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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4550-4554

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

(10) Xiang, Yibin a Hirth, Bradford a Kane Jr , John L a Liao, Junkai a Noson, Kevin D a Yee, Christopher a Asmussen, Gary a Fitzgerald, Maria a Klaus, Christine a Booker, Michael a

a GENZYME CORPORATION (United States)

Author keywords

3 Hydroxypyrrolidine 2 carboxamides; ADME; Enzyme; Heterocycles; Inhibitors; Oxadiazole; PK; SK1; Solubility; Sphingosine kinase

Indexed keywords

PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SOLUBILITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; MICROSOME; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BENZALDEHYDES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; LITHIUM; MICROSOMES, LIVER; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RATS;

RATTUS;

EID: 77955412772 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.019 Document Type: Article

Times cited : (43)

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