The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells

Molecular and Cellular Endocrinology

Volumn 122, Issue 1, 1996, Pages 59-67

  Meffert, Simone ^a,b   Stoll, Monika ^a,b   Steckelings, Ulrike M ^a,b   Bottari, Serge P ^c   Unger, Thomas ^a,b  

^a UNIVERSITY OF KIEL   (Germany)

^b German Institute for High Blood Pressure Research   (Germany)

^c CEA GRENOBLE   (France)

Author keywords

Angiotensin receptors; Differentiation; Growth; PC12W cells; PD123177: Losartan

Indexed keywords

1 (4 AMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDROIMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANTIMITOTIC AGENT; EPIDERMAL GROWTH FACTOR; LOSARTAN; TRITIUM; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; FETAL CALF SERUM; MITOGENESIS; NERVE CELL DIFFERENTIATION; NEURITE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; CELL STRAIN; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; IMIDAZOLES; PC12 CELLS; PYRIDINES; RATS; RECEPTORS, ANGIOTENSIN; SIGNAL TRANSDUCTION;

EID: 0030606680     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/0303-7207(96)03873-7     Document Type: Article

References (55)

1. [1] Timmermans, P.B.M.W.M., Wong, P.C., Chiu, A.T., Herblin, R.R., Say, J.A.M. and Smith, R.D. (1993) Angiotensin II receptors and angiotensin II receptors antagonists. Pharmacol. Rev. 45, 205-251.
2. [2] Mukoyama, M., Nakajama, M., Horiuchi, M., Sasamura, H., Pratt, R.E. and Dzau, V.J. (1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J. Biol. Chem. 268, 33, 24539-24542.
3. [3] Kambayashi, Y., Bardhan, S., Takakashi, K., Tsuzuki, S., Inui, H., Hamakubo, T. and Inagami, T. (1993) Molecular cloning of a novel angiotensin II receptor II isoform involved in phosphotyrosine phosphatase inhibition. J. Biol. Chem. 268, 24543-24546.
4. [4] Bottari, S.P., De Gasparo, M., Steckelings, U.M. and Levens, N. (1993) Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications, Frontiers Neuroendocrinol. 14, 123.
5. [5] Steckelings, U.M., Stoll, M., Metsärinne, K.P. and Unger, Th. (1993) New cardiovascular effects of angiotensin, II, Progress in Endocrinology 116, pp. 1-6, Parthenon Verlag, Baskerville.
6. [6] Geisterfer, A.A.T., Peach, M.J. and Owens, G.K. (1990) Angiotensin II induces hypertrophy but not hyperplasia of cultured rat aortic smooth muscle cells. Circ. Res. 62, 749-756.
7. [7] Paquet, J.C., Bandomin-Legros, M., Brunelle, G. and Meyer, P. (1990) Angiotensin II-induced proliferation of aortic myocytes inspontaneously hypertensive rats. J. Hypertens. 8, 565-572.
8. [8] Aceto, J.F. and Baker, K.M. (1990) [Sar1] angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am. J. Physiol. 258, H806-H813.
9. [9] Metsärinne, K.P., Stoll, M., Gohlke, P., Paul, M. and Unger, Th. (1993) Angiotensin II is antiproliferative for coronary endothelial cells in vitro. Pharmaceut. Pharmacol. Lett. 2, 150-152.
10. 2 receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 95, 651-657.
11. [11] Gehlert, D.R., Gachenheimer, S.L. and Schober, D.A. (1991) Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain. Neuroscience 44, 501-514.
12. [12] Obermüller, N., Unger Th, Culman, J., Gohlke, P., De Gasparo, M. and Bottari, S.P. (1991) Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci. Lett. 132, 11-15.
13. 2 angiotensin II receptor subtypes in the rat brain during development. Proc. Natl. Acad. Sci. USA 88, 11440-11444.
14. [14] Speth, R.C., Mei, L. and Yamamura, H.I. (1989) Angiotensin II receptor binding and actions in NG 108-15 cells. Peptide Res. 2, 232-239.
15. [15] Webb, M.L., Liu, E.C.K., Cohen, R.B., Hedberg, A., Bogosian, E.A., Monshizadegan, C.M., Serafino, R., Moreland, S., Murphy, T.J. and Dickenson, K.E.J. (1992) Molecular characterization of angiotensin type II receptors in rat pheochromocytoma cells, Peptides 13, 499-508.
16. [16] Leung, K.H., Roscoe, W.A., Smith, R.D., Timmermans, P.B.M.W.M. and Chiu, A.T. (1991) Regional distribution of two subtypes of angiotensin II receptor in rat brain using selective nonpeptide antagonists. Neurosci. Lett. 123, 95-98.
17. [17] Tsutsumi, K., Strömberg, C., Viswanathan, M. and Saavedra, J.M. (1991) Angiotensin II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensivity, and association with phosphoinoside hydrolysis. Endocrinology, 129, 1075-1082.
18. 2) in rat brain. Am. J. Physiol. 216, R209-R216.
19. 2 receptor modulates T-type calcium current in non-differentiated NG 108-15 cells. FEBS Lett. 309, 161-164.
20. 2+ current in non-differentiated NG 108-15 cells. J. Biol. Chem. 270, 1670-1674.
21. [21] Kater, S.B. and Mills, L.R. (1991) Regulation of growth cone behaviour by calcium. Neuroscience 11, 891-899.
22. [22] Greene, L.A. and Tischler, A.S. (1982) PC12 pheochromocytoma cultures in neurobiological research. Adv. Cell. Neurobiol. 3, 373-414.
23. [23] McPherson, G.A. (1985) Analysis of radioligand binding experiments: a collection of computer programs for the IBMPC. J. Pharmacol. Methods 14, 213-228.
24. [24] Glaser, B.M., D'Amore, P.A., Michels, P.G., Patz, A. and Fenselau, A. (1980) Demonstration of vasoproliferative activity from mammalian retina. J. Cell Biol. 84, 298-304.
25. 2 receptor (abstract). Circ. Res. (Suppl.), 2025.
26. [26] Nakajima, M., Horiuchi, M., Morishita, R., Yamada, T., Pratt, R.E. and Dzau, V.J. (1994) Growth inhibitory function of type 2 angiotensin II receptor. Gain of function study by in vivo gene transfer (abstract). Hypertension 24, 37.
27. 2 receptor gene highly expressed in fetal tissues. Receptors Channels 2, 271-280.
28. [28] Kang, J., Sumners, C. and Posner, P. (1993) Angiotensin II type 2 receptor-modulated changes in potassium currents in cultured neurons. Am. J. Physiol. 265, C607-C616.
29. + currents involves an inhibitory GTP binding protein. Am. J. Physiol. 267, C1389-C1397.
30. 2 receptor stimulates phospho tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem. Biophys. Res. Commun. 183, 206-211.
31. 2 Receptor mediated inhibition of particulate guanylate cyclase: a link with protein tyrosine phosphatase stimulation? Receptors Channels 2, 79-87.
32. 2 receptors are functionally coupled to tyrosine dephosphorylation in N1E-115 neuroblastoma cells. Biochem. J. 306, 87-92.
33. [33] Brechler, V., Reichlin, S., De Gasparo, M. and Bottari, S.P. (1994) Angiotensin II stimulates proteine tyrosine phosphatase activit through a G protein independent mechanism. Receptors Channels 2, 89-97.
34. [34] Lebrun, C., Blume, A., Herdegen, T., Seifert, K., Bravo, R. and Unger, Th. (1995) Angiotensin II induces a complex activation of transcription factors in the rat brain: expression of Fos, Jun and Krox proteins. Neuroscience 65, 93-99.
35. [35] Naftilan, A.J., Pratt, R.E. and Dzau, V.J. (1989) Angiotensin II induces c-fos expression in smooth muscle cells via transcriptional control. Hypertension 13, 706-711.
36. [36] Kawahara, Y., Sunako, M., Tsuda, T., Fukuzaki, H., Fukumoto, Y. and Takai, Y. (1988) Angiotensin II induces expression of c-fos gene through protein kinace C activation and calcium ion mobilization in cultured vascular smooth muscle cells. Biophsy. Biochem. Res. Commun. 150, 52-59.
37. 1 receptor subtype. Endocrinology 132, 2206-2212.
38. 1 receptors. FEBS Lett. 313, 43-46.
39. [39] Pietenpol, J.A., Holt, J.T., Stein, R.W. and Moses, H. (1990) TGFβ 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc. Natl. Acad. Sci. USA 87, 3758-3762.
40. [40] Ferez, P., Schonthal, A. and Aranda, A. (1993) Repression of c-fos gene expression by thyroid hormone and retinoic acid receptors. J. Biol. Chem. 268, 23538-23543.
41. [41] Trouche, D., Grigoriev, G., Lenormand, J.L., Robin, P., Leibovitch S A, Sassone-Corsi, P. and Harel-Bellan, A. (1993) Repression of c-fos promoter bei MyoD on cell differentiation. Nature 363, 79-82.
42. 2, J. Hypertens. 12 (Suppl. 3), 396.
43. [43] Roberts, T.M. (1992) A signal chain of events. Nature 360, 534-536.
44. [44] Sadoshima, J., Qiu, Z., Morgan, J.P. and Izumo, S. (1995) Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. Circ. Res. 76, 1-15.
45. [45] Traverse, S., Seedorf, K., Paterson, H., Marshall, C.J., Cohen, P. and Ullrich, A. (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4 (8), 694-701.
46. [46] Aparicio, L.F., Ocrant, I., Boylan, J.M. and Gruppuso, P.A. (1992) Protein tyrosine phosphatase activation during nerve growth factor-induced neuronal differentiation of PC12 cells. Cell Growth Differ. 3, 363-367.
47. [47] Lau, K.H.W. and Baylink, D.J. (1993) Phosphotyrosyl phosphatases: potential regulators of cell proliferation and differentiation. Crit. Rev. Oncogene. 4(4), 451-471.
48. [48] Nakafuku, M. and Kaziro, Y. (1993) Epidermal growth factor and transforming growth factor-alpha can induce neuronal differentiation of rat pheochromocytoma PC12 cells under particular culture conditions. FEBS Lett. 315, 227-232.
49. [49] Wu, C.F., Zhang, M. and Howard, B.D. (1993) K252a potentiates epidermal growth factor-induced differentiation of PC12 cells. J. Neurosci. Res. 36, 539-550.
50. [50] Griswold-Penner, I., Carlin, C.R. and Rosner, M.R. (1993) Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase. J. Biol. Chem. 268, 18, 13050-13054.
51. [51] Takemura, R., Okabe, S., Kobayashi and Hirokawa (1992) Reorganization of brain spectrin (fodrin) during differentiation of PC12 cells. Neuroscience 52, 381-391.
52. 2 receptors (abstract). Naunyn-Schmiedeberg's Arch. Pharmacol., (Suppl.), Vol. 351, 472.
53. [53] Bleuel, A., De Gasparo, M., Whitebread, S., Puttner, I. and Monard, D. (1994) Regulation of protease nexin-1 in cultured Schwann cells is mediated by angiotensin II receptors, J. Neurosci. 15, 750-761.
54. 125I]CGP42112 binding site in healing wounds of rat brain. Brain Res. 658, 265-270.
55. 125I]CGP42112 reveals a non-angiotensin II binding site in 1-methyl-4-phenylpyridine (MPP + )-induced brain injury Cell. Mol. Neurobiol. 14, 99-104.