Enrichment of Elevated Plasma F2t-Isoprostane Levels in Individuals with Autism Who Are Stratified by Presence of Gastrointestinal Dysfunction

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Gorrindo, Phillip ^a   Lane, Christianne Joy ^b   Lee, Evon Batey ^c,d   McLaughlin, BethAnn ^a,c,d   Levitt, Pat ^b,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROSTANE DERIVATIVE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; AUTISM; CAUSAL ATTRIBUTION; CHILD; COMORBIDITY; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE MARKER; DISEASE SEVERITY; FATTY ACID BLOOD LEVEL; FEMALE; GOLD STANDARD; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OXIDATIVE STRESS; PHENOTYPE; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SOCIAL BEHAVIOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; F2-ISOPROSTANES; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; MALE; TRIGLYCERIDES;

EID: 84879751691     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068444     Document Type: Article

References (46)

1. State MW, Levitt P, (2011) The conundrums of understanding genetic risks for autism spectrum disorders. Nature Neuroscience 14: 1-8.
2. Berg JM, Geschwind DH, (2012) Autism genetics: search for specificity and convergence. Genome Biology 13: 247-263.
3. Constantino JN, Todorov A, Hilton C, Law P, Zhang Y, et al. (2012) Autism recurrance in half siblings: strong support for genetic mechanisms of transmission in ASD. Molecular Psychiatry e-ahead of print.
4. Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, et al. (2012) Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism 3: 9.
5. Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, et al. (2012) Autism-associated promoter varient in MET impacts functional and structural brain networks. Neuron In Press.
6. Campbell DB, Buie TM, Winter H, Bauman M, Sutcliffe JS, et al. (2009) Distinct Genetic Risk Based on Association of MET in Families With Co-occurring Autism and Gastrointestinal Conditions. PEDIATRICS 123: 1018-1024.
7. Geschwind DH, (2009) Advances in autism. Annual review of medicine 60: 367-380.
8. Rice K, Moriuchi JM, Jones W, Klin A, (2012) Parsing heterogeneity in autism spectrum disorders: visual scanning of dynamic social scenes in school-aged children. J Am Acad Child Adolesc Psychiatry 51: 238-248.
9. Lu AT-H, Cantor RM (2010) Allowing for sex differences increases power in a GWAS of multiplex Autism families. Molecular Psychiatry.
10. Scott-Van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, et al. (2009) Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Science Translational Medicine 2: 1-6.
11. Buie T, Campbell DB, Fuchs GJ, 3rd, Furuta GT, Levy J, et al (2010) Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 125Suppl 1: S1-18.
12. Black C, Kaye JA, Jick H, (2002) Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. BMJ (Clinical research ed) 325: 419-421.
13. Molloy CA, Manning-Courtney P, (2003) Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism: the international journal of research and practice 7: 165-171.
14. Levy SE, Souders MC, Ittenbach RF, Giarelli E, Mulberg AE, et al. (2007) Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry 61: 492-497.
15. Valicenti-McDermott M, McVicar K, Rapin I, Wershil BK, Cohen H, et al. (2006) Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr 27: S128-136.
16. Ibrahim SH, Voigt RG, Katusic SK, Weaver AL, Barbaresi WJ, (2009) Incidence of gastrointestinal symptoms in children with autism: a population-based study. PEDIATRICS 124: 680-686.
17. Wang LW, Tancredi DJ, Thomas DW, (2011) The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. J Dev Behav Pediatrics 32: 351-360.
18. Gorrindo P, Williams KC, Lee EB, Walker LS, McGrew SG, et al. (2012) Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res 5: 101-108.
19. Buie TM, Fuchs GJ, Furuta GT, Kooros K, Levy J, et al. (2010) Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. PEDIATRICS 125Suppl 1: S19-29.
20. Oliveira G, Diogo L, Grazina M, Garcia P, Ataíde A, et al. (2005) Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Developmental medicine and child neurology 47: 185-189.
21. Giulivi C, Zhang Y-F, Omanska-Klusek A, Ross-Inta C, Wong S, et al. (2010) Mitochondrial dysfunction in autism. JAMA: the journal of the American Medical Association 304: 2389-2396.
22. Anney RJL, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E, et al. (2011) Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. European journal of human genetics: EJHG.
23. Bowers K, Li Q, Bressler J, Avramopoulos D, Newschaffer C, et al. (2011) Glutathione pathway gene variation and risk of autism spectrum disorders. Journal of Neurodevelopmental Disorders 3: 132-143.
24. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, et al. (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American journal of medical genetics Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics 141B: 947-956.
25. Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, et al. (2011) Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism. Journal of Autism and Developmental Disorders.
26. Milne GL, Sanchez SC, Musiek ES, Morrow JD, (2007) Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nature protocols 2: 221-226.
27. Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, et al. (2005) Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free radical biology & medicine 38: 698-710.
28. Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, et al. (2005) Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free radical biology & medicine 38: 711-718.
29. Cracowski J-L, Bonaz B, Bessard G, Bessard J, Anglade C, et al. (2002) Increased urinary F2-isoprostanes in patients with Crohn's disease. The American journal of gastroenterology 97: 99-103.
30. Oberg BP, McMenamin E, Lucas FL, McMonagle E, Morrow J, et al. (2004) Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney international 65: 1009-1016.
31. Zeiger SLH, Musiek ES, Zanoni G, Vidari G, Morrow JD, et al. (2009) Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Free radical biology & medicine 47: 1422-1431.
32. Walker LS, Caplan-Dover A, Rasquin-Weber A (2000) Manual for the Questionnaire on Pediatric Gastrointestinal Symptoms.
33. Drossman DA, (2006) The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130: 1377-1390.
34. Constantino JN, Todd RD, (2003) Autistic traits in the general population: a twin study. Arch Gen Psychiatry 60: 524-530.
35. Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, et al. (2003) Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J Autism Dev Disord 33: 427-433.
36. Albers E, Donahue BS, Milne G, Saville BR, Wang W, et al. (2012) Perioperative plasma F(2)-Isoprostane levels correlate with markers of impaired ventilation in infants with single-ventricle physiology undergoing stage 2 surgical palliation on the cardiopulmonary bypass. Pediatr Cardiol 33: 562-568.
37. Morrow JD, Roberts LJ 2nd (1999) Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol 300: 3-12.
38. Proudfoot JM, Barden AE, Loke WM, Croft KD, Puddey IB, et al. (2009) HDL is the major lipoprotein carrier of plasma F2-isoprostanes. J Lipid Res 50: 716-722.
39. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, et al. (2009) Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42: 377-381.
40. Gotham K, Risi S, Pickles A, Lord C, (2007) The Autism Diagnostic Observation Schedule: revised algorithms for improved diagnostic validity. J Autism Dev Disord 37: 613-627.
41. Baber KF, Anderson J, Puzanovova M, Walker LS, (2008) Rome II versus Rome III classification of functional gastrointestinal disorders in pediatric chronic abdominal pain. J Pediatr Gastroenterol Nutr 47: 299-302.
42. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, et al. (2008) Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke 39: 100-104.
43. Ming X, Stein T, Brimacombe M, Johnson W, Lambert G, et al. (2005) Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins, Leukotrienes and Essential Fatty Acids 73: 379-384.
44. Yao Y, Walsh WJ, McGinnis WR, Praticò D, (2006) Altered vascular phenotype in autism: correlation with oxidative stress. Archives of neurology 63: 1161-1164.
45. Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, et al. (2011) Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences 108: 3047-3052.
46. Cryan JF, Dinan TG, (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13: 701-712.