The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20835-20844

  Ying, Zheng ^a   Wang, Hongfeng ^a   Fan, Huadong ^a   Wang, Guanghui ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE FORMATION; ENDOPLASMIC RETICULUM; INCLUSION BODIES; LIGASES; NEURODEGENERATIVE DISORDERS; NEUROSERPIN; OVER-EXPRESSION; POINT MUTATIONS; PROTEIN LEVEL; UBIQUITINATION;

NEURODEGENERATIVE DISEASES; PROTEINS;

DEGRADATION;

MUTANT PROTEIN; NEUROSERPIN; PROTEIN GP78; PROTEIN HRD1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY MECHANISM; UBIQUITINATION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CEREBRAL CORTEX; ENDOPLASMIC RETICULUM; EPILEPSIES, MYOCLONIC; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; MICE; MUTATION; NEUROPEPTIDES; RECEPTORS, CYTOKINE; SERPINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 79957991349     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.200808     Document Type: Article

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