-
1
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
Marton, M. J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Med. 4, 1293-1301 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 1293-1301
-
-
Marton, M.J.1
-
2
-
-
0347473810
-
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
-
Parsons, A. B. et al. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nature Biotechnol. 22, 62-69 (2004).
-
(2004)
Nature Biotechnol.
, vol.22
, pp. 62-69
-
-
Parsons, A.B.1
-
3
-
-
0035940494
-
A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity
-
Birrell, G. W. et al. A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc. Natl Acad. Sci. USA 98, 12608-12613 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12608-12613
-
-
Birrell, G.W.1
-
4
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong, A. H. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004).
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Tong, A.H.1
-
5
-
-
10744225364
-
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
-
Lum, P. Y. et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116, 121-137 (2004).
-
(2004)
Cell
, vol.116
, pp. 121-137
-
-
Lum, P.Y.1
-
6
-
-
0242300176
-
Targets of the cyclin-dependent kinase Cdk1
-
Ubersax, J. A. et al. Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859-864 (2003).
-
(2003)
Nature
, vol.425
, pp. 859-864
-
-
Ubersax, J.A.1
-
7
-
-
0037161731
-
Comparative assessment of large-scale data sets of protein-protein interactions
-
von Mering, C. et al. Comparative assessment of large-scale data sets of protein-protein interactions. Nature 417, 399-403 (2002).
-
(2002)
Nature
, vol.417
, pp. 399-403
-
-
Von Mering, C.1
-
8
-
-
0030667434
-
Integrating genetic approaches into the discovery of anticancer drugs
-
Hartwell, L. H. et al. Integrating genetic approaches into the discovery of anticancer drugs. Science 278, 1064-1068 (1997).
-
(1997)
Science
, vol.278
, pp. 1064-1068
-
-
Hartwell, L.H.1
-
9
-
-
0024348798
-
The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol
-
Gaber, R. F. et al. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 9, 3447-3456 (1989).
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 3447-3456
-
-
Gaber, R.F.1
-
10
-
-
0028932101
-
Yeast multidrug resistance: The PDR network
-
Balzi, E. & Goffeau, A. Yeast multidrug resistance: the PDR network. J. Bioenerg. Biomembr. 27, 71-76 (1995).
-
(1995)
J. Bioenerg. Biomembr.
, vol.27
, pp. 71-76
-
-
Balzi, E.1
Goffeau, A.2
-
11
-
-
0035189738
-
A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays
-
Tugendreich, S. et al. A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays. Genome Res. 11, 1899-1912 (2001).
-
(2001)
Genome Res.
, vol.11
, pp. 1899-1912
-
-
Tugendreich, S.1
-
12
-
-
0035872473
-
Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast
-
Perkins, E. et al. Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast. Cancer Res. 61, 4175-4183 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4175-4183
-
-
Perkins, E.1
-
13
-
-
0023069259
-
ADP-ribosylation of proteins. Enzymology and biological significance
-
Althaus, F. R. & Richter, C. ADP-ribosylation of proteins. Enzymology and biological significance. Mol. Biol. Biochem. Biophys. 37, 1-237 (1987).
-
(1987)
Mol. Biol. Biochem. Biophys.
, vol.37
, pp. 1-237
-
-
Althaus, F.R.1
Richter, C.2
-
14
-
-
10744233684
-
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
-
Tentori, L. et al. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin. Cancer Res. 9, 5370-5379 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5370-5379
-
-
Tentori, L.1
-
15
-
-
0037075887
-
Cyclin D-dependent kinases, INK4 inhibitors and cancer
-
Ortega, S., Malumbres, M. & Barbacid, M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim. Biophys. Acta 1602, 73-87 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1602
, pp. 73-87
-
-
Ortega, S.1
Malumbres, M.2
Barbacid, M.3
-
16
-
-
0028179669
-
Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
-
Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev. 8, 9-22 (1994).
-
(1994)
Genes Dev.
, vol.8
, pp. 9-22
-
-
Polyak, K.1
-
17
-
-
0029119852
-
INK4b genes
-
INK4b genes. Oncogene 11, 635-645 (1995).
-
(1995)
Oncogene
, vol.11
, pp. 635-645
-
-
Quelle, D.E.1
-
18
-
-
10744230675
-
A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer
-
Liu, G. et al. A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer. Clin. Cancer Res. 10, 924-928 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 924-928
-
-
Liu, G.1
-
19
-
-
0032578601
-
INK4A protein and flavopiridol restore yeast cell growth inhibited by Cdk 4
-
INK4A protein and flavopiridol restore yeast cell growth inhibited by Cdk4. Biochem. Biophys. Res. Commun. 250, 791-797 (1998).
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.250
, pp. 791-797
-
-
Moorthamer, M.1
-
20
-
-
0037427412
-
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
-
Scorrano, L. & Korsmeyer, S. J. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem. Biophys. Res. Commun. 304, 437-444 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.304
, pp. 437-444
-
-
Scorrano, L.1
Korsmeyer, S.J.2
-
21
-
-
0031993255
-
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
-
Xu, Q. & Reed, J. C. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell 1, 337-346 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 337-346
-
-
Xu, Q.1
Reed, J.C.2
-
22
-
-
1642358490
-
Linking the epigenetic 'language' of covalent histone modifications to cancer
-
Hake, S. B., Xiao, A. & Allis, C. D. Linking the epigenetic 'language' of covalent histone modifications to cancer. Br. J. Cancer 90, 761-769 (2004).
-
(2004)
Br. J. Cancer
, vol.90
, pp. 761-769
-
-
Hake, S.B.1
Xiao, A.2
Allis, C.D.3
-
23
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
24
-
-
0021734287
-
Characterization of two genes required for the position-effect control of yeast mating-type genes
-
Shore, D., Squire, M. & Nasmyth, K. A. Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J. 3, 2817-2823 (1984).
-
(1984)
EMBO J.
, vol.3
, pp. 2817-2823
-
-
Shore, D.1
Squire, M.2
Nasmyth, K.A.3
-
25
-
-
0028841317
-
The SIR2 gene family, conserved from bacteria to humans, functions in silencing cell cycle progression, and chromosome stability
-
Brachmann, C. B. et al. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9, 2888-2902 (1995).
-
(1995)
Genes Dev.
, vol.9
, pp. 2888-2902
-
-
Brachmann, C.B.1
-
26
-
-
0031658303
-
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
-
Singer, M. S. et al. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150, 613-632 (1998).
-
(1998)
Genetics
, vol.150
, pp. 613-632
-
-
Singer, M.S.1
-
27
-
-
0037172665
-
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
-
Feng, Q. et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr. Biol. 12, 1052-1058 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1052-1058
-
-
Feng, Q.1
-
28
-
-
0023340731
-
Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
-
Rine, J. & Herskowitz, I. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116, 9-22 (1987).
-
(1987)
Genetics
, vol.116
, pp. 9-22
-
-
Rine, J.1
Herskowitz, I.2
-
29
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri, H. et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001).
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
-
30
-
-
0035913911
-
Negative control of p53 by Sir2α promotes cell survival under stress
-
Luo, J. et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (2001).
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
31
-
-
0036898253
-
Acetylation inactivates the transcriptional repressor BCL6
-
Bereshchenko, O. R., Gu, W. & Dalla-Favera, R. Acetylation inactivates the transcriptional repressor BCL6. Nature Genet. 32, 606-613 (2002).
-
(2002)
Nature Genet.
, vol.32
, pp. 606-613
-
-
Bereshchenko, O.R.1
Gu, W.2
Dalla-Favera, R.3
-
32
-
-
0038243177
-
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma
-
Pasqualucci, L. et al. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101, 2914-2923 (2003).
-
(2003)
Blood
, vol.101
, pp. 2914-2923
-
-
Pasqualucci, L.1
-
34
-
-
0035910031
-
Identification of a small molecule inhibitor of Sir2p
-
Bedalov, A. et al. Identification of a small molecule inhibitor of Sir2p. Proc. Natl Acad. Sci. USA 98, 15113-15118 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 15113-15118
-
-
Bedalov, A.1
-
35
-
-
0141781063
-
+ levels in Saccharomyces cerevisiae
-
+ levels in Saccharomyces cerevisiae. Mol. Cell. Biol. 23, 7044-7054 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7044-7054
-
-
Bedalov, A.1
-
36
-
-
0346101749
-
+-dependent deacetylases using phenotypic screens in yeast
-
+-dependent deacetylases using phenotypic screens in yeast. J. Biol. Chem. 278, 52773-52782 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52773-52782
-
-
Hirao, M.1
-
37
-
-
2342614837
-
Inhibitors of Sir2: Evaluation of splitomicin analogues
-
in the press
-
Posakony, J. et al. Inhibitors of Sir2: evaluation of splitomicin analogues. J. Med. Chem. (in the press).
-
J. Med. Chem.
-
-
Posakony, J.1
-
38
-
-
0035054387
-
Deficient DNA mismatch repair: A common etiologic factor for colon cancer
-
Peltomaki, P. Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum. Mol. Genet. 10, 735-740 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 735-740
-
-
Peltomaki, P.1
-
39
-
-
0141645511
-
Cancer epigenetics: DNA methylation and chromatin alterations in human cancer
-
Esteller, M. Cancer epigenetics: DNA methylation and chromatin alterations in human cancer. Adv. Exp. Med. Biol. 532, 39-49 (2003).
-
(2003)
Adv. Exp. Med. Biol.
, vol.532
, pp. 39-49
-
-
Esteller, M.1
-
40
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
41
-
-
0034795339
-
Use of isogenic human cancer cells for high-throughput screening and drug discovery
-
Torrance, C. J. et al. Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nature Biotechnol. 19, 940-945 (2001).
-
(2001)
Nature Biotechnol.
, vol.19
, pp. 940-945
-
-
Torrance, C.J.1
-
42
-
-
0037116617
-
Cell-based assays for identification of novel double-strand break-inducing agents
-
Dunstan, H. M. et al. Cell-based assays for identification of novel double-strand break-inducing agents. J. Natl Cancer Inst. 94, 88-94 (2002).
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, pp. 88-94
-
-
Dunstan, H.M.1
-
43
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill, D. P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (1998).
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
-
44
-
-
0035253403
-
Mitotic checkpoints: From yeast to cancer
-
Wassmann, K. & Benezra, R. Mitotic checkpoints: from yeast to cancer. Curr. Opin. Genet. Dev. 11, 83-90 (2001).
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 83-90
-
-
Wassmann, K.1
Benezra, R.2
-
45
-
-
0025941405
-
cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
-
Hoyt, M. A., Totis, L. & Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517 (1991).
-
(1991)
Cell
, vol.66
, pp. 507-517
-
-
Hoyt, M.A.1
Totis, L.2
Roberts, B.T.S.3
-
46
-
-
0033741369
-
Yeast three-hybrid system for detecting ligand-receptor interactions
-
Griffith, E. C., Licitra, E. J. & Liu, J. O. Yeast three-hybrid system for detecting ligand-receptor interactions. Methods Enzymol. 328, 89-103 (2000).
-
(2000)
Methods Enzymol.
, vol.328
, pp. 89-103
-
-
Griffith, E.C.1
Licitra, E.J.2
Liu, J.O.3
-
47
-
-
0034616930
-
Functional discovery via a compendium of expression profiles
-
Hughes, T. R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
-
48
-
-
9144222006
-
Proteomics-based target identification: Bengamides as a new class of methionine aminopeptidase inhibitors
-
Towbin, H. et al. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J. Biol. Chem. 278, 52964-52971 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52964-52971
-
-
Towbin, H.1
-
49
-
-
0242539836
-
Cancer epigenetics
-
Momparler, R. L. Cancer epigenetics. Oncogene 22, 6479-6483 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 6479-6483
-
-
Momparler, R.L.1
-
50
-
-
0344407016
-
Histone deacetylases: Unique players in shaping the epigenetic histone code
-
Thiagalingam, S. et al. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann. NY Acad. Sci. 983, 84-100 (2003).
-
(2003)
Ann. NY Acad. Sci.
, vol.983
, pp. 84-100
-
-
Thiagalingam, S.1
-
51
-
-
0035913911
-
Negative control of p53 by Sir2α promotes cell survival under stress
-
Luo, J. et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (2001).
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
52
-
-
0036898253
-
Acetylation inactivates the transcriptional repressor BCL6
-
Bereshchenko, O. R. et al. Acetylation inactivates the transcriptional repressor BCL6. Nature Genet. 32, 606-613 (2002).
-
(2002)
Nature Genet.
, vol.32
, pp. 606-613
-
-
Bereshchenko, O.R.1
-
53
-
-
0037011656
-
'SIRT8' expressed in thyroid cancer is actually SIRT7
-
Frye, R. 'SIRT8' expressed in thyroid cancer is actually SIRT7. Br. J. Cancer 87, 1479 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, pp. 1479
-
-
Frye, R.1
-
54
-
-
0034489925
-
Acute myeloid leukemia with inv(8)(p11q13)
-
Panagopoulos, I. et al. Acute myeloid leukemia with inv(8)(p11q13). Leuk. Lymphoma 39, 651-656 (2000).
-
(2000)
Leuk. Lymphoma
, vol.39
, pp. 651-656
-
-
Panagopoulos, I.1
-
55
-
-
0037130452
-
MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia
-
Emerling, B. M. et al. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene 21, 4849-4854 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 4849-4854
-
-
Emerling, B.M.1
-
56
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
-
57
-
-
0037441747
-
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
-
Keats, J. J. et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood 101, 1520-1529 (2003).
-
(2003)
Blood
, vol.101
, pp. 1520-1529
-
-
Keats, J.J.1
-
58
-
-
0037172665
-
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
-
Feng, Q. et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr. Biol. 12, 1052-1058 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1052-1058
-
-
Feng, Q.1
-
59
-
-
0037077178
-
Dot 1p modulates silencing in yeast by methylation of the nucleosome core
-
van Leeuwen, F. et al. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109, 745-756 (2002).
-
(2002)
Cell
, vol.109
, pp. 745-756
-
-
Van Leeuwen, F.1
|