Human liver cytochrome P450 3A4 ubiquitination: Molecularrecognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3308-3332

  Wang, YongQiang ^a   Kim, Sung Mi ^a   Trnka, Michael J ^b   Liu, Yi ^a   Burlingame, A L ^a   Correia, Maria Almira ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; CROSSLINKING; ENZYMES; PHOSPHORYLATION; PROTEINS; SUBSTRATES;

CHEMICAL CROSS-LINKING; CYTOCHROME P450 ENZYMES; DRUG-DRUG INTERACTIONS; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATIONS; INTERMOLECULAR ELECTROSTATIC INTERACTION; PROTEASOMAL DEGRADATION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

DRUG INTERACTIONS;

ASPARTIC ACID; AUTOCRINE MOTILITY FACTOR RECEPTOR; BINDING PROTEIN; C TERMINUS OF HSC70 INTERACTING PROTEIN; CYTOCHROME P450 3A4; GLUTAMIC ACID; GLYCOPROTEIN; GLYCOPROTEIN GP 78; PROTEIN KINASE; SERINE; THREONINE; UBC7 GP78 COMPLEX PROTEIN; UBCH5A CHIP HSC70 HSP40 E2 E3 COMPLEX PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; AMFR PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; PROTEIN BINDING;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HUMAN; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PEPTIDE MAPPING; PROTEIN CROSS LINKING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CYTOCHROME P-450 CYP3A; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, AUTOCRINE MOTILITY FACTOR; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84922352637     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.611525     Document Type: Article

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