Intestinal effects of isoprostanes: Evidence for the involvement of prostanoid EP and TP receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1198-1205

  Elmhurst, J L ^a   Betti, P A ^a   Rangachari, P K ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6,8 DIFLUORO 1,2,3,4 TETRAHYDRO 9 (4 METHYLSULFONYLBENZYL)CARBAZOLE 1 ACETIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 8 ISOPROSTAGLANDIN E2; 8 ISOPROSTAGLANDIN F2 ALPHA; ISOPROSTANE; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; UNCLASSIFIED DRUG; VAPIPROST;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; COLON MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOG; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; COLON; DINOPROST; DINOPROSTONE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; F2-ISOPROSTANES; ISOPROSTANES; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, THROMBOXANE;

EID: 0030931167     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. ANGEL, F., GO, V. L. W. AND SZURSZEWSKI, J. H.: Innervation of the muscularis mucosa of canine proximal colon. J. Physiol. (Lond.) 357: 93-108, 1984.
2. 2α, in rabbit lung in situ. Am. J. Physiol. 263: H660-H663, 1992.
3. CHRISTENSEN, J.: Gross and microscopic anatomy of the gastrointestinal tracct. In The Large Intestine: Physiology Pathology and Disease, ed. by S. F., Phillips, J. H. Pemberton and R. G. Shorter, pp. 13-35, Raven Press, New York, 1991.
4. COLEMAN, R. A., SMITH, W. L. AND NARUMIYA, S.: International Union of Pharmacology Classification of Prostanoid Receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharm. Rev. 46: 205-229, 1994.
5. 2α on the contractility of the human myometrium in vitro. Eur. J. Pharmacol 285: 151-158, 1995.
6. FORD-HUTCHINSON, A. W., GIRARD, Y., LORD, A., JONES, T. R., CIRINO, M., EVANS, J. F., GILLARD, J., HAMEL, P., LEVEILLE, C., MASSON, P. AND YOUNG, R.: The pharmacology of L-670596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can. J. Physiol. Pharmacol. 67: 989-993, 1989.
7. FUKUNAGA, M., MAKITA, N., ROBERTS, L. J. I. I., MORROW, J. D., TAKAHASHI, K. AND BADR K. F.: Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am. J. Physiol. 264: C1619-C1624, 1993a.
8. 2-isoprostane. Biochem. Biophys. Res. Commun. 195: 507-515, 1993b.
9. 2-isoprostane, on endothelin-1 release. J. Cardiovasc. Pharmacol. 26: (suppl. 3) S51-S52, 1995.
10. GOLDHILL, J. M., BURAKOFF, R., DONOVAN, V., ROSE, K. AND PERCY, W. H.: Defective modulation of colonic secretomotor neurons in a rabbit model of colitis. Am. J. Physiol. 264: G671-G677, 1993a
11. GOLDHILL, J. M., ZHAO, L., XU, Y., DONOVAN, V. AND BURAKOFF, R.: Defective stimulation of cyclic AMP by prostaglandin E2 in colonic epithelial cells in colitis. Eur. J. Pharmacol. 238: 387-390, 1993b
12. HALM, D. R. AND FRIZZEL, R. A,: Intestinal chloride secretion. In Textbook of Secretory Diarrhea, ed. by E. Leventhal, and M. Duffey, pp. 47-58, Raven Press, New York, 1990.
13. HUMANN, J., BETTI, P., RANGACHARI, P. K. AND CRANKSHAW, D. J.: Functional typing of receptors on epithelium and muscularis mucosa in canine proximal colon. Abstract from 8th International Conference on Prostaglandin and Related Compounds, Montreal, Canada, 1992.
14. KEENAN, C. M. AND RANGACHARI, P. K.: Eicosanoid interactions in the canine proximal colon. Am J. Physiol. 256: G673-G679, 1989.
15. 2 on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48: 247-256, 1994.
16. 2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br. J. Pharmacol. 97: 783-794, 1989.
17. MORROW, J. D., AWAD, J. A., BOSS, H. J., BLAIR, I. A. AND ROBERTS, L. J. I. I.: Non-cyclooxvgenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. USA 89: 10721-10725, 1992a.
18. MORROW, J. D., HARRIS, T. M. AND ROBERTS, L. J. I. I.: Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids. Anal. Biochem. 184: 1-10, 1990a.
19. 2-like compounds are in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. USA. 87: 9383-9387, 1990b.
20. MORROW, J. D., MINTON, T. A., MUKUNDAN, C. R., CAMPBELL, M. D., ZACKERT, W. E., DANIEL, V. C., BADR, K. F., BLAIR, I. A. AND ROBERTS, L. J. I. I.: Free radical-induced generation of isoprostanes in vivo: Evidence for the formation of D-ring and E-ring isoprostanes. J. Biol. Chem. 269: 4317-4326, 1994.
21. 2α, a potent agonist of the vascular thromboxane endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins 44: 155-163, 1992b.
22. MORROW, J. D. AND ROBERTS, L. J. I. I.: The isoprostanes: Current knowledge and directions for future research. Biochem. Pharmacol. 51: 1-9, 1996.
23. 1 receptors are not involved in contraction of canine gastric muscularis mucosae by adenosine analogues. Eur. J. Pharmacol. 251: 151-156, 1994.
24. 2 receptors and is mediated by thromboxane receptors (Abstract). Circulation 86: (suppl I): I-2998, 1992.
25. OGLETREE, M. L. AND ALLEN, G. T.: Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J. Pharmacol. Exp. Ther. 260: 789-793, 1992.
26. OGLETREE, M. L., HARRIS, D. N., GREENBERG, R., HASLANDER, M. F. AND NAKANE, M.: Pharmacological actions of SQ 29548, a novel selective thromboxane intagonist. J. Pharmacol. Exp. Ther. 234: 435-441, 1985.
27. PERCY, W. H., BURTON, M. B., ROSE, K., DONOVAN, V. AND BURAKOFF, R.: In vitro changes in the properties of rabbit colonic muscularis mucosae in colitis. Gasenterology 104: 369-376, 1993.
28. PERCY, W. H., ROSE, K. AND BURTON, M. B.: Pharmacological characterization of the muscularis mucosae in three regions of the rabbit colon. J. Pharmacol. Exp. Ther. 261: 1136-1142, 1991.
29. 2α J. Biol. Chem. 270: 9800-9808, 1995.
30. RACHMILEWITZ, D., SIMON, P. L., SCHWARTZ, L. W., GRISWOLD, D. E., FONDACARO, J. D. AND WASSERMAN, M. A.: Inflammatory mediators of experimental colitis in rats. Gastroenterology 97: 326-337, 1989.
31. 2 on canine proximal colon. Am. J. Physiol. 264: G886-G894, 1993.
32. RANGACHARI, P. K. AND PRIOR, T.: Functional subtyping of histamine receptors on the canine proximal colonic mucosa. J. Pharmacol. Exp. Ther. 271: 1016-1026, 1994.
33. SENCHYNA, M. AND CRANKSHAW, D. J.: Characterization of the TP prostanoid receptor population in human nonpregnant myometrium. J. Pharmacol. Exp. Ther. 279: 262-270, 1996.
34. WAINMAN, B. C., BURCEA, I. AND CRANKSHAW, D. J.: The effects of prostanoids on estrogen-dominated rat myometrial longitudinal muscle in vitro. Biol. Reprod. 39: 221-228, 1988.
35. 2 receptors in human platelets. J. Pharmacol. Exp. Ther. 270: 1192-1196, 1994.