Lung epithelial fluid transport and the resolution of pulmonary edema

Physiological Reviews

Volumn 82, Issue 3, 2002, Pages 569-600

  Matthay, Michael A ^a   Folkesson, Hans G ^a   Clerici, Christine ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANESTHETIC AGENT; ATRIAL NATRIURETIC FACTOR; CARRIER PROTEIN; CATECHOLAMINE; CHLORIDE TRANSPORTER; NITROGEN DERIVATIVE; REACTIVE NITROGEN METABOLITE; REACTIVE OXYGEN METABOLITE; SODIUM; SODIUM CHANNEL; SODIUM TRANSPORTER; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; WATER;

BIRTH; DISEASE COURSE; FLUID BALANCE; HUMAN; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG FLUID; MEDICAL RESEARCH; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SODIUM TRANSPORT; WATER TRANSPORT;

EID: 0036300549     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00003.2002     Document Type: Review

References (391)

1. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome A randomized, controlled, doubleblind, multicenter clinical trial TNF-alpha MAb Sepsis Study Group
2. Aquaporin null phenotypes: The importance of classical physiology
3. Aquaporin CHIP: The archetypal molecular water channel
4. +ATPase α1 gene expression through the interaction of aldosterone and cAMP-inducible transcriptional factors
5. Regulation of Na and Cl transport in sheep distal airways
6. + channel
7. Catecholamines increase lung edema clearance in rats with increased left atrial pressure
8. Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia
9. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
10. + transport in rat fetal distal lung epithelial cells
11. Is NO news bad news in acute respiratory distress syndrome?
12. Epidermal growth factor potentiates cyclic AMP accumulation in A-431 cells
13. Regional bioelectric properties of porcine airway epithelium
14. Bioelectric properties of proximal bronchiolar epithelium
15. + absorption
16. Role of γENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism
17. Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium
18. Stimulation of the dopamine 1 receptor increases lung edema clearance
19. Beta-adrenergic receptors and their regulation
20. Dexamethasone upregulates the Na-K-ATPase in rat alveolar epithelial cells
21. Significance of active ion transport in transalveolar water absorption: A study on isolated rat lung
22. Fluid absorption by rat lung in situ: Pathways for sodium entry in the luminal membrane of alveolar epithelium
23. Apical sodiumsugar transport in pulmonary epithelium in situ
24. Peroxynitrite inhibits sodium uptake in rat colonic membrane vesicles
25. Regulation of epithelial sodium channels by short actin filaments
26. Effect of exogenous cAMP and aminophylline on alveolar and lung liquid clearance in anesthetized sheep
27. Protein clearance from the airspaces and lungs of unanesthetized sheep over 144 h
28. Alveolar liquid and protein clearance from normal dog lungs
29. Protein kinase C activation does not stimulate lung liquid clearance in anesthetized sheep
30. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep
31. Short-term regulation of renal Na-KATPase activity: Physiological relevance and cellular mechanisms
32. +-ATPase activity by membrane insertion of α-subunits in lung alveolar cells
33. Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart
34. +-ATPase isozymes by protein kinases and arachidonic acid
35. + channel lacking the pore-forming region of its α subunit
36. TNFα stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats
37. Effects of EGF and dexamethasone on bioelectric properties of alveolar epithelial cell monolayers
38. Sodium transport proteins are expressed by rat alveolar epithelial type I cells
39. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: Expression of aquaporin 5
40. KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells
41. Human airway ion transport. Part one
42. Human airway ion transport. Part two
43. Endotoxin and lung injury
44. Increased sheep lung vascular permeability caused by Pseudomonas bacteremia
45. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb
46. Sodium-amino acid cotransport by type II alveolar epithelial cells
47. Molecular mechanisms of local anesthesia: A review
48. cAMP-sensitive endocytic trafficking in A6 epithelia
49. Alveolar fluid clearance persists in the presence of moderate left atrial hypertension in sheep
50. Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures
51. Membrane topology of the epithelial sodium channel in intact cells
52. + channel is made of three homologous subunits
53. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method
54. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method
55. Hyperoxic effects on alveolar sodium resorption and lung Na-K-ATPase
56. Effects of hyperoxia on type II cell Na-K-ATPase function and expression
57. The effects of bumetanide and furosemide on lung liquid secretion in fetal sheep
58. 99mTc DTPA radioaerosol inhalation lung scan
59. Effect of epinephrine on alveolar liquid clearance in the rat
60. Tight monolayers of rat alveolar epithelial cells: Bioelectric properties and active sodium transport
61. β-adrenergic regulation of amiloride-sensitive lung sodium channels
62. Soluble transforming growth factor-α is present in the pulmonary edema fluid of patients with acute lung injury
63. Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis
64. Hormonal regulation and genomic organization of the human amiloride-sensitive epithelial sodium channel α subunit gene
65. Lung surfactant: A personal perspective
66. Pulmonary surface tension and alveolar stability
67. 2 tension
68. Evidence for Na-K-Cl cotransport in alveolar epithelial cells: Effect of phorbol ester and osmotic stress
69. Sodium-dependent phosphate and alanine transports but sodium-independent hexose transport in type II alveolar epithelial cells in primary culture
70. β-adrenoceptor-mediated control over the conductive properties of the apical membrane in distal lung epithelia
71. + transport by an L-Arg-dependent mechanism
72. Modulation of bioelectric properties across alveolar type II cells by substratum
73. Stimulation of net active ion transport across alveolar type II cell monolayers
74. Effect of terbutaline on sodium transport in isolated perfused rat lung
75. Alveolar epithelial transport. Basic science to clinical medicine
76. Morphometric characteristics of cells in the alveolar region of mammalian lungs
77. +-ATPase by cAMP and dexamethasone in alveolar epithelial cells
78. The α subunit of the epithelial sodium channel in the mouse: Developmental regulation of its expression
79. Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells
80. Isolation and characterization of a digoxin-like immunoreactive substance from human urine by affinity chromatography
81. The type II epithelial cells of the lung. IV. Adaptation and behavior of isolated type II cells in culture
82. Cloning and widespread distribution of the rat rod-type cyclic nucleotide-gated cation channel
83. Inhibition of amiloride-sensitive sodium-channel activity in distal lung epithelial cells by nitric oxide
84. Highly water permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung
85. Maintenance of the differentiated type II cell phenotype by culture with an apical air surface
86. Changes in biochemical characteristics and pattern of lectin binding of alveolar type II cells with time in culture
87. Cell-specific expression of epithelial sodium channel α, β, and γ subunits in aldosterone-responsive epithelia from the rat: Localization by in situ hybridization and immunocytochemistry
88. 2-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats
89. +/glucose cotransport
90. + currents in Xenopus oocytes expressing αβγ-rENaC
91. Osmotic extraction of hypotonic fluid from the lungs
92. Fluid and solute transport in the airspaces of the lungs
93. Protein concentrations have little effect on reabsorption of fluid from isolated rat lungs
94. New evidence for active sodium transport from fluid-filled rat lungs
95. Expression of the cystic fibrosis gene in adult human lung
96. Noncoordinate regulation of epithelial Na channel and Na pump subunit mRNAs in kidney and colon by aldosterone
97. Number of subunits comprising the epithelial sodium channel
98. Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. I. Analysis, characterization and regulation of specific beta adrenergic receptors
99. 2-adrenergic receptor overexpression increases alveolar fluid clearance by upregulating solute transport proteins on both sides of the cell membrane
100. +-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats
101. Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen
102. 1 subunit gene
103. Novel role for CFTR in fluid absorption from the distal airspaces of the lung
104. + channel along rat respiratory tract
105. Identification of nonselective cation channels in cultured adult rat alveolar type II cells
106. +-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the α-subunit at Tyr-10
107. Ouabain-like factor quantification in mammalian tissues and plasma: Comparison of two independent assays
108. 2 in man
109. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment
110. Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs
111. The heterotetrameric architecture of the epithelial sodium channel (ENaC)
112. Transepithelial water permeability in microperfused distal airways: Evidence for channel-mediated water transport
113. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels
114. Alveolar epithelial clearance of protein
115. Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin
116. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats
117. Evidence for chloride transport in adult and developing guinea pig lung
118. Transforming growth factor-α increases alveolar liquid clearance in anesthetized ventilated rats
119. Permeability of the respiratory tract to different-sized macromolecules after intratracheal instillation in young and adult rats
120. β-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats
121. Relationship of interstitial fluid volume to alveolar fluid clearance in mice: Ventilated versus in situ studies
122. Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium
123. Early expression of β- and γ-subunits of epithelial sodium channel during human airway development
124. New in situ mouse model to quantify alveolar epithelial fluid clearance
125. Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats
126. Epithelial sodium channels: Function, structure, and regulation
127. Liquid and ion transport by fetal airway and lung epithelia of mice deficient in sodium-potassium-2-chloride transporter
128. +-ATPase function in alveolar type II cells
129. Lung fluid clearance
130. Evidence for regulation of sodium transport from airspace to vascular space by cAMP
131. Dome formation in primary cultured monolayers of alveolar epithelial cells
132. + transport by cultured monolayers of pulmonary alveolar epithelial cells
133. Evidence for active sodium transport across alveolar epithelium of isolated rat lung
134. Differential permeability of endothelial and epithelial barriers to albumin flux
135. Alveolar liquid clearance in multiple nonperfused canine lung lobes
136. Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms
137. Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs
138. Amiloride-sensitive sodium channels contribute to the woes of the flu
139. Breaking through the tight junction barrier
140. Intravenous keratinocyte growth factor protects against experimental pulmonary injury
141. + absorption across cultured alveolar type II monolayers
142. Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy
143. Mechanisms of peroxynitrite-induced injury to pulmonary surfactants
144. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury
145. Adrenoreceptor control of lung fluid and protein exchange
146. Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo
147. Modification of sodium transport and alveolar fluid clearance by hypoxia. Mechanisms and physiological implications
148. Hyperbaric oxygenation upregulates rat lung Na, K-ATPase
149. Upregulation of sodium conductive pathways in alveolar type II cells in sublethal hyperoxia
150. Clearance of different-sized proteins from the alveolar space in humans and rabbits
151. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits
152. Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway
153. Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells
154. Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice
155. Alveolar sodium and liquid transport in mice
156. 2+
157. Protective effect of α-human atrial natriuretic polypeptide (α-hANP) on chemical-induced pulmonary edema
158. Developmental changes of fetal rat lung Na-K-ATPase after maternal treatment with dexamethasone
159. Regulation of ion transport across porcine distal bronchi
160. The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium
161. +-ATPase activity in alveolar type II cells
162. Antisense oligonucleotides against the α-subunit of ENaC decrease lung epithelial cation-channel activity
163. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions
164. Alveolar liquid and protein clearance in anesthetized ventilated rats
165. - channels
166. - channel activation and transport function in cultures with an apical air interface
167. Evidence for the role of alveolar epithelial gp60 in active transalveolar albumin transport in the rat lung
168. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis
169. Polarity of alveolar epithelial cell acid-base permeability
170. A novel role for cyclic nucleotide-gated cation channels in lung liquid homeostasis in sheep
171. Loss of caveolin expression in type I pneumocytes as an indicator of subcellular alterations during lung fibrogenesis
172. Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels
173. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism
174. 2-Deoxy-D-glucose uptake by rat granular pneumocytes in primary culture
175. Tumor necrosis factor-α in ischemia and reperfusion injury in rat lungs
176. - fluxes to net ion transport by alveolar epithelium
177. Models for investigation of peptide and protein transport across cultured mammalian respiratory epithelial barriers
178. 14C]albumin transport across bullfrog alveolar epithelium
179. Man is not a rodent. Aquaporins in the airways
180. Aquaporin-1 water channel protein in lung. Ontogeny, steroid-induced expression, and distribution in rat
181. Aquaporin-5 is expressed in rat type I pneumocytes
182. Aquaporins in health and disease
183. + channels in A 6 cells
184. Subunit stoichiometry of the epithelial sodium channel
185. Expression and localization of epithelial aquaporins in the adult human lung
186. Mineralocorticoid receptors in the rat lung
187. + channels in respiratory epithelia
188. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia
189. Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats
190. α-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock
191. Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema
192. Terbutaline stimulates alveolar fluid resorption in hyperoxic lung injury
193. + transport in ATII cells by cAMP: We agree to disagree and do more experiments
194. + channels by dexamethasone
195. - secretion across rat fetal distal lung epithelial cells
196. A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase
197. 3 stimulation of alveolar epithelial Na,K-ATPase
198. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: Involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression
199. Osmotic regulation of aquaporin-5 regulation in alveolar epithelial cells in primary culture
200. The role of tumor necrosis factor in increased airspace epithelial permeability in acute lung inflammation
201. 2 adrenergic receptors are expressed in alveolar type I cells
202. Synthesis of surfactant components by cultured type II cells from human lung
203. + channel subunits in rat taste cells: Localization and regulation by aldosterone
204. + channel are differently regulated by aldosterone
205. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: Possible role of SGK
206. Lung fluid transport in aquaporin-5 knockout mice
207. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
208. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers
209. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia
210. Dose-response relationship between plasma epinephrine concentration and alveolar liquid clearance in dogs
211. Beta agonist regulation of sodium transport in fetal lung epithelium: Roles of cell volume, cytosolic chloride and protein tyrosine kinase
212. - in fetal rat alveolar epithelium
213. 2+-induced modulation of ion selectivity and amiloride sensitivity of a cation channel and beta agonist action in fetal lung epithelium
214. Transepithelial transport by pulmonary alveolar type II cells in primary culture
215. Mechanisms and regulation of ion transport in adult mammalian alveolar type II pneumocytes
216. + channels in alveolar epithelial cells
217. + conductive pathways in alveolar type II pneumocytes
218. Peroxynitrite inhibition of oxygen consumption and ion transport in alveolar type II pneumocytes
219. + conductance in adult alveolar pneumocytes
220. Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties, and physiological significance
221. Rates of protein transport across rat alveolar epithelial cell monolayers
222. Tyrosine kinase regulates epithelial sodium transport in A 6 cells
223. Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization
224. Pathophysiology of pulmonary edema
225. Severe sepsis - A new treatment with both anticoagulant and anti-inflammatory properties
226. Long-term clearance of liquid and protein from the lungs of unanesthetized sheep
227. Alveolar epithelial barrier and acute lung injury
228. Salt and water transport across alveolar and distal airway epithelium in the adult lung
229. Differential liquid and protein clearance from the alveoli of anesthetized sheep
230. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans
231. Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A 6 renal cells
232. + channel
233. + channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype
234. Lung β-adrenoreceptor blockade affects perinatal surfactant release but not lung water
235. The sodium pump needs its β subunit
236. 2-adrenergic receptors to type II cells increases alveolar fluid clearance
237. Diversity of channels generated by different combinations of epithelial sodium channel subunits
238. Rat lung alveolar type II cell line maintains sodium transport characteristics of primary culture
239. +-ATPase expression in alveolar type II cells
240. Inhibition of β-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock
241. Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats
242. Effects of halothane on surfactant biosynthesis by rat alveolar type II cells in primary culture
243. 1-proteinase inhibitor by peroxynitrite
244. 2-agonists to increase alveolar liquid clearance
245. Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein
246. A cyclic nucleotide-gated conductance in olfactory receptor cilia
247. Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: Implications for alveolar epithelial type I cell function
248. A novel alveolar type I cell-specific biochemical marker of human acute lung injury
249. 2-ARS) in the alveolar septum of the rat
250. Response of rat type II pneumocyte Na,K-ATPase to hyperoxic injury
251. Upregulation of rat lung Na-K-ATPase during hyperoxic injury
252. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia
253. Halothane does not decrease amiloride-sensitive alveolar fluid clearance in rabbits
254. cAMP activation of chloride and fluid secretion across the rabbit alveolar epithelium
255. Electrolyte composition of pulmonary alveolar subphase in anesthetized rabbits
256. + antiport in type II alveolar epithelial cells
257. Role of endogenous cortisol in basal liquid clearance from distal air spaces in adult guinea-pigs
258. Alveolar liquid clearance in the anesthetized ventilated guinea pig
259. Alveolar liquid clearance in late gestational guinea pigs after induction of labor: Mechanisms and regulation
260. Calcium-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs
261. Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats
262. Fetal lung liquid secretion. Insights using the tools of inhibitors and genetic knock-out experiments
263. Pulmonary edema fluid movement within the lung
264. + channel in the developing rat lung
265. + nor Na-glucose symport inhibitors slow neonatal lung water clearance
266. Amiloride impairs lung water clearance in newborn guinea pigs
267. - channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells
268. αENaC: Leading the charge
269. ANF decreases active sodium transport and increases alveolar epithelial permeability in rats
270. Active sodium transport and alveolar epithelial Na-K-ATPase increase during subacute hyperoxia in rats
271. Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats
272. Lung liquid clearance and Na,K-ATPase during acute hyperoxia and recovery in rats
273. Ion transport and water flow in the mammalian lung
274. Cation selective channel in fetal alveolar type II epithelium
275. Translational activation and repression by distinct elements within the 5′-UTR of ENaC α-subunit mRNA
276. Structure and hormone responsiveness of the gene encoding the α-subunit of the rat amiloride-sensitive epithelial sodium channel
277. Regulation of Na channels of the rat cortical collecting tubule by aldosterone
278. Tumor necrosis factor stimulates amino acid transport in plasma membrane vesicles from rat liver
279. Total lung lymph flow and fluid compartmentation in edematous dog lungs
280. β-agonists regulate Na,K-ATPase via novel MAPK/ERK and rapamycin-sensitive pathways
281. Airway structures. Tracheobronchial airway structure as revealed by casting techniques
282. Morphologic changes in the lung during the lifespan of Fischer 344 rats
283. 2 alters the bioelectric properties of fetal distal lung epithelium
284. Expression of α-, β-, and γ-hENaC mRNA in the human nasal, bronchial, and distal lung epithelium
285. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats
286. TGF-β is a critical mediator of acute lung injury
287. Endothelial exposure to Pseudomonas aeruginosa proteases increases the vulnerability of the alveolar epithelium to a second injury
288. Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats
289. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody
290. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats
291. Resistance of the alveolar epithelium to injury from septic shock in sheep
292. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells
293. Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line
294. 2-induced ENaC expression is associated with NF-κB activation and blocked by superoxide scavenger
295. Ultrastructural demonstration of guanylate cyclase in rat lung after activation by ANF
296. 2 upon transepithelial ion transport in fetal rat distal lung epithelial cells
297. - channel function
298. Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel
299. + channel in colon, lung and kidney
300. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism
301. Halothane and isoflurane decrease alveolar epithelial fluid clearance in rats
302. Single potassium channels blocked by lidocaine and quinidine in isolated turtle colon epithelial cells
303. Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells
304. Trafficking and cell surface stability of ENaC
305. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome
306. Active transport and passive liquid movement in isolated perfused rat lungs
307. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs
308. Alveolar fluid clearance in the resected human lung
309. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep
310. Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats
311. Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia
312. Dopamine restores lung ability to clear edema in rats exposed to hyperoxia
313. Electrolyte and fluid transport across the mature alveolar epithelium
314. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
315. Glucocorticoid induction of epithelial sodium channel expression in lung and renal epithelia occurs via transactivation of a hormone response element in the 5′-flanking region of the human epithelial sodium channel a subunit gene
316. Lung symptoms in pseudohypoal-dosteronism type 1 are associated with deficiency of the α-subunit of the epithelial sodium channel
317. The influence of intravascular fluid volume on the permeability of newborn and adult mouse lungs to ultrastructural protein tracers
318. Structure, function, and regulation of cellular tight junctions
319. +-ATPase in rat type II pneumocytes
320. The ultrastructural basis of alveolar-capillary membrane permeability to peroxidase used as a tracer
321. Aquaporin-1 in plasma membrane and caveolae provides mercury-sensitive water channels across lung endothelium
322. cGMP stimulates sodium and chloride currents in rat tracheal airway epithelia
323. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung
324. In vivo phosphorylation of the epithelial sodium channel
325. Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome
326. Nobel Lecture. The identification of the sodium pump
327. Alveolar and lung liquid clearance in anesthetized rabbits
328. + channel to the cell surface
329. Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits
330. Membrane topology of the amiloride-sensitive epithelial sodium channel
331. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: Studies in transgenic aquaporin null mice
332. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration
333. Pulmonary edema
334. The structure of the lungs relative to their principal function
335. +-ATPase pump in a mouse model in vivo augments resolution of high permeability pulmonary oedema
336. CFTR as a cAMP-dependent regulator of sodium channels
337. Electrical currents flow out of domes formed by cultured epithelial cells
338. +-ATPase function by hypoxia in rats
339. Modulation of transalveolar fluid absorption by endogenous aldosterone in adult rats
340. +-ATPase activity by β-adrenergic agonist in alveolar type II cells
341. 11Beta-hydroxysteroid dehydrogenase type 2 in human lung: Possible regulator of mineralocorticoid action
342. Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel
343. Mechanisms of lung liquid clearance during hyperoxia in isolated rat lungs
344. Epidermal growth factor increases lung liquid clearance in rat lungs
345. Quantitation and localization of ENaC subunit expression in fetal, newborn, and adult mouse lung
346. Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes
347. Permeability of the alveolar epithelium to solutes
348. Lung epithelial Na channel subunits are differentially regulated during development and by steroids
349. Evidence for functional ANP receptors in cultured alveolar type II cells
350. Genomic organization and the 5′ flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel
351. Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells
352. Hypoxia reduces airway epithelial sodium transport in rats
353. Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection
354. i cotransporter in alveolar type II cells
355. Sharp increase in rat lung water channel expression in the perinatal period
356. An epithelial serine protease activates the amiloride-sensitive sodium channel
357. Lidocaine blockade of basolateral potassium channels in the amphibian urinary bladder
358. Purinergic regulation of ion transport across nonciliated bronchiolar epithelial (Clara) cells
359. - transport across rabbit nonciliated bronchiolar epithelial (Clara) cells
360. + absorption by extracellular protease
361. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema
362. Role of aquaporin water channels in kidney and lung
363. Lessons on renal physiology from transgenic mice lacking aquaporin water channels
364. Physiological importance of aquaporins: Lessons from knockout mice
365. Aquaporin water channels and lung physiology
366. Structure and function of aquaporin water channels
367. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice
368. + reabsorption in aldosterone target epithelia
369. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: Reversal by beta adrenergic treatment
370. + channel: Biophysical properties, pharmacology, ontogenesis, and molecular cloning
371. The role of catecholamines in lung liquid absorption at birth
372. Rapid alveolar liquid removal by a novel convective mechanism
373. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and β-agonist therapy
374. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation
375. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
376. Lung morphometry and models in respiratory physiology
377. Strength of the pulmonary blood-gas barrier
378. How does cAMP increase active Na absorption across alveolar epithelium?
379. Yet another role for the cystic fibrosis transmembrane conductance regulator
380. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
381. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits
382. Sodium transport and intracellular sodium activity in cultured human nasal epithelium
383. Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung
384. 99mTc-DTPA during halothane anaesthesia
385. Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung
386. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats
387. Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats
388. Regulation of low-amiloride-affinity sodium channels in alveolar type II cells
389. Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages
390. Nitrated SP-A does not enhance adherence of Pneumocystis carinii to alveolar macrophages
391. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury