Hypothermic machine preservation reduces molecular markers of ischemia/reperfusion injury in human liver transplantation

American Journal of Transplantation

Volumn 12, Issue 9, 2012, Pages 2477-2486

  Henry, S D ^a   Nachber, E ^a   Tulipan, J ^a   Stone, J ^a   Bae, C ^a   Reznik, L ^a   Kato, T ^a   Samstein, B ^a   Emond, J C ^a   Guarrera, J V ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cytokines; hypothermic machine perfusion; ischemia reperfusion injury; liver transplantation; machine preservation; molecular; organ preservation; RT PCR

Indexed keywords

ACUTE PHASE PROTEIN; CD68 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; MOLECULAR MARKER;

APOPTOSIS; ARTICLE; CRYOPRESERVATION; GRAFT PRESERVATION; HUMAN; HUMAN TISSUE; HYPOTHERMIC MACHINE PRESERVATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LEUKOCYTE MIGRATION; LIVER; LIVER BIOPSY; LIVER TRANSPLANTATION; MACROPHAGE; NEUTROPHIL; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

ADULT; BIOLOGICAL MARKERS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPOTHERMIA, INDUCED; LIVER TRANSPLANTATION; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; OXIDATIVE STRESS; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84865590698     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04086.x     Document Type: Article

References (29)

1. Ploeg RJ, D'Alessandro AM, Knechtle SJ, et al,. Risk factors for primary dysfunction after liver transplantation-a multivariate analysis. Transplantation 1993; 55: 807-813. (Pubitemid 23122053)
2. Moers C, Smits JM, Maathuis MH, et al,. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360: 7-19.
3. Guarrera JV, Henry SD, Samstein B, et al,. Hypothermic machine preservation in human liver transplantation: The first clinical series. Am J Transplant 2010; 10: 372-381.
4. Clavien PA, Harvey PR, Strasberg SM,. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 1992; 53: 957-978.
5. Guarrera JV, Henry SD, Chen SW, et al,. Hypothermic machine preservation attenuates ischemia/reperfusion markers after liver transplantation: Preliminary results. J Surg Res 2011; 167: e365-e373.
6. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408. (Pubitemid 34164012)
7. Dutkowski P, Odermatt B, Heinrich T, et al,. Hypothermic oscillating liver perfusion stimulates ATP synthesis prior to transplantation. J Surg Res 1998; 80: 365-372. (Pubitemid 29019695)
8. St Peter SD, Imber CJ, Friend PJ,. Liver and kidney preservation by perfusion. Lancet 2002; 359: 604-613. (Pubitemid 34178447)
9. Gerlach J, Jorres A, Nohr R, Zeilinger K, Spatkowski G, Neuhaus P., Local liberation of cytokines during liver preservation. Transpl Int 1999; 12: 261-265. (Pubitemid 29423664)
10. Ohkohchi N., Mechanisms of preservation and ischemic/reperfusion injury in liver transplantation. Transplant Proc 2002; 34: 2670-2673. (Pubitemid 35304878)
11. Barber WH, Deierhoi MH, Phillips MG, Diethelm AG,. Preservation by pulsatile perfusion improves early renal allograft function. Transplant Proc 1988; 20: 865-868. (Pubitemid 18261329)
12. Sellers MT, Gallichio MH, Hudson SL, et al,. Improved outcomes in cadaveric renal allografts with pulsatile preservation. Clin Transplant 2000; 14: 543-549.
13. Tesi RJ, Elkhammas EA, Davies EA, Henry ML, Ferguson RM,. Pulsatile kidney perfusion for evaluation of high-risk kidney donors safely expands the donor pool. Clin Transplant 1994; 8 (2 Pt 1): 134-138. (Pubitemid 24105405)
14. Matsuoka L, Shah T, Aswad S, et al,. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation. Am J Transplant 2006; 6: 1473-1478. (Pubitemid 44030332)
15. Maheshwari A, Maley W, Li Z, Thuluvath PJ,. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl 2007; 13: 1645-1653.
16. Tulipan JE, Stone J, Samstein B, et al,. Molecular expression of acute phase mediators is attenuated by machine preservation in human liver transplantation: Preliminary analysis of effluent, serum, and liver biopsies. Surgery 2011; 150: 352-360.
17. Fujita S, Hamamoto I, Nakamura K, Tanaka K, Ozawa K., Evaluation of oxygen necessity during hypothermic liver perfusion. Nippon Geka Hokan 1993; 62: 228-240. (Pubitemid 24196150)
18. Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA,. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg 2006; 244: 968-976; discussion 76-7. (Pubitemid 44808636)
19. Fondevila C., Is extracorporeal support becoming the new standard for the preservation of DCD grafts? Am J Transplant 2010; 10: 1341-1342.
20. Ajamieh H, Merino N, Candelario-Jalil E, et al,. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacol Res 2002; 45: 333-339. (Pubitemid 35430529)
21. Galaris D, Barbouti A, Korantzopoulos P., Oxidative stress in hepatic ischemia-reperfusion injury: The role of antioxidants and iron chelating compounds. Curr Pharm Des 2006; 12: 2875-2890. (Pubitemid 44184622)
22. Gedik E, Girgin S, Ozturk H, Obay BD, Buyukbayram H., Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats. World J Gastroenterol 2008; 14: 7101-7106.
23. Llacuna L, Mari M, Lluis JM, Garcia-Ruiz C, Fernandez-Checa JC, Morales A., Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am J Pathol 2009; 174: 1776-1785.
24. Teoh NC, Farrell GC,. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003; 18: 891-902. (Pubitemid 37056167)
25. Montalvo-Jave EE, Escalante-Tattersfield T, Ortega-Salgado JA, Piña E, Geller DA,. Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res [doi: 10.1016/j.jss.2007.06.015]. 2008; 147: 153-159. (Pubitemid 351626076)
26. Ashany D, Song X, Lacy E, Nikolic-Zugic J, Friedman SM, Elkon KB,. Th1 CD4 +lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway. Proc Natl Acad Sci U S A. 1995; 92: 11225-11229.
27. Weller M, Frei K, Groscurth P, Krammer PH, Yonekawa Y, Fontana A., Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J Clin Invest 1994; 94: 954-964.
28. Richardson BC, Lalwani ND, Johnson KJ, Marks RM,. Fas ligation triggers apoptosis in macrophages but not endothelial cells. Eur J Immunol 1994; 24: 2640-2645. (Pubitemid 24342177)
29. Terman A, Brunk UT,. Lipofuscin. Int J Biochem Cell Biol 2004; 36: 1400-1404. (Pubitemid 38625820)