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Volumn 7, Issue 24, 2009, Pages 5103-5112

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Author keywords

[No Author keywords available]

Indexed keywords

AIR OXIDATION; ANTIPYRETIC AGENT; BUTYLATED HYDROXYTOLUENE; CO-SUBSTRATE; CYCLOOXYGENASES; DIFFERENT MECHANISMS; ELECTRON-RICH; HEME IRON; HEPATOCELLULAR CARCINOMA; HEPG2 CELLS; HYDROPEROXIDES; LIPID PEROXIDATION; LIPOXYGENASES; O-H BOND; OXIDATION POTENTIALS; PEROXYL RADICAL; PHENOLIC ANTIOXIDANT; PHENOLIC RINGS; PROTOPORPHYRINS;

EID: 72549112142     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b912528k     Document Type: Article
Times cited : (46)

References (68)
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  • 18
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    • These are 5-LOX, 12S-LOX, 15-LOX-1, 12R-LOX, 15-LOX-2. A sixth isoform exists, eLOX-3, which has been shown to isomerize 12R-HPETE to a 11,12-epoxy-8-hydroxyeicosatrienoic acid; see:
    • P. J. Harvison A. J. Forte S. D. Nelson J. Med. Chem. 1986 29 1737 1743
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    • Harvison, P.J.1    Forte, A.J.2    Nelson, S.D.3
  • 52
    • 34547954952 scopus 로고    scopus 로고
    • Ingold and co-workers have shown that this interaction depresses the rate, since the phenolic H-atom is no longer accessible for abstraction:
    • M. B. Ozsoy A. Pabuccuoglu J. Clin. Biochem. Nutr. 2007 41 27 31
    • (2007) J. Clin. Biochem. Nutr. , vol.41 , pp. 27-31
    • Ozsoy, M.B.1    Pabuccuoglu, A.2
  • 60
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    • The activity assay for COX is usually performed in presence of 500 μM phenol to protect the enzyme from oxidative inactivation and to enhance its catalytic activity. However, as phenol is a reducing co-substrate, its presence in the reaction medium would confound the results, and therefore it was omitted for these experiments
    • C. M. Markey A. Alward P. E. Weller L. J. Marnett J. Biol. Chem. 1987 262 6266
    • (1987) J. Biol. Chem. , vol.262 , pp. 6266
    • Markey, C.M.1    Alward, A.2    Weller, P.E.3    Marnett, L.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.