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Volumn 11, Issue 3, 2001, Pages 274-278

Of flies and men - Studying human disease in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; COMPLEMENTARY DNA; PROTEIN P53; PROTEIN P63; PROTEIN P73; RNA; SONIC HEDGEHOG PROTEIN;

EID: 0035370781     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00190-8     Document Type: Review
Times cited : (55)

References (49)
  • 1
    • 0034708480 scopus 로고    scopus 로고
    • Thegenome sequence of Drosophila melanogaster
    • Reports the sequencing of most of the ~120 Mb euchromatic portion of the Drosophila genome and describes its prominent features. A total of 13 601 genes (including previously known genes) were identified using computational methods. This paper also surveys genes known to be involved in basic cellular processes including DNA replication, metabolism and solute transport.
    • Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., et al. Thegenome sequence of Drosophila melanogaster. Science. 287:2000;2185-2195. Reports the sequencing of most of the ~120 Mb euchromatic portion of the Drosophila genome and describes its prominent features. A total of 13 601 genes (including previously known genes) were identified using computational methods. This paper also surveys genes known to be involved in basic cellular processes including DNA replication, metabolism and solute transport.
    • (2000) Science , vol.287 , pp. 2185-2195
    • Adams, M.D.1    Celniker, S.E.2    Holt, R.A.3    Evans, C.A.4    Gocayne, J.D.5    Amanatides, P.G.6    Scherer, S.E.7    Li, P.W.8    Hoskins, R.A.9    Galle, R.F.10
  • 2
    • 0034708444 scopus 로고    scopus 로고
    • Comparative genomics of the eukaryotes
    • The proteome of Drosophila is compared to that of the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae. Particular attention is paid to regulators of the cytoskeleton, the cell cycle, apoptosis, cell adhesion and cell signalling. Genes encoding components of the nervous system and the immune system are analyzed. Among 289 selected human disease genes, 62% were found to have Drosophila orthologues.
    • Rubin G.M., Yandell M.D., Wortman J.R., Gabor Miklos G.L., Nelson C.R., Hariharan I.K., Fortini M.E., Li P.W., Apweiler R., Fleischmann W., et al. Comparative genomics of the eukaryotes. Science. 287:2000;2204-2215. The proteome of Drosophila is compared to that of the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae. Particular attention is paid to regulators of the cytoskeleton, the cell cycle, apoptosis, cell adhesion and cell signalling. Genes encoding components of the nervous system and the immune system are analyzed. Among 289 selected human disease genes, 62% were found to have Drosophila orthologues.
    • (2000) Science , vol.287 , pp. 2204-2215
    • Rubin, G.M.1    Yandell, M.D.2    Wortman, J.R.3    Gabor Miklos, G.L.4    Nelson, C.R.5    Hariharan, I.K.6    Fortini, M.E.7    Li, P.W.8    Apweiler, R.9    Fleischmann, W.10
  • 3
    • 0033668724 scopus 로고    scopus 로고
    • The Drosophila genome
    • A succinct summary of the methods used to sequence the Drosophila genome, and of the main findings and their implications.
    • Celniker S.E. The Drosophila genome. Curr Opin Genet Dev. 10:2000;612-616. A succinct summary of the methods used to sequence the Drosophila genome, and of the main findings and their implications.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 612-616
    • Celniker, S.E.1
  • 5
    • 0031046284 scopus 로고    scopus 로고
    • A human homologue of the Drosophila eyes absent gene underlies branchio- oto-renal (BOR) syndrome and identifies a novel gene family
    • Abdelhak S., Kalatzis V., Heilig R., Compain S., Samson D., Vincent C., Weil D., Cruaud C., Sahly I., Leibovici M., et al. A human homologue of the Drosophila eyes absent gene underlies branchio- oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 15:1997;157-164.
    • (1997) Nat Genet , vol.15 , pp. 157-164
    • Abdelhak, S.1    Kalatzis, V.2    Heilig, R.3    Compain, S.4    Samson, D.5    Vincent, C.6    Weil, D.7    Cruaud, C.8    Sahly, I.9    Leibovici, M.10
  • 10
    • 0031007708 scopus 로고    scopus 로고
    • Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides
    • Guo H.F., The I., Hannan F., Bernards A., Zhong Y. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science. 276:1997;795-798.
    • (1997) Science , vol.276 , pp. 795-798
    • Guo, H.F.1    The, I.2    Hannan, F.3    Bernards, A.4    Zhong, Y.5
  • 11
    • 0034708076 scopus 로고    scopus 로고
    • A neurofibromatosis-1- regulated pathway is required for learning in Drosophila
    • This and the two preceding papers 9, 10 show that several Drosophila NF1 null mutant phenotypes are insensitive to genetic manipulation of Ras signalling, but rescued by increasing signaling through the adenylyl cyclase/protein kinase A pathway. A role for NF1 in cAMP-mediated learning reported in this paper is intriguing, as an estimated 40% of children with NF1 exhibit a cognitive defect.
    • Guo H.F., Tong J., Hannan F., Luo L., Zhong Y. A neurofibromatosis-1- regulated pathway is required for learning in Drosophila. Nature. 403:2000;895-898. This and the two preceding papers 9, 10 show that several Drosophila NF1 null mutant phenotypes are insensitive to genetic manipulation of Ras signalling, but rescued by increasing signaling through the adenylyl cyclase/protein kinase A pathway. A role for NF1 in cAMP-mediated learning reported in this paper is intriguing, as an estimated 40% of children with NF1 exhibit a cognitive defect.
    • (2000) Nature , vol.403 , pp. 895-898
    • Guo, H.F.1    Tong, J.2    Hannan, F.3    Luo, L.4    Zhong, Y.5
  • 12
    • 0034710151 scopus 로고    scopus 로고
    • A survey of human disease gene counterparts in the Drosophila genome
    • Details of the study described in 2•• that analyzed the Drosophila genome for orthologues of 289 human disease genes. Some of the new disease gene orthologues found by the sequencing effort, including menin and STK11, are highlighted.
    • Fortini M.E., Skupski M.P., Boguski M.S., Hariharan I.K. A survey of human disease gene counterparts in the Drosophila genome. JCell Biol. 150:2000;F23-F30. Details of the study described in 2•• that analyzed the Drosophila genome for orthologues of 289 human disease genes. Some of the new disease gene orthologues found by the sequencing effort, including menin and STK11, are highlighted.
    • (2000) JCell Biol , vol.150
    • Fortini, M.E.1    Skupski, M.P.2    Boguski, M.S.3    Hariharan, I.K.4
  • 13
    • 20244385424 scopus 로고    scopus 로고
    • Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    • 1 arrest, whereas expression of dominant negative Dmp53 transgenes blocked X-ray-induced apoptosis, but not cell-cycle arrest. These findings reveal an ancestral role for Dmp53 in apoptosis.
    • 1 arrest, whereas expression of dominant negative Dmp53 transgenes blocked X-ray-induced apoptosis, but not cell-cycle arrest. These findings reveal an ancestral role for Dmp53 in apoptosis.
    • (2000) Cell , vol.101 , pp. 91-101
    • Ollmann, M.1    Young, L.M.2    Di Como, C.J.3    Karim, F.4    Belvin, M.5    Robertson, S.6    Whittaker, K.7    Demsky, M.8    Fisher, W.W.9    Buchman, A.10
  • 14
    • 0034737292 scopus 로고    scopus 로고
    • Drosophila p53 binds a damage response element at the reaper locus
    • Results reported in this paper indicate that the proapoptotic reaper gene is a direct transcriptional target of Drosophila p53 following DNA damage. This defines a mechanism by which p53 induces apoptosis in Drosophila cells.
    • Brodsky M.H., Nordstrom W., Tsang G., Kwan E., Rubin G.M., Abrams J.M. Drosophila p53 binds a damage response element at the reaper locus. Cell. 101:2000;103-113. Results reported in this paper indicate that the proapoptotic reaper gene is a direct transcriptional target of Drosophila p53 following DNA damage. This defines a mechanism by which p53 induces apoptosis in Drosophila cells.
    • (2000) Cell , vol.101 , pp. 103-113
    • Brodsky, M.H.1    Nordstrom, W.2    Tsang, G.3    Kwan, E.4    Rubin, G.M.5    Abrams, J.M.6
  • 16
    • 0034674713 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in Drosophila
    • This paper reports the first successful gene targeting in Drosophila. Until recently, it was impossible to inactivate Drosophila genes by homologous recombination. This paper describes a 'knock in' of the wild-type version of the yellow gene into the mutant yellow locus by homologous recombination. As the yellow locus is close to the telomere, Engels 17 raises the possibility that this apparent homologous recombination resulted from break-induced replication.
    • Rong Y.S., Golic K.G. Gene targeting by homologous recombination in Drosophila. Science. 288:2000;2013-2018. This paper reports the first successful gene targeting in Drosophila. Until recently, it was impossible to inactivate Drosophila genes by homologous recombination. This paper describes a 'knock in' of the wild-type version of the yellow gene into the mutant yellow locus by homologous recombination. As the yellow locus is close to the telomere, Engels 17 raises the possibility that this apparent homologous recombination resulted from break-induced replication.
    • (2000) Science , vol.288 , pp. 2013-2018
    • Rong, Y.S.1    Golic, K.G.2
  • 17
    • 0034674604 scopus 로고    scopus 로고
    • Reversal of fortune for Drosophila geneticists?
    • Engels W.R. Reversal of fortune for Drosophila geneticists? Science. 288:2000;1973-1975.
    • (2000) Science , vol.288 , pp. 1973-1975
    • Engels, W.R.1
  • 18
    • 0035105893 scopus 로고    scopus 로고
    • A targeted gene knockout in Drosophila
    • A description of a targeted knockout of the pugilist gene. As pugilist maps far from the telomere, the targeted recombination is unlikely to result from break-induced replication. Thus this method of gene disruption is likely to be applicable to most, if not all, Drosophila genes.
    • Rong Y.S., Golic K.G. A targeted gene knockout in Drosophila. Genetics. 157:2001;1307-1312. A description of a targeted knockout of the pugilist gene. As pugilist maps far from the telomere, the targeted recombination is unlikely to result from break-induced replication. Thus this method of gene disruption is likely to be applicable to most, if not all, Drosophila genes.
    • (2001) Genetics , vol.157 , pp. 1307-1312
    • Rong, Y.S.1    Golic, K.G.2
  • 19
    • 0029024475 scopus 로고
    • Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
    • Guo S., Kemphues K.J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81:1995;611-620.
    • (1995) Cell , vol.81 , pp. 611-620
    • Guo, S.1    Kemphues, K.J.2
  • 20
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 21
    • 0032443021 scopus 로고    scopus 로고
    • Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway
    • Kennerdell J.R., Carthew R.W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell. 95:1998;1017-1026.
    • (1998) Cell , vol.95 , pp. 1017-1026
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 22
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • The authors show that loss-of-function phenotypes can be created by transfecting Drosophila cells with specific double-stranded RNAs. Cell Extracts contain a nuclease with an essential RNA component that specifically degrades cognate cellular RNAs.
    • Hammond S.M., Bernstein E., Beach D., Hannon G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:2000;293-296. The authors show that loss-of-function phenotypes can be created by transfecting Drosophila cells with specific double-stranded RNAs. Cell Extracts contain a nuclease with an essential RNA component that specifically degrades cognate cellular RNAs.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 24
    • 0033883114 scopus 로고    scopus 로고
    • Heritable gene silencing in Drosophila using double-stranded RNA
    • See annotation 25•
    • Kennerdell J.R., Carthew R.W. Heritable gene silencing in Drosophila using double-stranded RNA. Nat Biotechnol. 18:2000;896-898. See annotation 25•
    • (2000) Nat Biotechnol , vol.18 , pp. 896-898
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 25
    • 0034710618 scopus 로고    scopus 로고
    • Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila
    • Expression of transgenes encoding hairpin RNA structures allows heritable gene silencing and can be used to assess the functions of genes with late developmental roles.
    • Lam G., Thummel C.S. Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Curr Biol. 24:2000;957-963. Expression of transgenes encoding hairpin RNA structures allows heritable gene silencing and can be used to assess the functions of genes with late developmental roles.
    • (2000) Curr Biol , vol.24 , pp. 957-963
    • Lam, G.1    Thummel, C.S.2
  • 26
    • 0034532329 scopus 로고    scopus 로고
    • Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats
    • This paper describes tissue-specific genetic interference by expressing inverted-repeat RNAs using the GAL4/UAS binary transcription system. Expression of RNA hairpin loops representing the period gene interfered with circadian clock functioning.
    • Martinek S., Young M.W. Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats. Genetics. 156:2000;1717-1725. This paper describes tissue-specific genetic interference by expressing inverted-repeat RNAs using the GAL4/UAS binary transcription system. Expression of RNA hairpin loops representing the period gene interfered with circadian clock functioning.
    • (2000) Genetics , vol.156 , pp. 1717-1725
    • Martinek, S.1    Young, M.W.2
  • 27
  • 28
    • 0028896185 scopus 로고
    • An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster
    • Dalby B., Pereira A.J., Goldstein L.S. An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster. Genetics. 139:1995;757-766.
    • (1995) Genetics , vol.139 , pp. 757-766
    • Dalby, B.1    Pereira, A.J.2    Goldstein, L.S.3
  • 29
    • 0033760528 scopus 로고    scopus 로고
    • Targeted recovery of mutations in Drosophila
    • The authors describe the isolation of novel abnormal wing discs mutants by random EMS mutagenesis followed by mutation detection by denaturing high-performance liquid chromatography.
    • Bentley A., MacLennan B., Calvo J., Dearolf C.R. Targeted recovery of mutations in Drosophila. Genetics. 156:2000;1169-1173. The authors describe the isolation of novel abnormal wing discs mutants by random EMS mutagenesis followed by mutation detection by denaturing high-performance liquid chromatography.
    • (2000) Genetics , vol.156 , pp. 1169-1173
    • Bentley, A.1    MacLennan, B.2    Calvo, J.3    Dearolf, C.R.4
  • 31
    • 0027488367 scopus 로고
    • Preferential transposition of Drosophila P elements to nearby chromosomal sites
    • Tower J., Karpen G.H., Craig N., Spradling A.C. Preferential transposition of Drosophila P elements to nearby chromosomal sites. Genetics. 133:1993;347-359.
    • (1993) Genetics , vol.133 , pp. 347-359
    • Tower, J.1    Karpen, G.H.2    Craig, N.3    Spradling, A.C.4
  • 33
    • 0027375250 scopus 로고
    • Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila
    • Zhao J.J., Pick L. Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila. Nature. 365:1993;448-451.
    • (1993) Nature , vol.365 , pp. 448-451
    • Zhao, J.J.1    Pick, L.2
  • 34
    • 0032883802 scopus 로고    scopus 로고
    • The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
    • Spradling A.C., Stern D., Beaton A., Rhem E.J., Laverty T., Mozden N., Misra S., Rubin G.M. The Berkeley Drosophila Genome Project gene disruption project: single P-element insertions mutating 25% of vital Drosophila genes. Genetics. 153:1999;135-177.
    • (1999) Genetics , vol.153 , pp. 135-177
    • Spradling, A.C.1    Stern, D.2    Beaton, A.3    Rhem, E.J.4    Laverty, T.5    Mozden, N.6    Misra, S.7    Rubin, G.M.8
  • 35
    • 0034329159 scopus 로고    scopus 로고
    • Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease
    • Gusella J.F., MacDonald M.E. Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nat Rev Neurosci. 1:2000;109-115.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 109-115
    • Gusella, J.F.1    MacDonald, M.E.2
  • 36
    • 18544392423 scopus 로고    scopus 로고
    • Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    • See annotation 37•.
    • Warrick J.M., Paulson H.L., Gray-Board G.L., Bui Q.T., Fischbeck K.H., Pittman R.N., Bonini N.M. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell. 93:1998;939-949. See annotation 37•.
    • (1998) Cell , vol.93 , pp. 939-949
    • Warrick, J.M.1    Paulson, H.L.2    Gray-Board, G.L.3    Bui, Q.T.4    Fischbeck, K.H.5    Pittman, R.N.6    Bonini, N.M.7
  • 37
    • 0032168160 scopus 로고    scopus 로고
    • Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
    • These two papers 36•, 37• show that ectopic expression of polyglutamine-containing truncated ataxin-3 36• or huntingtin 37• protein fragments cause repeat length-dependent progressive cellular degeneration in the Drosophila eye. Expression of the viral apoptosis inhibitor p35 mitigated polyglutamine-induced cell degeneration in the ataxin-3, but not in the huntingtin model.
    • Jackson G.R., Salecker I., Dong X., Yao X., Arnheim N., Faber P.W., MacDonald M.E., Zipursky S.L. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 21:1998;633-642. These two papers 36•, 37• show that ectopic expression of polyglutamine-containing truncated ataxin-3 36• or huntingtin 37• protein fragments cause repeat length-dependent progressive cellular degeneration in the Drosophila eye. Expression of the viral apoptosis inhibitor p35 mitigated polyglutamine-induced cell degeneration in the ataxin-3, but not in the huntingtin model.
    • (1998) Neuron , vol.21 , pp. 633-642
    • Jackson, G.R.1    Salecker, I.2    Dong, X.3    Yao, X.4    Arnheim, N.5    Faber, P.W.6    MacDonald, M.E.7    Zipursky, S.L.8
  • 38
    • 0032727617 scopus 로고    scopus 로고
    • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
    • Warrick J.M., Chan H.Y., Gray-Board G.L., Chai Y., Paulson H.L., Bonini N.M. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet. 23:1999;425-428.
    • (1999) Nat Genet , vol.23 , pp. 425-428
    • Warrick, J.M.1    Chan, H.Y.2    Gray-Board, G.L.3    Chai, Y.4    Paulson, H.L.5    Bonini, N.M.6
  • 39
    • 0034703863 scopus 로고    scopus 로고
    • Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
    • Chan H.Y., Warrick J.M., Gray-Board G.L., Paulson H.L., Bonini N.M. Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum Mol Genet. 9:2000;2811-2820.
    • (2000) Hum Mol Genet , vol.9 , pp. 2811-2820
    • Chan, H.Y.1    Warrick, J.M.2    Gray-Board, G.L.3    Paulson, H.L.4    Bonini, N.M.5
  • 40
    • 0034629073 scopus 로고    scopus 로고
    • Genetic suppression of polyglutamine toxicity in Drosophila
    • This paper reports results of a genetic screen to identify enhancers and suppressors of neurotoxicity caused by eye-specific expression of a Q127 peptide. Two suppressors characterized in detail predict DNAJ domain containing putative chaperones related to human HSP40/HDJ1 and TPR2.
    • Kazemi-Esfarjani P., Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science. 287:2000;1837-1840. This paper reports results of a genetic screen to identify enhancers and suppressors of neurotoxicity caused by eye-specific expression of a Q127 peptide. Two suppressors characterized in detail predict DNAJ domain containing putative chaperones related to human HSP40/HDJ1 and TPR2.
    • (2000) Science , vol.287 , pp. 1837-1840
    • Kazemi-Esfarjani, P.1    Benzer, S.2
  • 41
    • 0034597833 scopus 로고    scopus 로고
    • Identification of genes that modify ataxin-1-induced neurodegeneration
    • This paper describes a large screen for genetic modifiers of a human ataxin-1-induced rough eye phenotype in Drosophila. Several modifiers highlight the role of protein folding and degradation in polyglutamine toxicity, whereas others encode proteins that had not previously been suspected of playing a role in this process. The latter include several RNA-binding proteins, transcriptional regulators, a putative nuclear pore protein, and enzymes involved in cellular detoxification.
    • Fernandez-Funez P., Nino-Rosales M.L., de Gouyon B., She W.C., Luchak J.M., Martinez P., Turiegano E., Benito J., Capovilla M., Skinner P.J., et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 408:2000;101-106. This paper describes a large screen for genetic modifiers of a human ataxin-1-induced rough eye phenotype in Drosophila. Several modifiers highlight the role of protein folding and degradation in polyglutamine toxicity, whereas others encode proteins that had not previously been suspected of playing a role in this process. The latter include several RNA-binding proteins, transcriptional regulators, a putative nuclear pore protein, and enzymes involved in cellular detoxification.
    • (2000) Nature , vol.408 , pp. 101-106
    • Fernandez-Funez, P.1    Nino-Rosales, M.L.2    De Gouyon, B.3    She, W.C.4    Luchak, J.M.5    Martinez, P.6    Turiegano, E.7    Benito, J.8    Capovilla, M.9    Skinner, P.J.10
  • 42
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Expression of wild-type or mutant human α-synuclein in Drosophila reproduces several essential features of Parkinson's disease, including adult-onset degeneration of dopaminergic neurons, locomotor dysfunction, and the formation of fibrous protein deposits resembling Lewy bodies.
    • Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature. 404:2000;394-398. Expression of wild-type or mutant human α-synuclein in Drosophila reproduces several essential features of Parkinson's disease, including adult-onset degeneration of dopaminergic neurons, locomotor dysfunction, and the formation of fibrous protein deposits resembling Lewy bodies.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 43
    • 0033638327 scopus 로고    scopus 로고
    • Functional ethanol tolerance in Drosophila
    • Scholz H., Ramond J., Singh C.M., Heberlein U. Functional ethanol tolerance in Drosophila. Neuron. 28:2000;261-271.
    • (2000) Neuron , vol.28 , pp. 261-271
    • Scholz, H.1    Ramond, J.2    Singh, C.M.3    Heberlein, U.4
  • 44
    • 0032518346 scopus 로고    scopus 로고
    • Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila
    • McClung C., Hirsh J. Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila. Curr Biol. 8:1998;109-112.
    • (1998) Curr Biol , vol.8 , pp. 109-112
    • McClung, C.1    Hirsh, J.2
  • 47
    • 0034629130 scopus 로고    scopus 로고
    • Correlates of sleep and waking in Drosophila melanogaster
    • Shaw P.J., Cirelli C., Greenspan R.J., Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science. 287:2000;1834-1837.
    • (2000) Science , vol.287 , pp. 1834-1837
    • Shaw, P.J.1    Cirelli, C.2    Greenspan, R.J.3    Tononi, G.4


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