Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: Role of the protective endothelium

Journal of Burn Care and Research

Volumn 32, Issue 3, 2011, Pages

  Zhang, Wan Fu ^a   Zhu, Xiong Xiang ^a   Hu, Da Hai ^a   Xu, Cheng Feng ^a   Wang, Yun Chuan ^a   Lv, Gen Fa ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUCOSE; INSULIN; MYELOPEROXIDASE; PROTEIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BURN; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; INSULIN TREATMENT; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INJURY; LUNG LAVAGE; LUNG WEIGHT; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ACUTE LUNG INJURY; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; BURNS; CASPASE 3; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIUM; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; INSULIN; LUNG; MALE; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES;

EID: 79955944824     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e318217f8ae     Document Type: Article

References (34)

1. Huang YS, Yang ZC, Liu XS, et al. Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. Burns 1998;24: 706-16.
2. Dhainaut JF, Abraham E, Opal SM. Proceedings of the third margaux conference on critical illness: the endothelium-an underrecognized organ in critical illness? Crit Care Med 2002;30:S179-348.
3. Murphy JT, Duffy S, Purdue GF, Hunt JL. Differential activation of coronary and pulmonary endothelial cells by thermal injury. Shock 2001;16:227-31. (Pubitemid 33598202)
4. Murphy JT, Duffy S. ZO-1 redistribution and F-actin stress fiber formation in pulmonary endothelial cells after thermal injury. J Trauma 2003;54:81-9.
5. Bochicchio GV, Sung J, Joshi M, et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005;58:921-4. (Pubitemid 40776893)
6. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000;355:773-8. (Pubitemid 30128815)
7. Gauglitz GG, Herndon DN, Jeschke MG. Insulin resistance postburn: underlying mechanisms and current therapeutic strategies. J Burn Care Res 2008;29:683-94.
8. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-67.
9. Dandona P, Mohanty P, Chaudhuri A, Garg R, Aljada A. Insulin infusion in acute illness. J Clin Invest 2005;115: 2069-72. (Pubitemid 41134145)
10. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care? J Clin Invest 2004;114: 1187-95. (Pubitemid 40385286)
11. Deng HP, Chai JK. The effects and mechanisms of insulin on systemic inflammatory response and immune cells in severe trauma, burn injury, and sepsis. Int Immunopharmacol 2009; 9:1251-9.
12. Zhang JP, Ying X, Liang WY, et al. Apoptosis in cardiac myocytes during the early stage after severe burn. J Trauma 2008;65:401-8.
13. Thorell A, Nygren J, Ljungqvist O. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care 1999;2:69-78. (Pubitemid 129628628)
14. Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med 2002;30: 2438-42. (Pubitemid 35351860)
15. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001;32: 2426-32. (Pubitemid 32954818)
16. Clement S, Braithwaite SS, Magee MF, et al; American Diabetes Association Diabetes in Hospitals Writing Committee. Management of diabetes and hyperglycemia in hospitals. Diabetes Care 2004;27:553-91. (Pubitemid 38174086)
17. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354: 449-61. (Pubitemid 43200296)
18. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004;79:992-1000. (Pubitemid 39007018)
19. Yung M, Wilkins B, Norton L, Slater A; Paediatric Study Group; Australian and New Zealand Intensive Care Society. Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med 2008;9:147-52. (Pubitemid 351355025)
20. Jeschke MG, Kulp GA, Kraft R, et al. Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med 2010;182:351-9.
21. Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL. Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery 2008;144: 629-35; discussion 635-7.
22. Pidcoke HF, Wade CE, Wolf SE. Insulin and the burned patient. Crit Care Med 2007;35:S524-30. (Pubitemid 47312189)
23. Whaley JG, Tharakan B, Smith B, Hunter FA, Childs EW. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. J Burn Care Res 2009;30:1018-27.
24. Langouche L, Vanhorebeek I, Vlasselaers D, et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Inves 2005;115:2277-86. (Pubitemid 41134169)
25. Gao F, Gao E, Yue TL, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemiareperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002;105: 1497-502. (Pubitemid 34263284)
26. Kim YM, Bombeck CA, Billiar TR. Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 1999;84:253-6. (Pubitemid 29095565)
27. Kim YM, Kim TH, Seol DW, Talanian RV, Billiar TR. Nitric oxide suppression of apoptosis occurs in association with aninhibition of Bcl-2 cleavage and cytochrome c release. J Biol Chem 1998;273:31437-41.
28. Ishii H, Ishibashi M, Takayama M, Nishida T, Yoshida M. The role of cytokine-induced neutrophil chemoattractant-1in neutrophil-mediated remote lung injury after intestinal ischaemia/reperfusion in rats. Respirology 2000;5:325-31. (Pubitemid 32049494)
29. Li J, Wu F, Zhang H, et al. Insulin inhibits leukocyteendothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion. J Mol Cell Cardiol 2009;47:512-9.
30. Chaudhuri A, Janicke D, Wilson MF, et al. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation 2004;109:849-54. (Pubitemid 38252736)
31. Dandona P, Aljada A, Mohanty P, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001;86: 3257-65. (Pubitemid 32674120)
32. Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002;106: 2067-72. (Pubitemid 35192812)
33. Shanmugam N, Reddy MA, Guha M, Natarajan R. High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 2003;52: 1256-64. (Pubitemid 36523365)
34. Steinberg HO, Tarshoby M, Monestel R, et al. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997;100:1230-9. (Pubitemid 27386309)