Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: Role of mTORC2/SGK1 pathway

Experimental Cell Research

Volumn 331, Issue 1, 2015, Pages 164-175

  He, Jing ^a   Qi, Di ^a   Wang, Dao xin ^a   Deng, Wang ^a   Ye, Yuan ^a   Feng, Long hua ^a   Zhu, Tao ^b   Zhao, Yan ^a   Zhang, Chun rong ^c  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Acute lung injury; Alveolar fluid clearance; Epithelial sodium channel; Insulin; Mammalian target of rapamycin complex; Serum and glucocorticoid induced kinase 1

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; 2 MORPHOLINO 8 PHENYLCHROMONE; EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL ALPHA; EPITHELIAL SODIUM CHANNEL BETA; EPITHELIAL SODIUM CHANNEL GAMMA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; RECOMBINANT HUMAN INSULIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; IMMEDIATE EARLY PROTEIN; INSULIN; MESSENGER RNA; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM CELL; LUNG EDEMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENZYME IMMUNOASSAY; GENETICS; IMMUNOPRECIPITATION; IN VITRO STUDY; LUNG ALVEOLUS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

MAMMALIA;

ACUTE LUNG INJURY; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; EPITHELIAL SODIUM CHANNELS; HUMANS; HYPOGLYCEMIC AGENTS; IMMEDIATE-EARLY PROTEINS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; IN VITRO TECHNIQUES; INSULIN; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ALVEOLI; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84921305474     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.09.024     Document Type: Article

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