A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia

Biochemical and Biophysical Research Communications

Volumn 390, Issue 4, 2009, Pages 1136-1141

  Geng, Qing ^a   Romero, Jacqueline ^a   Saini, Vikas ^a   Baker, Todd A ^a   Picken, Maria M ^a   Gamelli, Richard L ^a   Majetschak, Matthias ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

ATP; Heart; Hypothermia; Injury; Ischemia; Proteasome

Indexed keywords

26S PROTEASOME; ADENOSINE TRIPHOSPHATE; EPOXOMICIN; HEART MUSCLE EXTRACT; PEPTIDASE; PROTEASOME; UNCLASSIFIED DRUG; UNIVERSITY OF WISCONSIN SOLUTION;

ANIMAL TISSUE; ARTICLE; CELL DESTRUCTION; CELL ULTRASTRUCTURE; COLD ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART; HEART EDEMA; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ALLOPURINOL; ANIMALS; COLD ISCHEMIA; ENZYME ACTIVATION; GLUTATHIONE; HEART; HUMANS; INSULIN; MALE; MYOCARDIUM; OLIGOPEPTIDES; ORGAN PRESERVATION SOLUTIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; RAFFINOSE; RATS; RATS, INBRED LEW;

RATTUS;

EID: 70450162150     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.067     Document Type: Article

References (25)

1. Hicks M., Hing A., Gao L., Ryan J., and Macdonald P.S. Organ preservation. Methods Mol. Biol. 333 (2006) 331-374
2. Willis M.S., and Patterson C. Into the heart: the emerging role of the ubiquitin-proteasome system. J. Mol. Cell. Cardiol. 41 (2006) 567-579
3. Yu X., Patterson E., and Kem D.C. Targeting proteasomes for cardioprotection. Curr. Opin. Pharmacol. 9 (2009) 167-172
4. Majetschak M., Patel M.B., Sorell L.T., Liotta C., Li S., and Pham S.M. Cardiac proteasome dysfunction during cold ischemic storage and reperfusion in a murine heart transplantation model. Biochem. Biophys. Res. Commun. 365 (2008) 882-888
5. Bulteau A.L., Lundberg K.C., Humphries K.M., Sadek H.A., Szweda P.A., Friguet B., and Szweda L.I. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. J. Biol. Chem. 276 (2001) 30057-30063
6. Powell S.R., Wang P., Katzeff H., Shringarpure R., Teoh C., Khaliulin I., Das D.K., Davies K.J., and Schwalb H. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid. Redox. Signal. 7 (2005) 538-546
7. Das S., Powell S.R., Wang P., Divald A., Nesaretnam K., Tosaki A., Cordis G.A., Maulik N., and Das D.K. Cardioprotection with palm tocotrienol: antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H361-H367
8. Eytan E., Armon T., Heller H., Beck S., and Hershko A. Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex. J. Biol. Chem. 268 (1993) 4668-4674
9. Babbitt S.E., Kiss A., Deffenbaugh A.E., Chang Y.H., Bailly E., Erdjument-Bromage H., Tempst P., Buranda T., Sklar L.A., Baumler J., Gogol E., and Skowyra D. ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell 121 (2005) 553-565
10. Liu C.W., Li X., Thompson D., Wooding K., Chang T.L., Tang Z., Yu H., Thomas P.J., and DeMartino G.N. ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol. Cell 24 (2006) 39-50
11. Majetschak M., and Sorell L.T. Immunological methods to quantify and characterize proteasome complexes: development and application. J. Immunol. Methods 334 (2008) 91-103
12. Garcia-Covarrubias L., Manning III E.W., Sorell L.T., Pham S.M., and Majetschak M. Ubiquitin enhances the Th2 cytokine response and attenuates ischemia-reperfusion injury in the lung. Crit. Care Med. 36 (2008) 979-982
13. Meng L., Mohan R., Kwok B.H., Elofsson M., Sin N., and Crews C.M. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc. Natl. Acad. Sci. USA 96 (1999) 10403-10408
14. Beer M., Seyfarth T., Sandstede J., Landschutz W., Lipke C., Kostler H., von Kienlin M., Harre K., Hahn D., and Neubauer S. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J. Am. Coll. Cardiol. 40 (2002) 1267-1274
15. Powell S.R., Davies K.J., and Divald A. Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J. Mol. Cell. Cardiol. 42 (2007) 265-269
16. Campbell B., Adams J., Shin Y.K., and Lefer A.M. Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart. J. Mol. Cell. Cardiol. 31 (1999) 467-476
17. Pye J., Ardeshirpour F., McCain A., Bellinger D.A., Merricks E., Adams J., Elliott P.J., Pien C., Fischer T.H., Baldwin Jr. A.S., and Nichols T.C. Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H919-H926
18. Giguere C.J., and Schnellmann R.G. Limitations of SLLVY-AMC in calpain and proteasome measurements. Biochem. Biophys. Res. Commun. 371 (2008) 578-581
19. Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 78 (2009) 477-513
20. Dahlmann B., Kuehn L., and Reinauer H. Studies on the activation by ATP of the 26 S proteasome complex from rat skeletal muscle. Biochem. J. 309 Pt. 1 (1995) 195-202
21. Depraetere V. Getting activated with poly-ubiquitination. Nat. Cell. Biol. 3 (2001) E181
22. Haas A.L., and Bright P.M. The dynamics of ubiquitin pools within cultured human lung fibroblasts. J. Biol. Chem. 262 (1987) 345-351
23. Patel M.B., and Majetschak M. Distribution and interrelationship of ubiquitin proteasome pathway component activities and ubiquitin pools in various porcine tissues. Physiol. Res. 56 (2007) 341-350
24. Kisselev A.F., and Goldberg A.L. Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 8 (2001) 739-758
25. A. Kloss, S. Meiners, A. Ludwig, B. Dahlmann, Multiple cardiac proteasome subtypes differ in their susceptibility to proteasome inhibitors, Cardiovasc. Res. (2009) [Epub ahead of print].