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Volumn 35, Issue 6, 2003, Pages 1240-1247

The elements of stem cell self-renewal: A genetic perspective

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; GENETIC ENGINEERING; TRANSPLANTATION (SURGICAL);

EID: 0345168036     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/03356ss03     Document Type: Review
Times cited : (20)

References (57)
  • 1
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till, J. and E. McCulloch. 1961. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14:213-222.
    • (1961) Radiat. Res. , vol.14 , pp. 213-222
    • Till, J.1    McCulloch, E.2
  • 2
    • 0025016163 scopus 로고
    • Resting and activated subsets of mouse multipotent hematopoietic stem cells
    • Spangrude, G.J. and G.R. Johnson. 1990. Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 87:7433-7437.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7433-7437
    • Spangrude, G.J.1    Johnson, G.R.2
  • 3
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell, M.A., K. Brose, G. Paradis, A.S. Conner, and R.C. Mulligan. 1996. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183:1797-1806.
    • (1996) J. Exp. Med. , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 5
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa, M., K. Hanada, H. Hamada, and H. Nakauchi. 1996. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242-245.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 6
    • 0034749999 scopus 로고    scopus 로고
    • Upregulation of Flt3 expression within the bone marrow Lin(-)Scal (+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    • Adolfsson, J., O.J. Borge, D. Bryder, K. Theilgaard-Monch, I. Astrand-Grundstrom, E. Sitnicka, Y. Sasaki, and S.E. Jacobsen. 2001. Upregulation of Flt3 expression within the bone marrow Lin(-)Scal (+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15:659-669.
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1    Borge, O.J.2    Bryder, D.3    Theilgaard-Monch, K.4    Astrand-Grundstrom, I.5    Sitnicka, E.6    Sasaki, Y.7    Jacobsen, S.E.8
  • 7
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    • Christensen, J.L. and I.L. Weissman. 2001. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA 98:14541-14546.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 8
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude, G.J., S. Heimfeld, and I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells [published erratum appears in Science 1989 Jun 2;244(4908):1030]. Science 241:58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 9
    • 0344755679 scopus 로고
    • published erratum appears, Jun 2
    • Spangrude, G.J., S. Heimfeld, and I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells [published erratum appears in Science 1989 Jun 2;244(4908):1030]. Science 241:58-62
    • (1989) Science , vol.244 , Issue.4908 , pp. 1030
  • 10
    • 0026502896 scopus 로고
    • Searching for hematopoietic stem cells: Evidence that Thy-1.110 Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow
    • Uchida, N. and I.L. Weissman. 1992. Searching for hematopoietic stem cells: evidence that Thy-1.110 Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175:175-184.
    • (1992) J. Exp. Med. , vol.175 , pp. 175-184
    • Uchida, N.1    Weissman, I.L.2
  • 11
    • 0028534860 scopus 로고
    • The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    • Morrison, S.J. and I.L. Weissman. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1:661-673.
    • (1994) Immunity , vol.1 , pp. 661-673
    • Morrison, S.J.1    Weissman, I.L.2
  • 12
    • 0034677173 scopus 로고    scopus 로고
    • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    • Domen, J., S.H. Cheshier, and I.L. Weissman. 2000. The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of Bcl-2 increases both their number and repopulation potential. J. Exp. Med. 191:253-264.
    • (2000) J. Exp. Med. , vol.191 , pp. 253-264
    • Domen, J.1    Cheshier, S.H.2    Weissman, I.L.3
  • 13
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen, J., K.L. Gandy, and I.L. Weissman. 1998. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 91:2272-2282.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 14
    • 0030794452 scopus 로고    scopus 로고
    • The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
    • Huang, D.C., L.A. O'Reilly, A. Strasser, and S. Cory. 1997. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J. 16:4628-4638.
    • (1997) EMBO J. , vol.16 , pp. 4628-4638
    • Huang, D.C.1    O'Reilly, L.A.2    Strasser, A.3    Cory, S.4
  • 15
    • 0030476922 scopus 로고    scopus 로고
    • The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
    • O'Reilly, L.A., D.C. Huang, and A. Strasser. 1996. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 15:6979-6990.
    • (1996) EMBO J. , vol.15 , pp. 6979-6990
    • O'Reilly, L.A.1    Huang, D.C.2    Strasser, A.3
  • 17
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard, J. and G. Sauvageau. 2003. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423:255-260.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 18
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs, J.J., K. Kieboom, S. Marino, R.A. DePinho, and M. van Lohuizen. 1999. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 20
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky, A.V., R. Pardal, T. Iwashita, I.K. Park, M.F. Clarke, and S.J. Morrison. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962-967.
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5    Morrison, S.J.6
  • 21
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk, J., G. Sauvageau, and R.K. Humphries. 2002. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109: 39-45.
    • (2002) Cell , vol.109 , pp. 39-45
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 23
    • 0030729371 scopus 로고    scopus 로고
    • Effects of HOX homeobox genes in blood cell differentiation
    • Magli, M.C., C. Largman, and H.J. Lawrence. 1997. Effects of HOX homeobox genes in blood cell differentiation. J. Cell Physiol. 173:168-177.
    • (1997) J. Cell Physiol. , vol.173 , pp. 168-177
    • Magli, M.C.1    Largman, C.2    Lawrence, H.J.3
  • 24
  • 25
    • 0028869112 scopus 로고
    • Altered Hox expression and segmental identity in M11-mutant mice
    • Yu, B.D., J.L. Hess, S.E. Horning, G.A. Brown, and S.J. Korsmeyer. 1995. Altered Hox expression and segmental identity in M11-mutant mice. Nature 378:505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3    Brown, G.A.4    Korsmeyer, S.J.5
  • 26
    • 0032126677 scopus 로고    scopus 로고
    • Growth disturbance in fetal liver hematopoiesis of M11-mutant mice
    • Yagi, H., K. Deguchi, A. Aono, Y. Tani, T. Kishimoto, and T. Komori. 1998. Growth disturbance in fetal liver hematopoiesis of M11-mutant mice. Blood 92:108-117.
    • (1998) Blood , vol.92 , pp. 108-117
    • Yagi, H.1    Deguchi, K.2    Aono, A.3    Tani, Y.4    Kishimoto, T.5    Komori, T.6
  • 27
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term hematopoietic stem cells
    • Cheshier, S.H., S.J. Morrison, X. Liao, and I.L. Weissman. 1999. In vivo proliferation and cell cycle kinetics of long-term hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 96:3120-3125.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 29
    • 0033694302 scopus 로고    scopus 로고
    • Stem cell repopulation efficiency but not pool size is governed by p27(kip1)
    • Cheng, T., N. Rodrigues, D. Dombkowski, S. Stier, and D.T. Scadden. 2000. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat. Med. 6:1235-1240.
    • (2000) Nat. Med. , vol.6 , pp. 1235-1240
    • Cheng, T.1    Rodrigues, N.2    Dombkowski, D.3    Stier, S.4    Scadden, D.T.5
  • 33
    • 0037438686 scopus 로고    scopus 로고
    • Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice
    • Ito, C.Y., C.Y. Li, A. Bernstein, J.E. Dick, and W.L. Stanford. 2003. Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood 101:517-523.
    • (2003) Blood , vol.101 , pp. 517-523
    • Ito, C.Y.1    Li, C.Y.2    Bernstein, A.3    Dick, J.E.4    Stanford, W.L.5
  • 34
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison, S.J., K.R. Prowse, P. Ho, and I.L. Weissman. 1996. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5:207-216.
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 35
    • 0035896731 scopus 로고    scopus 로고
    • Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    • Allsopp, R.C., S. Cheshier, and I.L. Weissman. 2001. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J. Exp. Med. 193:917-924.
    • (2001) J. Exp. Med. , vol.193 , pp. 917-924
    • Allsopp, R.C.1    Cheshier, S.2    Weissman, I.L.3
  • 36
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp, R.C., G.B. Morin, R. DePinho, C.B. Harley, and I.L. Weissman. 2003. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102:517-520.
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 37
    • 0345636016 scopus 로고    scopus 로고
    • Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
    • Allsopp, R.C., G.B. Morin, J.W. Horner, R. DePinho, C.B. Harley, and I.L. Weissman. 2003. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat. Med. 9: 369-371.
    • (2003) Nat. Med. , vol.9 , pp. 369-371
    • Allsopp, R.C.1    Morin, G.B.2    Horner, J.W.3    DePinho, R.4    Harley, C.B.5    Weissman, I.L.6
  • 39
    • 0036529989 scopus 로고    scopus 로고
    • Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
    • Stier, S., T. Cheng, D. Dombkowski, N. Carlesso, and D.T. Scadden. 2002. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99: 2369-2378.
    • (2002) Blood , vol.99 , pp. 2369-2378
    • Stier, S.1    Cheng, T.2    Dombkowski, D.3    Carlesso, N.4    Scadden, D.T.5
  • 40
    • 0034613734 scopus 로고    scopus 로고
    • The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    • Karanu, F.N., B. Murdoch, L. Gallacher, D.M. Wu, Koremoto, S. Sakano, and M. Bhatia. 2000. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J. Exp. Med. 192: 1365-1372.
    • (2000) J. Exp. Med. , vol.192 , pp. 1365-1372
    • Karanu, F.N.1    Murdoch, B.2    Gallacher, L.3    Wu, D.M.4    Koremoto5    Sakano, S.6    Bhatia, M.7
  • 45
    • 0030581174 scopus 로고    scopus 로고
    • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
    • Porcher, C., W. Swat, K. Rockwell, Y. Fujiwara, F.W. Alt, and S.H. Orkin. 1996. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86:47-57.
    • (1996) Cell , vol.86 , pp. 47-57
    • Porcher, C.1    Swat, W.2    Rockwell, K.3    Fujiwara, Y.4    Alt, F.W.5    Orkin, S.H.6
  • 46
    • 0037472895 scopus 로고    scopus 로고
    • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    • Mikkola, H.K., J. Klintman, H. Yang, H. Hock, T.M. Schlaeger, Y. Fujiwara, and S.H. Orkin. 2003. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421:547-551.
    • (2003) Nature , vol.421 , pp. 547-551
    • Mikkola, H.K.1    Klintman, J.2    Yang, H.3    Hock, H.4    Schlaeger, T.M.5    Fujiwara, Y.6    Orkin, S.H.7
  • 48
    • 0033570359 scopus 로고    scopus 로고
    • Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    • Rowitch, D.H., S.-Jacques B., S.M. Lee, J.D. Flax, E.Y. Snyder, and A.P. McMahon. 1999. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci. 19:8954-8965.
    • (1999) J. Neurosci. , vol.19 , pp. 8954-8965
    • Rowitch, D.H.1    Jacques, B.S.2    Lee, S.M.3    Flax, J.D.4    Snyder, E.Y.5    McMahon, A.P.6
  • 49
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • Wechsler-Reya, R.J. and M.P. Scott. 1999. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-114.
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 50
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya, R. and M.P. Scott. 2001. The developmental biology of brain tumors. Annu. Rev. Neurosci. 24:385-428.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 51
    • 0033252592 scopus 로고    scopus 로고
    • Acquired and inherited basal cell carcinomas and the patched gene
    • Gailani, M.R. and A.E. Bale. 1999. Acquired and inherited basal cell carcinomas and the patched gene. Adv. Dermatol. 14:261-283.
    • (1999) Adv. Dermatol. , vol.14 , pp. 261-283
    • Gailani, M.R.1    Bale, A.E.2
  • 52
    • 0042809621 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell self-renewal
    • Reya, T. 2003. Regulation of hematopoietic stem cell self-renewal. Recent Prog. Horm. Res. 58:283-295.
    • (2003) Recent Prog. Horm. Res. , vol.58 , pp. 283-295
    • Reya, T.1
  • 53
    • 0030989287 scopus 로고    scopus 로고
    • A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
    • Austin, T.W., G.P. Solar, F.C. Ziegler, L. Liem, and W. Matthews. 1997. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89:3624-3635.
    • (1997) Blood , vol.89 , pp. 3624-3635
    • Austin, T.W.1    Solar, G.P.2    Ziegler, F.C.3    Liem, L.4    Matthews, W.5
  • 54
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoiesis
    • Van Den Berg, D.J., A.K. Sharma, E. Bruno, and R. Hoffman. 1998. Role of members of the Wnt gene family in human hematopoiesis. Blood 92:3189-3202.
    • (1998) Blood , vol.92 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.