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Volumn 13, Issue , 2012, Pages

Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury

Author keywords

Acute lung injury; Akt; Alveolar fluid clearance; Epithelial sodium channel; Insulin; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA EPITHELIAL SODIUM CHANNEL; BETA EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; GAMMA EPITHELIAL SODIUM CHANNEL; GLUCOSE; INSULIN; INTERLEUKIN 6; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; WORTMANNIN; ESCRT PROTEIN; LIPOPOLYSACCHARIDE; NEDD4 UBIQUITIN PROTEIN LIGASES; PEROXIDASE; UBIQUITIN PROTEIN LIGASE;

EID: 84859048501     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-13-29     Document Type: Article
Times cited : (70)

References (63)
  • 1
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • 10.1056/NEJM200005043421806, 10793167
    • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000, 342:1334-1349. 10.1056/NEJM200005043421806, 10793167.
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 3
    • 0034993527 scopus 로고    scopus 로고
    • Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
    • Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001, 163:1376-1383.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1376-1383
    • Ware, L.B.1    Matthay, M.A.2
  • 4
    • 0036893167 scopus 로고    scopus 로고
    • Lung edema clearance: 20 years of progress. Invited review: alveolar edema fluid clearance in the injured lung
    • Berthiaume Y, Folkesson HG, Matthay MA. Lung edema clearance: 20 years of progress. Invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol 2002, 93:2207-2213.
    • (2002) J Appl Physiol , vol.93 , pp. 2207-2213
    • Berthiaume, Y.1    Folkesson, H.G.2    Matthay, M.A.3
  • 5
    • 34447119669 scopus 로고    scopus 로고
    • Alveolar fluid clearance in acute lung injury: what have we learned from animalmodels and clinical studies?
    • 10.1007/s00134-007-0662-7, 17525842
    • Morty RE, Eickelberg O, Seeger W. Alveolar fluid clearance in acute lung injury: what have we learned from animalmodels and clinical studies?. Intensive Care Med 2007, 33:1229-1240. 10.1007/s00134-007-0662-7, 17525842.
    • (2007) Intensive Care Med , vol.33 , pp. 1229-1240
    • Morty, R.E.1    Eickelberg, O.2    Seeger, W.3
  • 6
    • 27144435896 scopus 로고    scopus 로고
    • Alveolar epithelium: role in lung fluid balance and acute lung injury
    • 10.1513/pats.200501-009AC, 16222039
    • Matthay MA, Robriquet L, Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc 2005, 2:206-213. 10.1513/pats.200501-009AC, 16222039.
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 206-213
    • Matthay, M.A.1    Robriquet, L.2    Fang, X.3
  • 7
    • 36248959309 scopus 로고    scopus 로고
    • Alveolar edema fluid clearance and acute lung injury
    • 10.1016/j.resp.2007.05.010, 2682357, 17604701
    • Berthiaume Y, Matthay MA. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 2007, 159:350-359. 10.1016/j.resp.2007.05.010, 2682357, 17604701.
    • (2007) Respir Physiol Neurobiol , vol.159 , pp. 350-359
    • Berthiaume, Y.1    Matthay, M.A.2
  • 8
    • 67651173244 scopus 로고    scopus 로고
    • The contribution of epithelial sodium channels to alveolar function in health and disease
    • 10.1146/annurev.physiol.010908.163250, 18831683
    • Eaton DC, Helms MN, Koval M, Bao HF, Jain L. The contribution of epithelial sodium channels to alveolar function in health and disease. Annu Rev Physiol 2009, 71:403-423. 10.1146/annurev.physiol.010908.163250, 18831683.
    • (2009) Annu Rev Physiol , vol.71 , pp. 403-423
    • Eaton, D.C.1    Helms, M.N.2    Koval, M.3    Bao, H.F.4    Jain, L.5
  • 10
    • 0033066855 scopus 로고    scopus 로고
    • Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance
    • 10.1146/annurev.physiol.61.1.627, 10099704
    • Matalon S, O'Brodovich H. Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol 1999, 61:627-661. 10.1146/annurev.physiol.61.1.627, 10099704.
    • (1999) Annu Rev Physiol , vol.61 , pp. 627-661
    • Matalon, S.1    O'Brodovich, H.2
  • 11
    • 0029935712 scopus 로고    scopus 로고
    • Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
    • 10.1038/ng0396-325, 8589728
    • Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 1996, 12:325-328. 10.1038/ng0396-325, 8589728.
    • (1996) Nat Genet , vol.12 , pp. 325-328
    • Hummler, E.1    Barker, P.2    Gatzy, J.3    Beermann, F.4    Verdumo, C.5    Schmidt, A.6    Boucher, R.7    Rossier, B.C.8
  • 13
    • 34548424944 scopus 로고    scopus 로고
    • The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid
    • 10.1152/ajplung.00373.2006, 17513453
    • Elias N, Rafii B, Rahman M, Otulakowski G, Cutz E, O' Brodovich H. The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am J Physiol Lung Cell Mol Physiol 2007, 293:L537-L545. 10.1152/ajplung.00373.2006, 17513453.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Elias, N.1    Rafii, B.2    Rahman, M.3    Otulakowski, G.4    Cutz, E.5    O' Brodovich, H.6
  • 14
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
    • 10.1146/annurev.biochem.68.1.965, 10872470
    • Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999, 68:965-1014. 10.1146/annurev.biochem.68.1.965, 10872470.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 16
    • 0031957003 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells
    • Record RD, Froelich LL, Vlahos CJ, Blazer-Yost BL. Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells. Am J Physiol 1998, 274:E611-E617.
    • (1998) Am J Physiol , vol.274
    • Record, R.D.1    Froelich, L.L.2    Vlahos, C.J.3    Blazer-Yost, B.L.4
  • 17
    • 0037573575 scopus 로고    scopus 로고
    • Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity
    • Blazer-Yost BL, Esterman MA, Vlahos CJ. Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity. Am J Physiol Cell Physiol 2003, 284:C1645-C1653.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Blazer-Yost, B.L.1    Esterman, M.A.2    Vlahos, C.J.3
  • 18
    • 0036097364 scopus 로고    scopus 로고
    • The origins of protein phosphorylation
    • 10.1038/ncb0502-e127, 11988757
    • Cohen P. The origins of protein phosphorylation. Nat Cell Biol 2002, 4:E127-E130. 10.1038/ncb0502-e127, 11988757.
    • (2002) Nat Cell Biol , vol.4
    • Cohen, P.1
  • 19
    • 0037600600 scopus 로고    scopus 로고
    • Role of Akt/protein kinase B in metabolism
    • 10.1016/S1043-2760(02)00662-8, 12431841
    • Whiteman EL, Cho H, Birnbaum MJ. Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab 2002, 13:444-451. 10.1016/S1043-2760(02)00662-8, 12431841.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 444-451
    • Whiteman, E.L.1    Cho, H.2    Birnbaum, M.J.3
  • 20
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006, 7:85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 21
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • 10.1161/01.RES.0000022200.71892.9F, 12089061
    • Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002, 90:1243-1250. 10.1161/01.RES.0000022200.71892.9F, 12089061.
    • (2002) Circ Res , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 22
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • 10.1016/S1097-2765(05)00089-4, 11090628
    • Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 2000, 6:909-919. 10.1016/S1097-2765(05)00089-4, 11090628.
    • (2000) Mol Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6    Williams, R.L.7
  • 23
    • 0022527271 scopus 로고
    • An improved method for isolating type II cells in high yield and purity
    • Dobbs L, Gonzales G, Williams M. An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis 1986, 134:141-145.
    • (1986) Am Rev Respir Dis , vol.134 , pp. 141-145
    • Dobbs, L.1    Gonzales, G.2    Williams, M.3
  • 24
    • 33846459017 scopus 로고    scopus 로고
    • Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in rats: the role of heme oxygenase-1
    • 10.1213/01.ane.0000252414.00363.c4, 17242094
    • Jin SW, Zhang L, Lian QQ, Liu D, Wu P, Yao SL, Ye DY. Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in rats: the role of heme oxygenase-1. Anesth Analg 2007, 104:369-377. 10.1213/01.ane.0000252414.00363.c4, 17242094.
    • (2007) Anesth Analg , vol.104 , pp. 369-377
    • Jin, S.W.1    Zhang, L.2    Lian, Q.Q.3    Liu, D.4    Wu, P.5    Yao, S.L.6    Ye, D.Y.7
  • 25
    • 33745477612 scopus 로고    scopus 로고
    • Totalliquid ventilation reduces lung injury in piglets after cardiopulmonary bypass
    • 10.1016/j.athoracsur.2006.02.018, 16798202
    • Jiang L, Wang Q, Liu Y, Du M, Shen X, Guo X, Wu S. Totalliquid ventilation reduces lung injury in piglets after cardiopulmonary bypass. Ann Thorac Surg 2006, 82:124-130. 10.1016/j.athoracsur.2006.02.018, 16798202.
    • (2006) Ann Thorac Surg , vol.82 , pp. 124-130
    • Jiang, L.1    Wang, Q.2    Liu, Y.3    Du, M.4    Shen, X.5    Guo, X.6    Wu, S.7
  • 26
    • 0015612949 scopus 로고
    • A new technique for measuring pulmonary edema
    • Noble WH, Obdrzalek J, Kay JC. A new technique for measuring pulmonary edema. J Appl Physiol 1973, 34:508-512.
    • (1973) J Appl Physiol , vol.34 , pp. 508-512
    • Noble, W.H.1    Obdrzalek, J.2    Kay, J.C.3
  • 28
    • 17044393948 scopus 로고    scopus 로고
    • Regulation of Akt/PKB Ser473 phosphorylation
    • 10.1016/j.molcel.2005.03.020, 15837416
    • Bayascas JR, Alessi DR. Regulation of Akt/PKB Ser473 phosphorylation. Mol Cell 2005, 18:143-145. 10.1016/j.molcel.2005.03.020, 15837416.
    • (2005) Mol Cell , vol.18 , pp. 143-145
    • Bayascas, J.R.1    Alessi, D.R.2
  • 29
    • 0029948974 scopus 로고    scopus 로고
    • Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome
    • 450168, 8665845
    • Schild L, Lu Y, Gautschi I, Schneeberger E, Lifton RP, Rossier BC. Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 1996, 15:2381-2387. 450168, 8665845.
    • (1996) EMBO J , vol.15 , pp. 2381-2387
    • Schild, L.1    Lu, Y.2    Gautschi, I.3    Schneeberger, E.4    Lifton, R.P.5    Rossier, B.C.6
  • 30
    • 0242362727 scopus 로고    scopus 로고
    • Acute respiratory distress syndrome
    • 10.1007/BF02256308, 14576460
    • Chen HI, Kao SJ, Wang D, Lee RP, Su CF. Acute respiratory distress syndrome. J Biomed Sci 2003, 10:588-592. 10.1007/BF02256308, 14576460.
    • (2003) J Biomed Sci , vol.10 , pp. 588-592
    • Chen, H.I.1    Kao, S.J.2    Wang, D.3    Lee, R.P.4    Su, C.F.5
  • 31
    • 49949089651 scopus 로고    scopus 로고
    • Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    • 10.1097/CCM.0b013e318180b3ba, 18596634
    • Hagiwara S, Iwasaka H, Hasegawa A, Koga H, Noguchi T. Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model. Crit Care Med 2008, 36:2407-2413. 10.1097/CCM.0b013e318180b3ba, 18596634.
    • (2008) Crit Care Med , vol.36 , pp. 2407-2413
    • Hagiwara, S.1    Iwasaka, H.2    Hasegawa, A.3    Koga, H.4    Noguchi, T.5
  • 33
    • 33644589506 scopus 로고    scopus 로고
    • Insulin attenuates endotoxin-induced acute lung injury in conscious rats
    • 10.1097/01.CCM.0000201902.37115.22, 16505662
    • Chen HI, Yeh DY, Liou HL, Kao SJ. Insulin attenuates endotoxin-induced acute lung injury in conscious rats. Crit Care Med 2006, 34:758-764. 10.1097/01.CCM.0000201902.37115.22, 16505662.
    • (2006) Crit Care Med , vol.34 , pp. 758-764
    • Chen, H.I.1    Yeh, D.Y.2    Liou, H.L.3    Kao, S.J.4
  • 34
    • 79955944824 scopus 로고    scopus 로고
    • Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: role of the protective endothelium
    • 10.1097/BCR.0b013e318217f8ae, 21436719
    • Zhang WF, Zhu XX, Hu DH, Xu CF, Wang YC, Lv GF. Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: role of the protective endothelium. J Burn Care Res 2011, 32:e51-e58. 10.1097/BCR.0b013e318217f8ae, 21436719.
    • (2011) J Burn Care Res , vol.32
    • Zhang, W.F.1    Zhu, X.X.2    Hu, D.H.3    Xu, C.F.4    Wang, Y.C.5    Lv, G.F.6
  • 35
    • 0031954181 scopus 로고    scopus 로고
    • A comparison among animal models of acute lung injury
    • 10.1097/00003246-199805000-00027, 9590322
    • Rosenthal C, Caronia C, Quinn C, Lugo N, Sagy M. A comparison among animal models of acute lung injury. Crit Care Med 1998, 26:912-916. 10.1097/00003246-199805000-00027, 9590322.
    • (1998) Crit Care Med , vol.26 , pp. 912-916
    • Rosenthal, C.1    Caronia, C.2    Quinn, C.3    Lugo, N.4    Sagy, M.5
  • 36
    • 0027242338 scopus 로고
    • Acute lung injury: what have we learned from animal models?
    • 10.1097/00000441-199308000-00010, 8362891
    • Windsor AC, Mullen PG, Fowler AA. Acute lung injury: what have we learned from animal models?. Am J Med Sci 1993, 306:111-116. 10.1097/00000441-199308000-00010, 8362891.
    • (1993) Am J Med Sci , vol.306 , pp. 111-116
    • Windsor, A.C.1    Mullen, P.G.2    Fowler, A.A.3
  • 37
    • 4344645520 scopus 로고    scopus 로고
    • Insulin attenuates the systemic inflammatory response in endotoxemic rats
    • 10.1210/en.2004-0592, 15192048
    • Jeschke MG, Klein D, Bolder U, Einspanier R. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 2004, 145:4084-4093. 10.1210/en.2004-0592, 15192048.
    • (2004) Endocrinology , vol.145 , pp. 4084-4093
    • Jeschke, M.G.1    Klein, D.2    Bolder, U.3    Einspanier, R.4
  • 38
    • 0029046988 scopus 로고
    • Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils
    • 10.1074/jbc.270.19.11684, 7744808
    • Ding J, Vlahos CJ, Liu R, Brown RF, Badwey JA. Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. J Biol Chem 1995, 270:11684-11691. 10.1074/jbc.270.19.11684, 7744808.
    • (1995) J Biol Chem , vol.270 , pp. 11684-11691
    • Ding, J.1    Vlahos, C.J.2    Liu, R.3    Brown, R.F.4    Badwey, J.A.5
  • 39
  • 40
    • 0035880870 scopus 로고    scopus 로고
    • Anticoagulants for acute respiratory distress syndrome: can they work?
    • Idell S. Anticoagulants for acute respiratory distress syndrome: can they work?. Am J Respir Crit Care Med 2001, 164:517-520.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 517-520
    • Idell, S.1
  • 41
    • 0037394676 scopus 로고    scopus 로고
    • Neutrophils and acute lung injury
    • 10.1097/01.CCM.0000057843.47705.E8, 12682440
    • Abraham E. Neutrophils and acute lung injury. Crit Care Med 2003, 31:S195-S199. 10.1097/01.CCM.0000057843.47705.E8, 12682440.
    • (2003) Crit Care Med , vol.31
    • Abraham, E.1
  • 43
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • 10.1074/jbc.M203298200, 12052830
    • Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002, 277:32124-32132. 10.1074/jbc.M203298200, 12052830.
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 44
    • 77954624419 scopus 로고    scopus 로고
    • Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway
    • 10.1016/j.ejphar.2010.05.012, 20519138
    • Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC. Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol 2010, 642:146-153. 10.1016/j.ejphar.2010.05.012, 20519138.
    • (2010) Eur J Pharmacol , vol.642 , pp. 146-153
    • Xu, C.Q.1    Liu, B.J.2    Wu, J.F.3    Xu, Y.C.4    Duan, X.H.5    Cao, Y.X.6    Dong, J.C.7
  • 45
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • 10.1016/j.freeradbiomed.2006.09.030, 17189821
    • Fialkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 2007, 42:153-164. 10.1016/j.freeradbiomed.2006.09.030, 17189821.
    • (2007) Free Radic Biol Med , vol.42 , pp. 153-164
    • Fialkow, L.1    Wang, Y.2    Downey, G.P.3
  • 47
    • 0033852068 scopus 로고    scopus 로고
    • LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na+ transport in A6 epithelia
    • Paunescu TG, Blazer-Yost BL, Vlahos CJ, Helman SI. LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na+ transport in A6 epithelia. Am J Physiol Cell Physiol 2000, 279:C236-C247.
    • (2000) Am J Physiol Cell Physiol , vol.279
    • Paunescu, T.G.1    Blazer-Yost, B.L.2    Vlahos, C.J.3    Helman, S.I.4
  • 48
    • 33847381862 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells
    • 10.1016/j.ejphar.2007.01.025, 17307160
    • Lin CC, Chiang LL, Lin CH, Shih CH, Liao YT, Hsu MJ, Chen BC. Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells. Eur J Pharmacol 2007, 560:101-109. 10.1016/j.ejphar.2007.01.025, 17307160.
    • (2007) Eur J Pharmacol , vol.560 , pp. 101-109
    • Lin, C.C.1    Chiang, L.L.2    Lin, C.H.3    Shih, C.H.4    Liao, Y.T.5    Hsu, M.J.6    Chen, B.C.7
  • 49
    • 0030734345 scopus 로고    scopus 로고
    • Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
    • 10.1210/me.11.13.1881, 9415393
    • Cong LN, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, Quon MJ. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 1997, 11:1881-1890. 10.1210/me.11.13.1881, 9415393.
    • (1997) Mol Endocrinol , vol.11 , pp. 1881-1890
    • Cong, L.N.1    Chen, H.2    Li, Y.3    Zhou, L.4    McGibbon, M.A.5    Taylor, S.I.6    Quon, M.J.7
  • 50
    • 20844455782 scopus 로고    scopus 로고
    • Functional specificity of Sgk1 and Akt1 on ENaC activity
    • Arteaga MF, Canessa C. Functional specificity of Sgk1 and Akt1 on ENaC activity. Am J Physiol Renal Physiol 2006, 289:90-96.
    • (2006) Am J Physiol Renal Physiol , vol.289 , pp. 90-96
    • Arteaga, M.F.1    Canessa, C.2
  • 51
    • 0035896534 scopus 로고    scopus 로고
    • The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
    • 10.1074/jbc.C000906200, 11244092
    • Harvey KF, Dinudom A, Cook DI, Kumar S. The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J Biol Chem 2001, 276:8597-8601. 10.1074/jbc.C000906200, 11244092.
    • (2001) J Biol Chem , vol.276 , pp. 8597-8601
    • Harvey, K.F.1    Dinudom, A.2    Cook, D.I.3    Kumar, S.4
  • 52
    • 0029874436 scopus 로고    scopus 로고
    • WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome
    • 450167, 8665844
    • Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J 1996, 15:2371-2380. 450167, 8665844.
    • (1996) EMBO J , vol.15 , pp. 2371-2380
    • Staub, O.1    Dho, S.2    Henry, P.3    Correa, J.4    Ishikawa, T.5    McGlade, J.6    Rotin, D.7
  • 53
    • 0037267232 scopus 로고    scopus 로고
    • The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels
    • Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S. The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J 2003, 17:70-72.
    • (2003) FASEB J , vol.17 , pp. 70-72
    • Fotia, A.B.1    Dinudom, A.2    Shearwin, K.E.3    Koch, J.P.4    Korbmacher, C.5    Cook, D.I.6    Kumar, S.7
  • 54
    • 20844435326 scopus 로고    scopus 로고
    • Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits
    • 10.1152/ajprenal.00179.2002, 15769939
    • Malik B, Yue Q, Yue G, Chen XJ, Price SR, Mitch WE, Eaton DC. Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits. Am J Physiol Renal Physiol 2005, 289:F107-F116. 10.1152/ajprenal.00179.2002, 15769939.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Malik, B.1    Yue, Q.2    Yue, G.3    Chen, X.J.4    Price, S.R.5    Mitch, W.E.6    Eaton, D.C.7
  • 55
    • 34547107368 scopus 로고    scopus 로고
    • Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC
    • 10.1074/jbc.M611329200, 17502380
    • Zhou R, Patel SV, Snyder PM. Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC. J Biol Chem 2007, 282:20207-20212. 10.1074/jbc.M611329200, 17502380.
    • (2007) J Biol Chem , vol.282 , pp. 20207-20212
    • Zhou, R.1    Patel, S.V.2    Snyder, P.M.3
  • 57
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J Cell Sci 2001, 114:2903-2910.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 59
    • 0036720843 scopus 로고    scopus 로고
    • Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport
    • Kamynina E, Staub O. Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am J Physiol Renal Physiol 2002, 283:F377-F387.
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Kamynina, E.1    Staub, O.2
  • 60
    • 35649027433 scopus 로고    scopus 로고
    • Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2
    • 10.1074/jbc.M701923200, 17715136
    • Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem 2007, 282:29866-29873. 10.1074/jbc.M701923200, 17715136.
    • (2007) J Biol Chem , vol.282 , pp. 29866-29873
    • Lee, I.H.1    Dinudom, A.2    Sanchez-Perez, A.3    Kumar, S.4    Cook, D.I.5
  • 62
    • 0037016772 scopus 로고    scopus 로고
    • Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
    • Snyder PM, Olson DR, Thomas BC. Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem 2002, 277:5-8.
    • (2002) J Biol Chem , vol.277 , pp. 5-8
    • Snyder, P.M.1    Olson, D.R.2    Thomas, B.C.3
  • 63
    • 0037303045 scopus 로고    scopus 로고
    • Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells
    • Alvarez De La Rosa D, Canessa CM. Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells. Am J Physiol Cell Physiol 2003, 284:C404-C414.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Alvarez De La Rosa, D.1    Canessa, C.M.2


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