Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice

Clinical Science

Volumn 128, Issue 2, 2015, Pages 95-109

  Valero Esquitino, Verónica ^a   Lucht, Kristin ^a   Namsolleck, Pawel ^a,b   Monnet Tschudi, Florianne ^c   Stubbe, Tobias ^a   Lucht, Franziska ^a   Liu, Meng ^d   Ebner, Friederike ^a   Brandt, Christine ^a   Danyel, Leon A ^a   Villela, Daniel C ^e   Paulis, Ludovit ^f   Thoene Reineke, Christa ^g   Dahlöf, Björn ^h   Hallberg, Anders ⁱ   Unger, Thomas ^b   Sumners, Colin ^d   Muscha Steckelings, U ^a,j  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d UNIVERSITY OF FLORIDA   (United States)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^f Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

^g Depart of Electrochemistry Research Institute for Precious Metals and Metal Chemistry Fem   (Germany)

^h SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

ⁱ UPPSALA UNIVERSITY   (Sweden)

^j UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

more..

Author keywords

Angiotensin type 2 receptor (AT2R); Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroinflammation; Neuroprotection; New therapies

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN TYPE 2 RECEPTOR AGONIST; GAMMA INTERFERON; HORMONE RECEPTOR STIMULATING AGENT; LIPOPOLYSACCHARIDE; MYELIN; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL CULTURE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MOUSE; MYELINATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION; THERAPY EFFECT; AGONISTS; ANIMAL; C57BL MOUSE; DEMYELINATING DISEASES; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; METABOLISM; MULTIPLE SCLEROSIS; SPINAL CORD; T LYMPHOCYTE;

ANIMALS; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; MICROGLIA; MULTIPLE SCLEROSIS; NITRIC OXIDE; RATS; RECEPTOR, ANGIOTENSIN, TYPE 2; SPINAL CORD; T-LYMPHOCYTES;

EID: 84921635386     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20130601     Document Type: Article

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