메뉴 건너뛰기




Volumn 10, Issue 1, 2015, Pages 225-233

Drugging sphingosine kinases

Author keywords

[No Author keywords available]

Indexed keywords

SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; SPHINGOSINE KINASE; ADENOSINE TRIPHOSPHATE; CERAMIDE; ENZYME INHIBITOR; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

EID: 84921380792     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5008426     Document Type: Review
Times cited : (87)

References (71)
  • 1
    • 84883455835 scopus 로고    scopus 로고
    • Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
    • Kunkel, G. T., Maceyka, M., Milstien, S., and Spiegel, S. (2013) Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond Nat. Rev. Drug Discovery 12, 688-702
    • (2013) Nat. Rev. Drug Discovery , vol.12 , pp. 688-702
    • Kunkel, G.T.1    Maceyka, M.2    Milstien, S.3    Spiegel, S.4
  • 2
    • 84897954440 scopus 로고    scopus 로고
    • Second generation S1P pathway modulators: Research strategies and clinical developments
    • Bigaud, M., Guerini, D., Billich, A., Bassilana, F., and Brinkmann, V. (2014) Second generation S1P pathway modulators: research strategies and clinical developments Biochim. Biophys. Acta 1841, 745-758
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 745-758
    • Bigaud, M.1    Guerini, D.2    Billich, A.3    Bassilana, F.4    Brinkmann, V.5
  • 3
    • 34250832664 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
    • Brinkmann, V. (2007) Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology Pharmacol. Ther. 115, 84-105
    • (2007) Pharmacol. Ther. , vol.115 , pp. 84-105
    • Brinkmann, V.1
  • 11
    • 84904323486 scopus 로고    scopus 로고
    • Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors
    • Plano, D., Amin, S., and Sharma, A. K. (2014) Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors J. Med. Chem. 57, 5509-5524
    • (2014) J. Med. Chem. , vol.57 , pp. 5509-5524
    • Plano, D.1    Amin, S.2    Sharma, A.K.3
  • 14
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • Laviad, E. L., Albee, L., Pankova-Kholmyansky, I., Epstein, S., Park, H., Merrill, A. H., Jr., and Futerman, A. H. (2008) Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate J. Biol. Chem. 283, 5677-5684
    • (2008) J. Biol. Chem. , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3    Epstein, S.4    Park, H.5    Merrill, A.H.6    Futerman, A.H.7
  • 18
    • 84857873334 scopus 로고    scopus 로고
    • Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis
    • Chipuk, J. E., McStay, G. P., Bharti, A., Kuwana, T., Clarke, C. J., Siskind, L. J., Obeid, L. M., and Green, D. R. (2012) Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis Cell 148, 988-1000
    • (2012) Cell , vol.148 , pp. 988-1000
    • Chipuk, J.E.1    McStay, G.P.2    Bharti, A.3    Kuwana, T.4    Clarke, C.J.5    Siskind, L.J.6    Obeid, L.M.7    Green, D.R.8
  • 22
    • 0030961305 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum
    • Yatomi, Y., Igarashi, Y., Yang, L., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Ozaki, Y., and Kume, S. (1997) Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum J. Biochem. 121, 969-973
    • (1997) J. Biochem. , vol.121 , pp. 969-973
    • Yatomi, Y.1    Igarashi, Y.2    Yang, L.3    Hisano, N.4    Qi, R.5    Asazuma, N.6    Satoh, K.7    Ozaki, Y.8    Kume, S.9
  • 23
    • 77952755702 scopus 로고    scopus 로고
    • Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia
    • Sensken, S. C., Bode, C., Nagarajan, M., Peest, U., Pabst, O., and Graler, M. H. (2010) Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia J. Immunol. 184, 4133-4142
    • (2010) J. Immunol. , vol.184 , pp. 4133-4142
    • Sensken, S.C.1    Bode, C.2    Nagarajan, M.3    Peest, U.4    Pabst, O.5    Graler, M.H.6
  • 25
    • 45149134896 scopus 로고    scopus 로고
    • S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake
    • Peest, U., Sensken, S. C., Andreani, P., Hanel, P., Van Veldhoven, P. P., and Graler, M. H. (2008) S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake J. Cell. Biochem. 104, 756-772
    • (2008) J. Cell. Biochem. , vol.104 , pp. 756-772
    • Peest, U.1    Sensken, S.C.2    Andreani, P.3    Hanel, P.4    Van Veldhoven, P.P.5    Graler, M.H.6
  • 29
    • 33947147299 scopus 로고    scopus 로고
    • The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis
    • Olivera, A., Mizugishi, K., Tikhonova, A., Ciaccia, L., Odom, S., Proia, R. L., and Rivera, J. (2007) The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis Immunity 26, 287-297
    • (2007) Immunity , vol.26 , pp. 287-297
    • Olivera, A.1    Mizugishi, K.2    Tikhonova, A.3    Ciaccia, L.4    Odom, S.5    Proia, R.L.6    Rivera, J.7
  • 30
    • 64049113731 scopus 로고    scopus 로고
    • Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
    • Marsolais, D. and Rosen, H. (2009) Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nat. Rev. Drug Discovery 8, 297-307
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 297-307
    • Marsolais, D.1    Rosen, H.2
  • 31
    • 59849085488 scopus 로고    scopus 로고
    • Regulation of vascular permeability by sphingosine 1-phosphate
    • Wang, L. and Dudek, S. M. (2009) Regulation of vascular permeability by sphingosine 1-phosphate Microvasc. Res. 77, 39-45
    • (2009) Microvasc. Res. , vol.77 , pp. 39-45
    • Wang, L.1    Dudek, S.M.2
  • 34
    • 84888279260 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptors and sphingosine kinase 1: Novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers
    • Pyne, S., Edwards, J., Ohotski, J., and Pyne, N. J. (2012) Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers Front. Oncol. 2, 168
    • (2012) Front. Oncol. , vol.2 , pp. 168
    • Pyne, S.1    Edwards, J.2    Ohotski, J.3    Pyne, N.J.4
  • 35
    • 58149231552 scopus 로고    scopus 로고
    • Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
    • Li, J., Guan, H. Y., Gong, L. Y., Song, L. B., Zhang, N., Wu, J., Yuan, J., Zheng, Y. J., Huang, Z. S., and Li, M. (2008) Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival Clin. Cancer Res. 14, 6996-7003
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6996-7003
    • Li, J.1    Guan, H.Y.2    Gong, L.Y.3    Song, L.B.4    Zhang, N.5    Wu, J.6    Yuan, J.7    Zheng, Y.J.8    Huang, Z.S.9    Li, M.10
  • 37
    • 0026656429 scopus 로고
    • Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways
    • Buehrer, B. M. and Bell, R. M. (1992) Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways J. Biol. Chem. 267, 3154-3159
    • (1992) J. Biol. Chem. , vol.267 , pp. 3154-3159
    • Buehrer, B.M.1    Bell, R.M.2
  • 39
    • 0034643903 scopus 로고    scopus 로고
    • Human sphingosine kinase: Molecular cloning, functional characterization and tissue distribution
    • Melendez, A. J., Carlos-Dias, E., Gosink, M., Allen, J. M., and Takacs, L. (2000) Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution Gene 251, 19-26
    • (2000) Gene , vol.251 , pp. 19-26
    • Melendez, A.J.1    Carlos-Dias, E.2    Gosink, M.3    Allen, J.M.4    Takacs, L.5
  • 44
    • 79956301884 scopus 로고    scopus 로고
    • FTY720 analogues as sphingosine kinase 1 inhibitors: Enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells
    • Lim, K. G., Tonelli, F., Li, Z., Lu, X., Bittman, R., Pyne, S., and Pyne, N. J. (2011) FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells J. Biol. Chem. 286, 18633-18640
    • (2011) J. Biol. Chem. , vol.286 , pp. 18633-18640
    • Lim, K.G.1    Tonelli, F.2    Li, Z.3    Lu, X.4    Bittman, R.5    Pyne, S.6    Pyne, N.J.7
  • 46
    • 78649876185 scopus 로고    scopus 로고
    • The sphingosine kinase 1 inhibitor 2-(p -hydroxyanilino)-4-(p -chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
    • Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J., and Pyne, S. (2010) The sphingosine kinase 1 inhibitor 2-(p -hydroxyanilino)-4-(p -chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells J. Biol. Chem. 285, 38841-38852
    • (2010) J. Biol. Chem. , vol.285 , pp. 38841-38852
    • Loveridge, C.1    Tonelli, F.2    Leclercq, T.3    Lim, K.G.4    Long, J.S.5    Berdyshev, E.6    Tate, R.J.7    Natarajan, V.8    Pitson, S.M.9    Pyne, N.J.10    Pyne, S.11
  • 47
    • 77952907876 scopus 로고    scopus 로고
    • A novel mode of action of the putative sphingosine kinase inhibitor 2-(p -hydroxyanilino)-4-(p -chlorophenyl) thiazole (SKI II): Induction of lysosomal sphingosine kinase 1 degradation
    • Ren, S., Xin, C., Pfeilschifter, J., and Huwiler, A. (2010) A novel mode of action of the putative sphingosine kinase inhibitor 2-(p -hydroxyanilino)-4-(p -chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation Cell. Physiol. Biochem. 26, 97-104
    • (2010) Cell. Physiol. Biochem. , vol.26 , pp. 97-104
    • Ren, S.1    Xin, C.2    Pfeilschifter, J.3    Huwiler, A.4
  • 48
    • 84905057004 scopus 로고    scopus 로고
    • Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II
    • Cingolani, F., Casasampere, M., Sanllehi, P., Casas, J., Bujons, J., and Fabrias, G. (2014) Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II J. Lipid Res. 55, 1711-1720
    • (2014) J. Lipid Res. , vol.55 , pp. 1711-1720
    • Cingolani, F.1    Casasampere, M.2    Sanllehi, P.3    Casas, J.4    Bujons, J.5    Fabrias, G.6
  • 49
    • 84871858878 scopus 로고    scopus 로고
    • Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis
    • Snider, A. J., Ruiz, P., Obeid, L. M., and Oates, J. C. (2013) Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis PLoS One 8, e53521
    • (2013) PLoS One , vol.8 , pp. 53521
    • Snider, A.J.1    Ruiz, P.2    Obeid, L.M.3    Oates, J.C.4
  • 50
    • 79951855994 scopus 로고    scopus 로고
    • Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2
    • Fitzpatrick, L. R., Green, C., Maines, L. W., and Smith, C. D. (2011) Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2 Pharmacology 87, 135-143
    • (2011) Pharmacology , vol.87 , pp. 135-143
    • Fitzpatrick, L.R.1    Green, C.2    Maines, L.W.3    Smith, C.D.4
  • 51
    • 34247150639 scopus 로고    scopus 로고
    • Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: Implications for angiogenic ocular diseases
    • Maines, L. W., French, K. J., Wolpert, E. B., Antonetti, D. A., and Smith, C. D. (2006) Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases Invest. Ophthalmol. Visual Sci. 47, 5022-5031
    • (2006) Invest. Ophthalmol. Visual Sci. , vol.47 , pp. 5022-5031
    • Maines, L.W.1    French, K.J.2    Wolpert, E.B.3    Antonetti, D.A.4    Smith, C.D.5
  • 52
  • 56
    • 84874670502 scopus 로고    scopus 로고
    • Characterization of isoenzyme-selective inhibitors of human sphingosine kinases
    • Gao, P., Peterson, Y. K., Smith, R. A., and Smith, C. D. (2012) Characterization of isoenzyme-selective inhibitors of human sphingosine kinases PLoS One 7, e44543
    • (2012) PLoS One , vol.7 , pp. 44543
    • Gao, P.1    Peterson, Y.K.2    Smith, R.A.3    Smith, C.D.4
  • 57
    • 79952343738 scopus 로고    scopus 로고
    • Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
    • Beljanski, V., Lewis, C. S., and Smith, C. D. (2011) Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts Cancer Biol. Ther. 11, 524-534
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 524-534
    • Beljanski, V.1    Lewis, C.S.2    Smith, C.D.3
  • 58
    • 77951085269 scopus 로고    scopus 로고
    • A novel sphingosine kinase inhibitor induces autophagy in tumor cells
    • Beljanski, V., Knaak, C., and Smith, C. D. (2010) A novel sphingosine kinase inhibitor induces autophagy in tumor cells J. Pharmacol. Exp. Ther. 333, 454-464
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 454-464
    • Beljanski, V.1    Knaak, C.2    Smith, C.D.3
  • 60
    • 79954625512 scopus 로고    scopus 로고
    • A phase i clinical trial of safingol in combination with cisplatin in advanced solid tumors
    • Dickson, M. A., Carvajal, R. D., Merrill, A. H., Jr., Gonen, M., Cane, L. M., and Schwartz, G. K. (2011) A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors Clin. Cancer Res. 17, 2484-2492
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2484-2492
    • Dickson, M.A.1    Carvajal, R.D.2    Merrill, A.H.3    Gonen, M.4    Cane, L.M.5    Schwartz, G.K.6
  • 67
    • 84860810481 scopus 로고    scopus 로고
    • Building a better sphingosine kinase-1 inhibitor
    • Lynch, K. R. (2012) Building a better sphingosine kinase-1 inhibitor Biochem. J. 444, e1-2
    • (2012) Biochem. J. , vol.444 , pp. 1-2
    • Lynch, K.R.1
  • 68
    • 84874255475 scopus 로고    scopus 로고
    • Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent
    • Liu, K., Guo, T. L., Hait, N. C., Allegood, J., Parikh, H. I., Xu, W., Kellogg, G. E., Grant, S., Spiegel, S., and Zhang, S. (2013) Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent PLoS One 8, e56471
    • (2013) PLoS One , vol.8 , pp. 56471
    • Liu, K.1    Guo, T.L.2    Hait, N.C.3    Allegood, J.4    Parikh, H.I.5    Xu, W.6    Kellogg, G.E.7    Grant, S.8    Spiegel, S.9    Zhang, S.10
  • 69
    • 79957775905 scopus 로고    scopus 로고
    • Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells
    • Kennedy, A. J., Mathews, T. P., Kharel, Y., Field, S. D., Moyer, M. L., East, J. E., Houck, J. D., Lynch, K. R., and Macdonald, T. L. (2011) Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells J. Med. Chem. 54, 3524-3548
    • (2011) J. Med. Chem. , vol.54 , pp. 3524-3548
    • Kennedy, A.J.1    Mathews, T.P.2    Kharel, Y.3    Field, S.D.4    Moyer, M.L.5    East, J.E.6    Houck, J.D.7    Lynch, K.R.8    Macdonald, T.L.9
  • 70
    • 84866379271 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate
    • Kharel, Y., Raje, M., Gao, M., Gellett, A. M., Tomsig, J. L., Lynch, K. R., and Santos, W. L. (2012) Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate Biochem. J. 447, 149-157
    • (2012) Biochem. J. , vol.447 , pp. 149-157
    • Kharel, Y.1    Raje, M.2    Gao, M.3    Gellett, A.M.4    Tomsig, J.L.5    Lynch, K.R.6    Santos, W.L.7
  • 71
    • 84886101285 scopus 로고    scopus 로고
    • Roles, regulation and inhibitors of sphingosine kinase 2
    • Neubauer, H. A. and Pitson, S. M. (2013) Roles, regulation and inhibitors of sphingosine kinase 2 FEBS J. 280, 5317-5336
    • (2013) FEBS J. , vol.280 , pp. 5317-5336
    • Neubauer, H.A.1    Pitson, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.