Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 4, 2015, Pages 696-707

  Urban, Philippe ^a,b   Truan, Gilles ^a,b   Pompon, Denis ^a,b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b UMR792 INGÉNIERIE DES SYSTÈMES BIOLOGIQUES ET DES PROCÉDÉS   (France)

Author keywords

CAVER; Channel; Chimera; CYP1A1; Polycyclic; Selectivity

Indexed keywords

2 METHYL ANTHRACENE; 2 VINYL ANTHRACENE; 4,5 METHYLENE PHENANTHRENE; 7 ETHOXY FLUORESCEIN ETHYL ESTER; 7 ETHOXY RESORUFIN; 7 METHOXY RESORUFIN; 7,12 DIMETHYL BENZATHRACENE; 9 METHYL ANTHRACENE; 9 PHENYL ANTHRACENE; 9,10 DIHYDRO PHENANTHRENE; ACENAPHTHENE; ANTHRACENE; BENZATHRACENE; BENZO[A]FLUORENE; BENZO[A]PYRENE; BENZO[B]FLUORENE; BENZO[E]PYRENE; CHEMICAL COMPOUND; CHRYSENE; CYTOCHROME P450 1A; FLUORANTHENE; FLUORENE; NAPHTHALENE; PYRENE; STILBENE; TRIPHENYLENE; UNCLASSIFIED DRUG; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2;

ARTICLE; BIOCATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; MULTIVARIATE ANALYSIS; MUTATIONAL ANALYSIS; NONHUMAN; PARTICLE SIZE; PERCEPTION; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS; BINDING SITE; CATALYSIS; CHEMISTRY; MOLECULAR DYNAMICS; PHYSIOLOGY;

BINDING SITES; CATALYSIS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; MOLECULAR DYNAMICS SIMULATION; SUBSTRATE SPECIFICITY;

EID: 84921302202     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.12.015     Document Type: Article

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