Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase

Inflammopharmacology

Volumn 19, Issue 2, 2011, Pages 75-87

  Fitzpatrick, Leo R ^a   Green, Cecelia ^b   Frauenhoffer, Elizabeth E ^a   French, Kevin J ^b   Zhuang, Yan ^b   Maines, Lynn W ^b   Upson, John J ^b   Paul, Emmanuel ^a   Donahue, Henry ^a   Mosher, Timothy J ^a   Smith, Charles D ^b,c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b APOGEE BIOTECHNOLOGY CORPORATION   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

ABC 294640; Arthritis; Rodents; Sphingosine kinase

Indexed keywords

3 (4 CHLOROPHENYL)ADAMANTANE 1 CARBOXYLIC ACID(PYRIDIN 4 YLMETHYL)AMIDE; ABC 294640; ANTIRHEUMATIC AGENT; COLLAGEN; ENZYME INHIBITOR; INDOMETACIN; METHOTREXATE; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; CARTILAGE DEGENERATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG POTENTIATION; DRUG SCREENING; FEMALE; HISTOLOGY; MICRO-COMPUTED TOMOGRAPHY; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPLENOMEGALY; STOMACH INJURY;

ADAMANTANE; ADMINISTRATION, ORAL; ANIMALS; ANKLE; ANKLE JOINT; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; DRUG THERAPY, COMBINATION; EDEMA; ENZYME INHIBITORS; FEMALE; FOOT; INDOMETHACIN; INFLAMMATION; METHOTREXATE; MICE; MICE, INBRED DBA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PYRIDINES; RATS; RATS, INBRED LEW; SPLENOMEGALY; X-RAY MICROTOMOGRAPHY;

EID: 79958190513     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-010-0060-6     Document Type: Article

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