Emerging concepts in liver graft preservation

World Journal of Gastroenterology

Volumn 21, Issue 2, 2015, Pages 396-407

  Bejaoui, Mohamed ^a   Pantazi, Eirini ^a   Folch Puy, Emma ^a   Baptista, Pedro M ^b   García Gil, Agustín ^b   Adam, René ^c   Roselló Catafau, Joan ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c HÔPITAL PAUL BROUSSE   (France)

Author keywords

Graft washout solutions; Machine perfusion and liver bioengineering; Preservation solutions; Static cold preservation; Suboptimal liver grafts

Indexed keywords

CARBONATE DEHYDRATASE II; MELATONIN; PRESERVATION SOLUTION; SIRTUIN 1;

AEROBIC METABOLISM; BIOENGINEERING; BODY TEMPERATURE; COOLING; COST EFFECTIVENESS ANALYSIS; CRYOPRESERVATION; GRAFT PRESERVATION; HUMAN; LIVER GRAFT; MACHINE PERFUSION; PERFUSION; REVIEW; ADVERSE EFFECTS; ANIMAL; COLD; DRUG EFFECTS; LIVER; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PATHOLOGY; PROCEDURES; REGENERATIVE MEDICINE; SURGERY; TISSUE SURVIVAL;

ANIMALS; COLD TEMPERATURE; HUMANS; LIVER; LIVER TRANSPLANTATION; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; PERFUSION; REGENERATIVE MEDICINE; TISSUE SURVIVAL;

EID: 84920991972     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i2.396     Document Type: Review

References (117)

1. Guan LY, Fu PY, Li PD, Li ZN, Liu HY, Xin MG, Li W. Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide. World J Gastrointest Surg 2014; 6: 122-128 [PMID: 25068009 DOI: 10.4240/wjgs. v6.i7.122]
2. Schlegel A, Dutkowski P. Role of hypothermic machine perfusion in liver transplantation. Transpl Int 2014; Epub ahead of print [PMID: 24852621 DOI: 10.1111/tri.12354]
3. Graham JA, Guarrera JV. Resuscitation of marginal liver allografts for transplantation with machine perfusion technology. J Hepatol 2014; 61: 418-431 [PMID: 24768755 DOI: 10.1016/j.jhep.2014.04.019]
4. McAnulty JF. Hypothermic organ preservation by static storage methods: Current status and a view to the future. Cryobiology 2010; 60: S13-S19 [PMID: 19538951 DOI: 10.1016/ j.cryobiol.2009.06.004]
5. Guibert EE, Petrenko AY, Balaban CL, Somov AY, Rodriguez JV, Fuller BJ. Organ Preservation: Current Concepts and New Strategies for the Next Decade. Transfus Med Hemother 2011; 38: 125-142 [PMID: 21566713 DOI: 10.1159/000327033]
6. Fuller BJ, Petrenko AY, Rodriguez JV, Somov AY, Balaban CL, Guibert EE. Biopreservation of hepatocytes: current concepts on hypothermic preservation, cryopreservation, and vitrification. Cryo Letters 2013; 34: 432-452 [PMID: 23995411]
7. Fahy GM, Wowk B, Wu J, Phan J, Rasch C, Chang A, Zendejas E. Cryopreservation of organs by vitrification: perspectives and recent advances. Cryobiology 2004; 48: 157-178 [PMID: 15094092 DOI: 10.1016/j.cryobiol.2004.02.002]
8. Scotte M, Eschwege P, Cherruau C, Fontaliran F, Moreau F, Houssin D. Liver preservation below 0 degrees C with UW solution and 2,3-butanediol. Cryobiology 1996; 33: 54-61 [PMID: 8812085 DOI: 10.1006/cryo.1996.0006]
9. al-Abdulla NA, Cole G, Braxton JH, Letsou GV, Liu W, Eisen RN, el-Gamel A, Baldwin JC. The effects of supercooling chemicals on myocardial ultrastructure: a transmission electron microscopy case study. Conn Med 1995; 59: 387-399 [PMID: 7671597]
10. Yoshida K, Matsui Y, Wei T, Kaibori M, Kwon AH, Yamane A, Kamiyama Y. A novel conception for liver preservation at a temperature just above freezing point. J Surg Res 1999; 81: 216-223 [PMID: 9927543 DOI: 10.1006/jsre.1998.5505]
11. Monzen K, Hosoda T, Hayashi D, Imai Y, Okawa Y, Kohro T, Uozaki H, Nishiyama T, Fukayama M, Nagai R. The use of a supercooling refrigerator improves the preservation of organ grafts. Biochem Biophys Res Commun 2005; 337: 534-539 [PMID: 16202974 DOI: 10.1016/j.bbrc.2005.09.082]
12. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med 2014; 20: 790-793 [PMID: 24973919 DOI: 10.1038/nm.3588]
13. Leake I. Liver transplantation. Out in the cold: new supercooling technique extends liver storage time. Nat Rev Gastroenterol Hepatol 2014; 11: 517 [PMID: 25023030 DOI: 10.1038/nrgastro.2014.125]
14. Marsh DC, Lindell SL, Fox LE, Belzer FO, Southard JH. Hypothermic preservation of hepatocytes. I. Role of cell swelling. Cryobiology 1989; 26: 524-534 [PMID: 2480865]
15. Stefanovich P, Ezzell RM, Sheehan SJ, Tompkins RG, Yarmush ML, Toner M. Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes. Cryobiology 1995; 32: 389-403 [PMID: 7656572 DOI: 10.1006/cryo.1995.1039]
16. Southard JH, Belzer FO. Organ preservation. Annu Rev Med 1995; 46: 235-247 [PMID: 7598460 DOI: 10.1146/annurev. med.46.1.235]
17. Morariu AM, Vd Plaats A, V Oeveren W, T Hart NA, Leuvenink HG, Graaff R, Ploeg RJ, Rakhorst G. Hyperaggregating effect of hydroxyethyl starch components and University of Wisconsin solution on human red blood cells: a risk of impaired graft perfusion in organ procurement? Transplantation 2003; 76: 37-43 [PMID: 12865783 DOI: 10.1097/01.TP.0000068044.84652.9F]
18. Zaouali MA, Ben Abdennebi H, Padrissa-Alts S, Mahfoudh-Boussaid A, Roselló-Catafau J. Pharmacological strategies against cold ischemia reperfusion injury. Expert Opin Pharmacother 2010; 11: 537-555 [PMID: 20163266 DOI: 10.151 7/14656560903547836]
19. Ben Abdennebi H, Steghens JP, Margonari J, Ramella-Virieux S, Barbieux A, Boillot O. High-Na+ low-K+ UW cold storage solution reduces reperfusion injuries of the rat liver graft. Transpl Int 1998; 11: 223-230 [PMID: 9638853]
20. Boudjema K, Grandadam S, Compagnon P, Salam E, Wolf P, Ducerf C, Le Treut P, Soubrane O, Cherqui D, Mouchel C, Renault A, Bellissant E. Efficacy and safety of Celsior preservation fluid in liver transplantation: one-year follow up of a prospective, multicenter, non-randomized study. Clin Transplant 2012; 26: 199-207 [PMID: 21517997 DOI: 10.1111/j.1399-0012.2011.01447.x]
21. OCallaghan JM, Morgan RD, Knight SR, Morris PJ. The effect of preservation solutions for storage of liver allografts on transplant outcomes: a systematic review and metaanalysis. Ann Surg 2014; 260: 46-55 [PMID: 24374537 DOI: 10.1097/SLA.0000000000000402]
22. Pokorny H, Rasoul-Rockenschaub S, Langer F, Windhager T, Rosenstingl A, Lange R, Königsrainer A, Ringe B, Mhlbacher F, Steininger R. Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation-a prospective multi-centre observation study. Transpl Int 2004; 17: 256-260 [PMID: 15160235 DOI: 10.1007/s00147-004-0709-4]
23. Stewart ZA, Cameron AM, Singer AL, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant 2009; 9: 286-293 [PMID: 19067658 DOI: 10.1111/ j.1600-6143.2008.02478.x]
24. Mosbah IB, Zaouali MA, Martel C, Bjaoui M, Abdennebi HB, Hotter G, Brenner C, Roselló-Catafau J. IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation. Cell Death Dis 2012; 3: e279 [PMID: 22402603 DOI: 10.1038/cddis.2012.12]
25. Ben Mosbah I, Casillas-Ramrez A, Xaus C, Serafn A, Roselló-Catafau J, Peralta C. Trimetazidine: is it a promising drug for use in steatotic grafts? World J Gastroenterol 2006; 12: 908-914 [PMID: 16521219]
26. Codas R, Petruzzo P, Morelon E, Lefrançois N, Danjou F, Berthillot C, Contu P, Espa M, Martin X, Badet L. IGL-1 solution in kidney transplantation: first multi-center study. Clin Transplant 2009; 23: 337-342 [PMID: 19210685 DOI: 10.1111/j.1399-0012.2009.00959.x]
27. Badet L, Abdennebi HB, Petruzzo P, McGregor B, Espa M, Hadj-Aissa A, Ramella-Virieux S, Steghens JP, Portoghese F, Morelon E, Martin X. [Evaluation of IGL-1, a new organ preservation solution: preclinical results in renal transplantation]. Prog Urol 2005; 15: 481-48; discussion 487 [PMID: 16097154]
28. Dondro F, Paugam-Burtz C, Danjou F, Stocco J, Durand F, Belghiti J. A randomized study comparing IGL-1 to the University of Wisconsin preservation solution in liver transplantation. Ann Transplant 2010; 15: 7-14 [PMID: 21183870]
29. Zaouali MA, Ben Abdennebi H, Padrissa-Alts S, Alfany-Fernandez I, Rimola A, Roselló-Catafau J. How Institut Georges Lopez preservation solution protects nonsteatotic and steatotic livers against ischemia-reperfusion injury. Transplant Proc 2011; 43: 77-79 [PMID: 21335159 DOI: 10.10 16/j.transproceed.2010.12.026]
30. Zaouali MA, Ben Mosbah I, Boncompagni E, Ben Abdennebi H, Mitjavila MT, Bartrons R, Freitas I, Rimola A, Roselló-Catafau J. Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxide. World J Gastroenterol 2010; 16: 3499-3509 [PMID: 20653058]
31. Ben Mosbah I, Roselló-Catafau J, Franco-Gou R, Abdennebi HB, Saidane D, Ramella-Virieux S, Boillot O, Peralta C. Preservation of steatotic livers in IGL-1 solution. Liver Transpl 2006; 12: 1215-1223 [PMID: 16724331 DOI: 10.1002/lt.20788]
32. Bradley JA. Effect of polyethylene glycol-based preservation solut ions on graf t injury in exper imental kidney transplantation (Br J Surg 2010; 98: 368-378). Br J Surg 2011; 98: 378-379 [PMID: 21254011 DOI: 10.1002/bjs.7389]
33. Savier E, Granger B, Charlotte F, Cormillot N, Siksik JM, Vaillant JC, Hannoun L. Liver preservation with SCOT 15 solution decreases posttransplantation cholestasis compared with University of Wisconsin solution: a retrospective study. Transplant Proc 2011; 43: 3402-3407 [PMID: 22099807 DOI: 10.1016/j.transproceed.2011.09.054]
34. Mosbah IB, Saidane D, Peralta C, Roselló-Catafau J, Abdennebi HB. Efficacy of polyethylene glycols in University of Wisconsin preservation solutions: a study of isolated perfused rat liver. Transplant Proc 2005; 37: 3948-3950 [PMID: 16386593 DOI: 10.1016/j.transproceed.2005.10.038]
35. Singh D, Chopra K. Effect of trimetazidine on renal ischemia/reperfusion injury in rats. Pharmacol Res 2004; 50: 623-629 [PMID: 15501702 DOI: 10.1016/j.phrs.2004.06.006]
36. Mahfoudh-Boussaid A, Zaouali MA, Hauet T, Hadj-Ayed K, Miled AH, Ghoul-Mazgar S, Saidane-Mosbahi D, Rosello-Catafau J, Ben Abdennebi H. Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment. J Biomed Sci 2012; 19: 71 [PMID: 22853733 DOI: 10.1186/1423-0127-19-71]
37. Elimadi A, Settaf A, Morin D, Sapena R, Lamchouri F, Cherrah Y, Tillement JP. Trimetazidine counteracts the hepatic injury associated with ischemia-reperfusion by preserving mitochondrial function. J Pharmacol Exp Ther 1998; 286: 23-28 [PMID: 9655837]
38. Zaouali MA, Boncompagni E, Reiter RJ, Bejaoui M, Freitas I, Pantazi E, Folch-Puy E, Abdennebi HB, Garcia-Gil FA, Roselló-Catafau J. AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail. J Pineal Res 2013; 55: 65-78 [PMID: 23551302 DOI: 10.1111/jpi.12051]
39. Ruixing Y, Wenwu L, Al-Ghazali R. Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemiareperfusion. Transl Res 2007; 149: 152-160 [PMID: 17320801 DOI: 10.1016/j.trsl.2006.11.004]
40. Khazanov VA, Kiseliova AA, Vasiliev KY, Chernyschova GA. Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. Bull Exp Biol Med 2008; 146: 218-222 [PMID: 19145322]
41. Dehina L, Vaillant F, Tabib A, Bui-Xuan B, Chevalier P, Dizerens N, Bui-Xuan C, Descotes J, Blanc-Guillemaud V, Lerond L, Timour Q. Trimetazidine demonstrated cardioprotective effects through mitochondrial pathway in a model of acute coronary ischemia. Naunyn Schmiedebergs Arch Pharmacol 2013; 386: 205-215 [PMID: 23263451 DOI: 10.1007/s00210-012-0826-z]
42. Settaf A, Zaim N, Bellouch M, Tillement JP, Morin D. [Trimetazidine prevents ischemia-reperfusion injury in hepatic surgery under vascular clamping]. Therapie 2001; 56: 569-574 [PMID: 11806295]
43. Zaoual MA, Reiter RJ, Padrissa-Alts S, Boncompagni E, Garca JJ, Ben Abnennebi H, Freitas I, Garca-Gil FA, Rosello-Catafau J. Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reper-fusion injury. J Pineal Res 2011; 50: 213-221 [PMID: 21108657 DOI: 10.1111/j.1600-079X.2010.00831.x]
44. Zaouali MA, Padrissa-Alts S, Ben Mosbah I, Ben Abdennebi H, Boillot O, Rimola A, Saidane-Mosbahi D, Roselló-Catafau J. Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution. World J Gastroenterol 2010; 16: 5693-5700 [PMID: 21128318 DOI: 10.3748/wjg.v16.i45.5693]
45. Zaouali MA, Padrissa-Alts S, Ben Mosbah I, Alfany-Fernandez I, Massip-Salcedo M, Casillas-Ramirez A, Bintanel-Morcillo M, Boillot O, Serafin A, Rimola A, Rods J, Roselló-Catafau J, Peralta C. Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution. Liver Transpl 2010; 16: 1098-1111 [PMID: 20818748 DOI: 10.1002/lt.22126]
46. Zaouali MA, Ben Mosbah I, Padrissa-Alts S, Calvo M, Ben Abdennebi H, Saidane-Mosbahi D, Bjaoui M, Garcia-Gil FA, Panisello A, Roselló-Catafau J. Relevance of epidermal growth factor to improve steatotic liver preservation in IGL-1 solution. Transplant Proc 2010; 42: 3070-3075 [PMID: 20970612 DOI: 10.1016/j.transproceed.2010.07.071]
47. Padrissa-Alts S, Zaouali MA, Bartrons R, Roselló-Catafau J. Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms. Clin Sci (Lond) 2012; 123: 93-98 [PMID: 22455352 DOI: 10.1042/CS20110093]
48. Geng Q, Romero J, Saini V, Baker TA, Picken MM, Gamelli RL, Majetschak M. A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia. Biochem Biophys Res Commun 2009; 390: 1136-1141 [PMID: 19944202 DOI: 10.1016/j.bbrc.2009.10.067]
49. Baker TA, Geng Q, Romero J, Picken MM, Gamelli RL, Majetschak M. Prolongation of myocardial viability by proteasome inhibition during hypothermic organ preservation. Biochem Biophys Res Commun 2010; 401: 548-553 [PMID: 20875792 DOI: 10.1016/j.bbrc.2010.09.093]
50. Zaouali MA, Bardag-Gorce F, Carbonell T, Oliva J, Pantazi E, Bejaoui M, Ben Abdennebi H, Rimola A, Roselló-Catafau J. Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury. Exp Mol Pathol 2013; 94: 352-359 [PMID: 23305864 DOI: 10.1016/ j.yexmp.2012.12.005]
51. Bejaoui M, Zaouali MA, Folch-Puy E, Pantazi E, Bardag-Gorce F, Carbonell T, Oliva J, Rimola A, Abdennebi HB, Roselló-Catafau J. Bortezomib enhances fatty liver preservation in Institut George Lopez-1 solution through adenosine monophosphate activated protein kinase and Akt/mTOR pathways. J Pharm Pharmacol 2014; 66: 62-72 [PMID: 24127984 DOI: 10.1111/jphp.12154]
52. Imtaiyaz Hassan M, Shajee B, Waheed A, Ahmad F, Sly WS. Structure, function and applications of carbonic anhydrase isozymes. Bioorg Med Chem 2013; 21: 1570-1582 [PMID: 22607884 DOI: 10.1016/j.bmc.2012.04.044]
53. Sjöblom M, Singh AK, Zheng W, Wang J, Tuo BG, Krabbenhöft A, Riederer B, Gros G, Seidler U. Duodenal acidity sensing but not epithelial HCO3-supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci USA 2009; 106: 13094-13099 [PMID: 19622732 DOI: 10.1073/pnas.0901488106]
54. Bejaoui M, Zaouali MA, Pantazi E, Folch-Puy E, Abdennebi HB, Hotter G, Roselló-Catafau J. New Insights in Fatty Liver Preservation: A Role for Carbonic Anhydrase II. Transplantation 2014; 98: 372
55. Endo A. The discovery and development of HMG-CoA reductase inhibitors. 1992. Atheroscler Suppl 2004; 5: 67-80 [PMID: 15531278 DOI: 10.1016/j.atherosclerosissup.2004.08. 026]
56. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 2005; 45: 89-118 [PMID: 15822172 DOI: 10.1146/annurev.pharmtox.45.120403.095748]
57. Guilln D, Cofn F, Ros E, Milln O, Cofn M, Brunet M. Biomarker assessment of the immunomodulator effect of atorvastatin in stable renal transplant recipients and hypercholesterolemic patients. Mol Diagn Ther 2010; 14: 357-366 [PMID: 21047146 DOI: 10.2165/11539620-000000000-00000]
58. Mooradian AD, Haas MJ, Batejko O, Hovsepyan M, Feman SS. Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats. Diabetes 2005; 54: 2977-2982 [PMID: 16186401]
59. Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y. Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway. Arterioscler Thromb Vasc Biol 2010; 30: 2205-2211 [PMID: 20705918 DOI: 10.1161/ ATVBAHA.110.210500]
60. Rikitake Y, Liao JK. Rho GTPases, statins, and nitric oxide. Circ Res 2005; 97: 1232-1235 [PMID: 16339495 DOI: 10.1161/01.RES.0000196564.18314.23]
61. Lai IR, Chang KJ, Tsai HW, Chen CF. Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction. Transplantation 2008; 85: 732-738 [PMID: 18337668 DOI: 10.1097/TP.0b013e3181664e70]
62. Gracia-Sancho J, Garca-Calderó H, Hide D, Marrone G, Guix-Muntet S, Peralta C, Garca-Pagn JC, Abraldes JG, Bosch J. Simvastatin maintains function and viability of steatotic rat livers procured for transplantation. J Hepatol 2013; 58: 1140-1146 [PMID: 23428876 DOI: 10.1016/j.jhep. 2013.02.005]
63. Cmara-Lemarroy CR, Guzmn-de la Garza FJ, Alarcón-Galvn G, Cordero-Prez P, Muoz-Espinosa L, Torres-Gonzlez L, Fernndez-Garza NE. Hepatic ischemia/reperfusion injury is diminished by atorvastatin in Wistar rats. Arch Med Res 2014; 45: 210-216 [PMID: 24726586 DOI: 10.1016/j.arcmed.2014.02.001]
64. Russo L, Gracia-Sancho J, Garca-Calderó H, Marrone G, Garca-Pagn JC, Garca-Cardea G, Bosch J. Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers. Hepatology 2012; 55: 921-930 [PMID: 22031447 DOI: 10.1002/hep.24755]
65. Hori YS, Kuno A, Hosoda R, Horio Y. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One 2013; 8: e73875 [PMID: 24040102 DOI: 10.1371/journal. pone.0073875]
66. Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S, Sadoshima J. Silent information regulator 1 protects the heart from ischemia/ reperfusion. Circulation 2010; 122: 2170-2182 [PMID: 21060073 DOI: 10.1161/CIRCULATIONAHA.110.958033]
67. Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 2012; 92: 1479-1514 [PMID: 22811431 DOI: 10.1152/physrev.00022.2011]
68. Pantazi E, Zaouali MA, Bejaoui M, Serafin A, Folch-Puy E, Petegnief V, De Vera N, Ben Abdennebi H, Rimola A, Roselló-Catafau J. Silent information regulator 1 protects the liver against ischemia-reperfusion injury: implications in steatotic liver ischemic preconditioning. Transpl Int 2014; 27: 493-503 [PMID: 24472096 DOI: 10.1111/tri.12276]
69. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci USA 2010; 107: 10268-10273 [PMID: 20479254 DOI: 10.1073/ pnas.1003833107]
70. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 2008; 283: 27628-27635 [PMID: 18687677 DOI: 10.1074/jbc.M805711200]
71. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010; 17: 41-52 [PMID: 20129246 DOI: 10.1016/j.ccr.2009.11.023]
72. Zhang L, Zhu Z, Liu J, Zhu Z, Hu Z. Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway. J Recept Signal Transduct Res 2014; 34: 396-400 [PMID: 24734887 DOI: 10.310 9/10799893.2014.908916]
73. Deng C, Sun Z, Tong G, Yi W, Ma L, Zhao B, Cheng L, Zhang J, Cao F, Yi D. A-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/ reperfusion injury through activation of PI3K/Akt/Nrf2 pathway. PLoS One 2013; 8: e58371 [PMID: 23505496 DOI: 10.1371/journal.pone.0058371]
74. Ben Mosbah I, Mouchel Y, Pajaud J, Ribault C, Lucas C, Laurent A, Boudjema K, Morel F, Corlu A, Compagnon P. Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat. PLoS One 2012; 7: e50235 [PMID: 23226251 DOI: 10.1371/journal. pone.0050235]
75. Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg 2014; 260: 118-127 [PMID: 24368646 DOI: 10.1097/SLA.0000000000000287]
76. Zaouali MA, Bejaoui M, Calvo M, Folch-Puy E, Pantazi E, Pasut G, Rimola A, Ben Abdennebi H, Adam R, Roselló-Catafau J. Polyethylene glycol rinse solution: An effective way to prevent ischemia-reperfusion injury. World J Gastroenterol 2014; 20: 16203-16214 [PMID: 25473175 DOI: 10.3748/wjg.v20.i43.16203]
77. Hauet T, Eugene M. A new approach in organ preservation: potential role of new polymers. Kidney Int 2008; 74: 998-1003 [PMID: 18633345 DOI: 10.1038/ki.2008.336]
78. Luo J, Borgens R, Shi R. Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury. J Neurochem 2002; 83: 471-480 [PMID: 12423257]
79. Mack JE, Kerr JA, Vreugdenhil PK, Belzer FO, Southard JH. Effect of polyethylene glycol on lipid peroxidation in cold-stored rat hepatocytes. Cryobiology 1991; 28: 1-7 [PMID: 2015757]
80. Bertuglia S, Veronese FM, Pasut G. Polyethylene glycol and a novel developed polyethylene glycol-nitric oxide normalize arteriolar response and oxidative stress in ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2006; 291: H1536-H1544 [PMID: 16489107 DOI: 10.1152/ajpheart.01 114.2005]
81. Malhotra R, Valuckaite V, Staron ML, Theccanat T, D Souza KM, Alverdy JC, Akhter SA. High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxiaand reoxygenation-induced cell death and preserves ventricular function. Am J Physiol Heart Circ Phy-siol 2011; 300: H1733-H1742 [PMID: 21335476 DOI: 10.1152/ajpheart. 01054.2010]
82. Dutheil D, Underhaug Gjerde A, Petit-Paris I, Mauco G, Holmsen H. Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection? J Chem Biol 2009; 2: 39-49 [PMID: 19568791 DOI: 10.1007/s12154-009-0014-x]
83. Luo J, Borgens R, Shi R. Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury. J Neurotrauma 2004; 21: 994-1007 [PMID: 15318999 DOI: 10.1089/08977150416510 97]
84. Taylor MJ, Baicu SC. Current state of hypothermic machine perfusion preservation of organs: The clinical perspective. Cryobiology 2010; 60: S20-S35 [PMID: 19857479 DOI: 10.1016/ j.cryobiol.2009.10.006]
85. Balfoussia D, Yerrakalva D, Hamaoui K, Papalois V. Advances in machine perfusion graft viability assessment in kidney, liver, pancreas, lung, and heart transplant. Exp Clin Transplant 2012; 10: 87-100 [PMID: 22432750]
86. Henry SD, Nachber E, Tulipan J, Stone J, Bae C, Reznik L, Kato T, Samstein B, Emond JC, Guarrera JV. Hypothermic machine preservation reduces molecular markers of ischemia/ reperfusion injury in human liver transplantation. Am J Transplant 2012; 12: 2477-2486 [PMID: 22594953 DOI: 10.1111/j.1600-6143.2012.04086.x]
87. Guarrera JV, Henry SD, Samstein B, Odeh-Ramadan R, Kinkhabwala M, Goldstein MJ, Ratner LE, Renz JF, Lee HT, Brown RS, Emond JC. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant 2010; 10: 372-381 [PMID: 19958323 DOI: 10.1111/ j.1600-6143.2009.02932.x]
88. Dutkowski P, Schönfeld S, Heinrich T, Watzka M, Winkelbach V, Krysiak M, Odermatt B, Junginger T. Reduced oxidative stress during acellular reperfusion of the rat liver after hypothermic oscillating perfusion. Transplantation 1999; 68: 44-50 [PMID: 10428265]
89. Bessems M, Doorschodt BM, Kolkert JL, Vetelainen RL, van Vliet AK, Vreeling H, van Marle J, van Gulik TM. Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation. Liver Transpl 2007; 13: 497-504 [PMID: 17394146 DOI: 10.1002/lt.21039]
90. Vekemans K, Liu Q, Brassil J, Komuta M, Pirenne J, Monbaliu D. Influence of flow and addition of oxygen during porcine liver hypothermic machine perfusion. Transplant Proc 2007; 39: 2647-2651 [PMID: 17954199 DOI: 10.1016/j.tra nsproceed.2007.08.007]
91. Schlegel A, Graf R, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) protects from biliary injury in a rodent model of DCD liver transplantation. J Hepatol 2013; 59: 984-991 [PMID: 23820408 DOI: 10.1016/j.jhep. 2013.06.022]
92. Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM. Improved rat liver preservation by hypothermic continuous machine perfusion using polysol, a new, enriched preservation solution. Liver Transpl 2005; 11: 539-546 [PMID: 15838888 DOI: 10.1002/lt.20388]
93. Bae C, Pichardo EM, Huang H, Henry SD, Guarrera JV. The benefits of hypothermic machine perfusion are enhanced with Vasosol and α-tocopherol in rodent donation after cardiac death livers. Transplant Proc 2014; 46: 1560-1566 [PMID: 24880463 DOI: 10.1016/j.transproceed.2013.12.050]
94. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20C and 30C recovers ischemic rat livers for successful transplantation. J Surg Res 2012; 175: 149-156 [PMID: 21550058 DOI: 10.1016/j.jss.2011.03.003]
95. Bruinsma BG, Yeh H, Ozer S, Martins PN, Farmer A, Wu W, Saeidi N, Op den Dries S, Berendsen TA, Smith RN, Markmann JF, Porte RJ, Yarmush ML, Uygun K, Izamis ML. Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation. Am J Transplant 2014; 14: 1400-1409 [PMID: 24758155 DOI: 10.1111/ajt.12727]
96. Imber CJ, St Peter SD, Lopez de Cenarruzabeitia I, Pigott D, James T, Taylor R, McGuire J, Hughes D, Butler A, Rees M, Friend PJ. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation 2002; 73: 701-709 [PMID: 11907414]
97. Tolboom H, Pouw RE, Izamis ML, Milwid JM, Sharma N, Soto-Gutierrez A, Nahmias Y, Uygun K, Berthiaume F, Yarmush ML. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation 2009; 87: 170-177 [PMID: 19155970 DOI: 10.1097/TP.0b013e 318192df6b]
98. Schön MR, Kollmar O, Wolf S, Schrem H, Matthes M, Akkoc N, Schnoy NC, Neuhaus P. Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg 2001; 233: 114-123 [PMID: 11141233]
99. St Peter SD, Imber CJ, Lopez I, Hughes D, Friend PJ. Extended preservation of non-heart-beating donor livers with normothermic machine perfusion. Br J Surg 2002; 89: 609-616 [PMID: 11972552 DOI: 10.1046/j.1365-2168.2002.02052.x]
100. Fondevila C, Hessheimer AJ, Maathuis MH, Muoz J, Taur P, Calatayud D, Leuvenink H, Rimola A, Ploeg RJ, Garca-Valdecasas JC. Superior preservation of DCD livers with continuous normothermic perfusion. Ann Surg 2011; 254: 1000-1007 [PMID: 21862925 DOI: 10.1097/SLA.0b013e31822b8b2f]
101. Ravikumar R, Coussios CC, Holroyd D, Heaton N, Friend PJ, Jassem W. Human Liver Transplantation Using Normothermic Machine Preservation. Liver Transplant 2014; 20: S103
102. Jamieson RW, Zilvetti M, Roy D, Hughes D, Morovat A, Coussios CC, Friend PJ. Hepatic steatosis and normothermic perfusion-preliminary experiments in a porcine model. Transplantation 2011; 92: 289-295 [PMID: 21681143 DOI: 10.1097/TP.0b013e318223d817]
103. Nagrath D, Xu H, Tanimura Y, Zuo R, Berthiaume F, Avila M, Yarmush R, Yarmush ML. Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo. Metab Eng 2009; 11: 274-283 [PMID: 19508897 DOI: 10.1016/j.ymben.2009.05.005]
104. Boehnert MU, Yeung JC, Bazerbachi F, Knaak JM, Selzner N, McGilvray ID, Rotstein OD, Adeyi OA, Kandel SM, Rogalla P, Yip PM, Levy GA, Keshavjee S, Grant DR, Selzner M. Normothermic acellular ex vivo liver perfusion reduces liver and bile duct injury of pig livers retrieved after cardiac death. Am J Transplant 2013; 13: 1441-1449 [PMID: 23668775 DOI: 10.1111/ajt.12224]
105. Nativ NI, Yarmush G, So A, Barminko J, Maguire TJ, Schloss R, Berthiaume F, Yarmush ML. Elevated sensitivity of macrosteatotic hepatocytes to hypoxia/reoxygenation stress is reversed by a novel defatting protocol. Liver Transpl 2014; 20: 1000-1011 [PMID: 24802973 DOI: 10.1002/lt.23905]
106. Baptista PM, Siddiqui MM, Lozier G, Rodriguez SR, Atala A, Soker S. The use of whole organ decellularization for the generation of a vascularized liver organoid. Hepatology 2011; 53: 604-617 [PMID: 21274881 DOI: 10.1002/hep.24067]
107. Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. Perfusion-decellularized matrix: using natures platform to engineer a bioartificial heart. Nat Med 2008; 14: 213-221 [PMID: 18193059 DOI: 10.1038/nm1684]
108. Baptista PM, Orlando G, Mirmalek-Sani SH, Siddiqui M, Atala A, Soker S. Whole organ decellularization-a tool for bioscaffold fabrication and organ bioengineering. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 6526-6529 [PMID: 19964173 DOI: 10.1109/IEMBS.2009.5333145]
109. Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB, Gavrilov K, Yi T, Zhuang ZW, Breuer C, Herzog E, Niklason LE. Tissue-engineered lungs for in vivo implantation. Science 2010; 329: 538-541 [PMID: 20576850 DOI: 10.1126/ science.1189345]
110. Song JJ, Guyette JP, Gilpin SE, Gonzalez G, Vacanti JP, Ott HC. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med 2013; 19: 646-651 [PMID: 23584091 DOI: 10.1038/nm.3154]
111. Wang Y, Cui CB, Yamauchi M, Miguez P, Roach M, Malavarca R, Costello MJ, Cardinale V, Wauthier E, Barbier C, Gerber DA, Alvaro D, Reid LM. Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. Hepatology 2011; 53: 293-305 [PMID: 21254177 DOI: 10.1002/hep.24012]
112. Badylak SF. Regenerative medicine and developmental biology: the role of the extracellular matrix. Anat Rec B New Anat 2005; 287: 36-41 [PMID: 16308858 DOI: 10.1002/ar.b. 20081]
113. Nowocin AK, Southgate A, Gabe SM, Ansari T. Biocompatibility and potential of decellularized porcine small intestine to support cellular attachment and growth. J Tissue Eng Regen Med 2013; Epub ahead of print [PMID: 23894134 DOI: 10.1002/term.1750]
114. Caralt M, Velasco E, Lanas A, Baptista PM. Liver bioengineering: from the stage of liver decellularized matrix to the multiple cellular actors and bioreactor special effects. Organogenesis 2014; 10: 250-259 [PMID: 25102189 DOI: 10.4161/org.29892]
115. Van Raemdonck D, Neyrinck A, Rega F, Devos T, Pirenne J. Machine perfusion in organ transplantation: a tool for exvivo graft conditioning with mesenchymal stem cells? Curr Opin Organ Transplant 2013; 18: 24-33 [PMID: 23254699 DOI: 10.1097/MOT.0b013e32835c494f]
116. Iwai S, Sakonju I, Okano S, Teratani T, Kasahara N, Yokote S, Yokoo T, Kobayash E. Impact of ex vivo administration of mesenchymal stem cells on the function of kidney grafts from cardiac death donors in rat. Transplant Proc 2014; 46: 1578-1584 [PMID: 24935331 DOI: 10.1016/j.transproceed.201 3.12.068]
117. Padrissa-Alts S, Zaouali MA, Boncompagni E, Bonaccorsi-Riani E, Carbonell T, Bardag-Gorce F, Oliva J, French SW, Bartrons R, Roselló-Catafau J. The use of a reversible proteasome inhibitor in a model of Reduced-Size Orthotopic Liver transplantation in rats. Exp Mol Pathol 2012; 93: 99-110 [PMID: 22475623 DOI: 10.1016/j.yexmp.2012.03.011]