Duodenal acidity "sensing" but not epithelial HCO 3- supply is critically dependent on carbonic anhydrase II expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 31, 2009, Pages 13094-13099

  Sjöblom, Markus ^a,b   Singh, Anurag Kumar ^a   Zheng, Wen ^a   Wang, Jian ^a   Tuo, Bi Guang ^a   Krabbenhöft, Anja ^a   Riederer, Brigitte ^a   Gros, Gerolf ^a   Seidler, Ursula ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Bicarbonate secretion; Duodenal mucosal protection; Duodenal ulcers; Gastric acid; Gastrointestinal phenotype

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; ACETAZOLAMIDE; ACID; BICARBONATE; CARBONATE DEHYDRATASE II; DYE; DYE SNARF 1F; FORSKOLIN; ISOFLURANE; METHAZOLAMIDE; PROSTAGLANDIN E2; SODIUM CARBONATE; UNCLASSIFIED DRUG; CARBON DIOXIDE;

ACIDIFICATION; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CLINICAL ASSESSMENT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG INHIBITION; DUODENUM PH; DUODENUM SECRETION; EPITHELIUM; FEMALE; IN VIVO STUDY; INFUSION; INTESTINE PERFUSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY ACIDOSIS; SIGNAL TRANSDUCTION; STOMACH ACID; STOMACH ACID SECRETION; TWO PHOTON CONFOCAL MICROSCOPY; VASCULARIZATION; WILD TYPE; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; DUODENUM; METABOLISM; PH; PHYSIOLOGY;

MURINAE; MUS;

16,16-DIMETHYLPROSTAGLANDIN E2; ACETAZOLAMIDE; ANIMALS; BICARBONATES; CARBON DIOXIDE; CARBONIC ANHYDRASE II; DUODENUM; FORSKOLIN; HYDROGEN-ION CONCENTRATION; METHAZOLAMIDE; MICE; MICE, INBRED C57BL;

EID: 69149085738     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901488106     Document Type: Article

References (42)

1. Allen A, Flemström G (2005) Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288:C1-C19.
2. Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 316:374-379.
3. Flemström G, Isenberg JI (2001) Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16:23-28.
4. Holm M, Johansson B, Pettersson A, Fändriks L (1998) Carbon dioxide mediates duodenal mucosal alkaline secretion in response to luminal acidity in the anesthetized rat. Gastroenterology 115:680-685.
5. 2 in rat duodenum. Gastroenterology 131:142-152.
6. 2 and pH regulation in rat duodenal mucosa. J Physiol 573:827-842.
7. - secretion in the human proximal duodenum. Gastroenterology 108:102-107.
8. Muallem R, et al. (1994) Role of carbonic anhydrase in basal and stimulated bicarbonate secretion by the guinea pig duodenum. Dig Dis Sci 39:1078-1084.
9. --ATPase, supernatant carbonic anhydrase and other enzyme activities isolated from rat intestinal mucosa: Effect of adrenalectomy and aldosterone administration. J Steroid Biochem 19:1419-1433.
10. + exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology 119:406-419.
11. Sugai N, Okamura H, Tsunoda R (1994) Histochemical localization of carbonic anhydrase in the rat duodenal epithelium. Fukushima J Med Sci 40:103-117.
12. Kivelä AJ, Kivelä J, Saarnio J, Parkkila S (2005) Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours. World J Gastroenterol 11:155-163.
13. Shousha S, Pestonjee D (1987) Distribution of carbonic anhydrase I in gastric and duodenal tissue sections. Arch Pathol Lab Med 111:279-281.
14. Lönnerholm G, Knutson L, Wistrand PJ, Flemström G (1989) Carbonic anhydrase in the normal rat stomach and duodenum and after treatment with omeprazole and ranitidine. Acta Physiol Scand 136:253-262.
15. Supuran CT (2008) Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 7:168-181.
16. Bloom SR, et al. (1978) Release of VIP, secretin and motilin after duodenal acidification in man. Acta Hepatogastroenterol (Stuttg) 25:365-368.
17. 2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer. Gastroenterology 99:951-955.
18. Ilies MA, Supuran CT, Scozzafava A (2000) Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances. Met Based Drugs 7:57-62.
19. - secretion. Am J Physiol Gastrointest Liver Physiol 272:G872-G878.
20. - secretion. Gastroenterology 130:349-358.
21. 2-mediated murine duodenal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 293:G279-G287.
22. - secretion. Acta Physiol (Oxf): 193:357-365.
23. Flemström G, Kivilaakso E (1983) Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 84:787-794.
24. Kaunitz JD, Akiba Y (2006) Duodenal carbonic anhydrase: Mucosal protection, luminal chemosensing, and gastric acid disposal. Keio J Med 55:96-106.
25. 2. Am J Physiol Gastrointest Liver Physiol 288:G557-563.
26. Akiba Y, et al. (2001) Acute adaptive cellular base uptake in rat duodenal epithelium. Am J Physiol Gastrointest Liver Physiol 280:G1083-G1092.
27. Akiba Y, et al. (2001) Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury. J Clin Invest 108:1807-1816.
28. Hirokawa M, et al. (2004) Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum. Gastroenterology 127:1162-1173.
29. +-lactate cotransport via monocarboxylate transporter 1. J Biol Chem 283:21655-21667.
30. - exchange in rabbit, rat, and human duodenum. Gastroenterology 122:709-724.
31. 2. Proc Natl Acad Sci USA 102:15247-15252.
32. Taylor-Clark TE, et al. (2008) Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 73:274-281.
33. - response. Dig Dis Sci 48:1850-1856.
34. Takeuchi K, Matsumoto J, Ueshima K, Okabe S (1991) Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Gastroenterology 101:954-961.
35. Iturriaga R, Lahiri S, Mokashi A (1991) Carbonic anhydrase and chemoreception in the cat carotid body. Am J Physiol 261:C565-C573.
36. Chesler M (2003) Regulation and modulation of pH in the brain. Physiol Rev 83:1183-1221.
37. Lewis SE, Erickson RP, Barnett LB, Venta PJ, Tashian RE (1988) N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: An animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci USA 85:1962-1966.
38. Spicer SS, Lewis SE, Tashian RE, Schulte BA (1989) Mice carrying a CAR-2 null allele lack carbonic anhydrase II immunohistochemically and show vascular calcification. Am J Pathol 134:947-954.
39. Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol 571:319-327.
40. 2-stimulated duodenal bicarbonate secretion in mice. Am J Physiol Gastrointest Liver Physiol 292:G899-904.
41. Tuo B, et al. (2009) Helicobacter pylori vacuolating cytotoxin inhibits duodenal bicarbonate secretion by a histamine-dependent mechanism in mice. J Infect Dis 199:505-512.
42. Chu S, Brownell WE, Montrose MH (1995) Quantitative confocal imaging along the crypt-to-surface axis of colonic crypts. Am J Physiol 269:C1557-C1564.