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Volumn 7, Issue 1, 2014, Pages 44-51

Anti-cancer drug discovery: Update and comparisons in yeast, Drosophila, and zebrafish

Author keywords

Anti cancer drug discovery; Drosophila; HTS; Model organism; Yeast; Zebrafish

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; AD 58; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; INDIRUBIN 3' MONOXIME; LEFLUNOMIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NIMESULIDE; RAPAMYCIN; ROSUVASTATIN; SMALL MOLECULE ENHANCER OF RAPAMYCIN; SU 4312; UNCLASSIFIED DRUG;

EID: 84921922905     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467207666140702113629     Document Type: Article
Times cited : (21)

References (68)
  • 1
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers, C. Targeted cancer therapy. Nature, 2004, 432, 294-297.
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 2
    • 0026586169 scopus 로고
    • How are cancer associated genes activated or inactivated
    • Wiedemann, L.M.; Morgan, G.J. How are cancer associated genes activated or inactivated. Eur. J. Cancer, 1992, 28A, 248-251.
    • (1992) Eur. J. Cancer , vol.28 A , pp. 248-251
    • Wiedemann, L.M.1    Morgan, G.J.2
  • 3
    • 21144440283 scopus 로고    scopus 로고
    • Chemical genetics to chemical genomics: Small molecules offer big insights
    • Spring, D.R. Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev., 2005, 34, 472-482.
    • (2005) Chem. Soc. Rev , vol.34 , pp. 472-482
    • Spring, D.R.1
  • 4
    • 0030667434 scopus 로고    scopus 로고
    • Integrating genetic approaches into the discovery of anticancer drugs
    • Hartwell, L.H.; Szankasi, P.; Roberts, C.J.; Murray, A.W.; Friend, S.H. Integrating genetic approaches into the discovery of anticancer drugs. Science, 1997, 278, 1064-1068.
    • (1997) Science , vol.278 , pp. 1064-1068
    • Hartwell, L.H.1    Szankasi, P.2    Roberts, C.J.3    Murray, A.W.4    Friend, S.H.5
  • 6
    • 77951672406 scopus 로고    scopus 로고
    • High-throughput screening and small animal models, where are we?
    • Giacomotto, J.; Segalat, L. High-throughput screening and small animal models, where are we? Br. J. Pharmacol., 2010, 160, 204- 216.
    • (2010) Br. J. Pharmacol , vol.160 , pp. 204-216
    • Giacomotto, J.1    Segalat, L.2
  • 8
    • 0842320997 scopus 로고    scopus 로고
    • Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm
    • Kurita, K.; Burgess, S.M.; Sakai, N. Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm. Proc. Natl. Acad. Sci. USA, 2004, 101, 1263-1267.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1263-1267
    • Kurita, K.1    Burgess, S.M.2    Sakai, N.3
  • 10
    • 0036022515 scopus 로고    scopus 로고
    • Cloned zebrafish by nuclear transfer from long-term-cultured cells
    • Lee, K.Y.; Huang, H.; Ju, B.; Yang, Z.; Lin, S. Cloned zebrafish by nuclear transfer from long-term-cultured cells. Nat. Biotechnol., 2002, 20, 795-799.
    • (2002) Nat. Biotechnol , vol.20 , pp. 795-799
    • Lee, K.Y.1    Huang, H.2    Ju, B.3    Yang, Z.4    Lin, S.5
  • 12
    • 0036389722 scopus 로고    scopus 로고
    • Construction of a zebrafish cDNA microarray: Gene expression profiling of the zebrafish during development
    • Ton, C.; Stamatiou, D.; Dzau, V.J.; Liew, C.C. Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. Biochem. Biophys. Res. Commun., 2002, 296, 1134-1142.
    • (2002) Biochem. Biophys. Res. Commun , vol.296 , pp. 1134-1142
    • Ton, C.1    Stamatiou, D.2    Dzau, V.J.3    Liew, C.C.4
  • 13
    • 0024283250 scopus 로고
    • Yeast: An experimental organism for modern biology
    • Botstein, D.; Fink, G.R. Yeast: an experimental organism for modern biology. Science, 1988, 240, 1439-1443.
    • (1988) Science , vol.240 , pp. 1439-1443
    • Botstein, D.1    Fink, G.R.2
  • 15
    • 0030747938 scopus 로고    scopus 로고
    • Human genetic diseases: A cross-talk between man and yeast
    • Foury, F. Human genetic diseases: A cross-talk between man and yeast. Gene, 1997, 195, 1-10.
    • (1997) Gene , vol.195 , pp. 1-10
    • Foury, F.1
  • 16
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
    • Wahl, G.M.; Carr, A.M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell Biol., 2001, 3, E277-E286.
    • (2001) Nat. Cell Biol , vol.3 , pp. E277-E286
    • Wahl, G.M.1    Carr, A.M.2
  • 17
    • 2942536377 scopus 로고    scopus 로고
    • Yeast as a model system for anticancer drug discovery
    • Simon, J.A.; Bedalov, A. Yeast as a model system for anticancer drug discovery. Nat. Rev. Cancer, 2004, 4, 481-492.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 481-492
    • Simon, J.A.1    Bedalov, A.2
  • 19
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • Tentori, L.; Leonetti, C.; Scarsella, M.; D'Amati, G.; Vergati, M.; Portarena, I.; Xu, W.; Kalish, V.; Zupi, G.; Zhang, J.; Graziani, G. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin. Cancer Res., 2003, 9, 5370-5379.
    • (2003) Clin. Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3    D'Amati, G.4    Vergati, M.5    Portarena, I.6    Xu, W.7    Kalish, V.8    Zupi, G.9    Zhang, J.10    Graziani, G.11
  • 21
    • 0028800996 scopus 로고
    • PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
    • Keith, C.T.; Schreiber, S.L. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science, 1995, 270, 50- 51.
    • (1995) Science , vol.270 , pp. 50-51
    • Keith, C.T.1    Schreiber, S.L.2
  • 22
    • 0037312507 scopus 로고    scopus 로고
    • Tor signalling in bugs, brain and brawn
    • Jacinto, E.; Hall, M.N. Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol., 2003, 4, 117-126.
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 117-126
    • Jacinto, E.1    Hall, M.N.2
  • 23
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti, M.A.; Houghton, P.J. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer, 2004, 4, 335-348.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 25
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • Bier, E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat. Rev. Genet., 2005, 6, 9-23.
    • (2005) Nat. Rev. Genet , vol.6 , pp. 9-23
    • Bier, E.1
  • 26
    • 9444236181 scopus 로고    scopus 로고
    • The genetics of cell death: Approaches, insights and opportunities in Drosophila
    • Hay, B.A.; Huh, J.R.; Guo, M. The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat. Rev. Genet., 2004, 5, 911-922.
    • (2004) Nat. Rev. Genet , vol.5 , pp. 911-922
    • Hay, B.A.1    Huh, J.R.2    Guo, M.3
  • 27
    • 0035370781 scopus 로고    scopus 로고
    • Of flies and men--studying human disease in Drosophila
    • Bernards, A.; Hariharan, I.K. Of flies and men--studying human disease in Drosophila. Curr. Opin. Genet. Dev., 2001, 11, 274-278.
    • (2001) Curr. Opin. Genet. Dev , vol.11 , pp. 274-278
    • Bernards, A.1    Hariharan, I.K.2
  • 28
    • 0034837386 scopus 로고    scopus 로고
    • A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    • Reiter, L.T.; Potocki, L.; Chien, S.; Gribskov, M.; Bier, E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res., 2001, 11, 1114-1125.
    • (2001) Genome Res , vol.11 , pp. 1114-1125
    • Reiter, L.T.1    Potocki, L.2    Chien, S.3    Gribskov, M.4    Bier, E.5
  • 29
    • 25144468434 scopus 로고    scopus 로고
    • The mechanism of telomere protection: A comparison between Drosophila and humans
    • Cenci, G.; Ciapponi, L.; Gatti, M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma, 2005, 114, 135-145.
    • (2005) Chromosoma , vol.114 , pp. 135-145
    • Cenci, G.1    Ciapponi, L.2    Gatti, M.3
  • 30
    • 80054960898 scopus 로고    scopus 로고
    • Chemical genetics and drug screening in Drosophila cancer models
    • Gladstone, M.; Su, T.T. Chemical genetics and drug screening in Drosophila cancer models. J. Genet. Genomics, 2011, 38, 497-504.
    • (2011) J. Genet. Genomics , vol.38 , pp. 497-504
    • Gladstone, M.1    Su, T.T.2
  • 33
    • 84861943484 scopus 로고    scopus 로고
    • Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
    • Dar, A.C.; Das, T.K.; Shokat, K.M.; Cagan, R.L. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature, 2012, 486, 80-84.
    • (2012) Nature , vol.486 , pp. 80-84
    • Dar, A.C.1    Das, T.K.2    Shokat, K.M.3    Cagan, R.L.4
  • 34
    • 0030601319 scopus 로고    scopus 로고
    • The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway
    • Sawamoto, K.; Okabe, M.; Tanimura, T.; Mikoshiba, K.; Nishida, Y.; Okano, H. The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway. Dev. Biol., 1996, 178, 13-22.
    • (1996) Dev. Biol , vol.178 , pp. 13-22
    • Sawamoto, K.1    Okabe, M.2    Tanimura, T.3    Mikoshiba, K.4    Nishida, Y.5    Okano, H.6
  • 35
    • 0032774518 scopus 로고    scopus 로고
    • Rhomboid and star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development
    • Guichard, A.; Biehs, B.; Sturtevant, M.A.; Wickline, L.; Chacko, J.; Howard, K.; Bier, E. Rhomboid and star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development, 1999, 126, 2663-2676.
    • (1999) Development , vol.126 , pp. 2663-2676
    • Guichard, A.1    Biehs, B.2    Sturtevant, M.A.3    Wickline, L.4    Chacko, J.5    Howard, K.6    Bier, E.7
  • 36
    • 78751513089 scopus 로고    scopus 로고
    • PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways
    • Gedaly, R.; Angulo, P.; Hundley, J.; Daily, M.F.; Chen, C.; Koch, A.; Evers, B.M. PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. Anticancer Res., 2010, 30, 4951- 4958.
    • (2010) Anticancer Res , vol.30 , pp. 4951-4958
    • Gedaly, R.1    Angulo, P.2    Hundley, J.3    Daily, M.F.4    Chen, C.5    Koch, A.6    Evers, B.M.7
  • 38
    • 0024505212 scopus 로고
    • Clonal origins of cells in the pigmented retina of the zebrafish eye
    • Streisinger, G.; Coale, F.; Taggart, C.; Walker, C.; Grunwald, D.J. Clonal origins of cells in the pigmented retina of the zebrafish eye. Dev. Biol., 1989, 131, 60-69.
    • (1989) Dev. Biol , vol.131 , pp. 60-69
    • Streisinger, G.1    Coale, F.2    Taggart, C.3    Walker, C.4    Grunwald, D.J.5
  • 39
    • 0036731971 scopus 로고    scopus 로고
    • Headwaters of the zebrafish-- emergence of a new model vertebrate
    • Grunwald, D.J.; Eisen, J.S. Headwaters of the zebrafish-- emergence of a new model vertebrate. Nat. Rev. Genet., 2002, 3, 717-724.
    • (2002) Nat. Rev. Genet , vol.3 , pp. 717-724
    • Grunwald, D.J.1    Eisen, J.S.2
  • 42
    • 84883183722 scopus 로고    scopus 로고
    • Zebrafish cancer: The state of the art and the path forward
    • White, R.; Rose, K.; Zon, L. Zebrafish cancer: the state of the art and the path forward. Nat. Rev. Cancer, 2013, 13, 624-636.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 624-636
    • White, R.1    Rose, K.2    Zon, L.3
  • 43
    • 80052972631 scopus 로고    scopus 로고
    • The developing zebrafish (Danio rerio): A vertebrate model for high-throughput screening of chemical libraries
    • Lessman, C.A. The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries. Birth Defects Res. C. Embryo Today, 2011, 93, 268-280.
    • (2011) Birth Defects Res. C. Embryo Today , vol.93 , pp. 268-280
    • Lessman, C.A.1
  • 44
    • 33751032262 scopus 로고    scopus 로고
    • A chemical genetic screen for cell cycle inhibitors in zebrafish embryos
    • Murphey, R.D.; Stern, H.M.; Straub, C.T.; Zon, L.I. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem. Biol. Drug Des., 2006, 68, 213-219.
    • (2006) Chem. Biol. Drug Des , vol.68 , pp. 213-219
    • Murphey, R.D.1    Stern, H.M.2    Straub, C.T.3    Zon, L.I.4
  • 50
    • 0029130826 scopus 로고
    • High degree of myeloid differentiation and granulocytosis is Associated with T(8-21) smoldering leukemia
    • Yamasaki, H.; Era, T.; Sanada, I.; Matutes, E.; Yamaguchi, K.; Takatsuki, K. High degree of myeloid differentiation and granulocytosis is Associated with T(8-21) smoldering leukemia. Leukemia, 1995, 9, 1147-1153.
    • (1995) Leukemia , vol.9 , pp. 1147-1153
    • Yamasaki, H.1    Era, T.2    Sanada, I.3    Matutes, E.4    Yamaguchi, K.5    Takatsuki, K.6
  • 52
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman, J. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov., 2007, 6, 273-286.
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 54
    • 77955513656 scopus 로고    scopus 로고
    • Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer
    • Wang, C;, Tao, W.; Wang, Y.; Bikow, J.; Lu, B.; Keating, A.; Verma, S.; Parker, T.G.; Han, R.; Wen, X.Y. Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer. Eur. Urol., 2010, 58, 418-426.
    • (2010) Eur. Urol , vol.58 , pp. 418-426
    • Wang, C.1    Tao, W.2    Wang, Y.3    Bikow, J.4    Lu, B.5    Keating, A.6    Verma, S.7    Parker, T.G.8    Han, R.9    Wen, X.Y.10
  • 55
    • 76049117207 scopus 로고    scopus 로고
    • Transgenic zebrafish line with over-expression of Hedgehog on the skin: A useful tool to screen hedgehog-inhibiting compounds
    • Chen, Y.H.; Wang, Y.H.; Yu, T.H.; Wu, H.J.; Pai, C.W. Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen hedgehog-inhibiting compounds. Transgenic Res., 2009, 18, 855-864.
    • (2009) Transgenic Res , vol.18 , pp. 855-864
    • Chen, Y.H.1    Wang, Y.H.2    Yu, T.H.3    Wu, H.J.4    Pai, C.W.5
  • 56
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • Zimmermann, G.R.; Lehar, J.; Keith, C.T. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today, 2007, 12, 34-42.
    • (2007) Drug Discov. Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3
  • 60
    • 37749012052 scopus 로고    scopus 로고
    • Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases
    • Ivey, F.D.; Wang, L.; Demirbas, D.; Allain, C.; Hoffman, C.S. Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. J. Biomol. Screen, 2008, 13, 62-71.
    • (2008) J. Biomol. Screen , vol.13 , pp. 62-71
    • Ivey, F.D.1    Wang, L.2    Demirbas, D.3    Allain, C.4    Hoffman, C.S.5
  • 61
    • 84862840406 scopus 로고    scopus 로고
    • A topoisomerase II poison screen of ethnomedicinal Thai plants using a yeast cellbased assay
    • Sangmalee, S.; Laorpaksa, A.; Sukrong, S. A topoisomerase II poison screen of ethnomedicinal Thai plants using a yeast cellbased assay. J. Ethnopharmacol., 2012, 142, 432-437.
    • (2012) J. Ethnopharmacol , vol.142 , pp. 432-437
    • Sangmalee, S.1    Laorpaksa, A.2    Sukrong, S.3
  • 63
    • 0346101749 scopus 로고    scopus 로고
    • Identification of selective inhibitors of NAD+- dependent deacetylases using phenotypic screens in yeast
    • Hirao, M.; Posakony, J.; Nelson, M.; Hruby, H.; Jung, M.; Simon, J.A.; Bedalov, A. Identification of selective inhibitors of NAD+- dependent deacetylases using phenotypic screens in yeast. J. Biol. Chem., 2003, 278, 52773-52782.
    • (2003) J. Biol. Chem , vol.278 , pp. 52773-52782
    • Hirao, M.1    Posakony, J.2    Nelson, M.3    Hruby, H.4    Jung, M.5    Simon, J.A.6    Bedalov, A.7
  • 64
    • 78951476128 scopus 로고    scopus 로고
    • Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae
    • Kadariya, Y.; Tang, B.; Myers, C.B.; Fukui, J.; Peterson, J.R.; Kruger, W.D. Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae. J. Biomol. Screen, 2011, 16, 44-52.
    • (2011) J. Biomol. Screen , vol.16 , pp. 44-52
    • Kadariya, Y.1    Tang, B.2    Myers, C.B.3    Fukui, J.4    Peterson, J.R.5    Kruger, W.D.6
  • 65
    • 0035909523 scopus 로고    scopus 로고
    • Studies on human colon cancer gene APC by targeted expression in Drosophila
    • Bhandari, P.; Shashidhara, L.S. Studies on human colon cancer gene APC by targeted expression in Drosophila. Oncogene, 2001, 20, 6871-6880.
    • (2001) Oncogene , vol.20 , pp. 6871-6880
    • Bhandari, P.1    Shashidhara, L.S.2
  • 67
    • 84860783068 scopus 로고    scopus 로고
    • A ranslation inhibitor identified in a drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer
    • Gladstone, M.; Frederick, B.; Zheng, D.; Edwards, A.; Yoon, P.; Stickel, S.; DeLaney, T.; Chan, D.C.; Raben, D.; Su, T.T. A ranslation inhibitor identified in a drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer. Dis. Model. Mech., 2012, 5, 342-350.
    • (2012) Dis. Model. Mech , vol.5 , pp. 342-350
    • Gladstone, M.1    Frederick, B.2    Zheng, D.3    Edwards, A.4    Yoon, P.5    Stickel, S.6    DeLaney, T.7    Chan, D.C.8    Raben, D.9    Su, T.T.10
  • 68
    • 84861461646 scopus 로고    scopus 로고
    • Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay
    • Li, Y.H.W.; Huang, S.; Du, J.; Huang, C. Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. Biochem. Bioph. Res. Co., 2012, 422, 85-90.
    • (2012) Biochem. Bioph. Res. Co , vol.422 , pp. 85-90
    • Li, Y.H.W.1    Huang, S.2    Du, J.3    Huang, C.4


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