The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment http://www.tandfonline.com/doi/pdf/10.4161/19336918.2014.968501

Cell Adhesion and Migration

Volumn 8, Issue 6, 2014, Pages 563-577

  Klamer, Sofieke ^a   Voermans, Carlijn ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Adhesion molecules; BIGH3; Bone marrow niche; Bone marrow regeneration; Differentiation; Extracellular matrix; Haematopoietic stem cells; Integrins; Matrix proteins; Periostin

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ANGIOPOIETIN; ANGIOPOIETIN RECEPTOR; BIGLYCAN; CALCIUM ION; CD164 ANTIGEN; CELL ADHESION MOLECULE; FIBRONECTIN; GLYCOPROTEIN; GLYCOPROTEIN GP 70; INTEGRIN; OSTEOPONTIN; PLASMA PROTEIN; PLASMIN; PLASMINOGEN; PROTEOGLYCAN; SELECTIN; STEM CELL FACTOR; THROMBOPOIETIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

BONE MARROW; CELL CYCLE; CELL DIFFERENTIATION; CELL FATE; CELL INTERACTION; CELLULAR DISTRIBUTION; EXTRACELLULAR MATRIX; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HUMAN; MICROENVIRONMENT; NERVE CELL; PHENOTYPE; REVIEW; STEM CELL NICHE; TISSUE REGENERATION; CELL ADHESION; METABOLISM; PHYSIOLOGY; REGENERATION;

BONE MARROW; CELL ADHESION; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; HUMANS; REGENERATION; STEM CELL NICHE;

EID: 84921731105     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/19336918.2014.968501     Document Type: Review

References (230)

1. Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; 17: 387-403; PMID: 11687494; http://dx.doi.org/10.1146/annurev.cellbio.17.1.387
2. Brown G, Hughes PJ, Michell RH, Rolink AG, Ceredig R. The sequential determination model of hematopoiesis. Trends Immunol 2007; 28: 442-8; PMID: 17825625; http://dx.doi.org/10.1016/j.it.2007.07.007
3. Ceredig R, Rolink AG, Brown G. Models of haematopoiesis: seeing the wood for the trees. Nat Rev Immunol 2009; 9: 293-300; http://dx.doi.org/10.1038/nri2525
4. Kawamoto H, Katsura Y. A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy. Trends Immunol 2009; 30: 193-200; PMID: 19356980; http://dx.doi.org/10.1016/j.it.2009.03.001
5. Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective. Biotechniques 2003; 35: 1240-7; PMID: 14682059
6. van der Wath RC, Wilson A, Laurenti E, Trumpp A, Lio P. Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics. PLoS One 2009; 4: e6972; PMID: 19771180; http://dx.doi.org/10.1371/journal.pone.0006972
7. Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008; 135: 1118-29; PMID: 19062086; http://dx.doi.org/10.1016/j.cell.2008.10.048
8. Seita J, Weissman IL. Hematopoietic stem cell: selfrenewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med 2010; 2: 640-53; PMID: 20890962; http://dx.doi.org/10.1002/wsbm.86
9. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978; 4: 7-25; PMID: 747780
10. Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol 2004; 2: e301; PMID: 15459755; http://dx.doi.org/10.1371/journal.pbio.0020301
11. Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet 2005; 1: e28; PMID: 16151515; http://dx.doi.org/10.1371/journal.pgen.0010028
12. Schroeder T. Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior. Cell Stem Cell 2010; 6: 203-7; PMID: 20207223; http://dx.doi.org/10.1016/j.stem.2010.02.006
13. van Hennik PB, de Koning AE, Ploemacher RE. Seeding efficiency of primitive human hematopoietic cells in nonobese diabeticsevere combined immune deficiency mice: implications for stem cell frequency assessment. Blood 1999; 94: 3055-61; PMID: 10556189
14. Kondo M, Wagers AJ, Manz MG, Prohaska SS, Scherer DC, Beilhack GF, Shizuru JA, Weissman IL. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 2003; 21: 759-806; PMID: 12615892; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141007
15. Majeti R, Park CY, Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 2007; 1: 635-45; PMID: 18371405; http://dx.doi.org/10.1016/j.stem.2007.10.001
16. Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica I, Dick JE. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011; 333: 218-21; PMID: 21737740; http://dx.doi.org/10.1126/science.1201219
17. Challen GA, Goodell MA. Bridge over troubled stem cells. Mol Ther 2011; 19: 1756-8; PMID: 21964307; http://dx.doi.org/10.1038/mt.2011.184
18. Kimura T, Wang J, Matsui K, Imai S, Yokoyama S, Nishikawa M, Ikehara S, Sonoda Y. Proliferative and migratory potentials of human cord blood-derived. Int J Hematol 2004; 79: 328-33; PMID: 15218959; http://dx.doi.org/10.1532/IJH97.03158
19. Kimura T, Asada R, Wang J, Kimura T, Morioka M, Matsui K, Kobayashi K, Henmi K, Imai S, Kita M, et al. Identification of long-term repopulating potential of human cord blood-derived CD34-flt3-severe combined immunodeficiency-repopulating cells by intra-bone marrow injection. Stem Cells 2007; 25: 1348-55; PMID: 17303816; http://dx.doi.org/10.1634/stemcells.2006-0727
20. Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A 2001; 98: 14541-6; PMID: 11724967; http://dx.doi.org/10.1073/pnas.261562798
21. Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121: 1109-21; PMID: 15989959; http://dx.doi.org/10.1016/j.cell.2005.05.026
22. Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell 2010; 6: 265-78; PMID: 20207229; http://dx.doi.org/10.1016/j.stem.2010.02.002
23. Benveniste P, Frelin C, Janmohamed S, Barbara M, Herrington R, Hyam D, Iscove NN. Intermediateterm hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell 2010; 6: 48-58; PMID: 20074534; http://dx.doi.org/10.1016/j.stem.2009.11.014
24. Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, et al. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 2009; 113: 6342-50; PMID: 19377048; http://dx.doi.org/10.1182/blood-2008-12-192054
25. Rieger MA, Hoppe PS, Smejkal BM, Eitelhuber AC, Schroeder T. Hematopoietic cytokines can instruct lineage choice. Science 2009; 325: 217-8; PMID: 19590005; http://dx.doi.org/10.1126/science.1171461
26. Muller-Sieburg CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood 2004; 103: 4111-8; PMID: 14976059; http://dx.doi.org/10.1182/blood-2003-10-3448
27. Breems DA, Blokland EA, Siebel KE, Mayen AE, Engels LJ, Ploemacher RE. Stroma-contact prevents loss of hematopoietic stem cell quality during ex vivo expansion of CD34C mobilized peripheral blood stem cells. Blood 1998; 91: 111-7; PMID: 9414274
28. Zhang CC, Lodish HF. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood 2004; 103: 2513-21; PMID: 14592820; http://dx.doi.org/10.1182/blood-2003-08-2955
29. Sauvageau G, Iscove NN, Humphries RK. In vitro and in vivo expansion of hematopoietic stem cells. Oncogene 2004; 23: 7223-32; PMID: 15378082; http://dx.doi.org/10.1038/sj.onc.1207942
30. Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 1997; 89: 3624-35; PMID: 9160667
31. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003; 423: 448-52; PMID: 12717451; http://dx.doi.org/10.1038/nature01611
32. Murdoch B, Chadwick K, Martin M, Shojaei F, Shah KV, Gallacher L, Moon RT, Bhatia M. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A 2003; 100: 3422-7; PMID: 12626754; http://dx.doi.org/10.1073/pnas.0130233100
33. Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R. Role of members of the Wnt gene family in human hematopoiesis. Blood 1998; 92: 3189-202; PMID: 9787155
34. Varnum-Finney B, Brashem-Stein C, Bernstein ID. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 2003; 101: 1784-9; PMID: 12411302; http://dx.doi.org/10.1182/blood-2002-06-1862
35. Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 2005; 106: 2693-9; PMID: 15976178; http://dx.doi.org/10.1182/blood-2005-03-1131
36. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, et al. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 2010; 16: 475-82; PMID: 20305662; http://dx.doi.org/10.1038/nm.2119
37. Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, et al. Dependence of human stem cell engraftment and repopulation of NODSCID mice on CXCR4. Science 1999; 283: 845-8; PMID: 9933168; http://dx.doi.org/10.1126/science.283.5403.845
38. Walasek MA, van OR, de HG. Hematopoietic stem cell expansion: challenges and opportunities. Ann N Y Acad Sci 2012; 1266: 138-50; PMID: 22901265; http://dx.doi.org/10.1111/j.1749-6632.2012.06549.x
39. Kaplan RN, Psaila B, Lyden D. Niche-to-niche migration of bone-marrow-derived cells. Trends Mol Med 2007; 13: 72-81; PMID: 17197241; http://dx.doi.org/10.1016/j.molmed.2006.12.003
40. Balabanian K, Lagane B, Pablos JL, Laurent L, Planchenault T, Verola O, Lebbe C, Kerob D, Dupuy A, Hermine O, et al. WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12. Blood 2005; 105: 2449-57; PMID: 15536153; http://dx.doi.org/10.1182/blood-2004-06-2289
41. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 1996; 184: 1101-9; PMID: 9064327; http://dx.doi.org/10.1084/jem.184.3.1101
42. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998; 393: 595-9; PMID: 9634238; http://dx.doi.org/10.1038/31269
43. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in C. Proc Natl Acad Sci U S A 1998; 95: 9448-53; PMID: 9689100; http://dx.doi.org/10.1073/pnas.95.16.9448
44. Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, Fujii N, Amagai T, Nagasawa T. A role of CXC chemokine ligand 12stromal cell-derived factor-1pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol 2003; 170: 4649-55; PMID: 12707343; http://dx.doi.org/10.4049/jimmunol.170.9.4649
45. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fujii N, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002; 3: 687-94; PMID: 12068293; http://dx.doi.org/10.1038/ni813
46. Lapidot T, Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 2002; 30: 973-81; PMID: 12225788; http://dx.doi.org/10.1016/S0301-472X(02)00883-4
47. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, Frenette PS. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006; 124: 407-21; PMID: 16439213; http://dx.doi.org/10.1016/j.cell.2005.10.041
48. Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, et al. Matrix-embedded osteocytes regulate mobilization of hematopoietic stemprogenitor cells. Cell Stem Cell 2013; 12: 737-47; PMID: 23746979; http://dx.doi.org/10.1016/j.stem.2013.05.001
49. Kawamori Y, Katayama Y, Asada N, Minagawa K, Sato M, Okamura A, Shimoyama M, Nakagawa K, Okano T, Tanimoto M, et al. Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche. Blood 2010; 116: 5528-35; PMID: 20813899; http://dx.doi.org/10.1182/blood-2010-04-279216
50. Levesque JP, Hendy J, Takamatsu Y, Williams B, Winkler IG, Simmons PJ. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 2002; 30: 440-49; PMID: 12031650; http://dx.doi.org/10.1016/S0301-472X(02)00788-9
51. Li S, Zhai Q, Zou D, Meng H, Xie Z, Li C, Wang Y, Qi J, Cheng T, Qiu L. A pivotal role of bone remodeling in granulocyte colony stimulating factor induced hematopoietic stemprogenitor cells mobilization. J Cell Physiol 2013; 228: 1002-9; PMID: 23042582; http://dx.doi.org/10.1002/jcp.24246
52. Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol 2006; 34: 1010-20; PMID: 16863907; http://dx.doi.org/10.1016/j.exphem.2006.04.004
53. Ratajczak MZ, Kim C, Wu W, Shin DM, Bryndza E, Kucia M, Ratajczak J. The role of innate immunity in trafficking of hematopoietic stem cells-an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids. Adv Exp Med Biol 2012; 946: 37-54; PMID: 21948361; http://dx.doi.org/10.1007/978-1-4614-0106-3-3
54. Ratajczak MZ, Lee H, Wysoczynski M, WanW, Marlicz W, Laughlin MJ, Kucia M, Janowska-Wieczorek A, Ratajczak J. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascademembrane attack complex. Leukemia 2010; 24: 976-85; PMID: 20357827; http://dx.doi.org/10.1038/leu.2010.53
55. Golan K, Kollet O, Lapidot T. Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling. Pharmaceuticals (Basel) 2013; 6: 1145-69; PMID: 24276423; http://dx.doi.org/10.3390/ph6091145
56. Marquez-Curtis LA, Turner AR, Sridharan S, Ratajczak MZ, Janowska-Wieczorek A. The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes. Stem Cell Rev 2011; 7: 590-607; PMID: 21140298; http://dx.doi.org/10.1007/s12015-010-9212-8
57. Geutskens SB, Andrews WD, van Stalborch AM, Brussen K, Holtrop-de Haan SE, Parnavelas JG, Hordijk PL, van Hennik PB. Control of human hematopoietic stemprogenitor cell migration by the extracellular matrix protein Slit3. Lab Invest 2012; 92: 1129-39; PMID: 22614124; http://dx.doi.org/10.1038/labinvest.2012.81
58. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425: 841-6; PMID: 14574413; http://dx.doi.org/10.1038/nature02040
59. Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425: 836-41; PMID: 14574412; http://dx.doi.org/10.1038/nature02041
60. Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012; 481: 457-62; PMID: 22281595; http://dx.doi.org/10.1038/nature10783
61. Winkler IG, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, Magnani JL, Levesque JP. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med 2012; 18: 1651-7; PMID: 23086476; http://dx.doi.org/10.1038/nm.2969
62. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010; 466: 829-34; PMID: 20703299; http://dx.doi.org/10.1038/nature09262
63. Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 2013; 502: 637-43; PMID: 24107994; http://dx.doi.org/10.1038/nature12612
64. Wilson A, Oser GM, Jaworski M, Blanco-Bose WE, Laurenti E, Adolphe C, Essers MA, Macdonald HR, Trumpp A. Dormant and self-renewing hematopoietic stem cells and their niches. Ann NY Acad Sci 2007; 1106: 64-75; PMID: 17442778; http://dx.doi.org/10.1196/annals.1392.021
65. Nilsson SK, Dooner MS, Tiarks CY, Weier HU, Quesenberry PJ. Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model. Blood 1997; 89: 4013-20; PMID: 9166840
66. Nilsson SK, Johnston HM, Coverdale JA. Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood 2001; 97: 2293-9; PMID: 11290590; http://dx.doi.org/10.1182/blood.V97.8.2293
67. Rodgers KD, San Antonio JD, Jacenko O. Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators. Dev Dyn 2008; 237: 2622-42; PMID: 18629873; http://dx.doi.org/10.1002/dvdy.21593
68. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol 2006; 7: 333-7; PMID: 16550195; http://dx.doi.org/10.1038/ni1331
69. Taichman RS, Reilly MJ, Emerson SG. Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures. Blood 1996; 87: 518-24; PMID: 8555473
70. Adams GB. Deconstructing the hematopoietic stem cell niche: revealing the therapeutic potential. Regen Med 2008; 3: 523-30; PMID: 18588474; http://dx.doi.org/10.2217/17460751.3.4.523
71. Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 2004; 103: 3258-64; PMID: 14726388; http://dx.doi.org/10.1182/blood-2003-11-4011
72. Lymperi S, Horwood N, Marley S, Gordon MY, Cope AP, Dazzi F. Strontium can increase some osteoblasts without increasing hematopoietic stem cells. Blood 2008; 111: 1173-81; PMID: 17971481; http://dx.doi.org/10.1182/blood-2007-03-082800
73. de Barros AP, Takiya CM, Garzoni LR, Leal-Ferreira ML, Dutra HS, Chiarini LB, Meirelles MN, Borojevic R, Rossi MI. Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model. PLoS One 2010; 5: e9093; PMID: 20161704; http://dx.doi.org/10.1371/journal.pone.0009093
74. Kiel MJ, Radice GL, Morrison SJ. Lack of evidence that hematopoietic stem cells depend on N-cadherinmediated adhesion to osteoblasts for their maintenance. Cell Stem Cell 2007; 1: 204-17; PMID: 18371351; http://dx.doi.org/10.1016/j.stem.2007.06.001
75. Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, et al. ThrombopoietinMPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007; 1: 685-97; PMID: 18371409; http://dx.doi.org/10.1016/j.stem.2007.10.020
76. Christopher MJ, Link DC. Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res 2008; 23: 1765-74; PMID: 18597629; http://dx.doi.org/10.1359/jbmr.080612
77. Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque JP, Chappel J, Ross FP, Link DC. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 2005; 106: 3020-7; PMID: 16037394; http://dx.doi.org/10.1182/blood-2004-01-0272
78. Itkin T, Ludin A, Gradus B, Gur-Cohen S, Kalinkovich A, Schajnovitz A, Ovadya Y, Kollet O, Canaani J, Shezen E, et al. FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation. Blood 2012; 120: 1843-55; PMID: 22645180; http://dx.doi.org/10.1182/blood-2011-11-394692
79. Ema H, Suda T. Two anatomically distinct niches regulate stem cell activity. Blood 2012; 120: 2174-81; PMID: 22786878; http://dx.doi.org/10.1182/blood-2012-04-424507
80. Nakamura-Ishizu A, Suda T. Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches. Biochim Biophys Acta 2013; 1830: 2404-9; PMID: 22967757; http://dx.doi.org/10.1016/j.bbagen.2012.08.023
81. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol 2013; 15: 533-43; PMID: 23624405; http://dx.doi.org/10.1038/ncb2730
82. Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS. PDGFRalpha and CD51 mark human nestin Csphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med 2013; 210: 1351-67; PMID: 23776077; http://dx.doi.org/10.1084/jem.20122252
83. Maijenburg MW, Kleijer M, Vermeul K, Mul EP, van Alphen FP, van der Schoot CE, Voermans C. The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica 2012; 97: 179-83; PMID: 21993672; http://dx.doi.org/10.3324/haematol.2011.047753
84. Tormin A, Li O, Brune JC, Walsh S, Schütz B, Ehinger M, Ditzel N, Kassem M, Scheding S. CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization. Blood 2011; 117: 5067-77; PMID: 21415267; http://dx.doi.org/10.1182/blood-2010-08-304287
85. Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nat Med 1996; 2: 1011-6; PMID: 8782459; http://dx.doi.org/10.1038/nm0996-1011
86. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725-9; PMID: 17554309; http://dx.doi.org/10.1038/nature05862
87. Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 2013; 495: 231-5; PMID: 23434755; http://dx.doi.org/10.1038/nature11885
88. Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013; 495: 227-30; PMID: 23434756; http://dx.doi.org/10.1038/nature11926
89. Hanoun M, Frenette PS. This niche is a maze; an amazing niche. Cell Stem Cell 2013; 12: 391-2; PMID: 23561440; http://dx.doi.org/10.1016/j.stem.2013.03.012
90. del Toro R, Mendez-Ferrer S. Autonomic regulation of hematopoiesis and cancer. Haematologica 2013; 98: 1663-6; PMID: 24186311; http://dx.doi.org/10.3324/haematol.2013.084764
91. Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C, BattistaM, Leboeuf M, Prophete C, van Rooijen N, et al. Bone marrow CD169C macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011; 208: 261-71; PMID: 21282381; http://dx.doi.org/10.1084/jem.20101688
92. Christopher MJ, Rao M, Liu F, Woloszynek JR, Link DC. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med 2011; 208: 251-60; PMID: 21282380; http://dx.doi.org/10.1084/jem.20101700
93. Winkler IG, Sims NA, Pettit AR, Barbier V, Nowlan B, Helwani F, Poulton IJ, van Rooijen N, Alexander KA, Raggatt LJ, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood 2010; 116: 4815-28; PMID: 20713966; http://dx.doi.org/10.1182/blood-2009-11-253534
94. Winkler IG, Barbier V, Wadley R, Zannettino AC, Williams S, Levesque JP. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood 2010; 116: 375-85; PMID: 20393133; http://dx.doi.org/10.1182/blood-2009-07-233437
95. Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 2014; 508: 269-73; PMID: 24590072; http://dx.doi.org/10.1038/nature13034
96. Takubo K, Goda N, Yamada W et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010; 7: 391-402; PMID: 20804974; http://dx.doi.org/10.1016/j.stem.2010.06.020
97. Miharada K, Karlsson G, Rehn M, Rörby E, Siva K, Cammenga J, Karlsson S. Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1alpha in the hypoxic bone marrow niche. Ann N Y Acad Sci 2012; 1266: 55-62; PMID: 22901256; http://dx.doi.org/10.1111/j.1749-6632.2012.06564.x
98. Miharada K, Karlsson G, Rehn M, Rörby E, Siva K, Cammenga J, Karlsson S. Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78. Cell Stem Cell 2011; 9: 330-44; PMID: 21982233; http://dx.doi.org/10.1016/j.stem.2011.07.016
99. Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010; 7: 380-90; PMID: 20804973; http://dx.doi.org/10.1016/j.stem.2010.07.011
100. Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 2011; 9: 298-310; PMID: 21982230; http://dx.doi.org/10.1016/j.stem.2011.09.010
101. Guitart AV, Hammoud M, Dello SP, Ivanovic Z, Praloran V. Slow-cyclingquiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen. Exp Hematol 2010; 38: 847-51; PMID: 20547202; http://dx.doi.org/10.1016/j.exphem.2010. 06.002
102. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T. Tie2angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004; 118: 149-61; PMID: 15260986; http://dx.doi.org/10.1016/j.cell.2004.07.004
103. Stier S, Ko Y, Forkert R, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 2005; 201: 1781-91; PMID: 15928197; http://dx.doi.org/10.1084/jem. 20041992
104. Nilsson SK, Johnston HM, Whitty GA, Williams B, Webb RJ, Denhardt DT, Bertoncello I, Bendall LJ, Simmons PJ, Haylock DN. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 2005; 106: 1232-9; PMID: 15845900; http://dx.doi.org/10.1182/blood-2004-11-4422
105. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2006; 439: 599-603; PMID: 16382241; http://dx.doi.org/10.1038/nature04247
106. Barker JE. SlSld hematopoietic progenitors are deficient in situ. Exp Hematol 1994; 22: 174-7; PMID: 7507859
107. Qian H, Buza-Vidas N, Hyland CD, Jensen CT, Antonchuk J, Mansson R, Thoren LA, Ekblom M, Alexander WS, Jacobsen SE. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007; 1: 671-84; PMID: 18371408; http://dx.doi.org/10.1016/j.stem.2007.10.008
108. Ottmann OG, Pelus LM. Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells. J Immunol 1988; 140: 2661-5; PMID: 3258618
109. Van Ranst PC, Snoeck HW, Lardon F, Lenjou M, Nijs G, Weekx SF, Rodrigus I, Berneman ZN, Van Bockstaele DR. TGF-beta and MIP-1 alpha exert their main inhibitory activity on very primitive CD34C2. Exp.Hematol. 1996; 24: 1509-15; PMID: 8950234
110. Fortunel NO, Hatzfeld A, Hatzfeld JA. Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis. Blood 2000; 96: 2022-36; PMID: 10979943
111. Veiby OP, Jacobsen FW, Cui L, Lyman SD, Jacobsen SE. The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta. J Immunol 1996; 157: 2953-60; PMID: 8816402
112. Batard P, Monier MN, Fortunel N, Ducos K, Sansilvestri-Morel P, Phan T, Hatzfeld A, Hatzfeld JA. TGF-(beta)1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation. J Cell Sci 2000; 113 (Pt 3): 383-90; PMID: 10639326
113. Cromar GL, Xiong X, Chautard E, Ricard-Blum S, Parkinson J. Toward a systems level view of the ECM and related proteins: a framework for the systematic definition and analysis of biological systems. Proteins 2012; 80: 1522-44; PMID: 22275077; http://dx.doi.org/10.1002/prot.24036
114. Hynes RO, Naba A. Overview of the matrisome-an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol 2012; 4: a004903; PMID: 21937732; http://dx.doi.org/10.1101/cshperspect.a004903
115. Klein G. The extracellular matrix of the hematopoietic microenvironment. Experientia 1995; 51: 914-26; PMID: 7556572; http://dx.doi.org/10.1007/BF01921741
116. Carter DH, Sloan P, Aaron JE. Immunolocalization of collagen types I and III, tenascin, and fibronectin in intramembranous bone. J Histochem Cytochem 1991; 39: 599-606; PMID: 1707904; http://dx.doi.org/10.1177/39.5.1707904
117. Hamilton R, Campbell FR. Immunochemical localization of extracellular materials in bone marrow of rats. Anat Rec 1991; 231: 218-24; PMID: 1746722; http://dx.doi.org/10.1002/ar.1092310210
118. Nilsson SK, Debatis ME, Dooner MS, Madri JA, Quesenberry PJ, Becker PS. Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ. J Histochem Cytochem 1998; 46: 371-7; PMID: 9487119; http://dx.doi.org/10.1177/002215549804600311
119. Savagner P, Karavanova I, Perantoni A, Thiery JP, Yamada KM. Slug mRNA is expressed by specific mesodermal derivatives during rodent organogenesis. Dev Dyn 1998; 213: 182-7; PMID: 9786418; http://dx.doi.org/10.1002/(SICI)1097-0177(199810)213:2%3c182::AID-AJA3%3e3.0.CO;2-C
120. Rodgers KD, San Antonio JD, Jacenko O. Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators. Dev Dyn 2008; 237: 2622-42; PMID: 18629873; http://dx.doi.org/10.1002/dvdy. 21593
121. Prosper F, Verfaillie CM. Regulation of hematopoiesis through adhesion receptors. J Leukoc Biol 2001; 69: 307-16; PMID: 11261776
122. Sahin AO, Buitenhuis M. Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells. Cell Adh Migr 2012; 6: 39-48; PMID: 22647939; http://dx.doi.org/10.4161/cam.18975
123. Pillozzi S, Becchetti A. Ion channels in hematopoietic and mesenchymal stem cells. Stem Cells Int 2012; 2012: 217910; PMID: 22919401; http://dx.doi.org/10.1155/2012/217910
124. Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 1993; 11: 767-804; PMID: 8476577; http://dx.doi.org/10.1146/annurev.iy.11.040193.004003
125. Choi JS, Harley BA. The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells. Biomaterials 2012; 33: 4460-8; PMID: 22444641; http://dx.doi.org/10.1016/j.biomaterials.2012.03.010
126. Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science 2009; 324: 1673-7; PMID: 19556500; http://dx.doi.org/10.1126/science.1171643
127. Holst J, Watson S, Lord MS, Eamegdool SS, Bax DV, Nivison-Smith LB, Kondyurin A, Ma L, Oberhauser AF, Weiss AS, et al. Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nat Biotechnol 2010; 28: 1123-8; PMID: 20890282; http://dx.doi.org/10.1038/nbt.1687
128. Muth CA, Steinl C, Klein G, Lee-Thedieck C. Regulation of hematopoietic stem cell behavior by the nanostructured presentation of extracellular matrix components. PLoS One 2013; 8: e54778; PMID: 23405094; http://dx.doi.org/10.1371/journal.pone.0054778
129. Lutolf MP, Doyonnas R, Havenstrite K, Koleckar K, Blau HM. Perturbation of single hematopoietic stem cell fates in artificial niches. Integr Biol (Camb) 2009; 1: 59-69; PMID: 20023792; http://dx.doi.org/10.1039/b815718a
130. Sharma MB, Limaye LS, Kale VP. Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells. Haematologica 2012; 97: 651-60; PMID: 22058199; http://dx.doi.org/10.3324/haematol.2011.050500
131. Raic A, Rodling L, Kalbacher H, Lee-Thedieck C. Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells. Biomaterials 2014; 35: 929-40; PMID: 24176196; http://dx.doi.org/10.1016/j.biomaterials.2013.10.038
132. Mahadik BP, Wheeler TD, Skertich LJ, Kenis PJ, Harley BA. Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment. Adv Healthc Mate. 2013; 3: 449-58; PMID: 23997020; http://dx.doi.org/10.1002/adhm.201300263
133. Vu TT, Lim C, Lim M. Characterization of leukemic cell behaviors in a soft marrow mimetic alginate hydrogel. J Biomed Mater Res B Appl Biomater 2012; 100: 1980-8; PMID: 22888018; http://dx.doi.org/10.1002/jbm.b.32765
134. Cuchiara ML, Horter KL, Banda OA, West JL. Covalent immobilization of stem cell factor and stromal derived factor 1alpha for in vitro culture of hematopoietic progenitor cells. Acta Biomater 2013; 9: 9258-69; PMID: 23958779; http://dx.doi.org/10.1016/j.actbio.2013.08.012
135. Ferreira MV, Labude N, Piroth D, Jahnen-Dechent W, Knüchel R, Hieronymus T, Zenke M, Neuss S. Compatibility of different polymers for cord bloodderived hematopoietic progenitor cells. J Mater Sci Mater Med 2012; 23: 109-16; PMID: 22071984; http://dx.doi.org/10.1007/s10856-011-4483-4
136. Gupta P, Oegema TR, Jr., Brazil JJ, Dudek AZ, Slungaard A, Verfaillie CM. Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche. Blood 1998; 92: 4641-51; PMID: 9845530
137. Schofield KP, Gallagher JT, David G. Expression of proteoglycan core proteins in human bone marrow stroma. Biochem J 1999; 343 Pt 3: 663-68; http://dx.doi.org/10.1042/0264-6021:3430663
138. Sweeney E, Roberts D, Jacenko O. Altered matrix at the chondro-osseous junction leads to defects in lymphopoiesis. Ann N Y Acad Sci 2011; 1237: 79-87; PMID: 22082369; http://dx.doi.org/10.1111/j.1749-6632.2011.06227.x
139. Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol 2005; 282: 152-62; PMID: 15936336; http://dx.doi.org/10.1016/j.ydbio.2005.03.003
140. Di GF, Lewandowski D, Cabannes E, Nancy-Portebois V, Petitou M, Fichelson S, Romeo PH. Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells. Haematologica 2012; 97: 491-99; PMID: 22180429; http://dx.doi.org/10.3324/haematol.2011.047662
141. Mazzon C, Anselmo A, Cibella J, Soldani C, Destro A, Kim N, Roncalli M, Burden SJ, Dustin ML, Sarukhan A, et al. The critical role of agrin in the hematopoietic stem cell niche. Blood 2011; 118: 2733-42; PMID: 21653324; http://dx.doi.org/10.1182/blood-2011-01-331272
142. Matrosova VY, Orlovskaya IA, Serobyan N, Khaldoyanidi SK. Hyaluronic acid facilitates the recovery of hematopoiesis following 5-fluorouracil administration. Stem Cells 2004; 22: 544-55; PMID: 15277700; http://dx.doi.org/10.1634/stemcells.22-4-544
143. Zuckerman KS, Rhodes RK, Goodrum DD, Patel VR, Sparks B, Wells J, Wicha MS, Mayo LA. Inhibition of collagen deposition in the extracellular matrix prevents the establishment of a stroma supportive of hematopoiesis in long-term murine bone marrow cultures. J Clin Invest 1985; 75: 970-5; PMID: 3980732; http://dx.doi.org/10.1172/JCI111798
144. Hurley RW, McCarthy JB, Verfaillie CM. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest 1995; 96: 511-9; PMID: 7542285; http://dx.doi.org/10.1172/JCI118063
145. Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y. Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood 2012; 119: 5429-37; PMID: 22553313; http://dx.doi.org/10.1182/blood-2011-11-393645
146. Knapp W, Strobl H, Scheinecker C, Bello-Fernandez C, Majdic O. Molecular characterization of CD34C human hematopoietic progenitor cells. Ann Hematol 1995; 70: 281-96; PMID: 7543291; http://dx.doi.org/10.1007/BF01696614
147. Kerst JM, Sanders JB, Slaper-Cortenbach IC, Doorakkers MC, Hooibrink B, van Oers RH, von dem Borne AE, van der Schoot CE. Alpha 4 beta 1 and alpha 5 beta 1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34C cells to fibronectin in an activation-dependent way. Blood 1993; 81: 344-51; PMID: 7678511
148. Coulombel L, Auffray I, Gaugler MH, Rosemblatt M. Expression and function of integrins on hematopoietic progenitor cells. Acta Haematol 1997; 97: 13-21; PMID: 8980606; http://dx.doi.org/10.1159/000203655
149. Hemler ME, Kassner PD, Chan BM. Functional roles for integrin alpha subunit cytoplasmic domains. Cold Spring Harb Symp Quant Biol 1992; 57: 213-20; PMID: 1339660; http://dx.doi.org/10.1101/SQB.1992.057.01.026
150. Diamond MS, Springer TA. The dynamic regulation of integrin adhesiveness. Curr Biol 1994; 4: 506-17; PMID: 7922371; http://dx.doi.org/10.1016/S0960-9822(00)00111-1
151. Teixido J, Hemler ME, Greenberger JS, Anklesaria P. Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest 1992; 90: 358-67; PMID: 1379610; http://dx.doi.org/10.1172/JCI115870
152. Papayannopoulou T, Nakamoto B. Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin. Proc Natl Acad Sci U S A 1993; 90: 9374-8; PMID: 7692447; http://dx.doi.org/10.1073/pnas.90.20.9374
153. Rettig MP, Ansstas G, DiPersio JF. Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4. Leukemia 2012; 26: 34-53; PMID: 21886173; http://dx.doi.org/10.1038/leu.2011.197
154. Mohle R, Murea S, Kirsch M, Haas R. Differential expression of L-selectin, VLA-4, and LFA-1 on CD34C progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery. Exp Hematol 1995; 23: 1535-42; PMID: 8542944
155. Zanjani ED, Flake AW, Almeida-Porada G, Tran N, Papayannopoulou T. Homing of human cells in the fetal sheep model: modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function. Blood 1999; 94: 2515-22; PMID: 10498625
156. Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, et al. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia 2002; 16: 1791-8; PMID: 12200695; http://dx.doi.org/10.1038/sj.leu.2402572
157. Pillozzi S, Brizzi MF, Bernabei PA, Bartolozzi B, Caporale R, Basile V, Boddi V, Pegoraro L, Becchetti A, Arcangeli A. VEGFR-1 (FLT-1), beta1 integrin, and hERG K Cchannel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood 2007; 110: 1238-50; PMID: 17420287; http://dx.doi.org/10.1182/blood-2006-02-003772
158. Pillozzi S, Becchetti A. Ion channels in hematopoietic and mesenchymal stem cells. Stem Cells Int 2012; 2012: 217910; PMID: 22919401; http://dx.doi.org/10.1155/2012/217910
159. Li H, Liu L, Guo L, Zhang J, Du W, Li X, Liu W, Chen X, Huang S. HERG KC channel expression in CD34CCD38-CD123(high) cells and primary leukemia cells and analysis of its regulation in leukemia cells. Int J Hematol 2008; 87: 387-92; PMID: 18415658; http://dx.doi.org/10.1007/s12185-008-0056-9
160. Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem 2001; 276: 47623-31; http://dx.doi.org/10.1074/jbc.M105997200
161. Zarbock A, Ley K, McEver RP, Hidalgo A. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 2011; 118: 6743-51; PMID: 22021370; http://dx.doi.org/10.1182/blood-2011-07-343566
162. Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luster AD, Scadden DT, Lin CP. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature 2005; 435: 969-73; PMID: 15959517; http://dx.doi.org/10.1038/nature03703
163. Schweitzer KM, Drager AM, van d VP, Thijsen SF, Zevenbergen A, Theijsmeijer AP, van der Schoot CE, Langenhuijsen MM. Constitutive expression of Eselectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol 1996; 148: 165-75; PMID: 8546203
164. Rood PM, Gerritsen WR, Kramer D, Ranzijn C, von dem Borne AE, van der Schoot CE. Adhesion of hematopoietic progenitor cells to human bone marrow or umbilical vein derived endothelial cell lines: a comparison. Exp Hematol 1999; 27: 1306-1314; PMID: 10428507; http://dx.doi.org/10.1016/S0301-472X(99)00068-5
165. Arbones ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon DJ, Tedder TF. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1994; 1: 247-60; PMID: 7534203; http://dx.doi.org/10.1016/1074-7613(94)90076-0
166. Kawashima H, Hirose M, Hirose J, Nagakubo D, Plaas AH, Miyasaka M. Binding of a large chondroitin sulfatedermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44. J Biol Chem 2000; 275: 35448-56; PMID: 10950950; http://dx.doi.org/10.1074/jbc.M003387200
167. Kawashima H, Atarashi K, Hirose M, Hirose J, Yamada S, Sugahara K, Miyasaka M. Oversulfated chondroitindermatan sulfates containing GlcAbeta1IdoAalpha1-3GalNAc(4,6-O-disulfate) interact with L-and P-selectin and chemokines. J Biol Chem 2002; 277: 12921-30; PMID: 11821431; http://dx.doi.org/10.1074/jbc.M200396200
168. Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, De Mol M, Dewerchin M, Moons L, Blasi F, et al. Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stemprogenitor cells. J Clin Invest 2009; 119: 1008-18; PMID: 19273908
169. Gong Y, Fan Y, Hoover-Plow J. Plasminogen regulates stromal cell-derived factor-1CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9. Arterioscler Thromb Vasc Biol 2011; 31: 2035-43; PMID: 21719761; http://dx.doi.org/10.1161/ATVBAHA.111.229583
170. Tjwa M, Janssens S, Carmeliet P. Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 2008; 112: 4048-50; PMID: 18723692; http://dx.doi.org/10.1182/blood-2008-07-166587
171. Gong Y, Hoover-Plow J. The plasminogen system in regulating stem cell mobilization. J Biomed Biotechnol 2012; 2012: 437920; PMID: 23118508; http://dx.doi.org/10.1155/2012/437920
172. Plow EF, Herren T, Redlitz A, Miles LA, Hoover-Plow JL. The cell biology of the plasminogen system. FASEB J 1995; 9: 939-45; PMID: 7615163
173. Bruno L, Hoffmann R, McBlane F, Brown J, Gupta R, Joshi C, Pearson S, Seidl T, Heyworth C, Enver T. Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro. Mol Cell Biol 2004; 24: 741-56; PMID: 14701746; http://dx.doi.org/10.1128/MCB.24.2.741-756.2004
174. Ciriza J, Garcia-Ojeda ME. Expression of migrationrelated genes is progressively upregulated in murine Lineage-Sca-1Cc-KitC population from the fetal to adult stages of development. Stem Cell Res Ther 2010; 1: 14; PMID: 20637061; http://dx.doi.org/10.1186/scrt14
175. Voermans C, Lento WE, Uqoezwa M, DiMascio LN, Chhotani A, Rattis FM, Reya T. Identification of novel regulators of hematopoietic stem cell mobilization. Blood (ASH Annu Meeting Abstr) 2005; 106: Abstract 1724
176. Ren J, Jin P, Sabatino M, Balakumaran A, Feng J, Kuznetsov SA, Klein HG, Robey PG, Stroncek DF. Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy 2011; 13: 661-74; PMID: 21250865; http://dx.doi.org/10.3109/14653249.2010.548379
177. Jeong JA, Hong SH, Gang EJ, Ahn C, Hwang SH, Yang IH, Han H, Kim H. Differential gene expression profiling of human umbilical cord blood-derived mesenchymal stem cells by DNA microarray. Stem Cells 2005; 23: 584-93; PMID: 15790779; http://dx.doi.org/10.1634/stemcells.2004-0304
178. Chiellini C, Cochet O, Negroni L, Samson M, Poggi M, Ailhaud G, Alessi MC, Dani C, Amri EZ. Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation. BMC Mol Biol 2008; 9: 26; PMID: 18302751
179. Kim JE, Kim EH, Han EH, Park RW, Park IH, Jun SH, Kim JC, Young MF, Kim IS. A TGF-beta-inducible cell adhesion molecule, betaig-h3, is downregulated in melorheostosis and involved in osteogenesis. J Cell Biochem 2000; 77: 169-78; PMID: 10723084; http://dx.doi.org/10.1002/(SICI)1097-4644(20000501)77:2%3c169::AID-JCB1%3e3.0.CO;2-L
180. Thapa N, Kang KB, Kim IS. Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation. Bone 2005; 36: 232-42; PMID: 15780949; http://dx.doi.org/10.1016/j.bone.2004.08.007
181. Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol 1992; 11: 511-22; PMID: 1388724; http://dx.doi.org/10.1089/dna.1992.11.511
182. Zhao YL, Piao CQ, Hei TK. Downregulation of Betaig-h3 gene is causally linked to tumorigenic phenotype in asbestos treated immortalized human bronchial epithelial cells. Oncogene 2002; 21: 7471-7; PMID: 12386809; http://dx.doi.org/10.1038/sj.onc.1205891
183. Billings PC, Whitbeck JC, Adams CS, Abrams WR, Cohen AJ, Engelsberg BN, Howard PS, Rosenbloom J. The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. J Biol Chem 2002; 277: 28003-9; PMID: 12034705; http://dx.doi.org/10.1074/jbc.M106837200
184. Wagner W, Wein F, Roderburg C, Saffrich R, Faber A, Krause U, Schubert M, Benes V, Eckstein V, Maul H, et al. Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cellcell interaction. Exp Hematol 2007; 35: 314-25; PMID: 17258080; http://dx.doi.org/10.1016/j.exphem.2006.10.003
185. Klamer SE, Kuijk CG, Hordijk PL, van der Schoot CE, von Lindern M, van Hennik PB, Voermans C. BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells. Cell Adh Migr 2013; 7: 434-49; PMID: 24152593; http://dx.doi.org/10.4161/cam.26596
186. Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 2011; 147: 1146-58; PMID: 22118468; http://dx.doi.org/10.1016/j.cell.2011. 09.053
187. Ruscetti FW, Bartelmez SH. Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance. Int J Hematol 2001; 74: 18-25; PMID: 11530800; http://dx.doi.org/10.1007/BF02982545
188. Scandura JM, Boccuni P, Massague J, Nimer SD. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc Natl Acad Sci U S A 2004; 101: 15231-6; PMID: 15477587; http://dx.doi.org/10.1073/pnas.0406771101
189. Ween MP, Lokman NA, Hoffmann P, Rodgers RJ, Ricciardelli C, Oehler MK. Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells. Int J Cancer 2011; 128: 1570-84; PMID: 20521251; http://dx.doi.org/10.1002/ijc.25494
190. McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr 2009; 90: 889-907; PMID: 19692494; http://dx.doi.org/10.3945/ajcn.2009.27930
191. Kim HJ, Kim PK, Bae SM, Son HN, Thoudam DS, Kim JE, Lee BH, Park RW, Kim IS. Transforming growth factor-beta-induced protein (TGFBIpbeta ig-h3) activates platelets and promotes thrombogenesis. Blood 2009; 114: 5206-15; PMID: 19738031; http://dx.doi.org/10.1182/blood-2009-03-212415
192. Bustamante M, Tasinato A, Maurer F, Elkochairi I, Lepore MG, Arsenijevic Y, Pedrazzini T, Munier FL, Schorderet DF. Overexpression of a mutant form of TGFBIBIGH3 induces retinal degeneration in transgenic mice. Mol Vis 2008; 14: 1129-37; PMID: 18568131
193. Kudo A. Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 2011; 68: 3201-7; PMID: 21833583; http://dx.doi.org/10.1007/s00018-011-0784-5
194. Bonnet N, Standley KN, Bianchi EN, Stadelmann V, Foti M, Conway SJ, Ferrari SL. The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity. J Biol Chem 2009; 284: 35939-50; PMID: 19837663; http://dx.doi.org/10.1074/jbc.M109.060335
195. Rios H, Koushik SV, Wang H, Wang J, Zhou HM, Lindsley A, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, et al. periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol. 2005; 25: 11131-44; PMID: 16314533; http://dx.doi.org/10.1128/MCB.25.24.11131-11144.2005
196. Lagergren A, Mansson R, Zetterblad J, Smith E, Basta B, Bryder D, Akerblad P, Sigvardsson M. The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells. J Biol Chem 2007; 282: 14454-62; PMID: 17374609; http://dx.doi.org/10.1074/jbc.M610263200
197. Oku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, et al. Periostin and bone marrow fibrosis. Int J Hematol 2008; 88: 57-63; PMID: 18465194; http://dx.doi.org/10.1007/s12185-008-0095-2
198. Shih CH, Lacagnina M, Leuer-Bisciotti K, Proschel C. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. J Neurosci 2014; 34: 2438-43; PMID: 24523534; http://dx.doi.org/10.1523/JNEUROSCI.2947-13.2014
199. Ozawa M, Huang RP, Furukawa T, Muramatsu T. A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. J Biol Chem 1988; 263: 3059-62; PMID: 2963822
200. Huang RP, Ozawa M, Kadomatsu K, Muramatsu T. Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Dev Biol 1993; 155: 307-14; PMID: 8432389; http://dx.doi.org/10.1006/dbio.1993.1030
201. Halestrap AP. Monocarboxylic Acid transport. Compr Physiol 2013; 3: 1611-43; PMID: 24265240; http://dx.doi.org/10.1002/cphy.c130008
202. Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 2005; 280: 27213-21; PMID: 15917240; http://dx.doi.org/10.1074/jbc.M411950200
203. Wilson MC, Kraus M, Marzban H, Sarna JR, Wang Y, Hawkes R, Halestrap AP, Beesley PW. The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface. PLoS One 2013; 8: e78654; PMID: 24260123; http://dx.doi.org/10.1371/journal.pone.0078654
204. Lain E, Carnejac S, Escher P, Wilson MC, Lømo T, Gajendran N, Brenner HR. A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction. J Biol Chem 2009; 284: 8930-39; PMID: 19164284; http://dx.doi.org/10.1074/jbc.M809491200
205. Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, Corcoran LM, Smyth GK, Nutt SL. Identification of Pax5 target genes in early B cell differentiation. J Immunol 2008; 180: 1719-28; PMID: 18209069; http://dx.doi.org/10.4049/jimmunol.180. 3.1719
206. Zannettino AC, Buhring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood 1998; 92: 2613-28; PMID: 9763543
207. Watt SM, Buhring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, et al. CD164, a novel sialomucin on CD34(C) and erythroid subsets, is located on human chromosome 6q21. Blood 1998; 92: 849-66; PMID: 9680353
208. Buhring HJ, Seiffert M, Bock TA, Scheding S, Thiel A, Scheffold A, Kanz L, Brugger W. Expression of novel surface antigens on early hematopoietic cells. Ann N Y Acad Sci 1999; 872: 25-38; PMID: 10372108; http://dx.doi.org/10.1111/j.1749-6632.1999.tb08450.x
209. Forde S, Tye BJ, Newey SE, Roubelakis M, Smythe J, McGuckin CP, Pettengell R, Watt SM. Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133C cells. Blood 2007; 109: 1825-33; PMID: 17077324; http://dx.doi.org/10.1182/blood-2006-05-023028
210. Tang J, Zhang L, She X, Zhou G, Yu F, Xiang J, Li G. Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo. Cancer Invest 2012; 30: 380-9; PMID: 22409183; http://dx.doi.org/10.3109/07357907.2012.666692
211. Havens AM, Jung Y, Sun YX, Wang J, Shah RB, Bühring HJ, Pienta KJ, Taichman RS. The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. BMC Cancer 2006; 6: 195; PMID: 16859559; http://dx.doi.org/10.1186/1471-2407-6-195
212. Guglielmelli P, Zini R, Bogani C, Salati S, Pancrazzi A, Bianchi E, Mannelli F, Ferrari S, Le Bousse-Kerdiles MC, Bosi A, et al. Molecular profiling of CD34C cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms' tumor gene 1 (WT1). Stem Cells 2007; 25: 165-73; PMID: 16990584; http://dx.doi.org/10.1634/stemcells.2006-0351
213. Uchida N, Yang Z, Combs J, Pourquie O, Nguyen M, Ramanathan R, Fu J, Welply A, Chen S, Weddell G, et al. The characterization, molecular cloning, and expression of a novel hematopoietic cell antigen from CD34C human bone marrow cells. Blood 1997; 89: 2706-16; PMID: 9108388
214. Degen WG, van Kempen LC, Gijzen EG, van Groningen JJ, van Kooyk Y, Bloemers HP, Swart GW. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). Am J Pathol 1998; 152: 805-13; PMID: 9502422
215. Hassan NJ, Barclay AN, Brown MH. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol 2004; 34: 930-40; PMID: 15048703; http://dx.doi.org/10.1002/eji.200424856
216. Chitteti BR, Cheng YH, Kacena MA, Srour EF. Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function. Bone 2013; 54: 58-67; PMID: 23369988; http://dx.doi.org/10.1016/j.bone.2013.01.038
217. Jeannet R, Cai Q, Liu H, Vu H, Kuo YH. Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal. Stem Cells 2013; 31: 560-71; PMID: 23280653; http://dx.doi.org/10.1002/stem.1309
218. Hansen AG, Arnold SA, Jiang M et al. ALCAMCD166 is a TGFbeta responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res 2014; 74: 1404-15; PMID: 24385212; http://dx.doi.org/10.1158/0008-5472.CAN-13-1296
219. Piao D, Jiang T, Liu G, Wang B, Xu J, Zhu A. Clinical implications of activated leukocyte cell adhesion molecule expression in breast cancer. Mol Biol Rep 2012; 39: 661-8; PMID: 21670959; http://dx.doi.org/10.1007/s11033-011-0783-5
220. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 2012; 148: 259-72; PMID: 22225612; http://dx.doi.org/10.1016/j.cell.2011.11.050
221. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, et al. Identification of CD166 as a surface marker for enriching prostate stemprogenitor and cancer initiating cells. PLoS One 2012; 7: e42564; PMID: 22880034; http://dx.doi.org/10.1371/journal.pone.0042564
222. Reinboth B, Thomas J, Hanssen E, Gibson MA. Beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromolecules. J Biol Chem 2006; 281: 7816-24; PMID: 16434404; http://dx.doi.org/10.1074/jbc.M511316200
223. Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 1994; 302 (Pt 2): 527-34; PMID: 8093006
224. Xu T, Bianco P, Fisher LW, Longenecker G, Smith E, Goldstein S, Bonadio J, Boskey A, Heegaard AM, Sommer B, et al. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet 1998; 20: 78-82; PMID: 9731537; http://dx.doi.org/10.1038/2477
225. Csont T, Gorbe A, Bereczki E, Szunyog A, Aypar E, Toth ME, Varga ZV, Csonka C, Fülöp F, Santha M, et al. Biglycan protects cardiomyocytes against hypoxiareoxygenation injury: role of nitric oxide. J Mol Cell Cardiol 2010; 48: 649-52; PMID: 20096286; http://dx.doi.org/10.1016/j.yjmcc.2010.01.013
226. Gu X, Ma Y, Xiao J, Zheng H, Song C, Gong Y, Xing X. Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers. Clin Exp Med 2012; 12: 195-9; PMID: 21879307; http://dx.doi.org/10.1007/s10238-011-0155-4
227. Wang B, Li GX, Zhang SG, Wang Q, Wen YG, Tang HM, Zhou CZ, Xing AY, Fan JW, Yan DW, et al. Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer. Exp Biol Med (Maywood) 2011; 236: 1247-53; PMID: 21998129; http://dx.doi.org/10.1258/ebm.2011.011124
228. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, et al. Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells. Br J Cancer 2012; 106: 1214-23; PMID: 22374465; http://dx.doi.org/10.1038/bjc.2012.59
229. Recktenwald CV, Leisz S, Steven A, Mimura K, Müller A, Wulfänger J, Kiessling R, Seliger B. HER-2neu-mediated down-regulation of biglycan associated with altered growth properties. J Biol Chem 2012; 287: 24320-9; PMID: 22582394; http://dx.doi.org/10.1074/jbc.M111.334425
230. Amenta AR, Creely HE, Mercado ML, Hagiwara H, McKechnie BA, Lechner BE, Rossi SG, Wang Q, Owens RT, Marrero E, et al. Biglycan is an extracellular MuSK binding protein important for synapse stability. J Neurosci 2012; 32: 2324-34; PMID: 22396407; http://dx.doi.org/10.1523/JNEUROSCI.4610-11.2012