-
1
-
-
14844341251
-
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila
-
DOI 10.1073/pnas.0500055102
-
Agrawal, N., Pallos, J., Slepko, N., Apostol, B. L., Bodai, L., Chang, L. W., Chiang, A. S., Thompson, L. M. and Marsh, J. L. (2005). Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc. Natl. Acad. Sci. USA 102, 3777-3781. (Pubitemid 40354688)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.10
, pp. 3777-3781
-
-
Agrawal, N.1
Pallos, J.2
Slepko, N.3
Apostol, B.L.4
Bodai, L.5
Chang, L.-W.6
Chiang, A.-S.7
Thompson, L.M.8
Marsh, J.L.9
-
2
-
-
0025232412
-
Metabolism and action of amino acid analog anti-cancer agents
-
Ahluwalia, G. S., Grem, J. L., Hao, Z. and Cooney, D. A. (1990). Metabolism and action of amino acid analog anti-cancer agents. Pharmacol. Ther. 46, 243-271. (Pubitemid 20094962)
-
(1990)
Pharmacology and Therapeutics
, vol.46
, Issue.2
, pp. 243-271
-
-
Ahluwalia, G.S.1
Grem, J.L.2
Hao, Z.3
Cooney, D.A.4
-
3
-
-
59449103448
-
Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway
-
Aritakula, A. and Ramasamy, A. (2008). Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway. J. Biosci. 33, 731-742.
-
(2008)
J. Biosci.
, vol.33
, pp. 731-742
-
-
Aritakula, A.1
Ramasamy, A.2
-
4
-
-
56549093146
-
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
-
Barrett, S. D., Bridges, A. J., Dudley, D. T., Saltiel, A. R., Fergus, J. H., Flamme, C. M., Delaney, A. M., Kaufman, M., Le Page, S., Leopold, W. R. et al. (2008). The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg. Med. Chem. Lett. 18, 6501-6504.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 6501-6504
-
-
Barrett, S.D.1
Bridges, A.J.2
Dudley, D.T.3
Saltiel, A.R.4
Fergus, J.H.5
Flamme, C.M.6
Delaney, A.M.7
Kaufman, M.8
Le Page, S.9
Leopold, W.R.10
-
5
-
-
0242641565
-
Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
-
DOI 10.1093/emboj/cdg548
-
Brumby, A. M. and Richardson, H. E. (2003). scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22, 5769-5779. (Pubitemid 37408816)
-
(2003)
EMBO Journal
, vol.22
, Issue.21
, pp. 5769-5779
-
-
Brumby, A.M.1
Richardson, H.E.2
-
6
-
-
23144434969
-
Using Drosophila melanogaster to map human cancer pathways
-
DOI 10.1038/nrc1671
-
Brumby, A. M. and Richardson, H. E. (2005). Using Drosophila melanogaster to map human cancer pathways. Nat. Rev. Cancer 5, 626-639. (Pubitemid 41081388)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.8
, pp. 626-639
-
-
Brumby, A.M.1
Richardson, H.E.2
-
7
-
-
41049102573
-
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
-
DOI 10.1038/nchembio.78, PII NCHEMBIO78
-
Chang, S., Bray, S. M., Li, Z., Zarnescu, D. C., He, C., Jin, P. and Warren, S. T. (2008). Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 4, 256-263. (Pubitemid 351419125)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.4
, pp. 256-263
-
-
Chang, S.1
Bray, S.M.2
Li, Z.3
Zarnescu, D.C.4
He, C.5
Jin, P.6
Warren, S.T.7
-
8
-
-
80052924401
-
Glutamine analogs promote cytoophidium assembly in human and Drosophila cells
-
Chen, K., Zhang, J., Tastan, O. Y., Deussen, Z. A., Siswick, M. Y. and Liu, J. L. (2011). Glutamine analogs promote cytoophidium assembly in human and Drosophila cells. J. Genet. Genomics 38, 391-402.
-
(2011)
J. Genet. Genomics
, vol.38
, pp. 391-402
-
-
Chen, K.1
Zhang, J.2
Tastan, O.Y.3
Deussen, Z.A.4
Siswick, M.Y.5
Liu, J.L.6
-
9
-
-
84860491077
-
Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
-
Colombani, J., Andersen, D. S. and Leopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 336, 582-585.
-
(2012)
Science
, vol.336
, pp. 582-585
-
-
Colombani, J.1
Andersen, D.S.2
Leopold, P.3
-
10
-
-
77955966751
-
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter
-
Cordero, J. B., Macagno, J. P., Stefanatos, R. K., Strathdee, K. E., Cagan, R. L. and Vidal, M. (2010). Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev. Cell 18, 999-1011.
-
(2010)
Dev. Cell
, vol.18
, pp. 999-1011
-
-
Cordero, J.B.1
Macagno, J.P.2
Stefanatos, R.K.3
Strathdee, K.E.4
Cagan, R.L.5
Vidal, M.6
-
11
-
-
84861943484
-
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
-
Dar, A. C., Das, T. K., Shokat, K. M. and Cagan, R. L. (2012). Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 486, 80-84.
-
(2012)
Nature
, vol.486
, pp. 80-84
-
-
Dar, A.C.1
Das, T.K.2
Shokat, K.M.3
Cagan, R.L.4
-
12
-
-
75149148563
-
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
De Berardinis, R. J. and Cheng, T. (2010). Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29, 313-324.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
De Berardinis, R.J.1
Cheng, T.2
-
13
-
-
0020032975
-
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma
-
DOI 10.1016/0024-3205(82)90527-6
-
Denton, J. E., Lui, M. S., Aoki, T., Sebolt, J. and Weber, G. (1982). Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma. Life Sci. 30, 1073-1080. (Pubitemid 12100133)
-
(1982)
Life Sciences
, vol.30
, Issue.13
, pp. 1073-1080
-
-
Denton, J.E.1
Lui, M.S.2
Aoki, T.3
-
15
-
-
79959678739
-
Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells
-
Edwards, A., Gladstone, M., Yoon, P., Raben, D., Frederick, B. and Su, T. T. (2011). Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis. Model. Mech. 4, 496-503.
-
(2011)
Dis. Model. Mech.
, vol.4
, pp. 496-503
-
-
Edwards, A.1
Gladstone, M.2
Yoon, P.3
Raben, D.4
Frederick, B.5
Su, T.T.6
-
16
-
-
0020656761
-
Cytidine triphosphate synthetase activity in lymphoproliferative disorders
-
Ellims, P. H., Gan, T. E. and Medley, G. (1983). Cytidine triphosphate synthetase activity in lymphoproliferative disorders. Cancer Res. 43, 1432-1435. (Pubitemid 13160081)
-
(1983)
Cancer Research
, vol.43
, Issue.3
, pp. 1432-1435
-
-
Ellims, P.H.1
Gan, T.E.2
Medley, G.3
-
17
-
-
84860487216
-
Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation
-
Garelli, A., Gontijo, A. M., Miguela, V., Caparros, E. and Dominguez, M. (2012). Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Science 336, 579-582.
-
(2012)
Science
, vol.336
, pp. 579-582
-
-
Garelli, A.1
Gontijo, A.M.2
Miguela, V.3
Caparros, E.4
Dominguez, M.5
-
18
-
-
80054960898
-
Chemical genetics and drug screening in Drosophila cancer models
-
Gladstone, M. and Su, T. T. (2011). Chemical genetics and drug screening in Drosophila cancer models. J. Genet. Genomics 38, 497-504.
-
(2011)
J. Genet. Genomics
, vol.38
, pp. 497-504
-
-
Gladstone, M.1
Su, T.T.2
-
19
-
-
0027406935
-
Oral idarubicin: An anthracycline derivative with unique properties
-
Goebel, M. (1993). Oral idarubicin - an anthracycline derivative with unique properties. Ann. Hematol. 66, 33-43. (Pubitemid 23066935)
-
(1993)
Annals of Hematology
, vol.66
, Issue.1
, pp. 33-43
-
-
Goebel, M.1
-
20
-
-
0016588948
-
L-[alphaS, 5S]-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (NSC-163501): A new amino acid antibiotic with the properties of an antagonist of L-glutamine
-
Jayaram, H. N., Cooney, D. A., Ryan, J. A., Neil, G., Dion, R. L. and Bono, V. H. (1975). L-[alphaS, 5S]-alpha-amino-3-chloro-4, 5-dihydro-5- isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine. Cancer Chemother. Rep. 59, 481-491.
-
(1975)
Cancer Chemother. Rep.
, vol.59
, pp. 481-491
-
-
Jayaram, H.N.1
Cooney, D.A.2
Ryan, J.A.3
Neil, G.4
Dion, R.L.5
Bono, V.H.6
-
21
-
-
0037154205
-
Life extension in Drosophila by feeding a drug
-
DOI 10.1073/pnas.022631999
-
Kang, H. L, Benzer, S. and Min, K. T. (2002). Life extension in Drosophila by feeding a drug. Proc. Natl. Acad. Sci. USA 99, 838-843. (Pubitemid 34106597)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.2
, pp. 838-843
-
-
Kang, H.-L.1
Benzer, S.2
Min, K.-T.3
-
22
-
-
0018926713
-
Increased cytidine 5'-triphosphate synthetase activity in rat and human tumors
-
Kizaki, H., Williams, J. C, Morris, H. P. and Weber, G. (1980). Increased cytidine 5-triphosphate synthetase activity in rat and human tumors. Cancer Res. 40, 3921-3927. (Pubitemid 10030406)
-
(1980)
Cancer Research
, vol.40
, Issue.11
, pp. 3921-3927
-
-
Kizaki, H.1
Williams, J.C.2
Morris, H.P.3
Weber, G.4
-
23
-
-
20044388322
-
Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of Fragile X syndrome
-
DOI 10.1016/j.neuron.2005.01.038
-
McBride, S. M., Choi, C. H., Wang, Y., Liebelt, D., Braunstein, E., Ferreiro, D., Sehgal, A., Siwicki, K. K., Dockendorff, T. C, Nguyen, H. T. et al. (2005). Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome. Neuron 45, 753-764. (Pubitemid 40320709)
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 753-764
-
-
McBride, S.M.J.1
Choi, C.H.2
Wang, Y.3
Liebelt, D.4
Braunstein, E.5
Ferreiro, D.6
Sehgal, A.7
Siwicki, K.K.8
Dockendorff, T.C.9
Nguyen, H.T.10
McDonald, T.V.11
Jongens, T.A.12
-
24
-
-
0016299357
-
Cytidine 5-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine
-
McPartland, R. P., Wang, M. C, Bloch, A. and Weinfeld, H. (1974). Cytidine 5-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine. Cancer Res. 34, 3107-3111.
-
(1974)
Cancer Res.
, vol.34
, pp. 3107-3111
-
-
McPartland, R.P.1
Wang, M.C.2
Bloch, A.3
Weinfeld, H.4
-
25
-
-
0021248051
-
+-dependent malic enzyme
-
Moreadith, R. W. and Lehninger, A. L. (1984). The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD (P) +- dependent malic enzyme. J. Biol Chem. 259, 6215-6221. (Pubitemid 14106333)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.10
, pp. 6215-6221
-
-
Moreadith, R.W.1
Lehninger, A.L.2
-
26
-
-
0242666126
-
A Genetic Screen in Drosophila for Metastatic Behavior
-
DOI 10.1126/science.1088474
-
Pagliarini, R. A. and Xu, T. (2003). A genetic screen in Drosophila for metastatic behavior. Science 302, 1227-1231. (Pubitemid 37421030)
-
(2003)
Science
, vol.302
, Issue.5648
, pp. 1227-1231
-
-
Pagliarini, R.A.1
Xu, T.2
-
27
-
-
79955749505
-
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
-
Pandey, U. B. and Nichols, C. D. (2011). Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol. Rev. 63, 411-436.
-
(2011)
Pharmacol. Rev.
, vol.63
, pp. 411-436
-
-
Pandey, U.B.1
Nichols, C.D.2
-
28
-
-
60649118070
-
An innate immune response of blood cells to tumors and tissue damage in Drosophila
-
Pastor-Pareja, J. C., Wu, M. and Xu, T. (2008). An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis. Model. Mech. 1, 144-154.
-
(2008)
Dis. Model. Mech.
, vol.1
, pp. 144-154
-
-
Pastor-Pareja, J.C.1
Wu, M.2
Xu, T.3
-
29
-
-
84155186685
-
Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens
-
Shah, S., Yarrow, C., Dunning, R., Cheek, B., Vass, S., Windass, J. and Hadfield, S. (2012). Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Pest Manag. Sci. 68, 38-48.
-
(2012)
Pest Manag. Sci.
, vol.68
, pp. 38-48
-
-
Shah, S.1
Yarrow, C.2
Dunning, R.3
Cheek, B.4
Vass, S.5
Windass, J.6
Hadfield, S.7
-
30
-
-
33750374340
-
Development of a Drosophila seizure model for in vivo high-throughput drug screening
-
DOI 10.1111/j.1460-9568.2006.05075.x
-
Stilwell, G. E., Saraswati, S., Littleton, J. T. and Chouinard, S. W. (2006). Development of a Drosophila seizure model for in vivo high-throughput drug screening. Eur. J. Neurosci. 24, 2211-2222. (Pubitemid 44622342)
-
(2006)
European Journal of Neuroscience
, vol.24
, Issue.8
, pp. 2211-2222
-
-
Stilwell, G.E.1
Saraswati, S.2
Littleton, J.T.3
Chouinard, S.W.4
-
31
-
-
0012470767
-
In vivo culture of Drosophila imaginal discs
-
F. H. Wilt and N. K. Wessells, New York, NY: Thomas Y. Cromwell Company
-
Ursprung, H. (1967). In vivo culture of Drosophila imaginal discs. In Methods in Developmental Biology (ed. F. H. Wilt and N. K. Wessells), pp. 485-492. New York, NY: Thomas Y. Cromwell Company.
-
(1967)
Methods in Developmental Biology
, pp. 485-492
-
-
Ursprung, H.1
-
32
-
-
18144392678
-
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma
-
DOI 10.1158/0008-5472.CAN-04-4561
-
Vidal, M., Wells, S., Ryan, A. and Cagan, R. (2005). ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res. 65, 3538-3541. (Pubitemid 40616327)
-
(2005)
Cancer Research
, vol.65
, Issue.9
, pp. 3538-3541
-
-
Vidal, M.1
Wells, S.2
Ryan, A.3
Cagan, R.4
-
33
-
-
80053321476
-
Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model
-
Willecke, M., Toggweiler, J. and Basler, K. (2011). Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. Oncogene 30, 4067-4074.
-
(2011)
Oncogene
, vol.30
, pp. 4067-4074
-
-
Willecke, M.1
Toggweiler, J.2
Basler, K.3
-
34
-
-
0017926507
-
Increased CTP synthetase activity in cancer cells
-
Williams, J. C., Kizaki, H., Weber, G. and Morris, H. P. (1978). Increased CTP synthetase activity in cancer cells. Nature 271, 71-73. (Pubitemid 8240069)
-
(1978)
Nature
, vol.271
, Issue.5640
, pp. 71-73
-
-
Williams, J.C.1
Kizaki, H.2
Weber, G.3
Morris, H.P.4
-
35
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
Wise, D. R. and Thompson, C. B. (2010). Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 35, 427-433.
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 427-433
-
-
Wise, D.R.1
Thompson, C.B.2
-
36
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
DOI 10.1177/108705719900400206
-
Zhang, J. H., Chung, T. D. and Oldenburg, K. R. (1999). A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4, 67-73. (Pubitemid 29278954)
-
(1999)
Journal of Biomolecular Screening
, vol.4
, Issue.2
, pp. 67-73
-
-
Zhang, J.-H.1
Chung, T.D.Y.2
Oldenburg, K.R.3
|