Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

Multiple Sclerosis

Volumn 15, Issue 2, 2009, Pages 262-265

  Kawajiri, Masakazu ^a   Mogi, M ^a   Higaki, N ^a   Matsuoka, T ^b   Ohyagi, Y ^b   Tsukuda, K ^a   Kohara, K ^a   Horiuchi, M ^a   Miki, T ^a   Kira, J I ^b  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Angiotensin converting enzyme; Cerebrospinal fluid; Multiple sclerosis; Renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; PATHOPHYSIOLOGY; PROTEIN CEREBROSPINAL FLUID LEVEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ADULT; ANGIOTENSIN II; BLOOD VOLUME; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PEPTIDYL-DIPEPTIDASE A; RENIN-ANGIOTENSIN SYSTEM;

EID: 59349113320     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458508097923     Document Type: Article

References (10)

1. Mogi M Li JM Iwanami J. Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. Hypertension 2006; 48: 141-148.
2. Li JM Mogi M Tsukuda K. Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol Endocrinol 2007; 21: 499-511.
3. Kawajiri M Mogi M Osoegawa M. Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis. Multiple Sclerosis 2008; 14: 557-560.
4. Ferrario CM. Angiotensin-converting enzyme 2 and angiotensin-(1-7): An evolving story in cardiovascular regulation. Hypertension 2006; 47: 515-521.
5. Constantinescu CS Goodman DB Grossman RI Mannon LJ Cohen JA. Serum angiotensin-converting enzyme in multiple sclerosis. Arch Neurol 1997; 54: 1012-1015.
6. McDonald WI Compston A Edan G. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121-127.
7. Kira J Kanai T Nishimura Y. Western versus Asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders. Ann Neurol 1996; 40: 569-574.
8. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452.
9. Gurley SB Allred A Le TH. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest 2006; 116: 2218-2225.
10. Wosik K Cayrol R Dodelet-Devillers A. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: Relevance to multiple sclerosis. J Neurosci 2007; 27: 9032-9042.