Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway

Biochemistry

Volumn 50, Issue 34, 2011, Pages 7361-7374

  Birukou, Ivan ^a   Maillett, David H ^b   Birukova, Anastasiya ^c   Olson, John S ^a  

^a RICE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EDWARDS LIFESCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AROMATIC RINGS; BIMOLECULAR RATE CONSTANTS; BOND FORMATION; DISTAL POCKET; FE ATOMS; GAS PRESSURES; GEMINATE RECOMBINATION; INTERNAL CAVITIES; LIGAND BINDING; LIGAND REBINDING; MIGRATION PATHWAY; NO BINDING; SIDE-CHAINS; STERIC HINDRANCES; WILD TYPES;

RATE CONSTANTS; XENON;

LIGANDS;

CARBON MONOXIDE; HEMOGLOBIN A; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; IRON; LEUCINE; NITROGEN OXIDE; OXYGEN; PHENYLALANINE; PROTEIN SUBUNIT; TRYPTOPHAN; VALINE; XENON;

ARTICLE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; HUMAN; LIGAND BINDING; OXYGENATION; PHOTOLYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE;

AMINO ACID SUBSTITUTION; CARBON MONOXIDE; HEMOGLOBIN A; HUMANS; LIGANDS; MODELS, MOLECULAR; MOVEMENT; MUTATION; PRESSURE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; XENON;

EID: 80051971672     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200923k     Document Type: Article

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