Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast

Pharmacogenetics

Volumn 6, Issue 6, 1996, Pages 489-499

  Gautier, Jean Charles ^a   Lecoeur, Sylvaine ^a   Cosme, José ^a   Perret, Alain ^b   Urban, Philippe ^b   Beaune, Phillippe ^a   Pompon, Denis ^b  

^a INSERM   (France)

^b CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

Author keywords

benzo a pyrene; heterologous expression; human cytochrome P450; metabolism

Indexed keywords

3 HYDROXYBENZO[A]PYRENE; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; BENZO[A]PYRENE; CYTOCHROME P450 ISOENZYME; EPOXIDE HYDROLASE; MUTAGENIC AGENT; PHENOL;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TURNOVER TIME; XENOBIOTIC METABOLISM; YEAST;

BENZO(A)PYRENE; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDROXYDIHYDROBENZOPYRENES; DNA PRIMERS; EPOXIDE HYDROLASES; HUMANS; ISOENZYMES; KINETICS; MICROSOMES, LIVER; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0030473382     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199612000-00002     Document Type: Article

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