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Volumn 11, Issue 6, 2014, Pages 580-587

Geniposide attenuates mitochondrial dysfunction and memory deficits in APP/PS1 transgenic mice

Author keywords

Alzheimer's disease; APP PS1 transgenic mice; Cytochrome c oxidase; Geniposide; Mitochondrial dysfunction; Oxidative stress

Indexed keywords

CYTOCHROME C OXIDASE; GENIPOSIDE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; IRIDOID; NOOTROPIC AGENT; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

EID: 84904760940     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011666140618095925     Document Type: Article
Times cited : (50)

References (45)
  • 1
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease. Nature reviews
    • LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nature reviews. Neurosci 8(7): 499-509 (2007).
    • (2007) Neurosci , vol.8 , Issue.7 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 2
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 430(7000): 631-639 (2004).
    • (2004) Nature , vol.430 , Issue.7000 , pp. 631-639
    • Mattson, M.P.1
  • 3
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
    • Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trend Mol Med 14(2): 45-53 (2008).
    • (2008) Trend Mol Med , vol.14 , Issue.2 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 4
    • 84862782041 scopus 로고    scopus 로고
    • Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: Involvement of oxidative stress and cholinergic dysfunction
    • Zhang W, Bai M, Xi Y, Hao J, Liu L, Mao N, et al. Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: involvement of oxidative stress and cholinergic dysfunction. Free Radic Biol Med 52(8): 1443-1452 (2012).
    • (2012) Free Radic Biol Med , vol.52 , Issue.8 , pp. 1443-1452
    • Zhang, W.1    Bai, M.2    Xi, Y.3    Hao, J.4    Liu, L.5    Mao, N.6
  • 5
    • 33646349444 scopus 로고    scopus 로고
    • Mitochondrial oxidative damage in aging and Alzheimer's disease: Implications for mitochondrially targeted antioxidant therapeutics
    • Reddy PH. Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotech 2006(3): 31372 (2006).
    • (2006) J Biomed Biotech , vol.2006 , Issue.3 , pp. 31372
    • Reddy, P.H.1
  • 6
    • 0034507919 scopus 로고    scopus 로고
    • Oxidative stress leading to loss of critical proteases in Alzheimer's disease. An alternative view of the etiology of AD
    • Carney JM. Oxidative stress leading to loss of critical proteases in Alzheimer's disease. An alternative view of the etiology of AD. Ann N Y Acad Sci 924: 160-163 (2000).
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 160-163
    • Carney, J.M.1
  • 11
    • 0036284936 scopus 로고    scopus 로고
    • Increase of brain oxidative stress in mild cognitive impairment: A possible predictor of Alzheimer disease
    • Pratico D, Clark CM, Liun F, Rokach J, Lee VY, Trojanowski JQ. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol 59(6): 972-976 (2002).
    • (2002) Arch Neurol , vol.59 , Issue.6 , pp. 972-976
    • Pratico, D.1    Clark, C.M.2    Liun, F.3    Rokach, J.4    Lee, V.Y.5    Trojanowski, J.Q.6
  • 12
    • 34247142905 scopus 로고    scopus 로고
    • Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: Implications for the role of nitration in the progression of Alzheimer's disease
    • Butterfield DA, Reed TT, Perluigi M, De Marco C, Coccia R, Keller JN, et al. Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Res 1148: 243-248 (2007).
    • (2007) Brain Res , vol.1148 , pp. 243-248
    • Butterfield, D.A.1    Reed, T.T.2    Perluigi, M.3    De Marco, C.4    Coccia, R.5    Keller, J.N.6
  • 13
    • 0036591849 scopus 로고    scopus 로고
    • Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress
    • Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 32(11): 1050-1060 (2002).
    • (2002) Free Radic Biol Med , vol.32 , Issue.11 , pp. 1050-1060
    • Butterfield, D.A.1    Lauderback, C.M.2
  • 15
    • 33846051882 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and Alzheimer's disease
    • Chen X, Stern D, Yan SD. Mitochondrial dysfunction and Alzheimer's disease. Curr Alzheimer Res 3(5): 515-520 (2006).
    • (2006) Curr Alzheimer Res , vol.3 , Issue.5 , pp. 515-520
    • Chen, X.1    Stern, D.2    Yan, S.D.3
  • 16
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29(28): 9090-9103 (2009).
    • (2009) J Neurosci , vol.29 , Issue.28 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6
  • 17
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
    • Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, et al. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet 13(12): 1225-1240 (2004).
    • (2004) Hum Mol Genet , vol.13 , Issue.12 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3    Manczak, M.4    Gutala, R.V.5    Partovi, D.6
  • 18
    • 33644845279 scopus 로고    scopus 로고
    • Amyloid precursor protein-mediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer's disease
    • Reddy PH. Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease. J Neurochem 96(1): 1-13 (2006).
    • (2006) J Neurochem , vol.96 , Issue.1 , pp. 1-13
    • Reddy, P.H.1
  • 19
    • 81255190781 scopus 로고    scopus 로고
    • Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
    • Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum Mol Genet 20(23): 4515-4529 (2011).
    • (2011) Hum Mol Genet , vol.20 , Issue.23 , pp. 4515-4529
    • Calkins, M.J.1    Manczak, M.2    Mao, P.3    Shirendeb, U.4    Reddy, P.H.5
  • 20
    • 79958721260 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
    • Manczak M, Calkins MJ, Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet 20(13): 2495-2509 (2011).
    • (2011) Hum Mol Genet , vol.20 , Issue.13 , pp. 2495-2509
    • Manczak, M.1    Calkins, M.J.2    Reddy, P.H.3
  • 21
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
    • de la Monte SM, Wands JR. Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimer's Dis 9(2): 167-181 (2006).
    • (2006) J Alzheimer's Dis , vol.9 , Issue.2 , pp. 167-181
    • de la Monte, S.M.1    Wands, J.R.2
  • 22
    • 84856002072 scopus 로고    scopus 로고
    • Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity
    • Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, et al. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PloS one 7(1): e28033 (2012).
    • (2012) PloS one , vol.7 , Issue.1
    • Lee, H.P.1    Pancholi, N.2    Esposito, L.3    Previll, L.A.4    Wang, X.5    Zhu, X.6
  • 23
    • 31344449552 scopus 로고    scopus 로고
    • Anti-inflammatory evaluation of gardenia extract, geniposide and genipin
    • Koo HJ, Lim KH, Jung HJ, Park EH. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol 103(3): 496-500 (2006).
    • (2006) J Ethnopharmacol , vol.103 , Issue.3 , pp. 496-500
    • Koo, H.J.1    Lim, K.H.2    Jung, H.J.3    Park, E.H.4
  • 24
    • 34848901678 scopus 로고    scopus 로고
    • Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway
    • Liu J, Yin F, Zheng X, Jing J, Hu Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochem Intern 51(6-7): 361-369 (2007).
    • (2007) Neurochem Intern , vol.51 , Issue.6-7 , pp. 361-369
    • Liu, J.1    Yin, F.2    Zheng, X.3    Jing, J.4    Hu, Y.5
  • 25
    • 34547734912 scopus 로고    scopus 로고
    • Penta-acetyl geniposideinduced apoptosis involving transcription of NGF/p75 via MAPKmediated AP-1 activation in C6 glioma cells
    • Peng CH, Huang CN, Hsu SP, Wang CJ. Penta-acetyl geniposideinduced apoptosis involving transcription of NGF/p75 via MAPKmediated AP-1 activation in C6 glioma cells. Toxicology 238(2-3): 130-139 (2007).
    • (2007) Toxicology , vol.238 , Issue.2-3 , pp. 130-139
    • Peng, C.H.1    Huang, C.N.2    Hsu, S.P.3    Wang, C.J.4
  • 26
    • 84883244791 scopus 로고    scopus 로고
    • Geniposide decreases the level of Abeta1-42 in the hippocampus of streptozotocin-induced diabetic rats
    • Liu J, Zhang Y, Deng X, Yin F. Geniposide decreases the level of Abeta1-42 in the hippocampus of streptozotocin-induced diabetic rats. Acta biochimica et biophysica Sinica 45(9): 787-791 (2013).
    • (2013) Acta biochimica et biophysica Sinica , vol.45 , Issue.9 , pp. 787-791
    • Liu, J.1    Zhang, Y.2    Deng, X.3    Yin, F.4
  • 28
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature protocols 1(2): 848-858 (2006).
    • (2006) Nature protocols , vol.1 , Issue.2 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 29
    • 84865708686 scopus 로고    scopus 로고
    • The effect of cadmium on Abeta levels in APP/PS1 transgenic mice
    • Li X, Lv Y, Yu S, Zhao H, Yao L. The effect of cadmium on Abeta levels in APP/PS1 transgenic mice. Exp Ther Med 4(1): 125-130 (2012).
    • (2012) Exp Ther Med , vol.4 , Issue.1 , pp. 125-130
    • Li, X.1    Lv, Y.2    Yu, S.3    Zhao, H.4    Yao, L.5
  • 30
    • 84860280814 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates oligomeric Abeta(1-42)-induced mitochondrial dysfunction
    • Huang T, Fang F, Chen L, Zhu Y, Zhang J, Chen X, et al. Ginsenoside Rg1 attenuates oligomeric Abeta(1-42)-induced mitochondrial dysfunction. Curr Alzheimer Res 9(3): 388-395 (2012).
    • (2012) Curr Alzheimer Res , vol.9 , Issue.3 , pp. 388-395
    • Huang, T.1    Fang, F.2    Chen, L.3    Zhu, Y.4    Zhang, J.5    Chen, X.6
  • 31
    • 0022492812 scopus 로고
    • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: Spectral and metabolic properties
    • Emaus RK, Grunwald R, Lemasters JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochimica et biophysica acta 850(3): 436-448 (1986).
    • (1986) Biochimica et biophysica acta , vol.850 , Issue.3 , pp. 436-448
    • Emaus, R.K.1    Grunwald, R.2    Lemasters, J.J.3
  • 32
    • 84891654431 scopus 로고    scopus 로고
    • Intermittent hypoxia protects cerebral mitochondrial function from calcium overload
    • Chen J, Liao W, Gao W, Huang J, Gao Y. Intermittent hypoxia protects cerebral mitochondrial function from calcium overload. Acta neurologica Belgica 113(4): 507-513 (2013).
    • (2013) Acta neurologica Belgica , vol.113 , Issue.4 , pp. 507-513
    • Chen, J.1    Liao, W.2    Gao, W.3    Huang, J.4    Gao, Y.5
  • 33
    • 0345120940 scopus 로고    scopus 로고
    • Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
    • Scaduto RC, Jr., Grotyohann LW. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J 76(1 Pt 1): 469-477 (1999).
    • (1999) Biophys J , vol.76 , Issue.1 Pt 1 , pp. 469-477
    • Scaduto Jr., R.C.1    Grotyohann, L.W.2
  • 34
    • 33846036424 scopus 로고    scopus 로고
    • Alzheimer's and dementia in the oldestold: A century of challenges
    • Kawas CH, Corrada MM. Alzheimer's and dementia in the oldestold: a century of challenges. Curr Alzheimer Res 3(5): 411-419 (2006).
    • (2006) Curr Alzheimer Res , vol.3 , Issue.5 , pp. 411-419
    • Kawas, C.H.1    Corrada, M.M.2
  • 35
    • 0033501744 scopus 로고    scopus 로고
    • Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
    • Dodart JC, Meziane H, Mathis C, Bales KR, Paul SM, Ungerer A. Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Behav Neurosci 113(5): 982-990 (1999).
    • (1999) Behav Neurosci , vol.113 , Issue.5 , pp. 982-990
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 36
    • 0035807829 scopus 로고    scopus 로고
    • Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques
    • Koistinaho M, Ort M, Cimadevilla JM, Vondrous R, Cordell B, Koistinaho J, et al. Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques. Proc Natl Acad Sci USA 98(25): 14675-14680 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.25 , pp. 14675-14680
    • Koistinaho, M.1    Ort, M.2    Cimadevilla, J.M.3    Vondrous, R.4    Cordell, B.5    Koistinaho, J.6
  • 37
    • 0033199822 scopus 로고    scopus 로고
    • Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease
    • King DL, Arendash GW, Crawford F, Sterk T, Menendez J, Mullan MJ. Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease. Behav Brain Res 103(2): 145-162 (1999).
    • (1999) Behav Brain Res , vol.103 , Issue.2 , pp. 145-162
    • King, D.L.1    Arendash, G.W.2    Crawford, F.3    Sterk, T.4    Menendez, J.5    Mullan, M.J.6
  • 38
    • 34447564164 scopus 로고    scopus 로고
    • Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
    • Knobloch M, Konietzko U, Krebs DC, Nitsch RM. Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging 28(9): 1297-1306 (2007).
    • (2007) Neurobiol Aging , vol.28 , Issue.9 , pp. 1297-1306
    • Knobloch, M.1    Konietzko, U.2    Krebs, D.C.3    Nitsch, R.M.4
  • 40
    • 16844382331 scopus 로고    scopus 로고
    • Evidence of increased oxidative damage in subjects with mild cognitive impairment
    • Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology 64(7): 1152-1156 (2005).
    • (2005) Neurology , vol.64 , Issue.7 , pp. 1152-1156
    • Keller, J.N.1    Schmitt, F.A.2    Scheff, S.W.3    Ding, Q.4    Chen, Q.5    Butterfield, D.A.6
  • 41
    • 79953855775 scopus 로고    scopus 로고
    • A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease
    • Bonardi C, de Pulford F, Jennings D, Pardon MC. A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease. Behav Brain Res 222(1): 89-97 (2011).
    • (2011) Behav Brain Res , vol.222 , Issue.1 , pp. 89-97
    • Bonardi, C.1    de Pulford, F.2    Jennings, D.3    Pardon, M.C.4
  • 42
    • 79952854710 scopus 로고    scopus 로고
    • Neuronal death and oxidative stress in the developing brain
    • Ikonomidou C, Kaindl AM. Neuronal death and oxidative stress in the developing brain. Antioxid Redox Signal 14(8): 1535-1550 (2011).
    • (2011) Antioxid Redox Signal , vol.14 , Issue.8 , pp. 1535-1550
    • Ikonomidou, C.1    Kaindl, A.M.2
  • 44
    • 78649815388 scopus 로고    scopus 로고
    • Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
    • Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci USA 107(43): 18670-18675 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.43 , pp. 18670-18675
    • Du, H.1    Guo, L.2    Yan, S.3    Sosunov, A.A.4    McKhann, G.M.5    Yan, S.S.6
  • 45
    • 70450231519 scopus 로고    scopus 로고
    • Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease
    • Tanaka N, Goto Y, Akanuma J, Kato M, Kinoshita T, Yamashita F, et al. Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease. Mitochondrion 10(1): 32-37 (2010).
    • (2010) Mitochondrion , vol.10 , Issue.1 , pp. 32-37
    • Tanaka, N.1    Goto, Y.2    Akanuma, J.3    Kato, M.4    Kinoshita, T.5    Yamashita, F.6


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