Serum and glucocorticoid regulated kinase and disturbed renal sodium transport in diabetes

Journal of Endocrinology

Volumn 199, Issue 3, 2008, Pages 343-349

  Hills, Claire E ^a   Squires, Paul E ^b   Bland, Rosemary ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; EPITHELIAL SODIUM CHANNEL; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ARTICLE; CELL VOLUME; DIABETES MELLITUS; DIABETIC HYPERTENSION; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HUMAN; HYPOTONIC BLADDER; KIDNEY CELL; KIDNEY EPITHELIUM; KIDNEY TUBULE ABSORPTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SODIUM TRANSPORT; TRANSCRIPTION REGULATION;

ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; IMMEDIATE-EARLY PROTEINS; ION TRANSPORT; KIDNEY; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; SODIUM;

EID: 57449117071     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0295     Document Type: Article

References (89)

1. Alvarez de la Rosa D, Coric T, Todorovic N, Shao D, Wang T & Canessa CM 2003 Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney. Journal of Physiology 551 455-466.
2. + -ATPase in amphibian renal epithelial cells. American Journal of Physiology. Cell Physiology 290 C492-C498.
3. Attune F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D et al. 2006 Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. Journal of Molecular Medicine 84 737-746,
4. Bell LM, Leong ML, Kim B, Wang E, Park J, Hemmings BA & Firestone GL 2000 Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inclucible protein kinase (Sgk) by a p38 MAPK-dependent pathway. Journal of Biological Chemistry 275 25262-25272.
5. + metabolism. PNAS 93 9424-9429.
6. + channel lacking the pore-forming region of its alpha subunit. Journal of Clinical Investigation 104 849-850.
7. Boyd C & Naray-Fejes-Toth A 2005 Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1. American Journal of Physiology. Renal Physiology 288 505-512.
8. Buse P, Tran SH, Luther E, Phu PT, Aponte GW & Firestone GL 1999 Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. Journal of Biological Chemistry 274 7253-7263.
9. Busjahn A, Aydin A, Uhlmann R, Krasko C, Bähring S, Szelestei T, Feng Y, Dahm S, Sharma AM, Luft FC et al. 2002 Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 40 256-260.
10. Capasso G, Cantone A, Evangelista C, Zacchia M, Trepiccione F, Acone D & Rizzo M 2005 Channels, carriers, and pumps in the pathogenesis of sodium-sensitive hypertension. Seminars in Nephrology 25 419-424.
11. Cohen DM 2005 TRPV4 and the mammalian kidney. Pflugers Archiv, 451 168-175.
12. Cordas E, Náray-Fejes-Tóth A & Fejes-Tóth G 2007 Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells. American Journal of Physiology. Cell Physiology 292 C1971-C1981.
13. +) channel cell surface expression. EMBO Journal 20 7052-7059.
14. Diakov A & Korbmacher C 2004 A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motifin the C terminus ofthe channel's alpha-subunit. Journal of Biological Chemistry 279 38134-38142.
15. Dieter M, Palmada, M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC & Lang F 2004 Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obesity Research 12 862-870.
16. Farjah M, Roxas BP, Geenen DL & Danziger RS 2003 Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension 41 874-878.
17. Feng Y, Wang Q, Wang Y, Yard B & Lang F 2005 SGK1-mediated fibronectin formation in diabetic nephropathy. Cellular Physiology and Biochemistry 16 237-244.
18. Firestone GL, Giampaolo JR & O'Keeffe BA 2003 Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cellular Physiology and Biochemistry 13 1-12.
19. + transport in cortical collecting duct cells. Journal of the American Society of Nephrology 16 2279-2287.
20. Grahammer F, Artunc E Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D et al. 2006 Renal function of gene-targeted mice lacking both SGK1 and SGK3. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290 R945-R950.
21. Guo C, Mártinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH et al. 2006 Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology 147 5363-5373.
22. Hager H, Kwon TH, Vinnikova AK, Masilamani S, Brooks HL, Frøkiaer J, Knepper MA & Nielsen S 2001 Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney. American Journal of Physiology. Renal Physiology 280 F1093-F1106.
23. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B & Lifton RP 1995 Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nature Genetics 11 76-82.
24. +-ATPase by the serum and glucocorticoid-dependent kinase isoforms. Kidney and Blood Pressure Research 25 370-374.
25. Hills CE, Bland R, Bennett J, Ronco PM & Squires PE 2006a High glucose up-regulates ENaC and SGK1 expression in HCD-cells. Cellular Physiology and Biochemistry 18 337-346.
26. Hills CE, Bland R, Wheelans DC, Bennett J, Ronco PM & Squires PE 2006 b Glucose-evoked alterations in connexin 43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy. American Journal of Physiology. Renal Physiology 291 F1045-F1051.
27. Hoffman BB, Sharma K, Zhu Y & Ziyadeh FN 1998 Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration. Kidney International 54 1107-1116.
28. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff F, Kuhl D, Vallon V & Lang F 2006a Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290 R935-R944.
29. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, Rajamanickam J, Palmada M, Wulff P, Kuhl D et al. 2006b Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet. American Journal of Physiology. Renal Physiology 291 F1264-F1273.
30. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R & Rossier BC 1996 Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nature Genetics 12 325-328.
31. Jasti J, Furukawa H, Gonzales EB & Gouaux E 2007 Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449 316-323.
32. Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S & Benos DJ 2006 Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. Journal of Biological Chemistry 281 8233-8241.
33. +) transport. American Journal of Physiology. Renal Physiology 283 F377-F387.
34. Kellenberger S & Schild L 2002 Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiological Reviews 82 735-767.
35. Kobayashi T & Cohen P 1999 Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochemical Journal 339 319-328.
36. Kobayashi T, Deak M, Morrice N & Cohen P 1999 Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochemical Journal 344 189-197.
37. Kosari F, Sheng S, Li J, Mak DO, Foskett JK & Kleyman TR 1998 Subunit stoichiometry of the epithelial sodium channel. Journal of Biological Chemistry 273 13469-13474.
38. Kumar JM, Brooks DP, Olson BA & Laping NJ 1999 Sgk, a putative serine/ threonine kinase, is differentially expressed in the kidney of diabetic once and humans. Journal of the American Society of Nephrology 10 2488-2494.
39. Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen L Steuer S et al. 2000 Deranged transcriptional regulation of cell-volume-sensirive kinase hSGK in diabetic nephropathy. PNAS 97 8157-8162.
40. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N & Vallon V 2006 (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiological Reviews 86 1151-1178.
41. Liddle GW, Bledsoe T & Coppage WS Jr 1963 A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Transactions of the Association of American Physicians 76 199-213.
42. Linden KC, DeHaan CL, Zhang Y, Glowacka S, Cox AJ, Kelly DJ & Rogers S 2006 Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. American Journal of Physiology. Renal Physiology 290 F205-F213.
43. Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D & Verrey F 2001 Aldosterone induces rapid apical translocation of ENaC in early portion ofrenal collecting system: possible role of SGK. American Journal of Physiology. Renal Physiology 280 F675-F682.
44. Loffing J, Flores SY & Staub O 2006 Sgk kinases and their role in epithelial transport. Annual Review of Physiology 68 461-490.
45. Loffing-Cueni D, Flores SY, Sauter D, Daidié D, Siegrist N, Meneton P, Staub O & Loffing J 2006 Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system. Journal of the American Society of Nephrology 17 1264-1274.
46. Malik B, Yoe Q, Yue G, Chen XJ, Price SR, Mitch WE & Eaton DC 2005 Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits. American Journal of Physiology. Renal Physiology 289 F107-F116.
47. Mason RM & Wahab A 2003 Extracellular matrix metabolism in diabetic nephropathy. Journal of the American Society of Nephrology 14 1358-1373.
48. McCormick JA, Feng Y, Dawson K, Belme MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM et al. 2004 Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Molecular Biology of the Cell 15 4278-4288.
49. McCormick JA, Bhilla V, Pao AC & Pearce D 2005 SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology 20 134-139.
50. Michlig S, Harris M, Loffing J, Rossier BC & Firsov D 2005 Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism. Journal of Biological Chemistry 280 38264-38270.
51. Morimoto T, Liu W, Woda C, Carattino MD, Wei Y, Hughey RP, Apodaca G, Sathn LM & Kleyman TP, 2006 Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. American Journal of Physiology. Renal Physiology 291 F663-F669.
52. 2+ influx channel in renal epithelial cells. American Journal of Physiology. Renal Physiology 273 F120-F128.
53. Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K & Lang F 2006 SGK1 kinase upregulates GLUT1 activity and plasma membrane expression. Diabetes 55 421-427.
54. Di Paolo S, Gesualdo L, Ranieri E, Grandaliano, G & Schena FP 1996 High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells. American Journal of Physiology 149 2095-2106.
55. Park J, Leong ML, Buse P, Maryar AC, Firestone GL & Hemmings BA 1999 Serum and glucocorticoid-inclucible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO Journal 18 3024-3033.
56. Pearce D 2003 SGK1 regulation of epithelial sodium transport. Cellular Physiology and Biochemistry 13 13-20.
57. Perrotti N, He RA, Phillips SA, Haft CR & Taylor SI 2001 Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. Journal of Biological Chemistry 276 9406-9412.
58. Pratt JH 2005 Central role for ENaC in development of hypertension. Journal of the American Society of Nephrology 16 3154-3159.
59. Reeves WB & Andreoli TE 2000 Transforming growth factor beta contributes to progressive diabetic nephropathy. PNAS 97 7667-7669.
60. Ritz E 1999 Nephropathy in type II diabetes. Journal of Internal Medicine 245 111-126.
61. + transport in A6 cells. American Journal of Physiology. Renal Physiology 283 F105-F113.
62. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E & Rossier BC 2003 Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. Journal of Clinical Investigation 112 554-565.
63. Saba C, Eckert GJ, Ambrosius WT, Chun TY, Wagner MA, Zhoa Q & Pratt JH 2005 Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Hypertension 46 481-487.
64. +) channels are regulated by flow. American Journal of Physiology. Renal Physiology 280 F1010-F1018.
65. Schuttert JB, Fiedler GM, Grupp C, Blaschke S & Grunewald RW 2002 Sorbitol transport in rat renal inner medullary interstitial cells. Kidney International 61 1407-1415.
66. Schwab M, Lupescu A, Mota M, Mota E, Frey A, Simon F, Mertens PR, Floege J, Luft F, Asante-Poku S et al. 2008 Association of SGK1 gene polymorphisms with type II diabetes. Cellular Physiology and Biochemistry 21 151-160.
67. Setiawan I, Henke G, Feng Y, Böhmer C, Vasilets LA, Schwarz W & Lang F 2002 Stimulation of Xenopus oocyte Na(+),K(+)ATPase by the serum and glucocorticoid-dependent kinase sgk1. Pflugers Archiv: European Journal of Physiology 444 426-431.
68. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW et al. 1994 Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79 407-414.
69. Simon P, Schneck M, Hochstetter T, Koutsouki E, Mittelbronn M, Merseburger A, Weigert C, Niess A & Lang F 2007 Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription. Cellular Physiology and Biochemistry 20 715-728.
70. Snyder PM, Cheng C, Prince LS, Rogers JC & Welsh MJ 1998 Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. Journal of Biological Chemistry 273 681-684.
71. Song J, Knepper MA, Verbalis JG & Ecelbarger CA 2003 Increased renal ENaC subunit and sodium transporter abundances in streptozotocin-induced type I diabetes. American Journal of Physiology. Renal Physiology 285 F1125-F1137.
72. Song J, Hu X, Riazi S, Tiwari S, Wade JB & Ecelbarger CA 2006 Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. American Journal of Physiology. Renal Physiology 290 F1055-F1064.
73. + transport in the distal nephron. Journal of the American Society of Nephrology 16 3167-3174.
74. +)-dependent glucose transporter SGLT1 is localized in the apical plasma membrane upon completion of tight junction formation in MDCK cells. Histochemistry and Cell Biology 106 529-533.
75. i in renal proximal tubular cells. Kidney International 54 1206-1213.
76. Taruno A, Niisato N & Marunaka Y 2008 Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells. American Journal of Physiology. Renal Physiology 294 F177-F186.
77. Tsugawa T, Shinohara R, Nagasaka A, Nakano I, Takeda F, Nagata M, Oda N, Sawai Y, Hayakawa N, Suzuki A et al. 2004 Alteration of urinary sorbitol excretion in WBN-kob diabetic rats - treatment with an aldose reducrase inhibitor. Journal of Endocrinology 181 429-435.
78. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F. Belaiba RS, Görlach A et al. 2006 SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. Journal of Molecular Medicine 84 396-404.
79. + influx in cultured renal collecting duct cells. Journal of the American Society of Nephrology 15 2537-2547.
80. Waldegger S, Barth F, Raber G & Lang F 1997 Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. PNAS 94 4440-4445.
81. Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R & Lang F 1999 h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 116 1081-1088.
82. Waldegger S, Gabrysch S, Batch P, Fillon S & Lang F 2000 h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cellular Physiology and Biochemistry 10 203-208.
83. Wang Q, Zhang X, Wang Y, Deng A, Zhu Z & Feng Y 2005 Significance and expression of serum and glucocorticoid-inducible kinase in kidney of mice with diabetic nephropathy. Journal of Huazhong University of Science and Technology. Medical Sciences 25 170-173.
84. Webster MK, Goya L, GE Y, Maiyar AC & Firestone GL 1993 Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Molecular and Cellular Biology 13 2031-2040.
85. von Wowern F, Berglund G, Carlson J, Månsson H, Hedblad B & Melander O 2005 Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney International 68 2164-2172.
86. Wu L, Gao X, Brown RC, Heller S & O'Neil RG 2007 Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. American Journal of Physiology. Renal Physiology 293 F1699-F1713.
87. Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K,Jansen M, Schlünz M, Klingel K, Loffing J et al. 2002 Impaired renal Na(+) retention in the sgk1-knockout mouse. Journal of Clinical Investigation 110 1263-1268.
88. Zecevic M, Heitzmann D, Camargo SM & Verrey F 2004 SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes. Pflugers Archiv: European Journal of Physiology 448 29-35.
89. Zhou R & Snyder PM 2005 Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. Journal of Biological Chemistry 280 4518-4523.