Promoting myelin repair and return of function in multiple sclerosis

FEBS Letters

Volumn 585, Issue 23, 2011, Pages 3813-3820

  Zhang, Jingya ^a   Kramer, Elisabeth G ^a   Asp, Linnea ^a   Dutta, Dipankar J ^a   Navrazhina, Kristina ^a   Pham, Trinh ^a   Mariani, John N ^a   Argaw, Azeb Tadesse ^a   Melendez Vasquez, Carmen V ^b   John, Gareth R ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Axonal transection; Demyelination; Multiple sclerosis; Neuroprotection; Regeneration

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 11; LEUKEMIA INHIBITORY FACTOR; MYELIN; NERVE GROWTH FACTOR; NEU DIFFERENTIATION FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NOTCH RECEPTOR; RECOMBINANT INTERLEUKIN 11; RECOMBINANT SOMATOMEDIN C; RETINOID X RECEPTOR; SOMATOMEDIN; STAT1 PROTEIN; STAT3 PROTEIN; WNT PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; DEGENERATIVE DISEASE; DEMYELINATION; DENDRITIC CELL; HUMAN; IMMUNOREGULATION; MULTIPLE SCLEROSIS; MYELINATION; NERVE DEGENERATION; NERVE FIBER TRANSECTION; NERVE REGENERATION; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; SPINAL CORD INJURY;

ANIMALS; HUMANS; MODELS, IMMUNOLOGICAL; MULTIPLE SCLEROSIS; MYELIN SHEATH; OLIGODENDROGLIA; SIGNAL TRANSDUCTION; WOUND HEALING;

MUS;

EID: 81755166392     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.017     Document Type: Review

References (136)

1. W.I. McDonald, and T.A. Sears Effect of demyelination on conduction in the central nervous system Nature 221 1969 182 183
2. B.D. Trapp, J. Peterson, R.M. Ransohoff, R. Rudick, S. Mork, and L. Bo Axonal transection in the lesions of multiple sclerosis N. Engl. J. Med. 338 1998 278 285 (Pubitemid 28065253)
3. E.J. Smith, W.F. Blakemore, and W.I. McDonald Central remyelination restores secure conduction Nature 280 1979 395 396 (Pubitemid 9235207)
4. J.W. Prineas, and F. Connell Remyelination in multiple sclerosis Ann. Neurol. 5 1979 22 31 (Pubitemid 9083248)
5. A. Chang, W.W. Tourtellotte, R. Rudick, and B.D. Trapp Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis N. Engl. J. Med. 346 2002 165 173 (Pubitemid 34438882)
6. J.H. Noseworthy, C. Lucchinetti, M. Rodriguez, and B.G. Weinshenker Multiple sclerosis N. Engl. J. Med. 343 2000 938 952
7. J.M. Redwine, and R.C. Armstrong In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination J. Neurobiol. 37 1998 413 428 (Pubitemid 28506925)
8. M. Watanabe, Y. Toyama, and A. Nishiyama Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion J. Neurosci. Res. 69 2002 826 836 (Pubitemid 34984700)
9. J.M. Gensert, and J.E. Goldman Endogenous progenitors remyelinate demyelinated axons in the adult CNS Neuron 19 1997 197 203 (Pubitemid 27333005)
10. R.C. Armstrong, H.H. Dorn, C.V. Kufta, E. Friedman, and M.E. Dubois-Dalcq Pre-oligodendrocytes from adult human CNS J. Neurosci. 12 1992 1538 1547
11. A. Nishiyama, X.H. Lin, N. Giese, C.H. Heldin, and W.B. Stallcup Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF J. Neurosci. Res. 43 1996 315 330 (Pubitemid 26054019)
12. G. Wolswijk Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells J. Neurosci. 18 1998 601 609 (Pubitemid 28041896)
13. Aktas, O.; Kieseier, B.; Hartung, H.P. Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis. Trends Neurosci 33, 140-52.
14. Van Der Walt, A.; Butzkueven, H.; Kolbe, S.; Marriott, M.; Alexandrou, E.; Gresle, M.; Egan, G.; Kilpatrick, T. Neuroprotection in multiple sclerosis: A therapeutic challenge for the next decade. Pharmacol Ther 126, 82-93.
15. C. Lubetzki, A. Williams, and B. Stankoff Promoting repair in multiple sclerosis: problems and prospects Curr. Opin. Neurol. 18 2005 237 244 (Pubitemid 40813749)
16. T. Taga, M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 58 1989 573 581 (Pubitemid 19203542)
17. D. Anhuf Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation J. Immunol. 165 2000 2535 2543 (Pubitemid 30660699)
18. M. Murakami, M. Hibi, N. Nakagawa, T. Nakagawa, K. Yasukawa, K. Yamanishi, T. Taga, and T. Kishimoto IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase Science 260 1993 1808 1810 (Pubitemid 23244207)
19. S. Davis, T.H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N.Y. Ip, and G.D. Yancopoulos LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor Science 260 1993 1805 1808 (Pubitemid 23244206)
20. C. Lutticken Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 Science 263 1994 89 92 (Pubitemid 24076262)
21. N. Stahl Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components Science 263 1994 92 95 (Pubitemid 24076263)
22. M. Ernst, and B.J. Jenkins Acquiring signalling specificity from the cytokine receptor gp130 Trends Genet. 20 2004 23 32 (Pubitemid 38032817)
23. Y. Masu, E. Wolf, B. Holtmann, M. Sendtner, G. Brem, and H. Thoenen Disruption of the CNTF gene results in motor neuron degeneration Nature 365 1993 27 32 (Pubitemid 23305564)
24. R.W. Oppenheim Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons J. Neurosci. 21 2001 1283 1291 (Pubitemid 32128773)
25. D.F. Emerich Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease Nature 386 1997 395 399 (Pubitemid 27154479)
26. B. Stankoff, M.S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki Ciliary neurotrophic factor (CNTF) enhances myelin formation: A novel role for CNTF and CNTF-related molecules J. Neurosci. 22 2002 9221 9227 (Pubitemid 35356165)
27. R. Marmur, J.A. Kessler, G. Zhu, S. Gokhan, and M.F. Mehler Differentiation of oligodendroglial progenitors derived from cortical multipotent cells requires extrinsic signals including activation of gp130/LIFbeta receptors J. Neurosci. 18 1998 9800 9811 (Pubitemid 28543759)
28. A. Valerio, M. Ferrario, M. Dreano, G. Garotta, P. Spano, and M. Pizzi Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells Mol. Cell. Neurosci. 21 2002 602 615 (Pubitemid 36062717)
29. B.A. Barres, R. Schmid, M. Sendnter, and M.C. Raff Multiple extracellular signals are required for long-term oligodendrocyte survival Development 118 1993 283 295 (Pubitemid 23191629)
30. M. Mayer, K. Bhakoo, and M. Noble Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro Development 120 1994 143 153 (Pubitemid 24031196)
31. H. Butzkueven LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival Nat. Med. 8 2002 613 619 (Pubitemid 34633440)
32. R.A. Linker CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation Nat. Med. 8 2002 620 624 (Pubitemid 34633441)
33. R.A. Linker Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: A new role for neurotrophic cytokines in neuroinflammation J. Immunol. 180 2008 2204 2213
34. J.F. Talbott, Q. Cao, J. Bertram, M. Nkansah, R.L. Benton, E. Lavik, and S.R. Whittemore CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo Exp. Neurol. 204 2007 485 489 (Pubitemid 46330291)
35. Cao, Q. et al. Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci 30, 2989-3001.
36. T. Kuhlmann Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis Am. J. Pathol. 169 2006 584 598 (Pubitemid 44156316)
37. H. Butzkueven, B. Emery, T. Cipriani, M.P. Marriott, and T.J. Kilpatrick Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss Glia 53 2006 696 703
38. M.P. Marriott Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair Glia 56 2008 686 698
39. M. Sendtner, H. Schmalbruch, K.A. Stockli, P. Carroll, G.W. Kreutzberg, and H. Thoenen Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy Nature 358 1992 502 504
40. R.G. Miller A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. RhCNTF ALS Study Group Ann. Neurol. 39 1996 256 260 (Pubitemid 26071576)
41. (1996). A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46, 1244-9.
42. B.T. Gurfein, Y. Zhang, C.B. Lopez, A.T. Argaw, A. Zameer, T.M. Moran, and G.R. John IL-11 regulates autoimmune demyelination J. Immunol. 183 2009 4229 4240
43. Y. Zhang, C. Taveggia, C. Melendez-Vasquez, S. Einheber, C.S. Raine, J.L. Salzer, C.F. Brosnan, and G.R. John Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation J. Neurosci. 26 2006 12174 12185 (Pubitemid 44808384)
44. Zhang, J. et al. Proapoptotic and Antiapoptotic Actions of Stat1 versus Stat3 Underlie Neuroprotective and Immunoregulatory Functions of IL-11. J Immunol.
45. F.A. McMorris, T.M. Smith, S. DeSalvo, and R.W. Furlanetto Insulin-like growth factor I/somatomedin C: A potent inducer of oligodendrocyte development Proc. Natl. Acad. Sci. USA 83 1986 822 826 (Pubitemid 16035567)
46. D. Chesik, N. Wilczak, and J. De Keyser The insulin-like growth factor system in multiple sclerosis Int. Rev. Neurobiol. 79 2007 203 226
47. K.D. Beck, L. Powell-Braxton, H.R. Widmer, J. Valverde, and F. Hefti Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons Neuron 14 1995 717 730
48. M.J. Carson, R.R. Behringer, R.L. Brinster, and F.A. McMorris Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice Neuron 10 1993 729 740 (Pubitemid 23127975)
49. P. Ye, J. Carson, and A.J. D'Ercole In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice J. Neurosci. 15 1995 7344 7356
50. J. Hsieh, J.B. Aimone, B.K. Kaspar, T. Kuwabara, K. Nakashima, and F.H. Gage IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes J. Cell Biol. 164 2004 111 122 (Pubitemid 38082462)
51. D.L. Yao, X. Liu, L.D. Hudson, and H.D. Webster Insulin-Like Growth-Factor-I Treatment Reduces Demyelination and up-Regulates Gene-Expression of Myelin-Related Proteins in Experimental Autoimmune Encephalomyelitis Proc. Natl. Acad. Sci. USA 92 1995 6190 6194
52. B. Cannella, D. Pitt, E. Capello, and C.S. Raine Insulin-like growth factor-1 fails to enhance central nervous system myelin repair during autoimmune demyelination Am. J. Pathol. 157 2000 933 943 (Pubitemid 32109385)
53. D. Gveric, M.L. Cuzner, and J. Newcombe Insulin-like growth factors and binding proteins in multiple sclerosis plaques Neuropathol. Appl. Neurobiol. 25 1999 215 225 (Pubitemid 29313226)
54. J.A. Frank A pilot study of recombinant insulin-like growth factor-1 in seven multiple sclerosis patients Mult. Scler. 8 2002 24 29 (Pubitemid 34193024)
55. Y.A. Barde, D. Edgar, and H. Thoenen Purification of a new neurotrophic factor from mammalian brain EMBO J. 1 1982 549 553
56. E.J. Huang, and L.F. Reichardt Neurotrophins: roles in neuronal development and function Annu. Rev. Neurosci. 24 2001 677 736 (Pubitemid 32695243)
57. S.S. Rosenberg, B.K. Ng, and J.R. Chan The quest for remyelination: A new role for neurotrophins and their receptors Brain Pathol. 16 2006 288 294
58. J. Xiao, T.J. Kilpatrick, and S.S. Murray The role of neurotrophins in the regulation of myelin development Neurosignals 17 2009 265 276
59. J.R. Chan, T.A. Watkins, J.M. Cosgaya, C. Zhang, L. Chen, L.F. Reichardt, E.M. Shooter, and B.A. Barres NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes Neuron 43 2004 183 191 (Pubitemid 38942959)
60. R.I. Cohen, R. Marmur, W.T. Norton, M.F. Mehler, and J.A. Kessler Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes J. Neurosci. 16 1996 6433 6442 (Pubitemid 26337367)
61. L. Tessarollo, K.S. Vogel, M.E. Palko, S.W. Reid, and L.F. Parada Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons Proc. Natl. Acad. Sci. USA 91 1994 11844 11848 (Pubitemid 24368560)
62. M.A. Kahn, S. Kumar, D. Liebl, R. Chang, L.F. Parada, and J. De Vellis Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells Glia 26 1999 153 165 (Pubitemid 29163394)
63. B.A. Barres, M.C. Raff, F. Gaese, I. Bartke, G. Dechant, and Y.A. Barde A crucial role for neurotrophin-3 in oligodendrocyte development Nature 367 1994 371 375 (Pubitemid 24062343)
64. H. Yan, and P.M. Wood NT-3 weakly stimulates proliferation of adult rat O1(-)O4(+) oligodendrocyte-lineage cells and increases oligodendrocyte myelination in vitro J. Neurosci. Res. 62 2000 329 335
65. N. Rubio, R. Rodriguez, and M.A. Arevalo In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene Glia 47 2004 78 87 (Pubitemid 38879708)
66. Y. Du, T.Z. Fischer, L.N. Lee, L.D. Lercher, and C.F. Dreyfus Regionally specific effects of BDNF on oligodendrocytes Dev. Neurosci. 25 2003 116 126 (Pubitemid 37100207)
67. K.R. Jones, I. Farinas, C. Backus, and L.F. Reichardt Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development Cell 76 1994 989 999 (Pubitemid 24106380)
68. A. Cellerino, P. Carroll, H. Thoenen, and Y.A. Barde Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking brain-derived neurotrophic factor Mol. Cell. Neurosci. 9 1997 397 408 (Pubitemid 27467491)
69. D.M. McTigue, P.J. Horner, B.T. Stokes, and F.H. Gage Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord J. Neurosci. 18 1998 5354 5365 (Pubitemid 28311952)
70. C. Girard, A.P. Bemelmans, N. Dufour, J. Mallet, C. Bachelin, B. Nait-Oumesmar, A. Baron-Van Evercooren, and F. Lachapelle Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord J. Neurosci. 25 2005 7924 7933 (Pubitemid 41254395)
71. Linker, R.A. et al. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 133, 2248-63.
72. Q. Cao Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells J. Neurosci. 25 2005 6947 6957 (Pubitemid 41077002)
73. D.L. Falls Neuregulins: functions, forms, and signaling strategies Exp. Cell Res. 284 2003 14 30 (Pubitemid 36335807)
74. V. Steinthorsdottir Multiple novel transcription initiation sites for NRG1 Gene 342 2004 97 105 (Pubitemid 39457182)
75. K.A. Nave, and J.L. Salzer Axonal regulation of myelination by neuregulin 1 Curr. Opin. Neurobiol. 16 2006 492 500 (Pubitemid 44466397)
76. C. Taveggia Neuregulin-1 type III determines the ensheathment fate of axons Neuron 47 2005 681 694 (Pubitemid 41208007)
77. A.N. Garratt, O. Voiculescu, P. Topilko, P. Charnay, and C. Birchmeier A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool J. Cell Biol. 148 2000 1035 1046
78. G.V. Michailov Axonal neuregulin-1 regulates myelin sheath thickness Science 304 2004 700 703 (Pubitemid 38560869)
79. G. Lopez-Bendito Tangential neuronal migration controls axon guidance. a role for neuregulin-1 in thalamocortical axon navigation Cell 125 2006 127 142
80. P.D. Canoll, J.M. Musacchio, R. Hardy, R. Reynolds, M.A. Marchionni, and J.L. Salzer GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors Neuron 17 1996 229 243 (Pubitemid 26296150)
81. T. Vartanian, A. Goodearl, A. Viehover, and G. Fischbach Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3 J. Cell Biol. 137 1997 211 220 (Pubitemid 27167308)
82. P.A. Fernandez, D.G. Tang, L. Cheng, A. Prochiantz, A.W. Mudge, and M.C. Raff Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve Neuron 28 2000 81 90
83. C. Taveggia, P. Thaker, A. Petrylak, G.L. Caporaso, A. Toews, D.L. Falls, S. Einheber, and J.L. Salzer Type III neuregulin-1 promotes oligodendrocyte myelination Glia 56 2008 284 293
84. B.G. Brinkmann Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system Neuron 59 2008 581 595
85. Lefebvre, P.; Benomar, Y.; Staels, B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab 21, 676-83.
86. K. Schrage, G. Koopmans, E.A. Joosten, and J. Mey Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury Eur. J. NeuroSci. 23 2006 285 295
87. Huang, J.K. et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci 14, 45-53.
88. R.J. Franklin, and C. Ffrench-Constant Remyelination in the CNS: from biology to therapy Nat. Rev. Neurosci. 9 2008 839 855
89. S.A. Back Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation Nat. Med. 11 2005 966 972 (Pubitemid 41294442)
90. T. Kuhlmann, V. Miron, Q. Cui, C. Wegner, J. Antel, and W. Bruck Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis Brain 131 2008 1749 1758 (Pubitemid 351957453)
91. B. Nait-Oumesmar, L. Decker, F. Lachapelle, V. Avellana-Adalid, C. Bachelin, and A.B. Van Evercooren Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination Eur. J. NeuroSci. 11 1999 4357 4366 (Pubitemid 30009267)
92. B. Nait-Oumesmar Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors Proc. Natl. Acad. Sci. USA 104 2007 4694 4699 (Pubitemid 47186287)
93. M.F. Mehler, P.C. Mabie, D. Zhang, and J.A. Kessler Bone morphogenetic proteins in the nervous system Trends Neurosci. 20 1997 309 317 (Pubitemid 27348741)
94. J. Massague, and D. Wotton Transcriptional control by the TGF-beta/Smad signaling system EMBO J. 19 2000 1745 1754 (Pubitemid 30204386)
95. A. Liu, and L.A. NiswanDer Bone morphogenetic protein signalling and vertebrate nervous system development Nat. Rev. Neurosci. 6 2005 945 954 (Pubitemid 41753088)
96. K.F. Liem Jr.; G. Tremml, and T.M. Jessell A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord Cell 91 1997 127 138 (Pubitemid 27431319)
97. Y. Tanabe, and T.M. Jessell Diversity and pattern in the developing spinal cord Science 274 1996 1115 1123
98. W.D. Richardson, N. Kessaris, and N. Pringle Oligodendrocyte wars Nat. Rev. Neurosci. 7 2006 11 18 (Pubitemid 41828927)
99. D.M. Orentas, and R.H. Miller The origin of spinal cord oligodendrocytes is dependent on local influences from the notochord Dev. Biol. 177 1996 43 53 (Pubitemid 26252479)
100. Q.R. Lu Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system Neuron 25 2000 317 329
101. J. Cai Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling Neuron 45 2005 41 53 (Pubitemid 40075348)
102. A. Vallstedt, J.M. Klos, and J. Ericson Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain Neuron 45 2005 55 67 (Pubitemid 40075349)
103. S. Mekki-Dauriac, E. Agius, P. Kan, and P. Cochard Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord Development 129 2002 5117 5130 (Pubitemid 35460676)
104. R.H. Miller, K. Dinsio, R. Wang, R. Geertman, C.E. Maier, and A.K. Hall Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4 J. Neurosci. Res. 76 2004 9 19 (Pubitemid 38445560)
105. J.B. Grinspan, E. Edell, D.F. Carpio, J.S. Beesley, L. Lavy, D. Pleasure, and J.A. Golden Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage J. Neurobiol. 43 2000 1 17 (Pubitemid 30191176)
106. J. See, X. Zhang, N. Eraydin, S.B. Mun, P. Mamontov, J.A. Golden, and J.B. Grinspan Oligodendrocyte maturation is inhibited by bone morphogenetic protein Mol. Cell. Neurosci. 26 2004 481 492 (Pubitemid 38969946)
107. L. Gao, W. Macklin, J. Gerson, and R.H. Miller Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina Dev. Biol. 290 2006 277 286 (Pubitemid 43163491)
108. T. Setoguchi, K. Yone, E. Matsuoka, H. Takenouchi, K. Nakashima, T. Sakou, S. Komiya, and S. Izumo Traumatic injury-induced BMP7 expression in the adult rat spinal cord Brain Res. 921 2001 219 225 (Pubitemid 33096301)
109. A.K. Hall, and R.H. Miller Emerging roles for bone morphogenetic proteins in central nervous system glial biology J. Neurosci. Res. 76 2004 1 8 (Pubitemid 38445559)
110. D.W. Hampton, R.A. Asher, T. Kondo, J.D. Steeves, M.S. Ramer, and J.W. Fawcett A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo Eur. J. NeuroSci. 26 2007 3024 3035 (Pubitemid 350135185)
111. C. Zhao, S.P. Fancy, L. Magy, J.E. Urwin, and R.J. Franklin Stem cells, progenitors and myelin repair J. Anat. 207 2005 251 258 (Pubitemid 41301000)
112. M.L. Fuller, A.K. DeChant, B. Rothstein, A. Caprariello, R. Wang, A.K. Hall, and R.H. Miller Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions Ann. Neurol. 62 2007 288 300 (Pubitemid 47525405)
113. J. Ara, J. See, P. Mamontov, A. Hahn, P. Bannerman, D. Pleasure, and J.B. Grinspan Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis J. Neurosci. Res. 86 2008 125 135
114. M. Deininger, R. Meyermann, and H. Schluesener Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and -5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions Acta Neuropathol. 90 1995 76 79
115. S. Wang, A.D. Sdrulla, G. diSibio, G. Bush, D. Nofziger, C. Hicks, G. Weinmaster, and B.A. Barres Notch receptor activation inhibits oligodendrocyte differentiation Neuron 21 1998 63 75 (Pubitemid 28355692)
116. S. Genoud Notch1 control of oligodendrocyte differentiation in the spinal cord J. Cell Biol. 158 2002 709 718 (Pubitemid 34920109)
117. B. D'Souza, A. Miyamoto, and G. Weinmaster The many facets of Notch ligands Oncogene 27 2008 5148 5167
118. Q.D. Hu F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation Cell 115 2003 163 175
119. Aguirre, A.; Rubio, M.E.; Gallo, V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 467, 323-7.
120. Y. Nyfeler, R.D. Kirch, N. Mantei, D.P. Leone, F. Radtke, U. Suter, and V. Taylor Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal EMBO J. 24 2005 3504 3515 (Pubitemid 41486787)
121. K. Mizutani, K. Yoon, L. Dang, A. Tokunaga, and N. Gaiano Differential Notch signalling distinguishes neural stem cells from intermediate progenitors Nature 449 2007 351 355 (Pubitemid 47443472)
122. G.R. John, S.L. Shankar, B. Shafit-Zagardo, A. Massimi, S.C. Lee, C.S. Raine, and C.F. Brosnan Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation Nat. Med. 8 2002 1115 1121 (Pubitemid 35175966)
123. Zhang Y, Z.J.; Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. (2010). TGFβ1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. Glia In Press.
124. M.F. Stidworthy, S. Genoud, W.W. Li, D.P. Leone, N. Mantei, U. Suter, and R.J. Franklin Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination Brain 127 2004 1928 1941 (Pubitemid 39150252)
125. Y. Zhang Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination Proc. Natl. Acad. Sci. USA 106 2009 19162 19167
126. J. Nakahara, K. Kanekura, M. Nawa, S. Aiso, and N. Suzuki Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis J. Clin. Invest. 119 2009 169 181
127. Taveggia, C.; Feltri, M.L.; Wrabetz, L. Signals to promote myelin formation and repair. Nat Rev Neurol 6, 276-87.
128. S. Shen, J. Li, and P. Casaccia-Bonnefil Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain J. Cell Biol. 169 2005 577 589 (Pubitemid 41002851)
129. M. Marin-Husstege, M. Muggironi, A. Liu, and P. Casaccia-Bonnefil Histone deacetylase activity is necessary for oligodendrocyte lineage progression J. Neurosci. 22 2002 10333 10345 (Pubitemid 35416871)
130. E. Bartova, J. Krejci, A. Harnicarova, G. Galiova, and S. Kozubek Histone modifications and nuclear architecture: A review J. Histochem. Cytochem. 56 2008 711 721 (Pubitemid 351991084)
131. F. Ye HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction Nat. Neurosci. 12 2009 829 838
132. H. Li, and W.D. Richardson Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration Nat. Neurosci. 12 2009 815 817
133. Y. He The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation Neuron 55 2007 217 230 (Pubitemid 47048909)
134. S.P. Fancy Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS Genes Dev. 23 2009 1571 1585
135. K. Feigenson, M. Reid, J. See, E.B. Crenshaw 3rd, and J.B. Grinspan Wnt signaling is sufficient to perturb oligodendrocyte maturation Mol. Cell. Neurosci. 42 2009 255 265
136. H. Fu A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development J. Neurosci. 29 2009 11399 11408