Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation

Journal of Surgical Research

Volumn 175, Issue 1, 2012, Pages 149-156

  Tolboom, Herman ^a   Izamis, Maria Louisa ^a   Sharma, Nripen ^a   Milwid, Jack M ^a   Uygun, Basak ^a   Berthiaume, François ^a   Uygun, Korkut ^a   Yarmush, Martin L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

liver transplantation; reperfusion injury; sub normothermic machine perfusion

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; COLD ISCHEMIA; CONTROLLED STUDY; CRYOPRESERVATION; IN VITRO SELECTION; LIVER PERFUSION; LIVER PRESERVATION; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SURVIVAL; TEMPERATURE; TREATMENT OUTCOME;

ANIMALS; COLD TEMPERATURE; DISEASE MODELS, ANIMAL; ISCHEMIA; LIVER; LIVER TRANSPLANTATION; MALE; ORGAN PRESERVATION; PERFUSION; RATS; RATS, INBRED LEW; WARM ISCHEMIA;

EID: 84860321534     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.03.003     Document Type: Article

References (38)

1. A.M. Miniño, M.P. Heron, and S.L. Murphy Deaths: Final data for 2004 Natl Vital Stat Rep 55 2007 1
2. S. Reddy, M. Zilvetti, and J. Brockmann Liver transplantation from non-heart-beating donors: Current status and future prospects Liver Transplantation 10 2004 1223
3. S.D. St Peter, C.J. Imber, and I. Lopez Extended preservation of non-heart-beating donor livers with normothermic machine perfusion Br J Surg 89 2002 609
4. M.R. Schön, G. Puhl, J. Frank, and P. Neuhaus Hemodialysis improves results of pig-liver perfusion after warm ischemic-injury Transplantation Proc 25 1993 3239
5. M.R. Schon, K. Otto, and W. Stephen Liver transplantation after organ preservation with normothermic extracorporeal perfusion Ann Surg 233 2001 114
6. C.Y. Lee, J.X. Zhang, and J.W. Jones Jr. Functional recovery of preserved livers following warm ischemia: Improvement by machine perfusion preservation Transplantation 74 2002 944
7. M. Bessems, B.M. Doorschodt, and J.L.P. Kolkert Preservation of steatotic livers: A comparison between cold storage and machine perfusion preservation Liver Transplantation 13 2007 497
8. H. Xu, C.Y. Lee, and M.G. Clemens Pronlonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers Transplantation 77 2004 1676
9. K. Uygun, H. Tolboom, and M. Izamis Diluted blood reperfusion as a model for transplantation of ischemic rat livers: Alanine aminotransferase is a direct indicator of viability Transplantation Proc 42 2010 2463
10. L. Delriviere, P. Gibbs, and E. Kobayashi Detailed modified technique for safer harvesting and preparation of liver graft in the rat Microsurgery 17 1996 690
11. H. Tolboom, R. Pouw, and K. Uygun A model for normothermic preservation of the rat liver Tissue Eng 13 2007 2143
12. B.H. Heijnen, S.Q. van Veen, and I.H. Straatsburg Pronounced effect of minor changes in body temperature on ischemia and reperfusion injury in rat liver J Appl Physiol 91 2001 265
13. P. Dutkowski, K. Furrer, and Y. Tian Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor Ann Surg 244 2006 968
14. L. Delriviere, P. Gibbs, and E. Kobayashi Technical details for safer venous and biliary anastomoses for liver transplantation in the rat Microsurgery 18 1998 12
15. N. Kamada, and R.Y. Calne Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage Transplantation 28 1979 47
16. T. Vogel, J.G. Brockmann, and P.J. Friend Ex vivo normothermic liver perfusion: An update Curr Opin Organ Transplant 15 2010 167
17. D. Monbaliu, and J. Brassil Machine perfusion of the liver: Past, present and future Curr Opin Organ Transplant 15 2010 160
18. K. Vekemans, Q. Liu, and J. Pirenne Artificial circulation of the liver: Machine perfusion as a preservation method in liver transplantation Anat Rec 291 2008 735
19. M.H. Maathuis, H.G. Leuvenink, and R.J. Ploeg Perspectives in organ preservation Transplantation 83 2007 1289
20. R.W. Jamieson, and P.J. Friend Organ reperfusion and preservation Front Biosci 13 2008 221
21. C.Y. Lee, S. Jain, and H.M. Duncan Survival transplantation of preserved non-heart-beating donor rat livers: Preservation by hypothermic machine perfusion Transplantation 76 2003 1432
22. H. Tolboom, R. Pouw, and M. Izamis Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion Transplantation 87 2009 170
23. J. Brockmann, S. Reddy, and C. Coussios Normothermic perfusion: A new paradigm for organ preservation Ann Surg 250 2009 1
24. O. de Rougemont, S. Breitenstein, and B. Leskoek One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death Ann Surg 250 2009 674
25. M. Vairetti, A. Ferrigno, and F. Carlucci Subnormothermic machine perfusion protects steatotic livers against preservation injury: A potential for donor pool increase? Liver Transplantation 15 2009 20
26. D. Nagrath, H. Xu, and Y. Tanimura Metabolic preconditioning of donor organs: Defatting fatty livers by normothermic perfusion ex vivo Metab Eng 22 2009 274
27. J.V. Guarrera, S.D. Henry, and S.W. Chen Hypothermic machine preservation attenuates ischemia/reperfusion markers after liver transplantation: Preliminary results J Surg Res 2010 Epub ahead of print
28. J.V. Guarrera, J. Estevez, and R. Boykin Hypothermic machine perfusion of liver grafts for transplantation: Technical development in human discard and miniature swine models Transplantation Proc 37 2005 323
29. 2 consumption, enzyme release, energy store, and morphology Nippon Geka Hokan 62 1993 58
30. M. Vairetti, A. Ferrigno, and V. Rizzo Correlation between the liver temperature employed during machine perfusion and reperfusion damage: Role of Ca2+ Liver Transplantation 14 2008 494
31. H. Xu, C.Y. Lee, and M.G. Clemens Prolonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers Tranplantation 77 2004 1676
32. P. Olschewski, P. Gass, and V. Aiyakhagorn The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers Cryobiology 60 2010 337
33. M.L. Izamis, K. Uygun, and F. Berthiaume In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury Biotechnol Bioeng 2010
34. A.J. Vardanian, R.W. Busuttil, and J.W. Kupiec-Weglinski Molecular mediators of liver ischemia and reperfusion injury: A brief review Mol Med 14 2007 337
35. H.K. Eltzschig, and C.D. Collard Vascular ischaemia and reperfusion injury Br Med Bulletin 70 2004 71
36. H. Jaeschke Mechanisms of liver injury. II Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions Am J Physiol Gastrointest Liver Physiol 290 2006 1083
37. H. Imamura, B. Rocheleau, and J. Cote Long-term consequence of rat orthotopic liver transplantation with and without hepatic arterial reconstruction: A clinical, pathological, and hemodynamic study Hepatology 26 1997 198
38. J. Brockmann, S. Reddy, and C. Coussios Normothermic perfusion: A new paradigm for organ preservation Ann Surg 250 2009 1