Sequence of Aβ-protein deposition in the human medial temporal lobe

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 8, 2000, Pages 733-748

  Thal, Dietmar Rudolf ^a   Rüb, Udo ^a   Schultz, Christian ^a   Sassin, Irena ^a   Ghebremedhin, Estifanos ^a   Del Tredici, Kelly ^a   Braak, Eva ^a   Braak, Heiko ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Alzheimer disease; A protein deposition; Cytoskeletal pathology; Neuritic plaques; Staging

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NEUROFILAMENT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENILE PLAQUE; TEMPORAL LOBE; TISSUE DISTRIBUTION; METABOLISM; MIDDLE AGED; NERVE TRACT; NEUROFIBRILLARY TANGLE; PATHOLOGY; VASCULAR AMYLOIDOSIS;

ADULT; AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; CEREBRAL AMYLOID ANGIOPATHY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURAL PATHWAYS; NEUROFIBRILLARY TANGLES; SENILE PLAQUES; TEMPORAL LOBE;

EID: 0033624303     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.8.733     Document Type: Article

References (55)

1. Uber eine eigenartige Erkrankung der Hirnrinde
2. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
3. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
4. Neuropathological stageing of Alzheimer-related changes
5. Frequency of stages of Alzheimer-related lesions in different age categories
6. The pathogenesis of senile plaques
7. Ageing and dementia
8. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Consensus recommendations for the post-mortem diagnosis of Alzheimer's disease
9. Progression of Neurofibrillary changes and PHF-(T) in end stage Alzheimer's disease is different from cortical plaque and microglial pathology
10. Occurrence of diffuse amyloid deposits in the parvopyramidal layer in Alzheimer's disease
11. Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease
12. Early amyloid-β deposits show different immunoreactivity to the amino- and carboxy-terminal regions of β-peptide in Alzheimer's disease and Down's syndrome brain
13. Neuronal origin of cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
14. Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon
15. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of A
16. Reexamination of the pathogenesis of the senile plaque
17. Diffuse, lake like amyloid-β deposits in the parvopyramidal layer of the presubiculum in Alzheimer disease
18. Subpialβ/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia
19. Silver labeling of Alzheimer neurofibrillary changes and brain β-amyloid
20. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
21. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
22. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
23. The presubicular region in Alzheimer's disease: Topography of amyloid deposits and neurofibrillary changes
24. Improved method facilitates reliable ApoE genotyping of genomic DNA extracted from formaldehyde-fixed pathology specimens
25. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
26. Cytoarchitektonik und Myeloarchitektonik der Grosshirnrinde
27. The human entorhinal cortex: Normal morphology and lamina-specific pathology in various diseases
28. 2-test
29. Entorhinal hippocampal connections: A speculative view of their function
30. Organization of the entorhinal hippocampal system: A review of current anatomical data
31. Cerebral Cortex
32. Morphological characteristics of layer II projection neurons in the rat medial entorhinal cortex
33. Neuropathological hallmarks of Alzheimer's and Parkinson's disease
34. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
35. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: A quantitative evaluation of a one year autopsy population from a geriatric hospital
36. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
37. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
38. Apolipoprotein E allele ε4 is linked to increased deposition of the amyloid β-peptide (A-β) in cases with or without Alzheimer's disease
39. Differential pattern of β-amyloid, amyloid precursor protein and apolipoprotein E expression in cortical senile plaques
40. Sequence of deposition of heterogeneous amyloid β-peptides and ApoE in Down syndrome: Implications for initial events in amyloid plaque formation
41. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: A regional quantitative analysis
42. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin I transgenes
43. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein VT17F (PDAPP) transgenic mouse
44. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
45. Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques
46. Disappearing senile plaques: Diffuse plaques with Aβ-granules in astrocytic secondary lysosomes
47. Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: Amorphic plaques and cytoskeletal changes occur independently
48. An anatomical cascade hypothesis for Alzheimer's disease
49. Alzheimer's disease: The amyloid cascade hypothesis
50. Amyloid, the presenilins and Alzheimer's disease
51. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex
52. Alzheimer's disease and neuroanatomy: Hypotheses and proposals
53. Alzheimer's disease
54. Memory related neural systems in Alzheimer's disease: An anatomic study
55. Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice