The angiotensin AT2 receptor in inflammation

Drug News and Perspectives

Volumn 23, Issue 2, 2010, Pages 104-111

  Rompe, Franziska ^a   Unger, Thomas ^a   Steckelings, Ulrike Muscha ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; CYCLOOXYGENASE 2; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; IRBESARTAN; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; RANTES; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; VALSARTAN; ANTIINFLAMMATORY AGENT;

ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; BRAIN ISCHEMIA; CHRONIC INFLAMMATION; DIABETIC NEPHROPATHY; DRUG ANTAGONISM; HEART FAILURE; HEART INFARCTION; HUMAN; KIDNEY DISEASE; KIDNEY INJURY; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; STROKE; ANIMAL; CARDIOVASCULAR DISEASE; DISEASE MODEL; INFLAMMATION; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM;

EID: 77952404323     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2010.23.2.1475901     Document Type: Review

References (69)

1. de Gasparo, M., Catt, K.J., Inagami, T., Wright, J.W., Unger, T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000, 52(3): 415-472
2. Bader, M., Ganten, D. Update on tissue renin-angiotensin systems. J Mol Med 2008, 86(6): 615-621
3. Suzuki, Y., Ruiz-Ortega, M., Lorenzo, O., Ruperez, M., Esteban, V., Egido, J. Inflammation and angiotensin II. Int J Biochem Cell Biol 2003, 35(6): 881-900.
4. Whitebread, S., Mele, M., Kamber, B., de Gasparo, M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989, 163(1): 284-291 (Pubitemid 19227303)
5. Chiu, A.T., Herblin, W.F., McCall, D.E. et al. Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989, 165(1): 196-203.
6. Speth, R.C., Kim, K.H. Discrimination of two angiotensin II receptor subtypes with a selective agonist analogue of angiotensin II, p-aminophenylalanine6 angiotensin II. Biochem Biophys Res Commun 1990, 169(3): 997-1006.
7. Hein, L., Barsh, G.S., Pratt, R.E., Dzau, V.J., Kobilka, B.K. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995, 377(6551): 744-7.
8. Ichiki, T., Labosky, P.A., Shiota, C. et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995, 377(6551): 748-750
9. Nio, Y., Matsubara, H., Murasawa, S., Kanasaki, M., Inada, M. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 1995, 95(1): 46-54.
10. Haywood, G.A., Gullestad, L., Katsuya, T., Hutchinson, H.G., Pratt, R.E., Horiuchi, M., Fowler, M.B. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation 1997, 95(5): 1201-1206
11. Horiuchi, M., Akishita, M., Dzau, V.J. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 1999, 33(2): 613-621 (Pubitemid 29091636)
12. Li, J., Culman, J., Hortnagl, H. et al. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005, 19(6): 617-619 (Pubitemid 40471263)
13. Akishita, M., Horiuchi, M., Yamada, H. et al. Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genomics 2000, 2(1): 13-20.
14. Savoia, C., Tabet, F., Yao, G., Schiffrin, E.L., Touyz, R.M. Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. J Hypertens 2005, 23(5): 1037-1045 (Pubitemid 40637923)
15. Stoll, M., Steckelings, U.M., Paul, M., Bottari, S.P., Metzger, R., Unger, T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995, 95(2): 651-657
16. Kurisu, S., Ozono, R., Oshima, T. et al. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 2003, 41(1): 99-107.
17. Wu, L., Iwai, M., Li, Z. et al. Regulation of Inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Mol Endocrinol 2004, 18(3): 666-678
18. Tani, T., Ayuzawa, R., Takagi, T., Kanehira, T., Maurya, D.K., Tamura, M. Angiotensin II bidirectionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. Mol Cell Biochem 2008, 315(1-2): 185-193
19. Horiuchi, M., Hayashida, W., Akishita, M., Tamura, K., Daviet, L., Lehtonen, J.Y., Dzau, V.J. Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstolk. Circ Res 1999, 84(8): 876-882 (Pubitemid 29196731)
20. Esteban, V., Lorenzo, O., Ruperez, M. et al. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol 2004, 15(6): 1514-1529 (Pubitemid 38679676)
21. Laflamme, L., Gasparo, M., Gallo, J.M., Payet, M.D., Gallo-Payet, N. Angiotensin II induction of neurite outgrowth by AT2 receptors in NC108-15 cells. Effect counteracted by the AT1 receptors. J Biol Chem 1996, 271(37): 22729-35.
22. Wan, Y., Wallinder, C., Plouffe, B. et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004, 47(24): 5995-6008.
23. Nakajima, M., Hutchinson, H.G., Fujinaga, M. et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci U S A 1995, 92(23): 10663-10667
24. Wu, L., Iwai, M., Nakagami, H. et al. Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation 2001, 104(22): 2716-2721 (Pubitemid 33108140)
25. Libby, P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 2006, 83(2): 456S-60S.
26. Sales, V.L., Sukhova, G.K., Lopez-Ilasaca, M.A., Libby, P., Dzau, V.J., Pratt, R.E. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005, 112(21): 3328-3336 (Pubitemid 43739379)
27. Johansson, M.E., Wickman, A., Fitzgerald, S.M., Gan, L.M., Bergstrom, G. Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice. J Hypertens 2005, 23(8): 1541-1549
28. Zulli, A., Burrell, L.M., Widdop, R.E., Black, M.J., Buxton, B.F., Hare, D.L. Immunolocallzation of ACE2 and AT2 receptors in rabbit atherosclerotic plaques. J Histochem Cytochem 2006, 54(2): 147-150 (Pubitemid 43201635)
29. Johansson, M.E., Fagerberg, B., Bergstrom, G. Angiotensin type 2 receptor is expressed in human atherosclerotic lesions. J Renin Angiotensin Aldosterone Syst 2008, 9(1): 17-21.
30. Iwai, M., Chen, R., Li, Z. et al. Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation 2005, 112(11): 1636-1643
31. Hu, C., Dandapat, A., Chen, J., Liu, Y., Hermonat, P.L., Carey, R.M., Mehta, J.L. Overexpression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression. Atherosclerosis 2008, 199(2): 288-294
32. Daugherty, A., Manning, M.W., Cassis, L.A. Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br J Pharmacol 2001, 134(4): 865-870 (Pubitemid 33016158)
33. Kintscher, U., Unger, T. Does the AT2-receptor mediate anti-atherosclerotic actions? J Hypertens 2005, 23(8): 1469-1470
34. Ereso, A.Q., Ramirez, R.M., Sadjadi, J., Cripps, M.W., Cureton, E.L., Curran, B., Victorino, G.P. Angiotensin II type 2 receptor provides an endogenous brake during inflammation-Induced microvascular fluid leak. J Am Coll Surg 2007, 205(4): 527-533 (Pubitemid 47446335)
35. Wang, Q., Tang, X.N., Yenari, M.A. The inflammatory response in stroke. J Neuroimmunol 2007, 184(1-2): 53-68.
36. Steckelings, U.M., Bottari, S.P., Unger, T. Angiotensin receptor subtypes in the brain. Trends Pharmacol Sci 1992, 13(9): 365-368
37. Culman, J., Baulmann, J., Blume, A., Unger, T. The renin-angiotensin system in the brain: an update. J Renin Angiotensin Aldosterone Syst 2001, 2(2): 96-102.
38. Chapman, N., Huxley, R., Anderson, C. et al. Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history: the PROGRESS Trial. Stroke 2004, 35(1): 116-121
39. Kizer, J.R., Dahlof, B., Kjeldsen, S.E. et al. Stroke reduction in hypertensive adults with cardiac hypertrophy randomized to losartan versus atenolol: the Losartan Intervention For Endpoint reduction in hypertension study. Hypertension 2005, 45(1): 46-52. (Pubitemid 40066412)
40. Schrader, J., Luders, S., Kulschewski, A. et al. Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005, 36(6): 1218-1226
41. Krikov, M., Thone-Reineke, C., Muller, S., Villringer, A., Unger, T. Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats. J Hypertens 2008, 26(3): 544-552 (Pubitemid 351317265)
42. Lu, Q., Zhu, Y.Z., Wong, P.T. Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats. Neuroreport 2005, 16(17): 1963-1967 (Pubitemid 41653523)
43. Iwai, M., Liu, H.W., Chen, R. et al. Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation 2004, 110(7): 843-848 (Pubitemid 39096013)
44. McCarthy, C.A., Vinh, A., Callaway, J.K., Widdop, R.E. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke 2009, 40(4): 1482-1489
45. Ciuffo, G.M., Viswanathan, M., Seltzer, A.M., Tsutsumi, K., Saavedra, J.M. Glomerular angiotensin II receptor subtypes during development of rat kidney. Am J Physiol 1993, 265(2 Pt 2): F264-71.
46. Ozono, R., Wang, Z.Q., Moore, A.F., Inagami, T., Siragy, H.M., Carey, R.M. Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension 1997, 30(5): 1238-46.
47. Miyata, N., Park, F., Li, X.F., Cowley, A.W., Jr. Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Am J Physiol 1999, 277(3 Pt 2): F437-46.
48. Cao, Z., Kelly, D.J., Cox, A. et al. Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney Int 2000, 58(6): 2437-2451
49. Tejera, N., Gomez-Garre, D., Lazaro, A. et al. Persistent proteinuria up-regulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells. Am J Pathol 2004, 164(5): 1817-1826 (Pubitemid 38529784)
50. Hashimoto, N., Maeshima, Y., Satoh, M. et al. Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model. Am J Physiol Renal Physiol 2004, 286(3): F516-25.
51. Standards of medical care in diabetes-2008. Diabetes Care 2008, 31(Suppl. 1): S12-54.
52. Okada, H., Watanabe, Y., Inoue, T. et al. Angiotensin II type 1 receptor blockade attenuates renal fibrogenesis in an immune-mediated nephritic kidney through counter-activation of angiotensin II type 2 receptor. Biochem Biophys Res Commun 2004, 314(2): 403-408 (Pubitemid 38084731)
53. Okada, H., Inoue, T., Kikuta, T. et al. A possible anti-inflammatory role of angiotensin II type 2 receptor in immune-mediated glomerulonephritis during type 1 receptor blockade. Am J Pathol 2006, 169(5): 1577-1589
54. Benndorf, R.A., Krebs, C., Hirsch-Hoffmann, B. et al. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Kidney Int 2009, 75(10): 1039-1049
55. Ruiz-Ortega, M., Ruperez, M., Esteban, V., Rodriguez-Vita, J., Sanchez-Lopez, E., Carvajal, C., Egido, J. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transplant 2006, 21(1): 16-20.
56. Wolf, G., Ziyadeh, F.N., Thaiss, F. et al. Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. J Clin Invest 1997, 100(5): 1047-1058
57. Gelosa, P., Pignieri, A., Fandriks, L. et al. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens 2009, 27(12): 2444-2451
58. Tsutsumi, Y., Matsubara, H., Ohkubo, N. et al. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Circ Res 1998, 83(10): 1035-1046
59. Busche, S., Gallinat, S., Bohle, R.M. et al. Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction. A single-cell reverse transcriptase-polymerase chain reaction study. Am J Pathol 2000, 157(2): 605-611
60. Bove, C.M., Gilson, W.D., Scott, C.D. et al. The angiotensin II type 2 receptor and improved adjacent region function post-Mi. J Cardiovasc Magn Reson 2005, 7(2): 459-464
61. Adachi, Y., Saito, Y., Kishimoto, I. et al. Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice. Circulation 2003, 107(19): 2406-2408
62. Yang, Z., Bove, C.M., French, B.A. et al. Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation 2002, 106(1): 106-11.
63. Oishi, Y., Ozono, R., Yano, Y. et al. Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling. Hypertension 2003, 41(3 Pt 2): 814-818
64. Oishi, Y., Ozono, R., Yoshizumi, M., Akishita, M., Horiuchi, M., Oshima, T. AT2 receptor mediates the cardioprotective effects of AT1 receptor antagonist in post-myocardial infarction remodeling. Life Sci 2006, 80(1): 82-88
65. Xu, J., Carretero, O.A., Liu, YH., Shesely, E.G., Yang, F., Kapke, A., Yang, X.P. Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice. Hypertension 2002, 40(3): 244-250
66. Ichihara, S., Senbonmatsu, T., Price, E., Jr., Ichiki, T., Gaffney, F.A., Inagami, T. Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation 2002, 106(17): 2244-2249
67. Kaschina, E., Grzesiak, A., Li, J. et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 2008, 118(24): 2523-32.
68. Santi, F., Wieland, A., Stroeder, K. et al. Angiotensin AT2 receptor stimulation or AT1 receptor blockade act anti-inflammatory and anti-fibrotic in a mouse model of scleroderma. J Hypertens [19th Eur Meet Hypertens (June 12-16, Milan) 2009] 2009, 27(Suppl. 4): Abst 7A.3.
69. Steckelings, U.M., Stroeder, K., Reichenbach, A. et al. AT2 receptor stimulation and AT1 receptor blockade act anti-apoptotic and tissue-protective in experimental diabetic retinopathy. J Hypertens [19th Eur Meet Hypertens (June 12-16, Milan) 2009] 2009, 27(Suppl. 4): Abst 7A.6.