Trimetazidine counteracts the hepatic injury associated with ischemia- reperfusion by preserving mitochondrial function

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 1, 1998, Pages 23-28

  Elimadi, Aziz ^a   Settaf, Abdellatif ^c   Morin, Didier ^a,b   Sapena, Rosa ^a   Lamchouri, Fatima ^c   Cherrah, Yahia ^c   Tillement, Jean Paul ^a  

^a FACULTÉ DE MÉDECINE   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c MOHAMMED V UNIVERSITY   (Morocco)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LIVER PROTECTIVE AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM CHLORIDE; TRIMETAZIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; INTRAMUSCULAR DRUG ADMINISTRATION; LIVER INJURY; LIVER ISCHEMIA; LIVER MITOCHONDRION; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ISCHEMIA; LIVER; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; NAD; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 0031869856     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Barnard ML, Snyder SJ, Engerson TD and Turrens JF (1993) Antioxidant enzyme status of ischemic and postischemic liver and ischemic kidney in rats. Free Radic Biol Med 15:227-232.
2. Caraceni P, Gasbarrini A, Van Thiel DH and Borle AB (1994) Oxygen free radical formation by rat hepatocytes during postanoxic reoxygenation: Scavenging effect of albumin. Am J Physiol 266:G451-G458.
3. Cruz C, Zaoui A, Ayoub S, Harpey C, Goupit P and Younes A (1987) Altérations des myocytes isolés des ventricules de coeur de rat adulte: Protection par la trimétazidine. Concours Med 36(suppl):3470-3475.
4. Detry JM (1993) Clinical features of an anti-anginal drug in angina pectoris. Eur Heart J 14(suppl G):18-24.
5. 2-dependent mitochondrial swelling. Fundam Clin Pharmacol 11:440-447.
6. Emaus RK, Grunwald R and Lemaster JJ (1986) Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria. Biochim Biophys Acta 850:436-448.
7. Fujii Y, Johnson ME and Gores GJ (1994) Mitochondrial dysfunction during anoxia-reperfusion injury of sinusoidal endothelial cells. Hepatology 20:177-185.
8. Gonzalez-Flecha B, Cutrin JC and Boveris A (1993) Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion. J Clin Invest 91:456-464.
9. Guarnieri C and Muscari C (1993) Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium. Pharmacology 46:324-331.
10. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin A is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomnerase and preventing it from interacting with the adenine nucleotide translocate. Biochem J 268:153-160.
11. Harpey C, Labrid C and Baud L (1987) Evidence for antioxidant properties of trimetazidine. Xth International Congress on Pharmacology, Sydney, Australia, August 23-28 Abstracts, p. 649.
12. Harpey C, Clauser P, Labrid C, Freyra JL and Poirier P (1989) Trimetazidine, a cellular anti-ischemic agent. Cardiovasc Drug Rev 6:292-312.
13. Jaeschke H and Mitchel JR (1989) Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. Biochim Biophys Res Commun 160:140-147.
14. Jaworec D, Greber W and Bergmeyer HV (1974) Adenosine 5′-triphosphate. In Methods in Enzymatic Analysis, ed. by Bergmeyer HV, pp. 2097-2101, Academic Press, New York.
15. Johnson D and Lardy HA (1967) Isolation of liver and kidney mitochondria. In Methods in Enzymology, ed. by Estabook RW and Pullman M, pp. 94-96, Academic Press, New York.
16. Koo A, Komatsu H, Tao G, Inoue M, Guth PH and Kaplowitz N (1992) Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: Evidence for a role for superoxide anion. Hepatology 15:507-514.
17. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
18. 2+ overload. J Physiol 476:459-471.
19. Nauta RJ, Uribe M, Walsh DB, Miller D and Butterfield A (1989) Description of a chronic in vivo model for the study of warm hepatic ischemia-reperfusion injury. Surg Res Commun 6:241-246.
20. Okuaki Y, Miyazaki H, Zeniya M, Ishikawa T, Ohkawa Y, Tsuno S, Sakguchi M, Hara M, Takahashi H and Toda G (1996) Splenectomy-reduced hepatic injury induced by ischemia/reperfusion in the rat. Liver 16:188-194.
21. Rao PS, Cohen MV and Mueller H (1983) Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J Mol Cell Cardiol 15:713-716.
22. Rosser BG and Gores GJ (1995) Liver cell necrosis: Cellular mechanisms and clinical implications. Gastroenterology 108:252-275.
23. Salducci MD, Chauvet-Monges AM, Tillement JP, Albengres E, Testa B, Carrupt P and Crevat A (1996) Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporin A in isolated rat liver mitochondria. J Pharmacol Exp Ther 277:417-422.
24. Tsimoyiannis EC, Moutesidou KJ, Moschos CM, Karianthi M, Karkabounas S and Kotoulas OB (1993) Trimetazidine for prevention of hepatic injury induced by ischemia and reperfusion in rats. Eur J Surg 159:89-93.
25. Yamamoto S, Shimizu K, Oonishi I, Hasebe K, Takamura H, Inoue T, Muraoka K, Tani T, Hashimoto T and Yagi M (1996) Genistein suppresses cellular injury following hepatic ischemia-reperfusion. Transplant Proc 28:1111-1115.