 1 2001 293 297
153. E.E. Reich, W.R. Markesbery, L.J. Roberts II, L.L. Swift, J.D. Morrow, and T.J. Montine Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease Adv. Exp. Med. Biol. 500 2001 253 256
154. T.J. Montine, K.S. Montine, E.E. Reich, E.S. Terry, N.A. Porter, and J.D. Morrow Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes Biochem. Pharmacol. 65 4 2003 611 617
155. 2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk Cancer Epidemiol. Biomarkers Prev. 15 4 Apr 2006 639 644
156. 2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan Carcinogenesis 29 5 May 2008 971 976
157. M. Epplein, A.A. Franke, R.V. Cooney, J.S. Morris, L.R. Wilkens, M.T. Goodman, S.P. Murphy, B.E. Henderson, L.N. Kolonel, and M.L. Le Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study Cancer Epidemiol. Biomarkers Prev. 18 7 Jul 2009 1962 1970
158. J.K. Gill, A.A. Franke, M.J. Steven, R.V. Cooney, L.R. Wilkens, M.L. Le, M.T. Goodman, B.E. Henderson, and L.N. Kolonel Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F(2 t) in serum or urine with prostate cancer risk: the multiethnic cohort Cancer Causes Control 20 7 Sep 2009 1161 1171
159. D.A. Barocas, S. Motley, M.S. Cookson, S.S. Chang, D.F. Penson, Q. Dai, G. Milne, L.J. Roberts, J. Morrow, and R.S. Concepcion Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer J. Urol. 185 6 Jun 2011 2102 2107
160. M. Brys, A. Morel, E. Forma, A. Krzeslak, J. Wilkosz, W. Rozanski, and B. Olas Relationship of urinary isoprostanes to prostate cancer occurrence Mol. Cell. Biochem. 372 1-2 Jan 2013 149 153
161. A.W. Asombang, V. Kayamba, M. Mwanza-Lisulo, G. Colditz, V. Mudenda, K. Yarasheski, R. Chott, D.C. Rubin, C.P. Gyawali, and E. Sinkala Gastric cancer in Zambian adults: a prospective case-control study that assessed dietary intake and antioxidant status by using urinary isoprostane excretion Am. J. Clin. Nutr. 97 5 May 2013 1029 1035
162. S. Siamakpour-Reihani, P.M. Scarbrough, F. Wang, I. Spasojevic, K. Base, R. Sedjo, R.B. D'Agostino Jr., and D. Il'yasova Systemic markers of oxidative status and colorectal adenomatous polyps Ann. Epidemiol. 22 8 Aug 2012 587 591
163. S.Y. Kong, R.M. Bostick, W.D. Flanders, W.M. McClellan, B. Thyagarajan, M.D. Gross, S. Judd, and M. Goodman Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammation Cancer Epidemiol. Biomarkers Prev. 23 3 Mar 2014 545 554
164. Q. Dai, Y.T. Gao, X.O. Shu, G. Yang, G. Milne, Q. Cai, W. Wen, N. Rothman, H. Cai, and H. Li Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's health study J. Clin. Oncol. 27 Apr 20 2009 2482 2488
165. 2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay Anal. Biochem. 269 2 May 1 1999 326 331
166. P.A. Thompson, and C. Ambrosone Molecular epidemiology of genetic polymorphisms in estrogen metabolizing enzymes in human breast cancer J. Natl. Cancer Inst. Monogr. 27 2000 125 134
167. 2-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes Kidney Int. 58 5 Nov 2000 1963 1972
168. T.A. McGowan, S.R. Dunn, B. Falkner, and K. Sharma Stimulation of urinary TGF-beta and isoprostanes in response to hyperglycemia in humans Clin. J. Am. Soc. Nephrol. 1 2006 263 268
169. C.F. Chang, R. Westbrook, J. Ma, and D. Cao Transforming growth factor-beta signaling in breast cancer Front. Biosci. 12 2007 4393 4401
170. 2-isoprostane biosynthesis and inhibition in man Chem. Phys. Lipids 128 2004 149 163
171. L.J. Roberts II, J.A. Oates, M.F. Linton, S. Fazio, B.P. Meador, M.D. Gross, Y. Shyr, and J.D. Morrow The relationship between dose of vitamin E and suppression of oxidative stress in humans Free Radic. Biol. Med. 43 2007 1388 1393
172. G. Block, C.D. Jensen, J.D. Morrow, N. Holland, E.P. Norkus, G.L. Milne, M. Hudes, T.B. Dalvi, P.B. Crawford, E.B. Fung, L. Schumacher, and P. Harmatz The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level Free Radic. Biol. Med. 45 2008 377 384
173. R. Belli, P. Amerio, L. Brunetti, G. Orlando, P. Toto, G. Proietto, M. Vacca, and A. Tulli Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin Int. J. Immunopathol. Pharmacol. 18 2005 497 502
174. A. Hoskins, J.L. Roberts II, G. Milne, L. Choi, and R. Dworski Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo Allergy 67 2012 676 682
175. M.G. Espey, P. Chen, B. Chalmers, J. Drisko, A.Y. Sun, M. Levine, and Q. Chen Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer Free Radic. Biol. Med. 50 2011 1610 1619
176. J.L. Welsh, B.A. Wagner, T.J. van't Erve, P.S. Zehr, D.J. Berg, T.R. Halfdanarson, N.S. Yee, K.L. Bodeker, J. Du, L.J. Roberts II, J. Drisko, M. Levine, G.R. Buettner, and J.J. Cullen Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial Cancer Chemother. Pharmacol. 71 2013 765 775
177. T. Traustadóttir, S.S. Davies, A.A. Stock, Y. Su, C.B. Heward, L.J. Roberts II, and S.M. Harman Tart cherry juice decreases oxidative stress in healthy older men and women J. Nutr. 139 2009 1896 1900
178. L.S. McAnulty, D.C. Nieman, C.L. Dumke, L.A. Shooter, D.A. Henson, A.C. Utter, G. Milne, and S.R. McAnulty Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running Appl. Physiol. Nutr. Metab. 36 2011 976 984
179. F. Khan, S. Ray, A.M. Craigie, G. Kennedy, A. Hill, K.L. Barton, J. Broughton, and J.J. Belch Lowering of oxidative stress improves endothelial function in healthy subjects with habitually low intake of fruit and vegetables: a randomized controlled trial of antioxidant- and polyphenol-rich blackcurrant juice Free Radic. Biol. Med. 72C 2014 232 237
180. J.M. Alvarez-Suarez, F. Giampieri, S. Tulipani, T. Casoli, G. Di Stefano, A.M. González-Paramás, C. Santos-Buelga, F. Busco, J.L. Quiles, M.D. Cordero, S. Bompadre, B. Mezzetti, and M. Battino One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans J. Nutr. Biochem. 25 2014 289 294
181. T.G. Nam, S.J. Nara, I. Zagol-Ikapitte, T. Cooper, L. Valgimigli, J.A. Oates, N.A. Porter, O. Boutaud, and D.A. Pratt Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis Org. Biomol. Chem. 7 2009 5103 5112
182. R.V. Shchepin, W. Liu, H. Yin, I. Zagol-Ikapitte, T. Amin, B.S. Jeong, L.J. Roberts II, J.A. Oates, N.A. Porter, and O. Boutaud Rational Design Of Novel Pyridinol-Fused Ring Acetaminophen Analogues ACS Med. Chem. Lett. 4 2013 710 714
183. D.R. Janz, J.A. Bastarache, J.F. Peterson, G. Sills, N. Wickersham, A.K. May, L.J. Roberts II, and L.B. Ware Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study Crit. Care Med. 41 2013 784 790
184. 2-isoprostanes in an observational cohort study of adults Free Radic. Biol. Med. 57 2013 201 209
185. S.M. Rink, P. Mendola, S.L. Mumford, J.K. Poudrier, R.W. Browne, J. Wactawski-Wende, N.J. Perkins, and E.F. Schisterman Self-report of fruit and vegetable intake that meets the 5 a day recommendation is associated with reduced levels of oxidative stress biomarkers and increased levels of antioxidant defense in premenopausal women J. Acad. Nutr. Diet. 113 2013 776 785
186. Y. Jiang, S.H. Wu, X.O. Shu, Y.B. Xiang, B.T. Ji, G.L. Milne, Q. Cai, X. Zhang, Y.T. Gao, W. Zheng, and G. Yang Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women J. Acad. Nutr. Diet. 114 2014 700 708
187. 2-isoprostanes in neonates at high risk of atopy Free Radic. Res. 38 2004 233 239
188. T.A. Mori Effect of fish and fish oil-derived omega-3 fatty acids on lipid oxidation Redox Rep. 9 2004 193 197
189. 2-isoprostanes but not prostaglandin F2alpha in healthy humans J. Nutr. 136 2006 1222 1228
190. 2-isoprostanes: results from two placebo-controlled interventions Free Radic. Res. 44 2010 983 990
191. S.R. McAnulty, D.C. Nieman, L.S. McAnulty, W.S. Lynch, F. Jin, and D.A. Henson Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling Int. J. Sport Nutr. Exerc. Metab. 21 2011 328 337
192. C. De Felice, C. Signorini, T. Durand, L. Ciccoli, S. Leoncini, M. D'Esposito, S. Filosa, C. Oger, A. Guy, V. Bultel-Poncé, J.M. Galano, A. Pecorelli, L. De Felice, G. Valacchi, and J. Hayek Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil Genes Nutr. 7 2012 447 458
193. A. Barden, E. Mas, P. Henry, T. Durand, J.M. Galano, L.J. Roberts, K.D. Croft, and T.A. Mori The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function Free Radic. Res. 45 2011 469 476
194. J.K. Kiecolt-Glaser, E.S. Epel, M.A. Belury, R. Andridge, J. Lin, R. Glaser, W.B. Malarkey, B.S. Hwang, and E. Blackburn Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: a randomized controlled trial Brain Behav. Immun. 28 2013 16 24
195. M.L. Jones, P.J. Mark, T.A. Mori, J.A. Keelan, and B.J. Waddell Maternal dietary omega-3 fatty acid supplementation reduces placental oxidative stress and increases fetal and placental growth in the rat Biol. Reprod. 88 2013 37
196. C. Signorini, C. De Felice, S. Leoncini, T. Durand, J.M. Galano, A. Cortelazzo, G. Zollo, R. Guerranti, S. Gonnelli, C. Caffarelli, M. Rossi, A. Pecorelli, G. Valacchi, L. Ciccoli, and J. Hayek Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation Prostaglandins Leukot. Essent. Fatty Acids Sep 6 2014 pii: S0952-3278(14)00129-X. http://dx.doi.org/10.1016/j.plefa.2014.08.002 (Epub ahead of print)
197. G. Deshpande, K. Simmer, M. Deshmukh, T.A. Mori, K.D. Croft, and J. Kristensen Fish oil (SMOFlipid) and olive oil lipid (clinoleic) in very preterm neonates J. Pediatr. Gastroenterol. Nutr. 58 2014 179 184
198. 3-isoprostanes) in vivo from eicosapentaenoic acid J. Biol. Chem. 281 20 2006 14092 14099
199. 3-isoprostanes) in vivo from eicosapentaenoic acid J. Biol. Chem. 283 18 2008 12043 12055
200. L.J. Roberts II, T.J. Montine, W.R. Markesbery, A.R. Tapper, P. Hardy, S. Chemtob, W.D. Dettbarn, and J.D. Morrow Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid J. Biol. Chem. 273 22 1998 13605 13612
201. 4-neuroprostanes) in vivo from docosahexaenoic acid Adv. Exp. Med. Biol. 507 2002 519 524
202. 4-neuroprostanes) in vivo from docosahexaenoic acid J. Biol. Chem. 277 39 2002 36076 36084
203. W.L. Song, G. Paschos, S. Fries, M.P. Reilly, Y. Yu, J. Rokach, C.T. Chang, P. Patel, J.A. Lawson, and G.A. Fitzgerald Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation J. Biol. Chem. 284 2009 23636 23643
204. 2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction PLoS One 8 7 2013 e68444
205. X. Ming, T.P. Stein, M. Brimacombe, W.G. Johnson, G.H. Lambert, and G.C. Wagner Increased excretion of a lipid peroxidation biomarker in autism Prostaglandins Leukot. Essent. Fat. Acids 73 5 2005 379 384
206. Z. Korade, L. Xu, K. Mirnics, and N.A. Porter Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome J. Inherit. Metab. Dis. 36 1 2013 113 122
207. S.A. Akohoue, S. Shankar, G.L. Milne, J. Morrow, K.Y. Chen, W.U. Ajayi, and M.S. Buchowski Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia Pediatr. Res. 61 2 2007 233 238
208. 2 alpha isoprostane in cystic fibrosis Lipids 34 6 1999 551 556
209. P. Montuschi, S.A. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, D.M. Geddes, M.E. Hodson, and P.J. Barnes Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis Thorax 55 3 2000 205 209
210. G. Ciabattoni, G. Davì, M. Collura, L. Iapichino, F. Pardo, A. Ganci, R. Romagnoli, J. Maclouf, and C. Patrono In vivo lipid peroxidation and platelet activation in cystic fibrosis Am. J. Respir. Crit. Care Med. 162 2000 1195 1201
211. P.J. McGuire, A. Parikh, and G.A. Diaz Profiling of oxidative stress in patients with inborn errors of metabolism Mol. Genet. Metab. 98 1-2 2009 173 180
212. S. Perrone, M. Longini, C.V. Bellieni, G. Centini, A. Kenanidis, L. De Marco, F. Petraglia, and G. Buonocore Early oxidative stress in amniotic fluid of pregnancies with Down syndrome Clin. Biochem. 40 3-4 2007 177 180
213. C. De Felice, L. Ciccoli, S. Leoncini, C. Signorini, M. Rossi, L. Vannuccini, G. Guazzi, G. Latini, M. Comporti, G. Valacchi, and J. Hayek Systemic oxidative stress in classic Rett syndrome Free Radic. Biol. Med. 47 4 2009 440 448
214. 4-neuroprostanes mediate neurological severity in Rett syndrome Clin. Chim. Acta 412 15-16 2011 1399 1406
215. 2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome J. Lipid Res. 52 12 2011 2287 2297
216. 2-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome Biochimie 95 1 2013 86 90
217. 2 receptor activation Br. J. Pharmacol. 171 Mar 20 2014 3115 3131
218. J.L. Elmhurst, P.A. Betti, and P.K. Rangachari Intestinal effects of isoprostanes: evidence for the involvement of prostanoid EP and TP receptors J. Pharmacol. Exp. Ther. 282 1997 1198 1205
219. L.J. Janssen, and T. Tazzeo Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature J. Pharmacol. Exp. Ther. 301 2002 1060 1066
220. W. Sametz, S. Hennerbichler, S. Glaser, R. Wintersteiger, and H. Juan Characterization of prostanoid receptors mediating actions of the isoprostanes, 8-iso-PGE(2) and 8-iso-PGF(2alpha), in some isolated smooth muscle preparations Br. J. Pharmacol. 130 2000 1903 1910
221. 2 receptor-dependent and independent manner Mol. Pharmacol. 63 2003 1075 1081
222. D.L. Clarke, M.A. Giembycz, H.J. Patel, and M.G. Belvisi E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype Br. J. Pharmacol. 141 2004 600 609
223. D.L. Clarke, M.G. Belvisi, E. Hardaker, R. Newton, and M.A. Giembycz E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase Mol. Pharmacol. 67 2005 383 393
224. C. Paredes, T. Tazzeo, and L.J. Janssen E-ring isoprostane augments cholinergic neurotransmission in bovine trachealis via FP prostanoid receptors Am. J. Respir. Cell Mol. Biol. 37 2007 739 747
225. 2-selective prostanoid receptors Am. J. Respir. Cell Mol. Biol. 38 2008 88 94
226. 2 stimulates anion efflux from airway epithelial cells via the EP4 prostanoid receptor Am. J. Respir. Cell Mol. Biol. 38 2008 143 152
227. 2, ex vivo Neurochem. Res. 34 2009 2170 2180
228. J.X. Chen, P.W. O'Mara, S.D. Poole, N. Brown, N.J. Ehinger, J.C. Slaughter, B.C. Paria, J.L. Aschner, and J. Reese Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus Pediatr. Res. 72 2012 122 128
229. 2t-isoprostane on chicken embryo ductus arteriosus Comp. Biochem. Physiol. A Mol. Integr. Physiol. 159 2011 436 444
230. S. van der Sterren, L. Kessels, F. Perez-Vizcaino, A.L. Cogolludo, and E. Villamor Prenatal exposure to hyperoxia modifies the thromboxane prostanoid receptor-mediated response to H2O2 in the ductus arteriosus of the chicken embryo J. Physiol. Pharmacol. 65 2014 283 293
231. 2-isoprostanes are elevated in newborns and inversely correlated to gestational age Free Radic. Biol. Med. 37 2004 724 732
232. A.R. Evans, H. Junger, M.D. Southall, G.D. Nicol, L.S. Sorkin, J.T. Broome, T.W. Bailey, and M.R. Vasko Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons J. Pharmacol. Exp. Ther. 293 2000 912 920
233. H. Junger, and L.S. Sorkin C-nociceptor sensitization by isoprostanes is cyclooxygenase dependent Brain Res. 867 2000 255 258
234. E.S. Musiek, H. Yin, G.L. Milne, and J.D. Morrow Recent advances in the biochemistry and clinical relevance of the isoprostane pathway Lipids 40 2005 987 994
235. E.S. Musiek, G.L. Milne, B. McLaughlin, and J.D. Morrow Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity Brain Pathol. 15 2005 149 158
236. G.L. Milne, E.S. Musiek, and J.D. Morrow The cyclopentenone (A2/J2) isoprostanes-unique, highly reactive products of arachidonate peroxidation Antioxid. Redox Signal. 7 2005 210 220
237. K. Stamatakis, and D. Pérez-Sala Prostanoids with cyclopentenone structure as tools for the characterization of electrophilic lipid-protein interactomes Ann. N. Y. Acad. Sci. 1091 2006 548 570
238. E.S. Musiek, B. McLaughlin, and J.D. Morrow Electrophilic cyclopentenone isoprostanes in neurodegeneration J. Mol. Neurosci. 33 2007 80 86